LOCUS       NM_022988               2638 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus Ngg1 interacting factor 3-like 1 (S. pombe) (Nif3l1),
            mRNA.
ACCESSION   NM_022988 XM_006496185
VERSION     NM_022988.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2638)
  AUTHORS   Akiyama,H., Fujisawa,N., Tashiro,Y., Takanabe,N., Sugiyama,A. and
            Tashiro,F.
  TITLE     The role of transcriptional corepressor Nif3l1 in early stage of
            neural differentiation via cooperation with Trip15/CSN2
  JOURNAL   J Biol Chem 278 (12), 10752-10762 (2003)
   PUBMED   12522100
  REMARK    GeneRIF: Nif3l1 participates in neural differentiation of P19 cells
            through cooperation with Trip15/CSN2.
REFERENCE   2  (bases 1 to 2638)
  AUTHORS   Tascou,S., Uedelhoven,J., Dixkens,C., Nayernia,K., Engel,W. and
            Burfeind,P.
  TITLE     Isolation and characterization of a novel human gene, NIF3L1, and
            its mouse ortholog, Nif3l1, highly conserved from bacteria to
            mammals
  JOURNAL   Cytogenet Cell Genet 90 (3-4), 330-336 (2000)
   PUBMED   11124544
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC118698.7, AK158616.1 and
            BC065163.1.
            
            On or before Sep 15, 2016 this sequence version replaced
            XM_006496185.1, NM_022988.2.
            
            Summary: This gene is a member of the NGG1-interacting factor
            3-like superfamily of transcriptional regulators and is
            ubiquitously expressed throughout embryonic development. The
            encoded protein interacts with a component of the constitutive
            photomorphogenesis 9 signalosome, and functions as a
            transcriptional corepressor of genes involved in neuronal
            differentiation. This gene is highly conserved from bacteria to
            human. [provided by RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF284439.1, AK131631.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AC118698.7         11189-11283
            96-1836             AK158616.1         2-1742
            1837-2638           BC065163.1         1360-2161
FEATURES             Location/Qualifiers
     source          1..2638
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 29.1 cM"
     gene            1..2638
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /note="Ngg1 interacting factor 3-like 1 (S. pombe)"
                     /db_xref="GeneID:65102"
                     /db_xref="MGI:MGI:1929485"
     exon            1..484
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            485..940
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             508..1638
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /EC_number="3.5.4.16"
                     /note="Ngg1 interacting factor 3 homolog-like 1; GTP
                     cyclohydrolase I; putative GTP cyclohydrolase 1 type 2
                     Nif3l1"
                     /codon_start=1
                     /product="NIF3-like protein 1"
                     /protein_id="NP_075364.2"
                     /db_xref="CCDS:CCDS14973.1"
                     /db_xref="GeneID:65102"
                     /db_xref="MGI:MGI:1929485"
                     /translation="MLSSAHLVPTSVQRAQSWICRSSRSFMDLKALLSSLNDFASLSF
                     AESWDNVGLLVEPSPPHTVNTLFLTNDLTEEVMDEALQKKADFILSYHPPIFRPMKHI
                     TWKTWKECLVIRALENRVAVYSPHTAYDAAPQGVNSWLAKGLGTCTTRPIHPSRAPDY
                     PTEGAHRLEFSVNRSQDLDKVMSTLRGVGGVSVTSFPARCDGEEQTRISLNCTQKTLM
                     QVLAFLSQDRQLYQKTEILSLEKPLLLHTGMGRLCTLDESVSLAIMIERIKTHLKLSH
                     LRLALGVGRTLESQVKVVALCAGSGGSVLQGVEADLYLTGEMSHHDVLDAASKGINVI
                     LCEHSNTERGFLSELQEMLGVHFENKINIILSETDRDPLRVV"
     exon            941..1103
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1104..1230
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1369
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1453
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..2589
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      1838
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /note="major polyA site"
     regulatory      2570..2575
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2589
                     /gene="Nif3l1"
                     /gene_synonym="1110030G24Rik"
ORIGIN      
        1 gcgctcagca ccactgctgc gggaacggaa aagcctcaac tacaagggcc ggcatgcctg
       61 cgggttccaa aggcgtgtct gtgcgccaca gaagtgaagc ccggagccct ccgcagggga
      121 cgccctactc tcccgtcagt ctctcctcat cacaccgact aggactcgga ggaccacgca
      181 cctcacccct cggcccctga gagctctacc cacaacctca ctaagaagca gaacccgctg
      241 tcgcccagca acttcataca gcggcctgga gtgggaagca gaacgcacag gaccaattcc
      301 gcccaacttc acacagcggc ctggagtcgg aagcagaacg cacaggacaa cttccgccca
      361 acttcacaca gcggcctgga gtcggaagca gaacgcacag gaccacttct gcccaactct
      421 ttccacaaag ccaggagctt cagagcagag cggaagtgat acactgaaag agcttctgcg
      481 actggcaccc ttctccctgg tttccgtatg ctgtcatcgg cacacctagt ccctacaagt
      541 gtgcaacgtg cccagtcgtg gatctgcagg tcttcccgtt ccttcatgga tctgaaggct
      601 cttctctcgt ccttgaatga ctttgcatcc ctctcatttg ctgagagctg ggacaatgtg
      661 ggattactgg tggagccaag cccaccccat actgtaaata cactcttcct gaccaatgac
      721 ctgacggagg aggtcatgga cgaggctctg caaaagaagg cagacttcat tctctcctac
      781 catccaccta ttttccggcc catgaagcac ataacttgga aaacctggaa ggagtgtctc
      841 gtgatccggg ctctggagaa cagagtcgct gtctactctc cccacacagc ctatgatgcg
      901 gcaccccagg gagtcaacag ctggttggcc aaagggcttg gaacttgcac taccaggccc
      961 atccaccctt ccagagctcc agactacccc acagagggag ctcaccgact agaattcagt
     1021 gtgaaccgca gccaagacct ggacaaagtc atgtctacac tgagaggggt tggaggtgtc
     1081 tctgtcactt cttttcctgc caggtgtgat ggtgaagagc aaacccggat cagcctgaat
     1141 tgtactcaga agactttgat gcaggtgcta gcctttcttt cccaggacag acaactttat
     1201 cagaaaactg aaattctttc attggagaag cctttgcttc tgcatactgg aatgggacgg
     1261 ttgtgcacac tggatgaatc tgtctccctg gcaataatga tagagcgaat caaaacacac
     1321 ctaaagctgt cgcatcttcg cttagctctt ggagtgggga gaacattaga gtcccaagtc
     1381 aaagttgtgg ccctgtgtgc tggttctggg ggcagtgttc tacaaggagt ggaggccgac
     1441 ctttacctca caggtgaaat gtcccaccat gatgttctgg atgctgcttc caaagggatc
     1501 aatgtcatcc tttgtgaaca cagcaacact gaaagaggct tcctttctga gcttcaagaa
     1561 atgctgggtg ttcactttga gaataagatt aacattatcc tgtctgagac agacagggac
     1621 cctctccgtg tggtttaaat gcaaggacgt caaggacacc atgatgacag aagccacaga
     1681 tcacctggat tgaaacggct gtgcaggagt tggtgttcca ccctctgcag agctgtattg
     1741 gacttctcat ttcagttcac gactctggct caacaaaagc catagctcat tcggtaaaac
     1801 tgtctgtaaa gagtacatta aaggcaaacc ttctctaatt tttgttttgt ttcttggtgg
     1861 tgcagggatc aaactggaca ctgtttacca ctctagttgg cagcatggac ttgagagtag
     1921 ggcctaaaaa tgaggtgagc tgatgtctca cgcaatagcc aagtttattc agagccatcg
     1981 gacaatttac actctgaggg ctaagagtca actgaataaa ggcacaatca caaggacaag
     2041 cctcatgtag caaaaccatg gtttccatgg aggtgtatga acaataagaa tagccagcca
     2101 actgtaagga atgatctaaa gtcacctcac tcctatctgc ttgctccact ggggaagggc
     2161 acagaagcac atcccaagaa caattttgtg tttttgaaga aactgttttc tcacaaacac
     2221 tcagaagtcc ctcacaggac tggactattc ttggactatg ttctagctct atgaatggaa
     2281 ggcaagtgtt ctaccactga actccaaact cctcctaatt aatggtgtta agtgttcaaa
     2341 atatgactga ttactaccca gcattttctg cagtcactgt acaagccaga cccagaaaga
     2401 aactggggtg cccgggggga aggggtggct ggagagatgg ctcagcagtt aagggcactg
     2461 actgctcttc cataggtcct gagttcaatt cccagcaacc acatgtaatg ggatccaatg
     2521 ccctcttcta gtgtgtgtaa agacagttac aatgtattca catacattaa ataaacctta
     2581 aaaaaaggaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaa
//
