LOCUS       NM_010917               5970 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus nidogen 1 (Nid1), mRNA.
ACCESSION   NM_010917
VERSION     NM_010917.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5970)
  AUTHORS   Elenbaas,J.S., Pudupakkam,U., Ashworth,K.J., Kang,C.J., Patel,V.,
            Santana,K., Jung,I.H., Lee,P.C., Burks,K.H., Amrute,J.M.,
            Mecham,R.P., Halabi,C.M., Alisio,A., Di Paola,J. and Stitziel,N.O.
  TITLE     SVEP1 is an endogenous ligand for the orphan receptor PEAR1
  JOURNAL   Nat Commun 14 (1), 850 (2023)
   PUBMED   36792666
  REMARK    Erratum:[Nat Commun. 2023 Mar 17;14(1):1511. doi:
            10.1038/s41467-023-37005-x.. PMID: 36932061]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5970)
  AUTHORS   Kumar,S., Fan,X., Rasouly,H.M., Sharma,R., Salant,D.J. and Lu,W.
  TITLE     ZEB2 controls kidney stromal progenitor differentiation and
            inhibits abnormal myofibroblast expansion and kidney fibrosis
  JOURNAL   JCI Insight 8 (1), e158418 (2023)
   PUBMED   36445780
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5970)
  AUTHORS   Ma,Y.B., Qiao,J.W. and Hu,X.
  TITLE     Transmembrane serine protease 2 cleaves nidogen 1 and inhibits
            extrahepatic liver cancer cell migration and invasion
  JOURNAL   Exp Biol Med (Maywood) 248 (2), 91-105 (2023)
   PUBMED   36408877
  REMARK    GeneRIF: Transmembrane serine protease 2 cleaves nidogen 1 and
            inhibits extrahepatic liver cancer cell migration and invasion.
REFERENCE   4  (bases 1 to 5970)
  AUTHORS   Janardhan,H.P., Dresser,K., Hutchinson,L. and Trivedi,C.M.
  TITLE     Pathological MAPK activation-mediated lymphatic basement membrane
            disruption causes lymphangiectasia that is treatable with
            ravoxertinib
  JOURNAL   JCI Insight 7 (17), e153033 (2022)
   PUBMED   36073544
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5970)
  AUTHORS   Perez-Diaz,S., Koumaiha,Z., Borok,M.J., Aurade,F., Pini,M.,
            Periou,B., Rouault,C., Baba-Amer,Y., Clement,K., Derumeaux,G.,
            Authier,F.J., Lafuste,P. and Relaix,F.
  TITLE     Obesity impairs skeletal muscle repair through NID-1 mediated
            extracellular matrix remodeling by mesenchymal progenitors
  JOURNAL   Matrix Biol 112, 90-115 (2022)
   PUBMED   35963565
  REMARK    GeneRIF: Obesity impairs skeletal muscle repair through NID-1
            mediated extracellular matrix remodeling by mesenchymal
            progenitors.
REFERENCE   6  (bases 1 to 5970)
  AUTHORS   Dong,L.J. and Chung,A.E.
  TITLE     The expression of the genes for entactin, laminin A, laminin B1 and
            laminin B2 in murine lens morphogenesis and eye development
  JOURNAL   Differentiation 48 (3), 157-172 (1991)
   PUBMED   1725162
REFERENCE   7  (bases 1 to 5970)
  AUTHORS   Aeschlimann,D. and Paulsson,M.
  TITLE     Cross-linking of laminin-nidogen complexes by tissue
            transglutaminase. A novel mechanism for basement membrane
            stabilization
  JOURNAL   J Biol Chem 266 (23), 15308-15317 (1991)
   PUBMED   1678389
REFERENCE   8  (bases 1 to 5970)
  AUTHORS   Jenkins,N.A., Justice,M.J., Gilbert,D.J., Chu,M.L. and
            Copeland,N.G.
  TITLE     Nidogen/entactin (Nid) maps to the proximal end of mouse chromosome
            13 linked to beige (bg) and identifies a new region of homology
            between mouse and human chromosomes
  JOURNAL   Genomics 9 (2), 401-403 (1991)
   PUBMED   1672300
REFERENCE   9  (bases 1 to 5970)
  AUTHORS   Chung,A.E. and Durkin,M.E.
  TITLE     Entactin: structure and function
  JOURNAL   Am J Respir Cell Mol Biol 3 (4), 275-282 (1990)
   PUBMED   2119632
  REMARK    Review article
REFERENCE   10 (bases 1 to 5970)
  AUTHORS   Mann,K., Deutzmann,R., Aumailley,M., Timpl,R., Raimondi,L.,
            Yamada,Y., Pan,T.C., Conway,D. and Chu,M.L.
  TITLE     Amino acid sequence of mouse nidogen, a multidomain basement
            membrane protein with binding activity for laminin, collagen IV and
            cells
  JOURNAL   EMBO J 8 (1), 65-72 (1989)
   PUBMED   2496973
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122465.4 and CT010431.7.
            
            On Dec 20, 2021 this sequence version replaced NM_010917.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X14194.1, AK166779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-260               AC122465.4         66203-66462         c
            261-560             AC122465.4         40108-40407         c
            561-787             AC122465.4         38593-38819         c
            788-1164            AC122465.4         35522-35898         c
            1165-1314           AC122465.4         31200-31349         c
            1315-1566           AC122465.4         27719-27970         c
            1567-1767           AC122465.4         25791-25991         c
            1768-2013           AC122465.4         21866-22111         c
            2014-2157           AC122465.4         20336-20479         c
            2158-2283           AC122465.4         17365-17490         c
            2284-2433           AC122465.4         14974-15123         c
            2434-2556           AC122465.4         13962-14084         c
            2557-2784           AC122465.4         4343-4570           c
            2785-2957           AC122465.4         3511-3683           c
            2958-3084           AC122465.4         1604-1730           c
            3085-3256           CT010431.7         36712-36883
            3257-3414           CT010431.7         37986-38143
            3415-3538           CT010431.7         39094-39217
            3539-3651           CT010431.7         39809-39921
            3652-5970           CT010431.7         40322-42640
FEATURES             Location/Qualifiers
     source          1..5970
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.26 cM"
     gene            1..5970
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /note="nidogen 1"
                     /db_xref="GeneID:18073"
                     /db_xref="MGI:MGI:97342"
     exon            1..260
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            261..560
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..787
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            788..1164
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1165..1314
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1566
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1567..1767
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1768..2013
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2014..2157
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2283
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2284..2433
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2556
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2557..2784
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2785..2957
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3084
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3085..3256
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3257..3414
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3415..3538
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3539..3651
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3652..5970
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5940..5945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /note="hexamer: AATAAT"
     polyA_site      5950
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
     regulatory      5964..5969
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /note="hexamer: AATAAA"
     polyA_site      5970
                     /gene="Nid1"
                     /gene_synonym="A630025O17; entactin; entactin-1; Nid;
                     nidogen-1"
                     /note="major polyA site"
ORIGIN      
        1 aaaccgccgg gattgtggga ccacagttgg gaaacatgct ggacgcgagc ggctgtagtt
       61 gggcgatgtg gacgtgggcg ctgttgcagc tgctgctact agtggggccc ggaggctgcc
      121 tgaatcgcca ggagctcttc cccttcggcc ctgggcaggg ggacctagag ctggaggccg
      181 gggacgacgt ggtatccccc tccctggaac tgatcggaga actgagcttc tatgatcgta
      241 cggacatcac gtcggtctat gtcaccacaa atggtatcat cgccatgagc gaacccccag
      301 ccacagaata ccatcccgga accttcccac ccagcttcgg ctcagtagcg cctttcctgg
      361 ctgacttgga cacaaccgat ggcctgggga atgtgtatta tcgagaagac ttatccccgt
      421 tcattattca gatggcagca gagtatgtcc agagaggctt cccggaggtc tctttccagc
      481 ccactagtgt ggtggttgtc acttgggaat ctgtggcccc ttatggaggg cccagcagca
      541 gccctgccga ggaaggcaag agaaacacgt tccaggctgt tctggcctcc tcaaattcca
      601 gctcctatgc cattttcctt tatcctgaag atggtctaca gttctttaca acattctcga
      661 agaaggatga aagccaagta cctgctgtgg ttggtttcag caaaggtcta gtaggatttc
      721 tatggaagag caacggagcc tataacatat ttgccaatga cagagaatca attgaaaatt
      781 tggctaagag cagcaacgct gggcaccagg gtgtgtgggt gtttgagatt ggaagtcctg
      841 ctaccgccaa gggcgtggtg tctgcagatg tgaacctgga cctggacgac gatggagcag
      901 actatgaaga tgaagattat gacctagtaa cctctcacct tggcctggag gatgtagcca
      961 ctccctcccc ctcccacagt ccaagaaggg gataccctga cccacacaat gtacctagga
     1021 tcctctctcc tggctatgag gctacagaga gaccccgtgg agtccccact gagaggacca
     1081 gatctttcca gctgccagcg gagaggttcc ctcagcatca cccccaggtc attgatgtgg
     1141 atgaagtaga ggaaacagga gttgtattca gctacaacac aggttcccag cagacttgtg
     1201 ccaacaatag acaccagtgc tccgtgcatg cagagtgcag agactatgct actggcttct
     1261 gctgcaggtg tgtggccaac tacacaggca atggcagaca gtgcgtggca gaaggctctc
     1321 cacaacgggt caatggcaag gtgaagggaa ggatcttcgt ggggagcagc caggtccccg
     1381 tggtgtttga gaacactgac ctgcactcct atgtggtgat gaaccacggg cgctcttaca
     1441 cagccatcag caccatccct gaaaccgtcg gctactctct gctccccctg gcacccattg
     1501 gaggcatcat cggatggatg tttgcagtgg agcaggatgg gttcaagaat gggtttagca
     1561 tcactggggg cgagtttacc cggcaagctg aggtgacctt cctggggcac ccaggcaagc
     1621 tggtcctgaa gcagcagttc agcggtattg atgaacatgg acacctgacc atcagcacgg
     1681 agctggaggg ccgcgtgccg cagatcccct atggagcctc ggtgcacatt gagccctaca
     1741 ccgaactgta ccactactcc agctcagtga tcacttcctc ctccacccgg gagtacacgg
     1801 tgatggagcc tgatcaggac ggcgctgcac cctcacacac ccatatttac cagtggcgtc
     1861 agaccatcac cttccaggag tgtgcccacg atgacgccag gccagccctg cccagcaccc
     1921 agcagctctc tgtggacagc gtgtttgtcc tgtacaacaa ggaggagagg atcttgcgct
     1981 atgccctcag caactccatc gggcctgtga gggatggctc ccctgatgcc cttcagaatc
     2041 catgctacat tggcacccat gggtgtgaca gcaatgctgc ctgtcgccct ggccctggaa
     2101 cacagttcac ctgcgaatgc tccatcggct tccgaggaga cgggcagact tgctatgata
     2161 ttgatgagtg ttcagagcag ccttcccgct gtgggaacca tgcggtctgc aacaacctcc
     2221 caggaacctt ccgctgcgag tgtgtagagg gctaccactt ctcagacagg ggaacatgtg
     2281 tggctgccga ggaccaacgt cccatcaact actgtgaaac tggtctccac aactgtgata
     2341 tcccccagcg agcccagtgc atctatatgg gtggttcctc ctacacctgc tcctgtctgc
     2401 ctggcttctc tggggatggc agagcctgcc gagacgtgga tgaatgccag cacagccgat
     2461 gtcaccccga tgccttctgc tacaacacac caggctcttt cacatgtcag tgcaagcctg
     2521 gctatcaggg ggatggcttc cgatgcatgc ccggagaggt gagcaaaacc cggtgtcaac
     2581 tggaacgaga gcacatcctt ggagcagccg gcggggcaga tgcacagcgg cccaccctgc
     2641 aggggatgtt tgtacctcag tgtgatgaat atggacacta tgtacccacc cagtgtcacc
     2701 acagcactgg ctactgctgg tgtgtggacc gagatggtcg ggagctggag ggtagccgta
     2761 ccccacctgg gatgaggccc ccgtgtctga gtacagtggc tcctcctatt caccagggac
     2821 cagtagtacc tacagctgtc atccccctgc ctccagggac acacttactc tttgctcaga
     2881 ctggaaagat tgaacgcctg cccctggaga gaaacaccat gaagaagaca gaagccaagg
     2941 cctttctcca tatccctgca aaagtcatca ttggactggc ctttgactgc gtggacaagg
     3001 tggtttactg gacagacatc agcgagcctt ccattgggag agccagcctc cacggtggag
     3061 agccaaccac catcattcga caagatcttg gaagccctga aggcattgcc cttgaccatc
     3121 ttggtcgaac catcttctgg acggactctc agttggatcg aatagaagtt gcaaagatgg
     3181 atggcaccca gcgccgagtg ctgtttgaca cgggtttggt gaatcccaga ggcattgtga
     3241 cagaccccgt aagagggaac ctttattgga cagattggaa cagagacaat cccaaaattg
     3301 agacttctca catggatggc accaaccgga ggattctcgc acaggacaac ctgggcttgc
     3361 ccaatggtct gacctttgat gcattctcat ctcagctttg ctgggtggat gcaggcaccc
     3421 atagggcaga atgcctgaac ccagctcagc ccggcagacg caaagttctc gaagggctcc
     3481 agtatccttt cgctgtgact agctatggga agaatttgta ctacacagac tggaagacga
     3541 attcagtgat tgccatggac cttgctatat ccaaagagat ggataccttc cacccacaca
     3601 agcagacccg gctatatggc atcaccatcg ccctgtccca gtgtccccaa ggccacaatt
     3661 actgctcagt gaataatggt ggatgtaccc acctctgctt gcccactcca gggagcagga
     3721 cctgccgatg tcctgacaac accctgggag ttgactgcat tgaacggaaa tgatgtcaag
     3781 aattccttgt tccctctcca agtatttcat agtaacactc tacttgaagt gacttgatcc
     3841 agactgaaaa gtgtcctgca gtggaatgac caccaggccc agatctagcc tagcctgagc
     3901 tctcacaacc tctccttaac cttccctaga acaattacct ttagctcagt aatgggaaaa
     3961 tctctaccct aacatgaggg caggacacac acacacacac acacaccctt tgatctcagt
     4021 ctttagacaa gtttataaag ttctggataa aaagccaagg gtagtggtac atgcctgcaa
     4081 ccctagcact tgggaggcag aggcaggaga atcaggagtt caaggccaat tatcttgtct
     4141 gtatagcagg gtttagaaat aacccgagtt acgtgagtcc cttccaaaaa aaaaatcagg
     4201 ataaaaatta tgtgtccatt ctagagccat aggacttctt cctaattcta gactctccca
     4261 tggtaagcag agccttagcg acctaaggag gctacttctt ggtggcatta caaactcaga
     4321 tattacccag tttctcaaca taccacccag atccagctta ggcaaggtca tactttttct
     4381 cttggttatg ctcccatcta actactctcc tgttgtatac cttcattctg cccaagactg
     4441 ctttcagtgc cttctctgcc atatgatcaa aacccaacca tattccaggg attcatggta
     4501 tttggtagat ggtaaaaagc aacccctccc aaattacaaa gtcctggcat ttcagcagtg
     4561 gccattgata atcacatagg taagtcaagg aaaagtcctg agagagggat ttgaagtcaa
     4621 gatgtttgaa gataggagat tattatcttg atgtgtcttg aattgtagca aattcttctt
     4681 ctttgccaaa gtacctgtat tagtttctgg tctatgacgt catgggaatc ttcagcccac
     4741 tcctggtacc agttttcaag tcttctcatg gagagtcatc tggagctcag gttggggtag
     4801 gactttgaca aagtagtgtc cagtcatagt ccctcacctt tagaattgtg tctctgtttc
     4861 tccctctctc tgtggccctt tctgactaga tcctcatctg aagacacaat ctaggaagat
     4921 ctagttgggc atttctagta gtggttcgga tccttatttg atcatcagta tagtttgagg
     4981 gactgttgct gccttccatg tttctgtctg tgatttgttt caaaaatatc cgctggccag
     5041 atgcatagct actctcctgt ctgttttgag gtgtctgtgt tattgattcc attctaggga
     5101 caacagtata aacttagtaa tcatttgttc ttttcttttt aaaaaacaaa acaacccttg
     5161 tcccctctct cttccttcta tctactatta tctatcacct atctctctac ttatctgtca
     5221 tctatctcta tctatctcct gttttccact gcttcctaga cactcaaagg attaataatt
     5281 ttggattgga agtcaagcat cagaagttcg gtttgcatgg tgtaaggtga gggcacagac
     5341 aagactcagg cagaactatt acaagtggtg gataaggatg gagaacaggg atggaaaatc
     5401 ccagaagaaa cagcagtgga gaggcttaaa ggcagctaaa actaaaagcc ttaaacaact
     5461 tcagagaaaa gtggcacatt tgccaaaaga atgtttatcc ttgaagacat aaaagaactt
     5521 ggcctgatgt ttttcttggg gaacagagcc ccctacctcc ttttcttcta ctttcactgt
     5581 actcagcccc caaccctatc tcctacctcc acctcgacct gcttacattg gactgggaat
     5641 ctaaattggg agggagtctt tacttaaata attggaattt aaatcacaaa gtttagggaa
     5701 cgtgtgactc tttcatgcac cctcataaag tacccctagt tttttttgtc atgttcctca
     5761 tgatatatat cttttataac ttttattcat ttttactaga ttccttctaa aatgttttac
     5821 atggtaaatt gttaagctgt ggaaaccact gaaggtgctt attaatggtt ctccagatgt
     5881 atacaagtat tggatgattc ctcaagttta cagctgtaca aatattagtg cagaaaaaaa
     5941 ataattaaaa tacaactgtt aaaaataaaa
//
