LOCUS       NM_001310547             466 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Mus musculus NELL2 interacting cell ontogeny regulator 1 (Nicol1),
            transcript variant 3, mRNA.
ACCESSION   NM_001310547
VERSION     NM_001310547.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 466)
  AUTHORS   Yang,J., Zhuang,H., Li,J., Nunez-Nescolarde,A.B., Luo,N., Chen,H.,
            Li,A., Qu,X., Wang,Q., Fan,J., Bai,X., Ye,Z., Gu,B., Meng,Y.,
            Zhang,X., Wu,D., Sia,Y., Jiang,X., Chen,W., Combes,A.N.,
            Nikolic-Paterson,D.J. and Yu,X.
  TITLE     The secreted micropeptide C4orf48 enhances renal fibrosis via an
            RNA-binding mechanism
  JOURNAL   J Clin Invest 134 (10), e178392 (2024)
   PUBMED   38625739
  REMARK    GeneRIF: The secreted micropeptide C4orf48 enhances renal fibrosis
            via an RNA-binding mechanism.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 466)
  AUTHORS   Kiyozumi,D., Shimada,K., Chalick,M., Emori,C., Kodani,M., Oura,S.,
            Noda,T., Endo,T., Matzuk,M.M., Wreschner,D.H. and Ikawa,M.
  TITLE     A small secreted protein NICOL regulates lumicrine-mediated sperm
            maturation and male fertility
  JOURNAL   Nat Commun 14 (1), 2354 (2023)
   PUBMED   37095084
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163329.6.
            
            On Feb 15, 2022 this sequence version replaced NM_001310547.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA059790.1, CJ236788.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-125               AC163329.6         23236-23360         c
            126-265             AC163329.6         22983-23122         c
            266-354             AC163329.6         22739-22827         c
            355-466             AC163329.6         21870-21981         c
FEATURES             Location/Qualifiers
     source          1..466
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 17.83 cM"
     gene            1..466
                     /gene="Nicol1"
                     /gene_synonym="Gm1673; NICOL"
                     /note="NELL2 interacting cell ontogeny regulator 1"
                     /db_xref="GeneID:381633"
                     /db_xref="MGI:MGI:2686519"
     exon            1..125
                     /gene="Nicol1"
                     /gene_synonym="Gm1673; NICOL"
                     /inference="alignment:Splign:2.1.0"
     exon            126..265
                     /gene="Nicol1"
                     /gene_synonym="Gm1673; NICOL"
                     /inference="alignment:Splign:2.1.0"
     CDS             148..420
                     /gene="Nicol1"
                     /gene_synonym="Gm1673; NICOL"
                     /EC_number="2.3.1.17"
                     /note="neuropeptide-like protein C4orf48 homolog;
                     NELL2-interacting cofactor for lumicrine signaling"
                     /codon_start=1
                     /product="NELL2-interacting cell ontogeny regulator 1
                     precursor"
                     /protein_id="NP_001297476.1"
                     /db_xref="CCDS:CCDS80261.1"
                     /db_xref="GeneID:381633"
                     /db_xref="MGI:MGI:2686519"
                     /translation="MAPALRSLLSPRTLLLLLLSLALLGARAEPATGSAVPAQSRPCV
                     DCHAFEFMQRALQDLRKTAYSLDARTETLLLQAERRALCACWPAGR"
     exon            266..354
                     /gene="Nicol1"
                     /gene_synonym="Gm1673; NICOL"
                     /inference="alignment:Splign:2.1.0"
     exon            355..466
                     /gene="Nicol1"
                     /gene_synonym="Gm1673; NICOL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      449..454
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nicol1"
                     /gene_synonym="Gm1673; NICOL"
                     /note="hexamer: AATAAA"
     polyA_site      466
                     /gene="Nicol1"
                     /gene_synonym="Gm1673; NICOL"
                     /note="major polyA site"
ORIGIN      
        1 cttcccgagt cgcccgcgct gcttgttcgc ggttccttga accgcggtaa gggtggggtg
       61 gtgtccacgg ggcccaaggc agggtgggac tgggctaagc gcacctgagc tcgcgggaca
      121 cgtgaggcgg cctgggctcc ttctgccatg gcccccgcgc tcaggtcctt gctgtcgcca
      181 cggactttac tgctgctgct gctgagcctg gcgctgctgg gcgcccgcgc cgagcccgcc
      241 accgggagcg ctgtccccgc tcagagccgc ccgtgcgtgg attgccacgc atttgaattc
      301 atgcagcgcg cccttcagga cctacggaaa accgcctaca gcctggacgc acggacggag
      361 accctcctgc tgcaggctga gcgccgggct ctgtgtgcct gctggccagc tggacgctga
      421 agatctttgg ccagtgatat tccttgtcaa taaatgcctg ctagca
//
