LOCUS       NM_025449               2119 bp    mRNA    linear   ROD 06-JUN-2024
DEFINITION  Mus musculus nicolin 1 (Nicn1), transcript variant 1, mRNA.
ACCESSION   NM_025449
VERSION     NM_025449.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2119)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2119)
  AUTHORS   Mulligan,M.K., Ponomarev,I., Hitzemann,R.J., Belknap,J.K.,
            Tabakoff,B., Harris,R.A., Crabbe,J.C., Blednov,Y.A., Grahame,N.J.,
            Phillips,T.J., Finn,D.A., Hoffman,P.L., Iyer,V.R., Koob,G.F. and
            Bergeson,S.E.
  TITLE     Toward understanding the genetics of alcohol drinking through
            transcriptome meta-analysis
  JOURNAL   Proc Natl Acad Sci U S A 103 (16), 6368-6373 (2006)
   PUBMED   16618939
REFERENCE   3  (bases 1 to 2119)
  AUTHORS   Janke,C., Rogowski,K., Wloga,D., Regnard,C., Kajava,A.V.,
            Strub,J.M., Temurak,N., van Dijk,J., Boucher,D., van Dorsselaer,A.,
            Suryavanshi,S., Gaertig,J. and Edde,B.
  TITLE     Tubulin polyglutamylase enzymes are members of the TTL domain
            protein family
  JOURNAL   Science 308 (5729), 1758-1762 (2005)
   PUBMED   15890843
REFERENCE   4  (bases 1 to 2119)
  AUTHORS   Garcia-Frigola,C., Burgaya,F., Calbet,M., Lopez-Domenech,G., de
            Lecea,L. and Soriano,E.
  TITLE     A collection of cDNAs enriched in upper cortical layers of the
            embryonic mouse brain
  JOURNAL   Brain Res Mol Brain Res 122 (2), 133-150 (2004)
   PUBMED   15010206
REFERENCE   5  (bases 1 to 2119)
  AUTHORS   Backofen,B., Jacob,R., Serth,K., Gossler,A., Naim,H.Y. and Leeb,T.
  TITLE     Cloning and characterization of the mammalian-specific nicolin 1
            gene (NICN1) encoding a nuclear 24 kDa protein
  JOURNAL   Eur J Biochem 269 (21), 5240-5245 (2002)
   PUBMED   12392556
REFERENCE   6  (bases 1 to 2119)
  AUTHORS   Backofen,B. and Leeb,T.
  TITLE     Genomic organization of the murine aminomethyltransferase gene
            (Amt)
  JOURNAL   DNA Seq 13 (4), 179-183 (2002)
   PUBMED   12487019
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC161260.2.
            
            On Jun 20, 2018 this sequence version replaced NM_025449.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146890.1, AK169135.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AC161260.2         179355-179574       c
            221-397             AC161260.2         176505-176681       c
            398-511             AC161260.2         175973-176086       c
            512-583             AC161260.2         175500-175571       c
            584-688             AC161260.2         175024-175128       c
            689-2119            AC161260.2         173519-174949       c
FEATURES             Location/Qualifiers
     source          1..2119
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.18 cM"
     gene            1..2119
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /note="nicolin 1"
                     /db_xref="GeneID:66257"
                     /db_xref="MGI:MGI:1913507"
     exon            1..220
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..730
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tubulin polyglutamylase complex subunit 5"
                     /codon_start=1
                     /product="nicolin-1 isoform 1"
                     /protein_id="NP_079725.1"
                     /db_xref="CCDS:CCDS40767.1"
                     /db_xref="GeneID:66257"
                     /db_xref="MGI:MGI:1913507"
                     /translation="MSRVLVPCHVKSTVALQVGDMRTSQGRPGVLVVDVTFPNIAPFE
                     LQEIMFKNYYTAFLSIRVRQQSSMHTAAKWVTCLRDYCLMPDPHSEEGAQDYVSLFKH
                     QMLCDMNRVLELRLILRQPSPLWLSFTVEELQIYQQGPKSPSLAFPKWLSHPVSNEQP
                     APRLEGLPDPSRVSSEVQQMWALTEMIRASHTSTRIGRFDVDGCYDLNLLSYT"
     exon            221..397
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /inference="alignment:Splign:2.1.0"
     exon            398..511
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /inference="alignment:Splign:2.1.0"
     exon            512..583
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /inference="alignment:Splign:2.1.0"
     exon            584..688
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /inference="alignment:Splign:2.1.0"
     exon            689..2119
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2099..2104
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /note="hexamer: AATAAA"
     polyA_site      2119
                     /gene="Nicn1"
                     /gene_synonym="1500032A17Rik; p24; PGs5"
                     /note="major polyA site"
ORIGIN      
        1 cttttggttg ataagggacg ccaataagag ctagtggttg gatggagact gtgagcggtg
       61 attttgcttg gttgtaatct cccaaatcat gtcccgtgtg ttggtgccct gtcatgtgaa
      121 aagcactgta gccctgcaag tgggcgacat gaggacctct caaggtcggc ctggcgtgct
      181 ggtcgtcgat gtcacttttc ccaacatcgc gcctttcgag ttgcaggaga tcatgtttaa
      241 gaattactac acagctttct tgagcatccg tgttcgtcaa caaagctcca tgcacacagc
      301 agccaagtgg gtaacttgtc ttcgggatta ctgtttgatg cctgacccac acagtgaaga
      361 gggagcccag gactatgtat cactgttcaa gcaccagatg ctgtgtgaca tgaacagagt
      421 gctggagctg cgtctgattc tgcggcagcc atcaccactg tggctgtctt tcacagtgga
      481 ggaactgcag atctaccaac agggaccaaa gagcccctcc ttggcgttcc ccaagtggct
      541 ttcccaccca gtgtccaatg agcagcctgc tccccgcctt gagggtctcc cagatcccag
      601 cagagtgtcc tctgaggtgc agcagatgtg ggcactgaca gagatgattc gggctagtca
      661 cacttccacg aggatcggcc gcttcgacgt ggatggctgt tatgatctga atttactctc
      721 ctacacatga acagcagctt ctacgtgaga tgttggcttt ctgtgcccat ctagatgggg
      781 tttggccacc agaggccgtt ccctgtgcat ccaagttcta tctgggcaaa aatctgcaga
      841 ttgggaattc ttgataccca tccagttgtt ttagcatgaa ttcctagtgg gggcacttct
      901 gtctctgact gtctgacatg taaattcagt ctcttcctct cagaattcac cggttctaat
      961 tagaatcctt gagctcctct tgcttgtcct gccaacacga acaccccagt ctgctaccat
     1021 ttccccccat tgctgagata aacctgtcac ttgtagcaag gaagccactg ttgttttgac
     1081 actcatgacc tgggaagctt gaggaagaca taccctctat tcattcctct gcttctgcta
     1141 gtagcccttg tccttttgta ttgtatccat gaaaagaaaa tgtcctagag ccaggcatgg
     1201 cacacacctt tcatcttagc attctgtgag ttcaagatca gccaggtcta cacactgaat
     1261 cccaaggcca atcagggcta catagtgaaa ctccatacta agaaaggaag gaagaaagaa
     1321 aagaaagaaa aaaggaagaa agaggaggaa ggaaggagag aaagaaaata gctctctttg
     1381 aaattgtctg cttccagcct gggaggcgaa gatgagactt ctgggagctt gagtgcttaa
     1441 gtccctacaa ttgctcctga aaagtgttct gtgtcagttc tgggtaggtg ctgttggcac
     1501 agctggggcc agagcacgag tcctcccttc ggactatttg tcatcagatt cagcatgaag
     1561 tacatccaac gatccctgtc ccttctctca gttgcttctg cccgtcatgc tcagggtgct
     1621 gagagagccc tgggggagtg cgtccaagcc aacgtctcac tgacactcat tgaggctgag
     1681 gccctccatt accccagagc aaccactaaa tgaggaagac tactgctctt tcctgtgatc
     1741 agattgtttc cctctagtcc ttcctggctt cgtccccggg cagtattatt aagccgtgct
     1801 gcaaggtgtc tcagatctgg aaaattggac acgagtatat gcaacagttt tctgggaaag
     1861 tctggccacc tttggtagct accttgcatc tctgcagtca gccctcttga aggtcctgtc
     1921 ttcacctaca ggatcatagt taagccccac tgacagggta attaccatag tccagtgttc
     1981 agggaacaat ggtcctcagt acacttgggc aaagaggatc ctgaagtggc aggggctatg
     2041 cataattcac agctgtgttc ctaagttcct agagctggag ctagtgtacg gcaagatcaa
     2101 taaatacttg tggaatatg
//
