LOCUS       NM_001384129            2453 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus niban apoptosis regulator 3 (Niban3), transcript
            variant 1, mRNA.
ACCESSION   NM_001384129 XM_006509531
VERSION     NM_001384129.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2453)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2453)
  AUTHORS   Hong,R., Lai,N., Xiong,E., Ouchida,R., Sun,J., Zhou,Y., Tang,Y.,
            Hikida,M., Tsubata,T., Tagawa,M., Wang,Y. and Wang,J.Y.
  TITLE     Distinct roles of BCNP1 in B-cell development and activation
  JOURNAL   Int Immunol 32 (1), 17-26 (2020)
   PUBMED   31412363
  REMARK    GeneRIF: The BCNP1-deficient spleen B cells show enhanced survival,
            proliferation and Ca2+ influx in response to BCR cross-linking as
            compared with wild-type spleen B cells.
REFERENCE   3  (bases 1 to 2453)
  AUTHORS   Hong,R., Lai,N., Ouchida,R., Xiong,E., Zhou,Y., Min,Q., Liu,J.,
            Tang,Y., Hikida,M., Tsubata,T., Wang,Y. and Wang,J.Y.
  TITLE     The B cell novel protein 1 (BCNP1) regulates BCR signaling and B
            cell apoptosis
  JOURNAL   Eur J Immunol 49 (6), 911-917 (2019)
   PUBMED   30888050
  REMARK    GeneRIF: These results demonstrate that BCNP1 promotes B-cell
            receptor signaling
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC162033.11.
            
            On Jun 1, 2020 this sequence version replaced XM_006509531.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5286962.51292.1,
                                           ERR3765653.859763.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               AC162033.11        53311-53426
            117-247             AC162033.11        54681-54811
            248-373             AC162033.11        55673-55798
            374-488             AC162033.11        56018-56132
            489-656             AC162033.11        57702-57869
            657-772             AC162033.11        57976-58091
            773-877             AC162033.11        58164-58268
            878-1040            AC162033.11        58367-58529
            1041-1231           AC162033.11        59240-59430
            1232-1390           AC162033.11        59524-59682
            1391-1507           AC162033.11        60341-60457
            1508-1615           AC162033.11        60531-60638
            1616-1727           AC162033.11        61210-61321
            1728-1811           AC162033.11        62264-62347
            1812-2453           AC162033.11        63108-63749
FEATURES             Location/Qualifiers
     source          1..2453
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 34.43 cM"
     gene            1..2453
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /note="niban apoptosis regulator 3"
                     /db_xref="GeneID:100037278"
                     /db_xref="MGI:MGI:3686743"
     exon            1..116
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     CDS             62..1873
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /note="isoform 1 is encoded by transcript variant 1; BCNP1
                     homolog; family with sequence similarity 129, member C"
                     /codon_start=1
                     /product="protein Niban 3 isoform 1"
                     /protein_id="NP_001371058.1"
                     /db_xref="GeneID:100037278"
                     /db_xref="MGI:MGI:3686743"
                     /translation="MGAQPSCPLGRRQRQQLQGQVNGMLRTFLPCYRRQLAAAVLRHI
                     SQELGPQDPAGCQLSHTKKLPRVREHQGPLTLLQGHPPQWQPTFCVLRGDGRLEWFSH
                     KENYESGGCPLGFAALTGYTLLTSQREYLCLLDDLCPSSSGDLALEEPLRVLEEPVSF
                     ALFLVHPFRAHLCFCARSRKAHRAWRLGLQGAIRLRATVLQRSRAPAACAFLDAVLLY
                     RRRRGYAGGDDGILGSDAEVLSAELMRELLPGLRAQTLRSLRGAGRARARACAEFLDA
                     VHTAVLAWASSGLRAFQPEKDALLAALERMVRADLEQILQQRALGARRIEAEIQGAVE
                     ACLCQKVDPQLPQLTLALLSPVEATLRAVRTLLIQGMDRLCHYLRKNPSGTRLCREVY
                     EFGEIPWDPELMQACYREAERNHSHLVQLAKPFDFLGMRSLVFGAQDLAQQLMAAAVT
                     TFLQLADQCLTSALDRSQAAEQLGKVRGLVLKKFTSDSETTRWRFTRDCLLRIFWPFV
                     WSQLRLRCNLEPPEVDGDILAMGWQVLTTEGVYRDVIQGLLLQRIDRELKKILGASDR
                     ACSLADCSVAQWVQEGADREHPDDSCHFTEEEADAQL"
     exon            117..247
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            248..373
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            374..488
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            489..656
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            657..772
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            773..877
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1040
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1231
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1390
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1507
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1615
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1727
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1811
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     exon            1812..2453
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2216..2221
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /note="hexamer: CATAAA"
     polyA_site      2243
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /note="major polyA site"
     regulatory      2429..2434
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
                     /note="hexamer: ATTAAA"
     polyA_site      2453
                     /gene="Niban3"
                     /gene_synonym="Bcnp1; Fam129c"
ORIGIN      
        1 actcagctgc catccagtat cctgagcaga gggacccagg acagctctgt atggtggcag
       61 gatgggggca cagccttcct gccccctggg tagacggcag cggcagcagc ttcagggtca
      121 ggtgaatggc atgctgagga ccttcctgcc ctgttaccgt aggcagctgg ctgcagctgt
      181 gctcagacac atttcccagg agctgggacc ccaggaccca gccggatgcc agctgtccca
      241 caccaaaaag ctgcctcgag tcagggagca ccaagggccc ttgaccctgc ttcagggcca
      301 cccaccacag tggcaaccaa ccttctgtgt tctgcgtgga gacggacgtc tagaatggtt
      361 cagtcacaag gagaactatg agtctggggg ttgtccgctg ggctttgcag ctctgacagg
      421 atatacactg ctcacgtccc agcgtgaata cctctgcctt ttggatgacc tctgccccag
      481 ctcctctgga gatcttgccc tggaggagcc cctgcgggtg ctggaggagc ccgtgagctt
      541 cgcgctcttc ctcgtgcacc ccttccgggc tcacctctgc ttctgcgctc gctctcggaa
      601 ggcgcaccgc gcctggaggc tcggcctgca gggtgccatt cgtctgagag ccaccgtcct
      661 gcagcgcagc cgagcgcccg cggcctgcgc cttcctggat gccgtgctgc tctatcgacg
      721 acgccggggc tacgctggtg gagacgacgg gatactgggc tccgacgcag aggtgctgag
      781 cgcggagctg atgcgggagt tgttgcccgg gctgcgagca cagacgctcc gaagcctgcg
      841 cggtgcggga cgtgcccgag cccgtgcttg cgcggagttc ctcgacgccg tgcacacggc
      901 cgtcctggcc tgggcatcct cggggctgcg tgccttccag ccagagaaag acgcactact
      961 ggcggctctg gagaggatgg tgcgcgcaga cctcgagcag atcctgcagc agcgcgcact
     1021 cggagcccgg agaatagaag ccgagatcca gggcgcagta gaggcatgcc tgtgtcagaa
     1081 ggtggacccg caactgcccc agcttaccct tgcgctgctg agccctgtgg aagccacgct
     1141 ccgagctgtt cggacccttc tcatccaggg gatggaccgg ctgtgtcact accttcgcaa
     1201 gaacccttct ggcactcggc tgtgcaggga ggtttatgaa tttggggaga taccatggga
     1261 cccagagttg atgcaggcct gctaccggga ggcagagagg aaccacagcc atctggtcca
     1321 gctggcaaaa ccctttgact tcctggggat gcggagcctg gtgtttgggg cccaggacct
     1381 tgcacaacag ctcatggcgg ccgcagttac caccttcctg cagctggctg accagtgtct
     1441 gacatcagct ctggatcgta gccaagcagc tgagcagctg gggaaagtca ggggccttgt
     1501 attgaagaag ttcacctcag acagtgagac tacgcgatgg aggttcaccc gggactgtct
     1561 gctgaggatc ttctggccct ttgtatggag ccagctccgg ctgagatgta acttggaacc
     1621 gccagaggtg gatggggaca tcctggccat gggctggcag gttctgacca ctgagggtgt
     1681 ctacagagat gtcatccagg gcctcttgct gcagaggatt gacagagaat tgaagaagat
     1741 tctcggtgcc agtgacagag cctgctctct agctgactgc tcagtagccc agtgggtcca
     1801 ggaaggagca gacagggaac atccagatga cagctgtcat ttcacagagg aggaagctga
     1861 cgctcagctc taagagagag aaagagagag aaagagagag agacttactc tgcaggccaa
     1921 atgcggccac tccatacaac atggcttcca agaacagtcg agagcagagt cttgacccac
     1981 ccacacccat cctggaggac agtggataaa gacctggagt ggcctccctg ggccaagggt
     2041 atgaacgctt ctggctttgt aacttatgta ttcaacaaag catcatagat ggtgttcctg
     2101 ctaaaatttg tacactcagg ttctgagcta gcctacccta ccataataag ataccgtctc
     2161 taaaaaaaca acccaaaacc tctgttaata tgatacatgt aatgacttat tttttcataa
     2221 acatttgtac ctttcttttt aaatatgttt actttgtatg tgtgtgtccc ggcacatgtg
     2281 tgagcctgtg gaggtcagag gacagtttac aggagttggg ttttctcttt ccatctagtg
     2341 ggtcttgagg atcaaactca ccaagcttag tggcaagtac ctgctaagct gtctcactgg
     2401 ccctgttttt acatttatca attgcttgat taaaaactgt ttgaatgact aaa
//
