LOCUS       NM_026631               1008 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus NHP2 ribonucleoprotein (Nhp2), transcript variant 1,
            mRNA.
ACCESSION   NM_026631
VERSION     NM_026631.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1008)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1008)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1008)
  AUTHORS   Kappei,D., Butter,F., Benda,C., Scheibe,M., Draskovic,I.,
            Stevense,M., Novo,C.L., Basquin,C., Araki,M., Araki,K.,
            Krastev,D.B., Kittler,R., Jessberger,R., Londono-Vallejo,J.A.,
            Mann,M. and Buchholz,F.
  TITLE     HOT1 is a mammalian direct telomere repeat-binding protein
            contributing to telomerase recruitment
  JOURNAL   EMBO J 32 (12), 1681-1701 (2013)
   PUBMED   23685356
REFERENCE   4  (bases 1 to 1008)
  AUTHORS   Egan,E.D. and Collins,K.
  TITLE     Specificity and stoichiometry of subunit interactions in the human
            telomerase holoenzyme assembled in vivo
  JOURNAL   Mol Cell Biol 30 (11), 2775-2786 (2010)
   PUBMED   20351177
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645602.14.
            
            On Jul 3, 2018 this sequence version replaced NM_026631.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019134.1, BY710231.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-205               AL645602.14        23968-24172
            206-275             AL645602.14        24277-24346
            276-381             AL645602.14        26680-26785
            382-1008            AL645602.14        27287-27913
FEATURES             Location/Qualifiers
     source          1..1008
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.14 cM"
     gene            1..1008
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
                     /note="NHP2 ribonucleoprotein"
                     /db_xref="GeneID:52530"
                     /db_xref="MGI:MGI:1098547"
     exon            1..205
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
                     /inference="alignment:Splign:2.1.0"
     CDS             46..507
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nucleolar protein family A, member 2; h/ACA
                     ribonucleoprotein complex subunit 2; snoRNP protein NHP2;
                     H/ACA small nucleolar RNPs; NHP2 ribonucleoprotein
                     homolog"
                     /codon_start=1
                     /product="H/ACA ribonucleoprotein complex subunit 2
                     isoform 1"
                     /protein_id="NP_080907.1"
                     /db_xref="CCDS:CCDS24655.1"
                     /db_xref="GeneID:52530"
                     /db_xref="MGI:MGI:1098547"
                     /translation="MTKVKAAPEESEAQAEGCSEERTYKELLVNLNPIAQPLASRRLT
                     RKLYKCIKKAVKQKQIRRGVKEVQKFVNKGEKGIMVLAGDTLPIEVYCHLPVLCEDQN
                     LPYVYIPSKTDLGAATGSKRPTCVIMVKPHEEYQETYDKCLEEVQALPTPL"
     exon            206..275
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
                     /inference="alignment:Splign:2.1.0"
     exon            276..381
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..1008
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      704..709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
                     /note="hexamer: AGTAAA"
     polyA_site      727
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
                     /note="major polyA site"
     regulatory      979..984
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
                     /note="hexamer: AATATA"
     polyA_site      1008
                     /gene="Nhp2"
                     /gene_synonym="2410130M07Rik; D11Ertd175e; Nola2"
ORIGIN      
        1 ggccgcgtgg ttcctctatg ccgggacgga gttgtagttg ctaagatgac caaagtaaag
       61 gccgctcccg aagagtccga ggcgcaggcg gagggctgca gcgaggagcg cacgtacaaa
      121 gagctgctgg tcaatctgaa ccccatcgcg cagcccctgg cttcccgccg cctgacgcgc
      181 aagctctaca agtgcatcaa gaaggctgtg aagcagaagc agattcgtcg cggggtgaag
      241 gaggttcaga aatttgtcaa caagggcgag aaagggatca tggttttggc aggagataca
      301 ttgccgattg aggtgtactg ccatcttcca gttctgtgcg aggaccagaa cttgccctac
      361 gtctacatcc cctctaagac ggacttgggt gcagccacag gctccaagcg tcccacttgt
      421 gtgatcatgg tgaagcccca tgaagaatat caggagacct acgacaagtg cctggaggag
      481 gtgcaggcac tgcctacacc tctgtgagag acttgggctg caacccagcc cctttccaag
      541 agatctggct ggctgcaggc agctgcccac cctaacagca tctccccgat ttcttgctgt
      601 gtgagtcttc ccaggcagct ccagcagtgt tggaggtgga gcctgcatct ctgccatctc
      661 ctcctgagct ttgatgaaga cagttccaag aatgtgggat agaagtaaat gctaaggcga
      721 aaacgtggca agtgtgtggg tgttcttgaa gttggcagga ggagcaaaag cagcctttca
      781 gcacagagcc tcaagggtgt acctggcaaa tgttctgcac tggctctaca gcccacccgt
      841 cttcatttcc cactctagga cagttggggt gaggagatga ggcatcaagg cccaaacccc
      901 acttcacaca cctccaagag tgatacgcat atatatacac acaagaccat gcaatcattg
      961 gtaaggagaa gggctatgaa tatatttgct caaagttata aaacagca
//
