LOCUS       NM_025811               3934 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus NHL repeat containing 2 (Nhlrc2), mRNA.
ACCESSION   NM_025811
VERSION     NM_025811.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3934)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3934)
  AUTHORS   Hiltunen,A.E., Vuolteenaho,R., Ronkainen,V.P., Miinalainen,I.,
            Uusimaa,J., Lehtonen,S. and Hinttala,R.
  TITLE     Nhlrc2 is crucial during mouse gastrulation
  JOURNAL   Genesis 60 (3), e23470 (2022)
   PUBMED   35258166
  REMARK    GeneRIF: Nhlrc2 is crucial during mouse gastrulation.
REFERENCE   3  (bases 1 to 3934)
  AUTHORS   Hiltunen,A.E., Kangas,S.M., Ohlmeier,S., Pietila,I., Hiltunen,J.,
            Tanila,H., McKerlie,C., Govindan,S., Tuominen,H., Kaarteenaho,R.,
            Hallman,M., Uusimaa,J. and Hinttala,R.
  TITLE     Variant in NHLRC2 leads to increased hnRNP C2 in developing neurons
            and the hippocampus of a mouse model of FINCA disease
  JOURNAL   Mol Med 26 (1), 123 (2020)
   PUBMED   33297935
  REMARK    GeneRIF: Variant in NHLRC2 leads to increased hnRNP C2 in
            developing neurons and the hippocampus of a mouse model of FINCA
            disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3934)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3934)
  AUTHORS   Paakkola,T., Salokas,K., Miinalainen,I., Lehtonen,S., Manninen,A.,
            Kaakinen,M., Ruddock,L.W., Varjosalo,M., Kaarteenaho,R., Uusimaa,J.
            and Hinttala,R.
  TITLE     Biallelic mutations in human NHLRC2 enhance myofibroblast
            differentiation in FINCA disease
  JOURNAL   Hum Mol Genet 27 (24), 4288-4302 (2018)
   PUBMED   30239752
REFERENCE   6  (bases 1 to 3934)
  AUTHORS   Uusimaa,J., Kaarteenaho,R., Paakkola,T., Tuominen,H.,
            Karjalainen,M.K., Nadaf,J., Varilo,T., Uusi-Makela,M.,
            Suo-Palosaari,M., Pietila,I., Hiltunen,A.E., Ruddock,L., Alanen,H.,
            Biterova,E., Miinalainen,I., Salminen,A., Soininen,R., Manninen,A.,
            Sormunen,R., Kaakinen,M., Vuolteenaho,R., Herva,R., Vieira,P.,
            Dunder,T., Kokkonen,H., Moilanen,J.S., Rantala,H., Nogee,L.M.,
            Majewski,J., Ramet,M., Hallman,M. and Hinttala,R.
  TITLE     NHLRC2 variants identified in patients with fibrosis,
            neurodegeneration, and cerebral angiomatosis (FINCA):
            characterisation of a novel cerebropulmonary disease
  JOURNAL   Acta Neuropathol 135 (5), 727-742 (2018)
   PUBMED   29423877
REFERENCE   7  (bases 1 to 3934)
  AUTHORS   Perez-Garcia,V., Fineberg,E., Wilson,R., Murray,A., Mazzeo,C.I.,
            Tudor,C., Sienerth,A., White,J.K., Tuck,E., Ryder,E.J., Gleeson,D.,
            Siragher,E., Wardle-Jones,H., Staudt,N., Wali,N., Collins,J.,
            Geyer,S., Busch-Nentwich,E.M., Galli,A., Smith,J.C., Robertson,E.,
            Adams,D.J., Weninger,W.J., Mohun,T. and Hemberger,M.
  TITLE     Placentation defects are highly prevalent in embryonic lethal mouse
            mutants
  JOURNAL   Nature 555 (7697), 463-468 (2018)
   PUBMED   29539633
REFERENCE   8  (bases 1 to 3934)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC166746.7 and
            AC116849.11.
            
            On Apr 29, 2007 this sequence version replaced NM_025811.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK033384.1, BC138191.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-600               AC166746.7         127598-128197
            601-753             AC166746.7         131096-131248
            754-1209            AC166746.7         149753-150208
            1210-1331           AC166746.7         154095-154216
            1332-1461           AC166746.7         155492-155621
            1462-1561           AC116849.11        42985-43084
            1562-1793           AC116849.11        46391-46622
            1794-1916           AC116849.11        47208-47330
            1917-2123           AC116849.11        48475-48681
            2124-2343           AC116849.11        49615-49834
            2344-3934           AC116849.11        52071-53661
FEATURES             Location/Qualifiers
     source          1..3934
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.89 cM"
     gene            1..3934
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /note="NHL repeat containing 2"
                     /db_xref="GeneID:66866"
                     /db_xref="MGI:MGI:1914116"
     exon            1..600
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             423..2600
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /codon_start=1
                     /product="NHL repeat-containing protein 2"
                     /protein_id="NP_080087.1"
                     /db_xref="CCDS:CCDS29918.1"
                     /db_xref="GeneID:66866"
                     /db_xref="MGI:MGI:1914116"
                     /translation="MAAPGARGASLSGLLPAQTSLEYALLDAVTQQEKDELVYQYLQK
                     VDGWEQDLAVPEFPEGLEWLNTEEPLSIYKDLCGKVVVLDFFTYCCINCIHVLPDLHA
                     LERRFSDKDGLLIVGVHSAKFPNEKVLDNIKSAVLRYNITHPVVNDADASLWQELEVS
                     CWPTLVILGPRGNLLFSLIGEGHRDKLFSYTSIALKYYKDRGQIRDGKIGIKLFKESL
                     PPSPLLFPGKVAVDHATGRLVVADTGHHRILVIQKNGRIQSSIGGPNPGRKDGMFSES
                     SFNSPQGVAIADNVIYVADTENHLIRKIDLEAEKVTTVAGVGIQGTDTEGGEEGDKQP
                     ISSPWDVALGTSGSEVQRNDILWIAMAGTHQIWALLLDSGTLPKKSDLKKGTCIRFAG
                     SGNEENRNNAYPHKAGFAQPSGLALASEEPWSCLFVADSESSTVRTVSLRDGAVKHLV
                     GGERDPMNLFAFGDVDGAGINAKLQHPLGVAWDEERQVLYVADSYNHKIKVVDPKTKG
                     CTTLAGTGDASDASSSFAESAFNEPGGLCIGESGRLLYVADTNNHQIKVMDLEARTVS
                     VLPVCKSDSAVVDGSFPREKQKTVPKVPKSAAHIGLPPVTVHPGQALQLRLKLQLPPG
                     AKLTEGAPSCWFLEAEGNEWLLQEQTPSGDIENISNQPAISLQIPTHCLSLEAVVSVV
                     VFLYYCSADSSACMMKGVVFRQPLQITSTQPACAAPVELAYAF"
     exon            601..753
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            754..1209
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1331
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1332..1461
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1462..1561
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1793
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1916
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2123
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2124..2343
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..3934
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2708..2713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2732
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /note="major polyA site"
     regulatory      3558..3563
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /note="hexamer: AATACA"
     polyA_site      3578
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
     polyA_site      3610
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
     regulatory      3808..3813
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
                     /note="hexamer: TATAAA"
     polyA_site      3829
                     /gene="Nhlrc2"
                     /gene_synonym="1200003G01Rik"
ORIGIN      
        1 agtttaagag tgggacacac aaatgggcag gcttttctta agtcggctct tttaaacgtg
       61 tacatggtta tttgaatttt atttgtcttg gaattccctg ccgggcttca aaggcaatgg
      121 gttcccagct cctctggagc gcgaccctag cagccttccc cgtgtcgaat ctggcgctct
      181 gaacgtccag gcttcgcggc ggcccggaac ctggaagggg cggggtgggc aactctggag
      241 tttaattacg cgccagggaa gcacggccct ttggactttg gcgtccggag gaaggcttat
      301 tggaggcgga agcgtgtgtg gcgcagggcc gggctggcca ggccccgctc tgagtcaaga
      361 gggcggcgca cgctggtccg acccgcgccc tcggccccgg agccctcggg agctcgcgca
      421 acatggcggc tcccggagcg cgcggcgcga gcctctcggg cctgctgccc gcgcagacct
      481 cgctcgagta cgccctgctg gacgccgtca cccagcaaga gaaggatgag ttggtctacc
      541 agtatctgca gaaggtggac ggctgggagc aggacctagc ggtgcccgag tttccggaag
      601 gcttagaatg gctgaacacg gaggagcctc tgtccattta caaggacctg tgtggaaaag
      661 tggttgtcct tgatttcttc acctactgct gcataaactg cattcatgtg ctgcctgatc
      721 tccacgccct ggagcgcaga ttctctgata aagatggcct tctgattgtc ggtgttcact
      781 cggctaagtt tcccaatgag aaggtcctgg acaacatcaa gagtgctgtc ctcagataca
      841 acatcaccca ccctgtggtt aacgatgcag atgccagcct ttggcaggag cttgaagtct
      901 cttgctggcc aacactggtc atactgggac cccgtggaaa cctgctgttt tctttgattg
      961 gagagggaca cagagataaa ctattttcat atacgtctat tgctttaaag tattacaaag
     1021 acaggggaca gatcagagat ggaaaaattg gaataaaact cttcaaagag tctctgccac
     1081 cttcaccatt gctgttccct ggcaaagtag cagtggacca tgctactggt cgacttgtgg
     1141 tggcagacac agggcaccat aggatcttgg tcatccagaa gaatgggcgc attcagagca
     1201 gcattggagg acctaaccct ggaaggaaag atgggatgtt ttcagagtcg tcttttaatt
     1261 ctccacaggg tgtagctata gcagataatg tcatctatgt ggccgacact gagaaccacc
     1321 ttataagaaa gatagacctg gaagctgaga aggtgaccac tgtggctggt gtcggtattc
     1381 aagggacaga tacagaaggg ggcgaggagg gagacaagca gcccatcagc tccccgtggg
     1441 acgttgcgct tgggacctca ggttcagagg tccaaagaaa tgacatcctg tggatagcca
     1501 tggcagggac tcatcagata tgggcactcc tcctagactc tggcacactg ccaaagaaaa
     1561 gtgacctaaa aaaaggaacc tgcattcgtt ttgctggaag tggaaatgaa gagaaccgaa
     1621 acaacgcata tcctcacaag gcaggctttg cccagccgtc aggcctcgct ctcgcctcag
     1681 aagagccctg gagctgcctc tttgtggctg acagtgagag cagcaccgtg cggaccgtct
     1741 cgctgagaga cggagctgtg aagcacctcg taggcggaga gcgagacccc atgaatttat
     1801 ttgcttttgg tgatgttgat ggagcaggca tcaatgcgaa gcttcagcat ccacttgggg
     1861 ttgcatggga cgaggagagg caagtgctct acgtggccga ctcctacaat cacaagatta
     1921 aagttgtgga tccaaaaaca aaaggctgta caacgttagc agggactggg gacgccagtg
     1981 atgccagttc cagttttgcg gagtcagcct ttaatgagcc cggaggcttg tgtatcggtg
     2041 agagtggtcg gctgttatat gtagcagaca ctaataatca ccaaattaaa gtgatggatt
     2101 tagaagcaag aacagtttct gtgctcccag tctgcaagtc tgacagtgct gtggtagatg
     2161 gctccttccc tagagagaaa cagaagacag tgcccaaggt gccgaagtct gccgcacaca
     2221 tcggcctccc ccctgtgacg gtgcatccgg gccaggctct gcagcttagg ctcaagctcc
     2281 agctcccgcc aggagcaaag ctgaccgaag gcgcgcccag ctgctggttc ctggaagctg
     2341 aaggcaatga atggctactt caagaacaga ccccatctgg agacatagag aatatttcca
     2401 atcagccggc gatttccctg cagattccta cccattgctt gtcactggaa gctgtggtgt
     2461 ctgtcgtcgt gtttctttat tactgcagtg cagacagcag cgcatgtatg atgaagggag
     2521 tcgtgttcag gcagcctttg cagataacca gcacccagcc agcttgtgca gctcctgtag
     2581 agctcgcata cgcattctag aaggctggcc agcagccctc agcacaggcc ctgtccatcc
     2641 tgccattcgt cgcttaggga aaaagcatta tagtaaccca ttgctcagtt gtaacaactg
     2701 ataccaaaat aaagctgtgc tccttattag tattttaatt ctaaacaaat ttcttcattt
     2761 tagctgtgtg ctagccaagt cattgaccat cattttacca cggcactgta agctttgctg
     2821 ttatttgttt taaaagcaac agtccatgct atatcagaga gtattatatt tgtagtcaaa
     2881 actaatcatg ccagatagtt taaataacct gcctttatca gtagtggtta tccattcgtg
     2941 tgtaaatttc cagtaacttg agatgggcct aagctgtgcg cctttgtgtc aggatacctg
     3001 ctgtttagtg tctaaggtct gcttaaagcc agaacagaaa gtattcactc ggcacaaact
     3061 cagcgtgtat gagtagttac ttacctccgg tgatttttct cacttgaggt atttttaaaa
     3121 gagagtttta atctattttt attataaatt atttgtttta acattctatt attaatgcct
     3181 tataacttta tataaaaaag aaaaatatag aatttctaaa ggcatgcaga cctaccttta
     3241 actgtattta atgagcataa ttcctagcag gcaatgcctg gctcccagag gcatgctgac
     3301 ctgggtgtgg gtggagactg ctgtgttgct gtgtgtgatg ggttattgta gtggctaggc
     3361 tggctgtcat gagcatcatg ctattttgga aatttagatg tcagttttaa gagttaagta
     3421 acagaattgt tgggtttgag atttttgtta ctgttttggt tcccatattt agaatttaaa
     3481 ttatgatcat taattctgat attttgaaaa atcacatgta aaccttcaat ttgctatttt
     3541 cagggtatag ttatactaat acactttcat ttaaaatatt agggctgaaa cacacagtga
     3601 tttactgata ctgttttggt atgtgttttc tttaaccccg taagaaacag cactggaagg
     3661 gatcctggag aggtttggtt ttcattgtta acttgaatta tcatagatta tcatcataac
     3721 tgtttaagag ccttgctctt ctaaaactga gtggacatgt gttttactaa gactacaagg
     3781 tttcagaagc attgtctgag ccccacctat aaatttaata agcatttaag catagtctac
     3841 ctatttatta gttaattttt gcagtagttt ttgataggta acatttgctt gttttattgt
     3901 tcagttaact aaaaaaaaaa aaaaatctga agtg
//
