LOCUS       NM_178777               3353 bp    mRNA    linear   ROD 05-FEB-2024
DEFINITION  Mus musculus nescient helix loop helix 2 (Nhlh2), mRNA.
ACCESSION   NM_178777
VERSION     NM_178777.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3353)
  AUTHORS   Moreau,M.X., Saillour,Y., Elorriaga,V., Bouloudi,B., Delberghe,E.,
            Deutsch Guerrero,T., Ochandorena-Saa,A., Maeso-Alonso,L.,
            Marques,M.M., Marin,M.C., Spassky,N., Pierani,A. and Causeret,F.
  TITLE     Repurposing of the multiciliation gene regulatory network in fate
            specification of Cajal-Retzius neurons
  JOURNAL   Dev Cell 58 (15), 1365-1382 (2023)
   PUBMED   37321213
REFERENCE   2  (bases 1 to 3353)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3353)
  AUTHORS   Filova,I., Pysanenko,K., Tavakoli,M., Vochyanova,S., Dvorakova,M.,
            Bohuslavova,R., Smolik,O., Fabriciova,V., Hrabalova,P.,
            Benesova,S., Valihrach,L., Cerny,J., Yamoah,E.N., Syka,J.,
            Fritzsch,B. and Pavlinkova,G.
  TITLE     ISL1 is necessary for auditory neuron development and contributes
            toward tonotopic organization
  JOURNAL   Proc Natl Acad Sci U S A 119 (37), e2207433119 (2022)
   PUBMED   36074819
REFERENCE   4  (bases 1 to 3353)
  AUTHORS   Carraro,R.S., Nogueira,G.A., Sidarta-Oliveira,D., Gaspar,R.S.,
            Dragano,N.R., Morari,J., Bobbo,V.C.D., Araujo,E.P., Mendes,N.F.,
            Zanesco,A.M., Tobar,N., Ramos,C.D., Toscaro,J.M., Bajgelman,M.C.
            and Velloso,L.A.
  TITLE     Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass and
            Attenuates Obesity-Associated Anxiety/Depression-like Behavior
  JOURNAL   J Neurosci 41 (48), 10004-10022 (2021)
   PUBMED   34675088
  REMARK    GeneRIF: Arcuate Nucleus Overexpression of NHLH2 Reduces Body Mass
            and Attenuates Obesity-Associated Anxiety/Depression-like Behavior.
REFERENCE   5  (bases 1 to 3353)
  AUTHORS   Leon,S., Talbi,R., McCarthy,E.A., Ferrari,K., Fergani,C., Naule,L.,
            Choi,J.H., Carroll,R.S., Kaiser,U.B., Aylwin,C.F., Lomniczi,A. and
            Navarro,V.M.
  TITLE     Sex-specific pubertal and metabolic regulation of Kiss1 neurons via
            Nhlh2
  JOURNAL   Elife 10, e69765 (2021)
   PUBMED   34494548
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3353)
  AUTHORS   Haire,M.F. and Chiaramello,A.
  TITLE     Transient expression of the basic helix-loop-helix protein NSCL-2
            in the mouse cerebellum during postnatal development
  JOURNAL   Brain Res Mol Brain Res 36 (1), 174-178 (1996)
   PUBMED   9011755
REFERENCE   7  (bases 1 to 3353)
  AUTHORS   Watanabe,H., Suzuki,Y., Makino,M. and Fujiwara,M.
  TITLE     Toxoplasma gondii: induction of toxoplasmic encephalitis in mice
            with chronic infection by inoculation of a murine leukemia virus
            inducing immunodeficiency
  JOURNAL   Exp Parasitol 76 (1), 39-45 (1993)
   PUBMED   8385626
REFERENCE   8  (bases 1 to 3353)
  AUTHORS   Lipkowitz,S., Gobel,V., Varterasian,M.L., Nakahara,K., Tchorz,K.
            and Kirsch,I.R.
  TITLE     A comparative structural characterization of the human NSCL-1 and
            NSCL-2 genes. Two basic helix-loop-helix genes expressed in the
            developing nervous system
  JOURNAL   J Biol Chem 267 (29), 21065-21071 (1992)
   PUBMED   1328219
REFERENCE   9  (bases 1 to 3353)
  AUTHORS   Brown,L., Espinosa,R. 3rd, Le Beau,M.M., Siciliano,M.J. and Baer,R.
  TITLE     HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are
            coexpressed in a human neuroblastoma
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8492-8496 (1992)
   PUBMED   1528853
REFERENCE   10 (bases 1 to 3353)
  AUTHORS   Gobel,V., Lipkowitz,S., Kozak,C.A. and Kirsch,I.R.
  TITLE     NSCL-2: a basic domain helix-loop-helix gene expressed in early
            neurogenesis
  JOURNAL   Cell Growth Differ 3 (3), 143-148 (1992)
   PUBMED   1633105
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031747.1 and AC166072.2.
            
            [WARNING] On Mar 12, 2024 this sequence was replaced by
            NM_178777.4.
            
            On Jul 16, 2009 this sequence version replaced NM_178777.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031747.1, AK084160.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2358              AK031747.1         3-2360
            2359-3353           AC166072.2         120754-121748
FEATURES             Location/Qualifiers
     source          1..3353
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 44.3 cM"
     gene            1..3353
                     /gene="Nhlh2"
                     /gene_synonym="6230401I09Rik; bHLHa34; Hen2; Nscl-2;
                     NSCL2"
                     /note="nescient helix loop helix 2"
                     /db_xref="GeneID:18072"
                     /db_xref="MGI:MGI:97324"
     exon            1..181
                     /gene="Nhlh2"
                     /gene_synonym="6230401I09Rik; bHLHa34; Hen2; Nscl-2;
                     NSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            182..506
                     /gene="Nhlh2"
                     /gene_synonym="6230401I09Rik; bHLHa34; Hen2; Nscl-2;
                     NSCL2"
                     /inference="alignment:Splign:2.1.0"
     exon            507..3353
                     /gene="Nhlh2"
                     /gene_synonym="6230401I09Rik; bHLHa34; Hen2; Nscl-2;
                     NSCL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             515..922
                     /gene="Nhlh2"
                     /gene_synonym="6230401I09Rik; bHLHa34; Hen2; Nscl-2;
                     NSCL2"
                     /note="HEN-2"
                     /codon_start=1
                     /product="helix-loop-helix protein 2"
                     /protein_id="NP_848892.1"
                     /db_xref="CCDS:CCDS17685.1"
                     /db_xref="GeneID:18072"
                     /db_xref="MGI:MGI:97324"
                     /translation="MMLSPDQAADSDHPSSTHSDPESLGGADTKVLGSVSDLEPVEEA
                     DGDGKGGSRAALYPHPQQLSREEKRRRRRATAKYRSAHATRERIRVEAFNLAFAELRK
                     LLPTLPPDKKLSKIEILRLAICYISYLNHVLDV"
ORIGIN      
        1 aggctaaatc aattggtacc agaagagcca agaagccaca caggcagctg cctctcctct
       61 ctggctctcc caagctcccc tttctctgct tccctgtcac tgttactcca gaagacgtcc
      121 acttctctcc aatctctctc cagcatctcc aagctactga ctatatacat ttcaccacaa
      181 gccctttgag tggggaggcg tgaggtttca acacttcgac ttataaagat caacaacgaa
      241 ttttcctgaa atgtttaaga acagttaaaa acaaaccaac aaacaaacaa acgggcgttt
      301 tcaatccatc aactaagtga acaaccatac acccgctaag acaccgccgc tcgttgtggt
      361 ggtcggcgag atgacagctg ctttttcatc tgcgaatgta ataaatattg gctgctttta
      421 atatttgcca ggatctctcc tccttgtttc ctggaatttt aactctaaaa gattgacgaa
      481 aagattatcg acagggctct tgcaagcctc caaaatgatg ctgagtccgg accaagccgc
      541 cgactcagat caccccagct cgacgcactc ggacccggag tctctgggcg gcgcagacac
      601 caaggttctg ggcagcgtgt cggacctaga gccagtggag gaggcggacg gcgacggcaa
      661 gggaggcagc cgggccgcgc tctacccgca cccgcagcag ctgagccgcg aagaaaagcg
      721 ccgccgccgg cgcgccacgg ccaagtaccg atcggcccac gccacccgcg agcgcatccg
      781 agtggaggct ttcaacctgg ccttcgccga gctccgcaaa ctactaccca cgctgcctcc
      841 ggacaagaag ctctccaaga tcgagattct gcgcttggcc atctgctaca tctcctatct
      901 caaccatgtc ctggacgtgt agggagggct acgccgcggg aggccgcggg tccggaagac
      961 tgccaaaggc gactcatccg gactgccagg ctagaggttt gcccagagac acttgaacgc
     1021 aggagaaagc tttgcagcct gttctttcta gtcatcaagg caacaggaga agatttccca
     1081 gcctgggagg tggggttggg tagaaagacc tggggcttgc aaggggattt tcctggccag
     1141 aaaatccttc tggaggcacc tagaatgaga tgccctgggg cctcccctca gtgtgttagg
     1201 accccccgag ggggtggttg gtttaagcta ctggaggctt ttcatttccc tgtatttcta
     1261 tcctacacac cttcacgttc tgaaagaatg aggacagctt agcccaggct gatggcttca
     1321 aactatgact atctgggatt tttctaactg acaaatcacc aaaccttggg gagaaaaaaa
     1381 aagatgaaaa tcttttccat atctagatta agacacagaa aggtgtacca gcaaactttt
     1441 tgttaccatg gcaaatgaaa aattacattc taatctaaat aaaatcctga atatttggtg
     1501 aggttaaaaa aaatacattc agaacagaca gacatacact gtggcaggat ttgagcttgg
     1561 tgagacttta accccaagat aggacactaa agtagataga aaaatccata tttaaatgga
     1621 aaatgtaaca tctgattgct ttttcgggca aaatgcccct ttaaatatcc aaaaacaccc
     1681 cgtctatttg tgaccttaac atgtggactc atagatgcag ttagaaaaag acaacctatt
     1741 tttatttatg ttagaaggag tagagtattt ttttcaagac atttattttt cagagtggtg
     1801 ataattttac tttggatact ctgtgccaat ttatttatag tcaagtgttt acactccctc
     1861 ccaacccccg tgaaataatt gcgtctaact ctttatgtgt ttgttgagat tatcttgtgg
     1921 ttttgcctct ttttttttcc tgattatatt gcacttgtac aagagagtcc ctgcttcccc
     1981 ctgtttctaa gcatatttta tatatcaaga agttggttct ttggttgtga gatcagcaac
     2041 actagccctt cactattata gttttataaa aagttaagtg ttgttattct taccagtagt
     2101 tttgtctgaa aagtacttta ctgtttttaa ggagagtagc tcctttgtgt gtgtgcgtga
     2161 cgtttgtgcg tgggatgatt ttaggaaatt acattatttt cctaaaaaag aaacgaaaaa
     2221 agaattcaga actactttcc tctgtgacaa ccaaaaagaa aagtctatga cctagaaatg
     2281 tttcatgttc tcagctgtga aactcttaaa gtaagaggtg tattttagag acaaggaaga
     2341 aagaagaaga agaagaagaa gaagaagaag aagaagaaga agaagaagaa gaagaagaag
     2401 aaccacatct gctatccaaa gattttagtc tttttcaggg tttttttgtg tctctgttgc
     2461 tttatataat gcaatatttt gtagtgaaaa tagatataac ctggtttcta cctgacgagt
     2521 ttttcatatc tcatgactgg tgcgctgttt tgcatataaa taaaggtatc agattaaagc
     2581 tctcctcttt attttaagca tctgtctaga aatcaaacat cctggccagg cgtgaaatgt
     2641 cataagggac tcagttcttt agaaaggagt tagttaagca aaaacacgaa caaaatttta
     2701 tacacatata aaattcgtat gcagcccagc ctgggatggt atagatcagg tctcgtccat
     2761 gaggaaaagc agggagatgt gtccataaga gcagtacagg gatcataaga tgccttttct
     2821 atcctaaaag gaacttcgta actgtctaac ccaagctctt gggaaaactc ggggctaagg
     2881 aggtgtctgc atccagtggc agggaagatc agggagtggc ccctacatcc atcaacccag
     2941 cacctgagag ttggagatgg gagaaccaga ggcttaaggt catctatcct cagctatgcg
     3001 gtgaaattga ggccagcctg ggctacgtga gaccctgccc aaaagaaaaa ggcagtgaac
     3061 agaccctttt tgacagcttt ccctctgggc acttaagcac aaagcatgtg tcactgaaac
     3121 atctaattgg tacccacgct cagcaccatg acacacttgc cttaaaacaa ctttttatca
     3181 ggaacactca tctgcacaaa cctgggtctg gcatactgta taagcagaac ccatgaataa
     3241 cttgtaactg tattcctgta tgtacatacg tatctagact atttgaacta taccacacca
     3301 aatctccagt ttccatatta aaaagtgact atatggattg tcagtttatg tcc
//
