LOCUS       NM_010916               2506 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus nescient helix loop helix 1 (Nhlh1), mRNA.
ACCESSION   NM_010916
VERSION     NM_010916.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2506)
  AUTHORS   Butts,J.C., Wu,S.R., Durham,M.A., Dhindsa,R.S., Revelli,J.P.,
            Ljungberg,M.C., Saulnier,O., McLaren,M.E., Taylor,M.D. and
            Zoghbi,H.Y.
  TITLE     A single-cell transcriptomic map of the developing Atoh1 lineage
            identifies neural fate decisions and neuronal diversity in the
            hindbrain
  JOURNAL   Dev Cell 59 (16), 2171-2188 (2024)
   PUBMED   39106860
REFERENCE   2  (bases 1 to 2506)
  AUTHORS   Masuda,A., Nishida,K., Ajima,R., Saga,Y., Bakhtan,M., Klar,A.,
            Hirata,T. and Zhu,Y.
  TITLE     A global gene regulatory program and its region-specific regulator
            partition neurons into commissural and ipsilateral projection types
  JOURNAL   Sci Adv 10 (21), eadk2149 (2024)
   PUBMED   38781326
REFERENCE   3  (bases 1 to 2506)
  AUTHORS   Ishii,C., Nakano,H., Higashiseto,R., Ooki,Y., Umemura,M.,
            Takahashi,S. and Takahashi,Y.
  TITLE     Nescient helix-loop-helix 1 (Nhlh1) is a novel activating
            transcription factor 5 (ATF5) target gene in olfactory and
            vomeronasal sensory neurons in mice
  JOURNAL   Cell Tissue Res 396 (1), 85-94 (2024)
   PUBMED   38388750
  REMARK    GeneRIF: Nescient helix-loop-helix 1 (Nhlh1) is a novel activating
            transcription factor 5 (ATF5) target gene in olfactory and
            vomeronasal sensory neurons in mice.
            Erratum:[Cell Tissue Res. 2024 May;396(2):291-292. doi:
            10.1007/s00441-024-03891-w.. PMID: 38530437]
REFERENCE   4  (bases 1 to 2506)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 2506)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   6  (bases 1 to 2506)
  AUTHORS   Sugiyama,S., Utani,A., Yamada,S., Kozak,C.A. and Yamada,Y.
  TITLE     Cloning and expression of the mouse laminin gamma 2 (B2t) chain, a
            subunit of epithelial cell laminin
  JOURNAL   Eur J Biochem 228 (1), 120-128 (1995)
   PUBMED   7882992
REFERENCE   7  (bases 1 to 2506)
  AUTHORS   Lipkowitz,S., Gobel,V., Varterasian,M.L., Nakahara,K., Tchorz,K.
            and Kirsch,I.R.
  TITLE     A comparative structural characterization of the human NSCL-1 and
            NSCL-2 genes. Two basic helix-loop-helix genes expressed in the
            developing nervous system
  JOURNAL   J Biol Chem 267 (29), 21065-21071 (1992)
   PUBMED   1328219
REFERENCE   8  (bases 1 to 2506)
  AUTHORS   Brown,L., Espinosa,R. 3rd, Le Beau,M.M., Siciliano,M.J. and Baer,R.
  TITLE     HEN1 and HEN2: a subgroup of basic helix-loop-helix genes that are
            coexpressed in a human neuroblastoma
  JOURNAL   Proc Natl Acad Sci U S A 89 (18), 8492-8496 (1992)
   PUBMED   1528853
REFERENCE   9  (bases 1 to 2506)
  AUTHORS   Begley,C.G., Lipkowitz,S., Gobel,V., Mahon,K.A., Bertness,V.,
            Green,A.R., Gough,N.M. and Kirsch,I.R.
  TITLE     Molecular characterization of NSCL, a gene encoding a
            helix-loop-helix protein expressed in the developing nervous system
  JOURNAL   Proc Natl Acad Sci U S A 89 (1), 38-42 (1992)
   PUBMED   1729708
REFERENCE   10 (bases 1 to 2506)
  AUTHORS   Gough,N.M., Lipkowitz,S., Kirsch,I.R. and Begley,C.G.
  TITLE     Localization of murine HLH gene NSCL to chromosome 1 by use of
            recombinant inbred strains
  JOURNAL   Mamm Genome 3 (3), 182-183 (1992)
   PUBMED   1617226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149315.1, BC051018.1 and BC054760.1.
            
            On Dec 11, 2007 this sequence version replaced NM_010916.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC054760.1, BC051018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK149315.1         2-26
            26-1352             BC051018.1         1-1327
            1353-2485           BC051018.1         1329-2461
            2486-2506           BC054760.1         2463-2483
FEATURES             Location/Qualifiers
     source          1..2506
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 79.54 cM"
     gene            1..2506
                     /gene="Nhlh1"
                     /gene_synonym="bHLHa35; Hen1; Nscl; Tal2"
                     /note="nescient helix loop helix 1"
                     /db_xref="GeneID:18071"
                     /db_xref="MGI:MGI:98481"
     exon            1..310
                     /gene="Nhlh1"
                     /gene_synonym="bHLHa35; Hen1; Nscl; Tal2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..2487
                     /gene="Nhlh1"
                     /gene_synonym="bHLHa35; Hen1; Nscl; Tal2"
                     /inference="alignment:Splign:2.1.0"
     CDS             482..883
                     /gene="Nhlh1"
                     /gene_synonym="bHLHa35; Hen1; Nscl; Tal2"
                     /note="HEN-1; NSCL-1; HELIX-LOOP-HELIX PROTEIN 1 (HEN1)
                     (NSCL)"
                     /codon_start=1
                     /product="helix-loop-helix protein 1"
                     /protein_id="NP_035046.1"
                     /db_xref="CCDS:CCDS15506.1"
                     /db_xref="GeneID:18071"
                     /db_xref="MGI:MGI:98481"
                     /translation="MMLNSDTMELDLPPTHSETESGFSDCGGGPGPDGAGSGDPGVVQ
                     VRSSELGESGRKDLQHLSREERRRRRRATAKYRTAHATRERIRVEAFNLAFAELRKLL
                     PTLPPDKKLSKIEILRLAICYISYLNHVLDV"
     regulatory      2460..2465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nhlh1"
                     /gene_synonym="bHLHa35; Hen1; Nscl; Tal2"
                     /note="hexamer: ATTAAA"
     polyA_site      2485
                     /gene="Nhlh1"
                     /gene_synonym="bHLHa35; Hen1; Nscl; Tal2"
                     /note="major polyA site"
ORIGIN      
        1 agctcaggtg tgtgtatatg tgtctgtgag tgtgtgaatg tgtaggtgtg tgtatgtatg
       61 tgtgagtgtg ggtgactcca gttctggact aagtaagagc atcccttttg cctaggcctt
      121 acaaatcctc atcatgtgta cccttctcat ctgtcctgga tcctgttcag ccacaagctg
      181 cccctaagag ctctagaaac tgctcactaa ctttgcagac agatgaccct tgagcagcga
      241 gaagagactg gggctctcta cgctgtccct ctcacttgcc agcttggatc ccttggcaga
      301 gtccttctag gctccaggct ggaatcttga ccatggaact ttgaagtaac tgcttcccag
      361 agctcagtgg cagaccccgg cactccaggc ccttgctgct ttcctcctaa ccctctttga
      421 agctcctaaa gggaggggtg gggagaggat ccgcatttcc ctaggtgggg ggttttccac
      481 catgatgctc aactccgata ccatggagct ggacctgcct cccacccact cggagaccga
      541 gtcgggcttt agcgactgtg ggggcggacc gggccccgat ggtgctggat ccggggatcc
      601 aggagtggtc caggtccgga gctcagagct tggagagtcc ggccgcaaag acctgcagca
      661 cttgagtcgt gaggagcgca ggcgccggcg ccgcgccacg gccaagtacc gcacggcaca
      721 cgccacgcgg gagcgcatcc gcgtggaagc cttcaaccta gccttcgccg agctgcgcaa
      781 gctgctgccc actctgcccc cggacaagaa gctctctaag attgagatcc tacgcctggc
      841 catctgctat atctcctacc tgaaccatgt gctggacgtc tgaactcagc ccgcatccca
      901 ccctggattc tccccatttc cctgggcctc tccagagccc cctgtcacca tacattactt
      961 agaatggccg gccccctccc atcccagagg accaggctca catcgctagt cctgaaggcg
     1021 gtttcttttc attggcccag gaatgtgaag gatgttctta tgggttcctt cagagagttg
     1081 ttccggccta gcttggtcag agttgcttgc cagagtggtc agaatggagt ccgtgctggg
     1141 tttactaagc ctagcctctc tgcacagctg ctgcctcatc tatcctatgc ccaagttttc
     1201 agagacccca gaccctaact ctctttctgg caatggtggg actcaaaatc ggaatgggaa
     1261 ctgactagcg gcagaggttg aaggagcggg tccccaactc ccagactttt cggtccattg
     1321 gggggggggc agtggcgggg gtgggggggg ggaggaatgg gctcttggga tggcagagag
     1381 atgacggagg tgaatcctgg gtagccaggg attataggaa aattctgcct ttcttttgtc
     1441 tctctcagtc ctgaggctta ggatatacag acctcagatc taacttggta gtgagtgcct
     1501 tgccttcttg gagctgtccg gccgctcccg gtcccctccc acccctgcca cccagaattc
     1561 tccctttccc tgtgccggct agaaaaagga aaaccttagt cctgggataa ggatgacacc
     1621 cccaaacagc ccagggcacc ttgcagaagg ctcaggccct gggtggggcc gctccacagc
     1681 agctccttcc atcccagggg acccttgaaa acatgcaaac cccatcagct cctccctcag
     1741 atgcaagggc atgcctgcta ctgccctcta cgaatgctct agggccttct tattacattt
     1801 ttccccttcc tttcttaaac cgccgtggga aggaaggtga cccgcccatg ctgctgagcc
     1861 ccacccacct gcccattgta gccttgcgac ccagagtcta tgggccttaa attccctgta
     1921 gaagaactca ctgcttttct ctgctccatc catcctcaca ccaaactcct agctctacaa
     1981 ggatatttat ttatgtattt atttattcac ttatttattt atgtatttat ttatttataa
     2041 atattactat ttattaccga gttatgcact ttggggtagg gtgagggggg ctccttgcag
     2101 cttgctttag ctgaggtcct cttgctctct cccgggtcac ttctcttctt ctttctctag
     2161 tgcaagtatg tgtggggatc ccttcaccca ccatactggt accccttctt cagctccatc
     2221 tgtccctatc ccctttcctc tggaatagtg tcccttctca gcctcccagc ttctaggggg
     2281 tcctttctca atctctccct gctgccccca ccccgacaat ccccctccag tcctgtgtac
     2341 tccattcctc ttaccagccc tgcttttccc caaaccacca agagcagacc ctgggatctg
     2401 tgtctggtgt cctgtgtgtc tttgtctggt tgcattccta atttcctaca aaaagaaaaa
     2461 ttaaagtgac ctcgatctag taccagaaaa aaaaaaaaaa aaaaaa
//
