LOCUS       NM_133226               2181 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus NHERF family PDZ scaffold protein 4 (Nherf4), mRNA.
ACCESSION   NM_133226
VERSION     NM_133226.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2181)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2181)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2181)
  AUTHORS   Pouly,D., Chenaux,S., Martin,V., Babis,M., Koch,R., Nagoshi,E.,
            Katanaev,V.L., Gachon,F. and Staub,O.
  TITLE     USP2-45 Is a Circadian Clock Output Effector Regulating Calcium
            Absorption at the Post-Translational Level
  JOURNAL   PLoS One 11 (1), e0145155 (2016)
   PUBMED   26756164
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2181)
  AUTHORS   Shalom-Barak,T., Zhang,X., Chu,T., Timothy Schaiff,W., Reddy,J.K.,
            Xu,J., Sadovsky,Y. and Barak,Y.
  TITLE     Placental PPARgamma regulates spatiotemporally diverse genes and a
            unique metabolic network
  JOURNAL   Dev Biol 372 (1), 143-155 (2012)
   PUBMED   22967998
REFERENCE   5  (bases 1 to 2181)
  AUTHORS   Lee,J.H., Nam,J.H., Park,J., Kang,D.W., Kim,J.Y., Lee,M.G. and
            Yoon,J.S.
  TITLE     Regulation of SLC26A3 activity by NHERF4 PDZ-mediated interaction
  JOURNAL   Cell Signal 24 (9), 1821-1830 (2012)
   PUBMED   22627094
REFERENCE   6  (bases 1 to 2181)
  AUTHORS   Zachos,N.C., Hodson,C., Kovbasnjuk,O., Li,X., Thelin,W.R., Cha,B.,
            Milgram,S. and Donowitz,M.
  TITLE     Elevated intracellular calcium stimulates NHE3 activity by an IKEPP
            (NHERF4) dependent mechanism
  JOURNAL   Cell Physiol Biochem 22 (5-6), 693-704 (2008)
   PUBMED   19088451
  REMARK    GeneRIF: Regulation of NHE3 depends on the nature of the NHERF
            family member associating with NHE3 and the accompanying NHE3
            complexes.[IKEPP]
REFERENCE   7  (bases 1 to 2181)
  AUTHORS   Kim,H.J., Yang,D.K. and So,I.
  TITLE     PDZ domain-containing protein as a physiological modulator of TRPV6
  JOURNAL   Biochem Biophys Res Commun 361 (2), 433-438 (2007)
   PUBMED   17645868
  REMARK    GeneRIF: PDZK2 is an essential TRPV6 interacting protein as a
            physiological modulator of TRPV6.
REFERENCE   8  (bases 1 to 2181)
  AUTHORS   Kameya,S., Hawes,N.L., Chang,B., Heckenlively,J.R., Naggert,J.K.
            and Nishina,P.M.
  TITLE     Mfrp, a gene encoding a frizzled related protein, is mutated in the
            mouse retinal degeneration 6
  JOURNAL   Hum Mol Genet 11 (16), 1879-1886 (2002)
   PUBMED   12140190
REFERENCE   9  (bases 1 to 2181)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK052748.1 and BY368735.1.
            
            On Jul 25, 2007 this sequence version replaced NM_133226.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF334612.1, AK052748.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2117              AK052748.1         2-2118
            2118-2181           BY368735.1         219-282
FEATURES             Location/Qualifiers
     source          1..2181
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 24.84 cM"
     gene            1..2181
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /note="NHERF family PDZ scaffold protein 4"
                     /db_xref="GeneID:170761"
                     /db_xref="MGI:MGI:2429554"
     exon            1..25
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..1506
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /note="PDZ domain containing 2; natrium-phosphate
                     cotransporter IIa C-terminal-associated protein 2;
                     NHERF-4; PDZ domain-containing protein 2; PDZ
                     domain-containing protein 3; sodium-hydrogen exchanger
                     regulatory factor 4; na/Pi cotransporter
                     C-terminal-associated protein 2; sodium-phosphate
                     cotransporter IIa C-terminal-associated protein 2; PDZ
                     domain containing 3"
                     /codon_start=1
                     /product="Na(+)/H(+) exchange regulatory cofactor NHE-RF4"
                     /protein_id="NP_573489.2"
                     /db_xref="CCDS:CCDS23099.1"
                     /db_xref="GeneID:170761"
                     /db_xref="MGI:MGI:2429554"
                     /translation="MEAAADLRDTALLTLKFKFNPRLGIDNPVLSLAEDQDQSDPWNL
                     HRPRFCLLSKEEEKTFGFHLQQHLGKADHVVCRVDPGTSAQRQGLREGDRILAVNNNI
                     VAHEDHAVVVRYIRASGPRVLLTVLAQHVHDVARVLQGSDAFLCPTLPSGVRPRLCHV
                     VKDEGGFGFSVTHGSRGPFWLVLSAGGAAERAGVPPGARLLEVNGASVEKLTYNQLNR
                     KLWQSGDQVTLLVAGLEVEEQCHQLGMPLAAPLAEGWALPAKPRCLNIEKGPEGFGFL
                     LREEKGLDGRLGQFLWDVDPGLPADKAGMKAGDRLVAVAGESVDGLGHEETVSRIRAQ
                     GSCVSLIVVDPEADRFFSMVRLSPLLFLENTEIAAPPLAETKDLPVEDTVEPSGLAGS
                     CQCFLYPGPGGGYGFRLCCVASGPCLFISQVTPGGSAARAGLQVGDTVLEVNGYPVGG
                     DSELDRLQQLTEAEPPLCLKLGARNPQGLEAWISLESGEDWTLASELL"
     exon            26..53
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     exon            54..127
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     exon            128..339
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     exon            340..529
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     exon            530..666
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     exon            667..871
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1068
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1275
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1476
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..2181
                     /gene="Nherf4"
                     /gene_synonym="NaPi-Cap2; Pdzd3; Pdzk2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatccaacta tggaggcagc tgcagatctt cgggacacgg ccttgttaac tctgaagttt
       61 aagtttaatc caaggctggg cattgacaat cctgtcctct ccctcgctga agaccaggac
      121 caatctgatc cctggaacct gcaccggcct cgcttttgtc tgttgagcaa ggaggaggaa
      181 aagacttttg ggttccattt gcagcagcat ctaggcaagg ctgaccatgt ggtgtgcagg
      241 gtcgatccgg gcacctcagc ccagcgccag ggtctccggg aaggagatcg gatcctagcg
      301 gtgaacaata atattgtggc acatgaggac cacgcggtgg tagtgcgcta catccgggcc
      361 agcggtcccc gggtattgct gacagtcttg gcacaacacg tgcatgatgt ggcgcgtgtt
      421 ctgcagggga gtgacgcttt cctctgtcct accctaccct cgggggtcag gccccggttg
      481 tgccatgtag taaaagatga aggcggcttt ggcttcagcg tcacccacgg aagtcgaggt
      541 cctttctggt tggtgctcag tgcaggagga gctgctgaga gggcaggggt gccccctgga
      601 gccaggctgc tggaagtgaa tggggccagt gtggagaagc tcacatacaa ccagctcaat
      661 aggaagcttt ggcagagtgg agatcaggtg actctgctgg tggcagggct ggaggtagag
      721 gaacagtgtc accaactagg aatgcctctt gctgcacccc tggcagaggg ctgggcattg
      781 cccgccaagc cccgatgtct aaacatagag aaaggacctg aaggctttgg gttcctgctc
      841 cgggaggaga agggcctgga tggccgactt gggcagttct tgtgggacgt ggatccagga
      901 ctaccagctg acaaggctgg gatgaaggct ggagaccgcc tggtggctgt ggccggggaa
      961 agcgtggatg ggctgggcca tgaggaaaca gtgtctagaa tccgggcaca gggctcttgt
     1021 gtctctctca ttgtcgtcga tcctgaggct gaccgcttct tcagcatggt acgcctgtct
     1081 cccctcctct tcttggagaa cactgagatt gctgctcctc ctctggcaga gaccaaggat
     1141 cttccggttg aagacacagt tgagccttct ggccttgctg gctcctgcca atgcttcttg
     1201 tacccggggc ctggaggtgg ctatggattc agactctgct gtgtggccag tgggccttgt
     1261 cttttcatct cccaggtgac cccaggaggc tcagctgccc gggcagggct gcaagtggga
     1321 gatacagttt tggaggtgaa cggatatcct gtgggcggag acagtgaact ggacaggctt
     1381 cagcaactga ctgaggctga gccacccctc tgcctgaagc taggagctag gaatccgcag
     1441 ggcttagaag cctggatttc cttggagtct ggagaggact ggactctggc ttcagagttg
     1501 ctataggaca tccctgttca gcctagctta ccagcataga cttgcctagt agttctcctg
     1561 ccctcgctct gcaccctgag gtggagggag ctgggaacaa tctcttgaag ttggaattgg
     1621 gagctggagg attcagaaac caccaatcac aggactgcca gggaccttct cctttctcat
     1681 gagcctacct ccagcagagg ggtgtggaca gagaccgaag gcgggctcca cagggagcct
     1741 gagacgccac aggatgctat atgtggacat tttggggagc tgtgcgccaa agatgcagtt
     1801 ctgctcaaga agatgacgct gtggagccac cgaggattga agccatggag aacataggtt
     1861 agatgtggct ctgttgtcat ctggcagaag gattgattgg aggtgtatct tccttctact
     1921 gtggatacct tagagtcttg ggagctggtt cttggctatt gtaatgtcct ggtacagcct
     1981 ttcccagctg gctggtgaga tagcttaaaa ggtaaaggtg ctggcttcta agcctggcaa
     2041 ccggagttga ctcaccagaa ccacacggta gaagaagaga accagctcct ggaatttgcc
     2101 ctctgacctc tttgtgagca ctttagtata catacgctac tgtccaaata aataagtaaa
     2161 tgtatgtata tgtatacaga c
//
