LOCUS       NM_012030               1922 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus NHERF family PDZ scaffold protein 1 (Nherf1), mRNA.
ACCESSION   NM_012030
VERSION     NM_012030.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1922)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1922)
  AUTHORS   Ding,Y., Lang,D., Yan,J., Bu,H., Li,H., Jiao,K., Yang,J., Ni,H.,
            Morotti,S., Le,T., Clark,K.J., Port,J., Ekker,S.C., Cao,H.,
            Zhang,Y., Wang,J., Grandi,E., Li,Z., Shi,Y., Li,Y., Glukhov,A.V.
            and Xu,X.
  TITLE     A phenotype-based forward genetic screen identifies Dnajb6 as a
            sick sinus syndrome gene
  JOURNAL   Elife 11, e77327 (2022)
   PUBMED   36255053
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1922)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1922)
  AUTHORS   Scheibner,K., Schirge,S., Burtscher,I., Buttner,M., Sterr,M.,
            Yang,D., Bottcher,A., Ansarullah, Irmler,M., Beckers,J.,
            Cernilogar,F.M., Schotta,G., Theis,F.J. and Lickert,H.
  TITLE     Epithelial cell plasticity drives endoderm formation during
            gastrulation
  JOURNAL   Nat Cell Biol 23 (7), 692-703 (2021)
   PUBMED   34168324
  REMARK    Erratum:[Nat Cell Biol. 2021 Aug;23(8):925. doi:
            10.1038/s41556-021-00735-5.. PMID: 34294885]
REFERENCE   5  (bases 1 to 1922)
  AUTHORS   Kammala,A.K., Bahal,D., Yang,C., Panettieri,R.A. Jr., Das,R. and
            Subramanian,H.
  TITLE     Na+/H+ Exchanger Regulatory Factor 1 Mediates the Pathogenesis of
            Airway Inflammation in a Murine Model of House Dust Mite-Induced
            Asthma
  JOURNAL   J Immunol 206 (10), 2301-2311 (2021)
   PUBMED   33952618
  REMARK    GeneRIF: Na(+)/H(+) Exchanger Regulatory Factor 1 Mediates the
            Pathogenesis of Airway Inflammation in a Murine Model of House Dust
            Mite-Induced Asthma.
REFERENCE   6  (bases 1 to 1922)
  AUTHORS   Itoh,K., Sakakibara,M., Yamasaki,S., Takeuchi,A., Arase,H.,
            Miyazaki,M., Nakajima,N., Okada,M. and Saito,T.
  TITLE     Cutting edge: negative regulation of immune synapse formation by
            anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly
  JOURNAL   J Immunol 168 (2), 541-544 (2002)
   PUBMED   11777944
REFERENCE   7  (bases 1 to 1922)
  AUTHORS   He,J., Lau,A.G., Yaffe,M.B. and Hall,R.A.
  TITLE     Phosphorylation and cell cycle-dependent regulation of Na+/H+
            exchanger regulatory factor-1 by Cdc2 kinase
  JOURNAL   J Biol Chem 276 (45), 41559-41565 (2001)
   PUBMED   11533036
REFERENCE   8  (bases 1 to 1922)
  AUTHORS   Gisler,S.M., Stagljar,I., Traebert,M., Bacic,D., Biber,J. and
            Murer,H.
  TITLE     Interaction of the type IIa Na/Pi cotransporter with PDZ proteins
  JOURNAL   J Biol Chem 276 (12), 9206-9213 (2001)
   PUBMED   11099500
REFERENCE   9  (bases 1 to 1922)
  AUTHORS   Weinman,E.J., Steplock,D., Zhang,X., Akhter,S. and Shenolikar,S.
  TITLE     Molecular cloning of the cDNA and promoter sequences for the mouse
            sodium-hydrogen exchanger regulatory factor
  JOURNAL   Biochim Biophys Acta 1447 (1), 71-76 (1999)
   PUBMED   10500246
REFERENCE   10 (bases 1 to 1922)
  AUTHORS   Hall,R.A., Premont,R.T., Chow,C.W., Blitzer,J.T., Pitcher,J.A.,
            Claing,A., Stoffel,R.H., Barak,L.S., Shenolikar,S., Weinman,E.J.,
            Grinstein,S. and Lefkowitz,R.J.
  TITLE     The beta2-adrenergic receptor interacts with the Na+/H+-exchanger
            regulatory factor to control Na+/H+ exchange
  JOURNAL   Nature 392 (6676), 626-630 (1998)
   PUBMED   9560162
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB660628.1 and AK153558.1.
            
            On Sep 21, 2006 this sequence version replaced NM_012030.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085210.1, AK168894.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-650               BB660628.1         2-651
            651-1922            AK153558.1         651-1922
FEATURES             Location/Qualifiers
     source          1..1922
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.65 cM"
     gene            1..1922
                     /gene="Nherf1"
                     /gene_synonym="EBP-50; NHE-RF; NHERF-1; Slc9a3r1"
                     /note="NHERF family PDZ scaffold protein 1"
                     /db_xref="GeneID:26941"
                     /db_xref="MGI:MGI:1349482"
     exon            1..611
                     /gene="Nherf1"
                     /gene_synonym="EBP-50; NHE-RF; NHERF-1; Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            612..773
                     /gene="Nherf1"
                     /gene_synonym="EBP-50; NHE-RF; NHERF-1; Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            774..927
                     /gene="Nherf1"
                     /gene_synonym="EBP-50; NHE-RF; NHERF-1; Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            928..968
                     /gene="Nherf1"
                     /gene_synonym="EBP-50; NHE-RF; NHERF-1; Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1058
                     /gene="Nherf1"
                     /gene_synonym="EBP-50; NHE-RF; NHERF-1; Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1922
                     /gene="Nherf1"
                     /gene_synonym="EBP-50; NHE-RF; NHERF-1; Slc9a3r1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1922
                     /gene="Nherf1"
                     /gene_synonym="EBP-50; NHE-RF; NHERF-1; Slc9a3r1"
                     /note="major polyA site"
ORIGIN      
        1 agacgccgcg cagggcgggg attggccggc tcccttcctg tgcgttcgca accgcggttc
       61 ccgggacacc tgttccctgt gccccgtgcg gtgctcagct cccaactcga gctctgcggc
      121 tcggggagaa aggtcgtgag tccccggcct ccgacggcac ccgcgctgag ccttcgcaga
      181 acaagatgag cgcggacgca gcggccgggg agcctctgcc ccggctctgc tgcctggaga
      241 agggtccaaa tggctacggc ttccacctgc acggggagaa gggcaaggtg ggccagttta
      301 tccgtctggt agaacctggc tcgccggccg agaagtcggg gttgttggct ggagaccgat
      361 tggtggaggt gaacggtgag aatgtggaga aggagacgca tcagcaggtg gtgagccgca
      421 tccgcgcagc gctgaacgcc gtgcgcctgc tggtggtcga cccggagacc gacgagcgtc
      481 tcaagaagct gggcgtctcg atccgggaag agctgctgcg cccccaggag aagtccgaac
      541 aagccgagcc tccagcggcc gccgacactc atgaggctgg ggaccagaat gaggccgaaa
      601 agagccactt gcgcgagctc cggccccggc tctgcaccat gaagaaaggc cccaatggct
      661 atggcttcaa cctgcacagc gacaagtcta agccaggcca gttcatccga gcagtggacc
      721 cagactcacc ggcggaggcg tctggactcc gggcccagga ccgaattgtg gaggtcaatg
      781 gtgtctgcat ggagggcaag cagcacgggg acgtggtgtc cgccatcaag ggtggaggtg
      841 atgaggccaa gctgctggtg gtagacaagg aaacagatga gttcttcaag aagtgcaaag
      901 tgatcccatc ccaggagcac ctggatggcc ccttgcctga gcccttcagc aatggagaga
      961 tacagaagga gagcagccgt gaagccctgg tggagccagc ttcagagagc cccaggccag
     1021 ccctggcaag atctgcctcc agcgatacca gtgaggagct aaattcccaa gacagcccca
     1081 agagacaagt ttccacagag ccctcatcta cctcctcctc ctcctctgac cccatcttgg
     1141 acctcaacat ctccttggct gtggctaaag agagggccca ccagaagcgc agtagcaaga
     1201 gggccccgca gatggactgg agcaagaaaa atgaactctt cagcaacctc tgagcatccc
     1261 acctccgtgg gcttgtgcta gagggtgggg ctgcccaccc tacctagctc cccttccctt
     1321 ctccccaggt gcccaccaat caacattcag atcagcatca gcacccaccc cacttcctga
     1381 caaatctgat ttttctagaa tcctgttctt ccctcacctt agggaaggag aatgtttgtc
     1441 ctgtctccct acacttccct gagggcttct tcctaccaaa gtgtcccctc accagtctgc
     1501 ctagagcatc actggaaccc gcactaaaca aggacctttg gaccagacaa gaagtcttcc
     1561 ctcaactacg tgtgatgacc aagtccaagg ttgaccaggg actgtctaca gcagccacag
     1621 ccactgtgca caatggacag ggtgcccagg tcctcggagc tttggcttgg catcttgggt
     1681 tcatttgatt ttttttttta aagagtgtag tattgagatt ttagagttct cgttttcatg
     1741 attcttgtga ttttcctggt cgttgtaccc agggcatggc aatggcctca tccttaaaat
     1801 gttatttcta ctctcaccct gagagacctg ggcagccagg ctttccccag gctgcccgcc
     1861 ctgagccagg tgccaccact gtaaggaaat gccttcagaa attcactggt tccttcaaag
     1921 cg
//
