LOCUS       NM_029342               1415 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus non-homologous end joining factor 1 (Nhej1), mRNA.
ACCESSION   NM_029342 XM_992746
VERSION     NM_029342.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1415)
  AUTHORS   Bery,A., Etienne,O., Mouton,L., Mokrani,S., Granotier-Beckers,C.,
            Gauthier,L.R., Feat-Vetel,J., Kortulewski,T., Peres,E.A.,
            Desmaze,C., Lestaveal,P., Barroca,V., Laugeray,A., Boumezbeur,F.,
            Abramovski,V., Mortaud,S., Menuet,A., Le Bihan,D., Villartay,J.P.
            and Boussin,F.D.
  TITLE     XLF/Cernunnos loss impairs mouse brain development by altering
            symmetric proliferative divisions of neural progenitors
  JOURNAL   Cell Rep 42 (4), 112342 (2023)
   PUBMED   37027298
  REMARK    GeneRIF: XLF/Cernunnos loss impairs mouse brain development by
            altering symmetric proliferative divisions of neural progenitors.
REFERENCE   2  (bases 1 to 1415)
  AUTHORS   Vincendeau,E., Wei,W., Zhang,X., Planchais,C., Yu,W.,
            Lenden-Hasse,H., Cokelaer,T., Pipoli da Fonseca,J., Mouquet,H.,
            Adams,D.J., Alt,F.W., Jackson,S.P., Balmus,G., Lescale,C. and
            Deriano,L.
  TITLE     SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but
            critical for productive class switch recombination
  JOURNAL   Nat Commun 13 (1), 3707 (2022)
   PUBMED   35764636
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1415)
  AUTHORS   Roch,B., Abramowski,V., Etienne,O., Musilli,S., David,P.,
            Charbonnier,J.B., Callebaut,I., Boussin,F.D. and de Villartay,J.P.
  TITLE     An XRCC4 mutant mouse, a model for human X4 syndrome, reveals
            interplays with Xlf, PAXX, and ATM in lymphoid development
  JOURNAL   Elife 10, e69353 (2021)
   PUBMED   34519267
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1415)
  AUTHORS   Gago-Fuentes,R. and Oksenych,V.
  TITLE     Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs Maintain
            the Neural Stem and Progenitor Cell Population
  JOURNAL   Biomolecules 11 (1), 20 (2020)
   PUBMED   33379193
  REMARK    GeneRIF: Non-Homologous End Joining Factors XLF, PAXX and DNA-PKcs
            Maintain the Neural Stem and Progenitor Cell Population.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1415)
  AUTHORS   Castaneda-Zegarra,S., Zhang,Q., Alirezaylavasani,A.,
            Fernandez-Berrocal,M., Yao,R. and Oksenych,V.
  TITLE     Leaky severe combined immunodeficiency in mice lacking
            non-homologous end joining factors XLF and MRI
  JOURNAL   Aging (Albany NY) 12 (23), 23578-23597 (2020)
   PUBMED   33289702
  REMARK    GeneRIF: Leaky severe combined immunodeficiency in mice lacking
            non-homologous end joining factors XLF and MRI.
REFERENCE   6  (bases 1 to 1415)
  AUTHORS   Ahnesorg,P., Smith,P. and Jackson,S.P.
  TITLE     XLF interacts with the XRCC4-DNA ligase IV complex to promote DNA
            nonhomologous end-joining
  JOURNAL   Cell 124 (2), 301-313 (2006)
   PUBMED   16439205
REFERENCE   7  (bases 1 to 1415)
  AUTHORS   Buck,D., Malivert,L., de Chasseval,R., Barraud,A., Fondaneche,M.C.,
            Sanal,O., Plebani,A., Stephan,J.L., Hufnagel,M., le Deist,F.,
            Fischer,A., Durandy,A., de Villartay,J.P. and Revy,P.
  TITLE     Cernunnos, a novel nonhomologous end-joining factor, is mutated in
            human immunodeficiency with microcephaly
  JOURNAL   Cell 124 (2), 287-299 (2006)
   PUBMED   16439204
REFERENCE   8  (bases 1 to 1415)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 1415)
  AUTHORS   VanBuren,V., Piao,Y., Dudekula,D.B., Qian,Y., Carter,M.G.,
            Martin,P.R., Stagg,C.A., Bassey,U.C., Aiba,K., Hamatani,T.,
            Kargul,G.J., Luo,A.G., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Assembly, verification, and initial annotation of the NIA mouse
            7.4K cDNA clone set
  JOURNAL   Genome Res 12 (12), 1999-2003 (2002)
   PUBMED   12466305
REFERENCE   10 (bases 1 to 1415)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY095373.1, BC107252.1, BY432477.1 and AV512639.1.
            
            [WARNING] On Aug 3, 2024 this sequence was replaced by NM_029342.5.
            
            On Oct 20, 2007 this sequence version replaced NM_029342.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164143
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                BY095373.1         2-82
            82-1252             BC107252.1         1-1171
            1253-1401           BY432477.1         247-395
            1402-1415           AV512639.1         122-135
FEATURES             Location/Qualifiers
     source          1..1415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 38.56 cM"
     gene            1..1415
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /note="non-homologous end joining factor 1"
                     /db_xref="GeneID:75570"
                     /db_xref="MGI:MGI:1922820"
     exon            1..91
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /inference="alignment:Splign:2.1.0"
     exon            92..346
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1057
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /note="XRCC4-like factor; protein cernunnos; nonhomologous
                     end-joining factor 1"
                     /codon_start=1
                     /product="non-homologous end-joining factor 1"
                     /protein_id="NP_083618.3"
                     /db_xref="GeneID:75570"
                     /db_xref="MGI:MGI:1922820"
                     /translation="MEELEQDLLLQPWAWLQLAENSLLAKVSITKHGYALLISDLQQV
                     WHEQVDTSVVSQRAKELNKRLTAPPAALLCHLDEALRPLFKDSAHPSKATFSCDRGEE
                     GLILRVQSELSGLPFSWHFHCIPASSSLVSQHLIHPLMGVSLALQSHVRELAALLRMK
                     DLEIQAYQESGAVLSRSRLKTEPFEENSFLEQFMAEKLPEACAVGDGKPFAMSLQSLY
                     VAVTKQQIQARQAHKDSGETQASSSTSPRGTDNQPEEPVSLSSTLSEPEYEPVAASGP
                     MHRARLVKSKRKKPRGLFS"
     exon            347..559
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /inference="alignment:Splign:2.1.0"
     exon            560..698
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /inference="alignment:Splign:2.1.0"
     exon            699..757
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /inference="alignment:Splign:2.1.0"
     exon            758..875
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /inference="alignment:Splign:2.1.0"
     exon            876..982
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1405
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1376..1381
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /note="hexamer: AATAAA"
     polyA_site      1400
                     /gene="Nhej1"
                     /gene_synonym="1700029B21Rik; cernunnos; XLF"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtgttg tgtgtggggg ggtggcctct cagtttgcgc accaggacag gcccgccttg
       61 aggagggtgg gagttcccgc agccgttgac gttgacatgg aggtgtgagc cgccctcttg
      121 aaggctgact ttcctgagga cactgtgctg aattaggact tttctgcaga tggaagagct
      181 agagcaagac ctgttgctgc agccatgggc atggttacaa cttgcggaga actcactctt
      241 agccaaggtg tctatcacca agcacggtta tgccttgctg atttcggatc ttcaacaggt
      301 gtggcatgaa caggtggaca cttcggtggt cagccagcga gccaaggagc tgaacaagcg
      361 cctcactgcg cctcctgcag ctttgctctg tcacctggat gaagcacttc gcccactgtt
      421 taaagattct gctcacccta gcaaagctac tttctcctgt gaccgaggag aggagggact
      481 gatcctgcgg gtgcagagtg agctctcggg tcttcccttc agttggcatt tccactgtat
      541 tccagctagt tcttcactgg tctctcagca tttgattcat cctctgatgg gtgtgagcct
      601 ggcactgcag agtcatgtga gggagctagc agcattgctt cggatgaagg accttgagat
      661 ccaggcctac caggagagtg gggctgtgct gagccgaagt cgattgaaga cagagccatt
      721 tgaagaaaat tctttcttgg aacagtttat ggcagagaaa ttgccagagg cgtgtgctgt
      781 tggtgatgga aagccatttg ccatgagtct gcagagtctg tatgtggcag ttacaaaaca
      841 gcagatccaa gcaaggcagg cacataaaga ctctggagag actcaggcat caagcagcac
      901 ctcccctcga ggaactgata accagccaga agagccggtc tccctctctt ccaccctctc
      961 agagcctgaa tatgagcctg tggctgcttc aggccctatg catagagctc ggctggtgaa
     1021 gtccaagagg aagaagccca ggggactctt cagttaactc tccatgtctc agccaccacg
     1081 aagagagcaa aaccgcttcc tagcatcacc tggaaggagc ttgcatggca gagcatccct
     1141 cagaggcctg agtttgtgtt gacaggccac ctggatgggg actttaccag gggaagcctg
     1201 actccaactc actggcattc cggatatgag tgacaccagc tccttgcttg ggtagtgttc
     1261 tttctctaga actagcaccc tatggcaaac ttaggtacat gaagcaagtt tacaaagagg
     1321 cgcatgccca gaactcctgg ctgcctttca caggggtctc tctctctcaa cacagaataa
     1381 aggatgctca cactcctcga ctgttaaaaa aaaaa
//
