LOCUS       NM_008694               1176 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus neutrophilic granule protein (Ngp), mRNA.
ACCESSION   NM_008694
VERSION     NM_008694.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1176)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1176)
  AUTHORS   Hong,J., Qu,P., Wuest,T.R., Huang,H., Huang,C. and Lin,P.C.
  TITLE     Neutrophilic Granule Protein Is a Novel Murine LPS Antagonist
  JOURNAL   Immune Netw 19 (5), e34 (2019)
   PUBMED   31720045
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1176)
  AUTHORS   Boutte,A.M., Friedman,D.B., Bogyo,M., Min,Y., Yang,L. and Lin,P.C.
  TITLE     Identification of a myeloid-derived suppressor cell cystatin-like
            protein that inhibits metastasis
  JOURNAL   FASEB J 25 (8), 2626-2637 (2011)
   PUBMED   21518852
REFERENCE   4  (bases 1 to 1176)
  AUTHORS   Bowman,T.V., McCooey,A.J., Merchant,A.A., Ramos,C.A., Fonseca,P.,
            Poindexter,A., Bradfute,S.B., Oliveira,D.M., Green,R., Zheng,Y.,
            Jackson,K.A., Chambers,S.M., McKinney-Freeman,S.L., Norwood,K.G.,
            Darlington,G., Gunaratne,P.H., Steffen,D. and Goodell,M.A.
  TITLE     Differential mRNA processing in hematopoietic stem cells
  JOURNAL   Stem Cells 24 (3), 662-670 (2006)
   PUBMED   16373690
REFERENCE   5  (bases 1 to 1176)
  AUTHORS   Iwama,A., Zhang,P., Darlington,G.J., McKercher,S.R., Maki,R. and
            Tenen,D.G.
  TITLE     Use of RDA analysis of knockout mice to identify myeloid genes
            regulated in vivo by PU.1 and C/EBPalpha
  JOURNAL   Nucleic Acids Res 26 (12), 3034-3043 (1998)
   PUBMED   9611252
REFERENCE   6  (bases 1 to 1176)
  AUTHORS   Scott,L.M., Mueller,L. and Collins,S.J.
  TITLE     E3, a hematopoietic-specific transcript directly regulated by the
            retinoic acid receptor alpha
  JOURNAL   Blood 88 (7), 2517-2530 (1996)
   PUBMED   8839844
REFERENCE   7  (bases 1 to 1176)
  AUTHORS   Moscinski,L.C. and Hill,B.
  TITLE     Molecular cloning of a novel myeloid granule protein
  JOURNAL   J Cell Biochem 59 (4), 431-442 (1995)
   PUBMED   8749713
REFERENCE   8  (bases 1 to 1176)
  AUTHORS   Moscinski,L.C. and Prystowsky,M.B.
  TITLE     Identification of a series of differentiation-associated gene
            sequences from GM-CSF stimulated bone marrow
  JOURNAL   Oncogene 5 (1), 31-37 (1990)
   PUBMED   2181376
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DY244714.1, AK009649.1 and AI842361.1.
            
            On Jan 9, 2008 this sequence version replaced NM_008694.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: U95002.1, L37297.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-231               DY244714.1         88-318              c
            232-1038            AK009649.1         186-992
            1039-1176           AI842361.1         1-138               c
FEATURES             Location/Qualifiers
     source          1..1176
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 59.92 cM"
     gene            1..1176
                     /gene="Ngp"
                     /gene_synonym="bectenecin"
                     /note="neutrophilic granule protein"
                     /db_xref="GeneID:18054"
                     /db_xref="MGI:MGI:105983"
     exon            1..231
                     /gene="Ngp"
                     /gene_synonym="bectenecin"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..558
                     /gene="Ngp"
                     /gene_synonym="bectenecin"
                     /note="clone B6; myeloid granule protein; cystatin-like
                     protein; myeloid bactenecin protein; myeloid secondary
                     granule protein"
                     /codon_start=1
                     /product="neutrophilic granule protein precursor"
                     /protein_id="NP_032720.2"
                     /db_xref="CCDS:CCDS23566.1"
                     /db_xref="GeneID:18054"
                     /db_xref="MGI:MGI:105983"
                     /translation="MAGLWKTFVLVVALAVVSCEALRQLRYEEIVDRAIEAYNQGRQG
                     RPLFRLLSATPPSSQNPATNIPLQFRIKETECTSTQERQPKDCDFLEDGEERNCTGKF
                     FRRRQSTSLTLTCDRDCSREDTQETSFNDKQDVSEKEKFEDVPPHIRNIYEDAKYDII
                     GNILKNF"
     exon            232..333
                     /gene="Ngp"
                     /gene_synonym="bectenecin"
                     /inference="alignment:Splign:2.1.0"
     exon            334..420
                     /gene="Ngp"
                     /gene_synonym="bectenecin"
                     /inference="alignment:Splign:2.1.0"
     exon            421..1161
                     /gene="Ngp"
                     /gene_synonym="bectenecin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1139..1144
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ngp"
                     /gene_synonym="bectenecin"
                     /note="hexamer: AATAAA"
     polyA_site      1161
                     /gene="Ngp"
                     /gene_synonym="bectenecin"
                     /note="major polyA site"
ORIGIN      
        1 agtctcaata tcatctacat aaaaggggcc aagagtggta gtgtgtcaga gacaatggca
       61 gggctgtgga agacctttgt attggtggtg gccttggctg tggtctcctg tgaggccctt
      121 cgacaactaa gatatgagga gattgttgat agagccatag aggcatacaa ccaagggcgg
      181 caaggaagac ccctcttccg cctgctaagt gccactccgc cttctagtca gaatcctgct
      241 accaatatcc cactccagtt caggattaaa gagacagagt gtacttccac ccaggagaga
      301 cagcctaaag actgcgactt cctggaggat ggggaggaga gaaattgcac agggaaattc
      361 ttcagaaggc ggcagtcaac ctccctgacc ttgacctgcg acagggattg cagtcgagag
      421 gatacccaag aaaccagttt taatgataag caagacgtct ctgaaaagga aaagttcgaa
      481 gatgtgcccc ctcacatcag gaacatttat gaagatgcca agtatgatat catcggcaac
      541 atcctgaaaa atttctaggg ctggaaagag gagggaggtg ctccctgcat actatgacct
      601 cctctttacc tccactaccc atctccccct gctgcattca ggatctgccc ctccttcctg
      661 cccttcccag gaacaccccc tctagagtag ctctagctcc taaaacatcc atacctttgt
      721 ccatttgctt ccttctgctg ggccttcctg ccttaccctc tatctgaaac ccttattgat
      781 tcttcaaggc ccaagttcaa aagtcccctc cagcgggaag cctcctcatt ctcccagagc
      841 caaagtcctg cccacatcag ttcactcata atcttcaaac cacattggta ttacctgctg
      901 tgtccccagc cagacaaccc tgtatctatt cacagctggg cctcccgggc cagttgcagg
      961 tagaatgaat atttcaatga tgtgtccctg gaatcctggg aggacagaac cctgtagact
     1021 cctgctctct gcctagtcac tgtgacacca aatgcccctt tacataccca gatcccttaa
     1081 tggggatgtg gcaggtgggt gtggtcagat caccttgtga ggcctataag agaggttcaa
     1141 taaaaatgct tctgagatta aaaaaaaaaa aaaaaa
//
