LOCUS       NM_033217               3409 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus nerve growth factor receptor (TNFR superfamily, member
            16) (Ngfr), mRNA.
ACCESSION   NM_033217
VERSION     NM_033217.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3409)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 3409)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   3  (bases 1 to 3409)
  AUTHORS   Ding,F., Zheng,P., Yan,X.Y., Chen,H.J., Fang,H.T., Luo,Y.Y.,
            Peng,Y.X., Zhang,L. and Yan,Y.E.
  TITLE     Adipocyte-secreted PRELP promotes adipocyte differentiation and
            adipose tissue fibrosis by binding with p75NTR to activate FAK/MAPK
            signaling
  JOURNAL   Int J Biol Macromol 279 (Pt 4), 135376 (2024)
   PUBMED   39244119
  REMARK    GeneRIF: Adipocyte-secreted PRELP promotes adipocyte
            differentiation and adipose tissue fibrosis by binding with
            p75[NTR] to activate FAK/MAPK signaling.
REFERENCE   4  (bases 1 to 3409)
  AUTHORS   Pagella,P., Lai,C.F., Pirenne,L., Cantu,C., Schwab,M.E. and
            Mitsiadis,T.A.
  TITLE     An unexpected role of neurite outgrowth inhibitor A as regulator of
            tooth enamel formation
  JOURNAL   Int J Oral Sci 16 (1), 60 (2024)
   PUBMED   39426966
  REMARK    Erratum:[Int J Oral Sci. 2024 Nov 8;16(1):64. doi:
            10.1038/s41368-024-00330-y. PMID: 39511159]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3409)
  AUTHORS   Traynor,S., Bhattacharya,S., Batmanov,K., Cheng,L., Weller,A.,
            Moore,N., Flesher,C. and Merrick,D.
  TITLE     Developmental regulation of dermal adipose tissue by BCL11b
  JOURNAL   Genes Dev 38 (15-16), 772-783 (2024)
   PUBMED   39266447
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3409)
  AUTHORS   Chao,M.V.
  TITLE     Neurotrophin receptors: a window into neuronal differentiation
  JOURNAL   Neuron 9 (4), 583-593 (1992)
   PUBMED   1327010
  REMARK    Review article
REFERENCE   7  (bases 1 to 3409)
  AUTHORS   Serikawa,T., Kuramoto,T., Hilbert,P., Mori,M., Yamada,J.,
            Dubay,C.J., Lindpainter,K., Ganten,D., Guenet,J.L., Lathrop,G.M. et
            al.
  TITLE     Rat gene mapping using PCR-analyzed microsatellites
  JOURNAL   Genetics 131 (3), 701-721 (1992)
   PUBMED   1628813
REFERENCE   8  (bases 1 to 3409)
  AUTHORS   Lee,K.F., Li,E., Huber,L.J., Landis,S.C., Sharpe,A.H., Chao,M.V.
            and Jaenisch,R.
  TITLE     Targeted mutation of the gene encoding the low affinity NGF
            receptor p75 leads to deficits in the peripheral sensory nervous
            system
  JOURNAL   Cell 69 (5), 737-749 (1992)
   PUBMED   1317267
REFERENCE   9  (bases 1 to 3409)
  AUTHORS   Cornall,R.J., Friedman,J.M. and Todd,J.A.
  TITLE     Mouse microsatellites from a flow-sorted 4:6 Robertsonian
            chromosome
  JOURNAL   Mamm Genome 3 (11), 620-624 (1992)
   PUBMED   1450512
REFERENCE   10 (bases 1 to 3409)
  AUTHORS   Sutter,A., Riopelle,R.J., Harris-Warrick,R.M. and Shooter,E.M.
  TITLE     Nerve growth factor receptors. Characterization of two distinct
            classes of binding sites on chick embryo sensory ganglia cells
  JOURNAL   J Biol Chem 254 (13), 5972-5982 (1979)
   PUBMED   571871
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662875.14.
            
            On Nov 17, 2006 this sequence version replaced NM_033217.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC038365.1, AK037248.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-215               AL662875.14        215289-215503       c
            216-357             AL662875.14        208758-208899       c
            358-717             AL662875.14        205779-206138       c
            718-970             AL662875.14        201996-202248       c
            971-1131            AL662875.14        199625-199785       c
            1132-3409           AL662875.14        196623-198900       c
FEATURES             Location/Qualifiers
     source          1..3409
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.01 cM"
     gene            1..3409
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NGFR; p75NTR; Tnfrsf16"
                     /note="nerve growth factor receptor (TNFR superfamily,
                     member 16)"
                     /db_xref="GeneID:18053"
                     /db_xref="MGI:MGI:97323"
     exon            1..215
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NGFR; p75NTR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1424
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NGFR; p75NTR; Tnfrsf16"
                     /note="tumor necrosis factor receptor superfamily member
                     16; NGF receptor; low affinity neurotrophin receptor
                     p75NTR; low-affinity nerve growth factor receptor; p75
                     neurotrophin receptor; low-affinity nerve growth factor
                     receptor p75NGR; low-affinity nerve growth factor receptor
                     p75NGFR"
                     /codon_start=1
                     /product="tumor necrosis factor receptor superfamily
                     member 16 precursor"
                     /protein_id="NP_150086.2"
                     /db_xref="CCDS:CCDS25279.1"
                     /db_xref="GeneID:18053"
                     /db_xref="MGI:MGI:97323"
                     /translation="MRRAGAACSAMDRLRLLLLLLLLLGVSFGGAKETCSTGMYTHSG
                     ECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECLGLQSMSAPC
                     VEADDAVCRCSYGYYQDEETGRCEACSVCGVGSGLVFSCQDKQNTVCEECPEGTYSDE
                     ANHVDPCLPCTVCEDTERQLRECTPWADAECEEIPGRWITRSTPPEGSDVTTPSTQEP
                     EAPPERDLIASTVADTVTTVMGSSQPVVTRGTADNLIPVYCSILAAVVVGLVAYIAFK
                     RWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQTHTQTASGQALKG
                     DGNLYSSLPLTKREEVEKLLNGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWGA
                     QDSATLDALLAALRRIQRADIVESLCSESTATSPV"
     exon            216..357
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NGFR; p75NTR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     exon            358..717
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NGFR; p75NTR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     exon            718..970
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NGFR; p75NTR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1131
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NGFR; p75NTR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
     exon            1132..3409
                     /gene="Ngfr"
                     /gene_synonym="LNGFR; p75; p75NGFR; p75NTR; Tnfrsf16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcgagtg gagcctccgc cagctccggc gggcagcggg cgctggagcg cagcgcagcg
       61 cagctcagct cagcgcgcag caccatcggt ccgcagagcg gactgagcta gaagctgagc
      121 gctgtcgccg gaggcgagca atgaggaggg caggtgctgc ctgcagcgcc atggaccggc
      181 tgcgcctgct gctgctgctg ctgctgcttc taggggtgtc ctttggaggt gccaaggaga
      241 catgttccac aggcatgtac acccacagtg gagagtgctg caaagcctgc aacctgggcg
      301 aaggtgtggc ccagccttgc ggagccaacc agaccgtgtg tgaaccctgc ctggacagtg
      361 ttacgttctc tgacgtggtg agcgccaccg agccgtgcaa gccgtgcacc gagtgcctgg
      421 gcctgcagag tatgtccgct ccctgtgtgg aggcagacga tgccgtgtgc cgatgctcct
      481 atggctacta ccaggacgag gagactggcc gctgcgaggc ttgcagcgtg tgcggggtgg
      541 gctcaggact cgtgttctcc tgccaggaca aacagaacac agtgtgtgaa gagtgcccag
      601 agggcacata ctcagatgaa gccaaccacg tggacccgtg cctaccctgc acggtgtgcg
      661 aggacactga gcgccagtta cgcgagtgca cgccctgggc tgacgccgaa tgcgaggaga
      721 tccctggccg atggatcaca aggtctacgc ccccggaggg ctctgacgtc acaacaccca
      781 gcacccagga gccggaggca cctccagagc gagacctcat agccagcaca gtggccgata
      841 cggtgaccac tgtgatgggc agctcccagc ctgtagtgac ccgaggcacc gctgacaacc
      901 tcattcctgt ctattgctcc atcttggctg ctgtggttgt gggccttgtg gcctatattg
      961 ctttcaagag atggaacagc tgcaagcaaa ataaacaagg agccaacagc cggccggtga
     1021 accagacacc cccaccagag ggagagaaac tgcacagcga cagcggcatc tctgtggaca
     1081 gccagagcct gcacgaccag cagacccaca cacagactgc ctcaggccaa gccctcaagg
     1141 gtgatggcaa cctctacagt agcctgcccc tgaccaagcg tgaggaggtc gagaagctgc
     1201 tcaatggtga cacctggcga catctggcag gcgagctggg ctaccagccg gagcatatag
     1261 actcctttac ccacgaggcc tgcccagtcc gagccctgct ggccagctgg ggtgcccagg
     1321 acagcgcgac gctcgatgcc cttttagccg ccctgcgacg catccagaga gctgacattg
     1381 tggagagcct gtgcagcgag tccactgcca cgtcccctgt gtgagctcac cgactgggag
     1441 cccctgtcct gtcccacatt ccgaccgctg atgttctagc ccccacagag ccgcccccct
     1501 ctcccttggg gtggcccaac agtcagaacc gagcatctct gtgtagggcc tctgtgtccc
     1561 gctccccaaa ccacagccct gttgctgctc ctgaggggac ctttgcttct gaccacactc
     1621 tctctccggc gagagatagg accaccccaa gcctgtcttg ccccgtgacc atctcaggcc
     1681 tttcctttct ttctacacat taactgtgtc agatctaggg gtctgacact agagaaggta
     1741 acaggggcac ccctaagact cagggggtac taatgaacca gagccatgga ctccacactg
     1801 tgaactggag aacagggggg gcattgtggt aggccagacc ttcctcaacc cctcccttct
     1861 cccatctggc caaagatgaa gaggattaca ggcctatctg agctgaaagc aggtttggag
     1921 cccagtccac actccttctc ttacacatag gatggtaaag cccagagagg cagggactaa
     1981 cctaggccac ccaacaacag ggagatcaat tgtaggctga cacactcctt tctgaatgag
     2041 ggcgtcaagt gcttgttggc agggatggag tgactttcag ggaaacatct ggaaacgacg
     2101 tctgccccgc cctcaaccac ttccaggccc ctacccaacc cttgtgcaga tgaactgtct
     2161 gttcaaaacc tggtccattg gcctgttctg atggagtcgg gctaatgtcc tggggagtgg
     2221 ggtgctgcct tcctctgtct gtcaggctta gccacagggc atttgtggag ggatgaatct
     2281 gttagcaccc tcattcgtgt cataagcctg aagccaacag tggcccttgg agtcaaccct
     2341 aggggtcagg gaccaaggac ccaccccata atccaacacc acacacacac acacacacac
     2401 acacacacac agagagagag agagagagag agagagagag agagagagag agagatcatg
     2461 cttttccccc catggctctt tttgggctga gaccagatcc tgctggaagt cgctggctgc
     2521 cagagaaaga tggaagggga ccgagatgag cttcgtgggg ctgtcttcct cacctcccgg
     2581 ctctggcagg ccaagaactg ctgcatctga gctggcgtgc gtgcgtccgt ccctgtccgt
     2641 cggtctccaa tggcctgtgt gtggaggaat gctcacaccg ctccctctcc tccccttctt
     2701 gaagcccaac tttggctgca cccagaaaac agtgaagaaa agcaggctgc tgtgagaaca
     2761 caagaaaatg cagatgctgg cccgcagtct gaggcaactt tctcctcagt ttcatggccc
     2821 ctgcaaagga ccaatttcct gggcatggcc aggaagggac ccgagtgctc attggccggc
     2881 gctttcacct ggctccttgg cctgttctgt tttgcttgct gttggaatga gtgggctccc
     2941 cctctattta gcatgaagga gccccaggca gggtatgcac agactgactg ccatccctcc
     3001 ccacccaggg tccacccagc cctgtaagga gacaaggagc cttgtgctcg gtggtatttt
     3061 tatggacctc gatctgcaat tagtagaagg accccaccgg ctggccctcc ccggacacct
     3121 gggaagtggg acattctttg tgtatttatt ttcctccccc agaagctggg ggtgggtggg
     3181 tgggggagga gctgcaggac cagtttagca tgtgtttggt tctgggggtc tctccagcct
     3241 tattttgggt caagatggaa cctctggccc tccagctggc gactatgaga tccagacctc
     3301 ttcatgttcc ctgacacttc ccctttgcat cctgtgtaat catttcttgg gccctcccaa
     3361 aacctacaca taaaacatac gtgatgacca ttaaatagca aaaaaaaaa
//
