LOCUS       NM_001112698            1069 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus nerve growth factor (Ngf), transcript variant 2, mRNA.
ACCESSION   NM_001112698
VERSION     NM_001112698.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1069)
  AUTHORS   Patel,V.N., Aure,M.H., Choi,S.H., Ball,J.R., Lane,E.D., Wang,Z.,
            Xu,Y., Zheng,C., Liu,X., Martin,D., Pailin,J.Y., Prochazkova,M.,
            Kulkarni,A.B., van Kuppevelt,T.H., Ambudkar,I.S., Liu,J. and
            Hoffman,M.P.
  TITLE     Specific 3-O-sulfated heparan sulfate domains regulate salivary
            gland basement membrane metabolism and epithelial differentiation
  JOURNAL   Nat Commun 15 (1), 7584 (2024)
   PUBMED   39217171
  REMARK    Erratum:[Nat Commun. 2024 Oct 10;15(1):8784. doi:
            10.1038/s41467-024-53230-4.. PMID: 39389981]
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1069)
  AUTHORS   Li,W., Lipsius,K., Burns,N.G., Sato,R., Rehman,A., Xue,H.,
            Combs,C., Minichiello,L., Gangrade,H., Tampakakis,E. and
            Mukouyama,Y.S.
  TITLE     Vascular smooth muscle cell-derived nerve growth factor regulates
            sympathetic collateral branching to innervate blood vessels in
            embryonic skin
  JOURNAL   Biol Open 13 (5) (2024)
   PUBMED   38639409
REFERENCE   3  (bases 1 to 1069)
  AUTHORS   Zhang,T., Tong,Y., Zhu,R., Liang,Y., Zhang,J., Hu,C., He,M., Hu,Z.,
            Shen,Z., Niu,J., Zhang,J., Yu,Y., Jin,B., Lei,S., Zeng,Z., Wu,Y.,
            Cheng,Z., Xiao,Z., Guo,B., Zhao,S., Xu,G., Pan,W. and Chen,T.
  TITLE     HDAC6-dependent deacetylation of NGF dictates its ubiquitination
            and maintains primordial follicle dormancy
  JOURNAL   Theranostics 14 (6), 2345-2366 (2024)
   PUBMED   38646645
  REMARK    GeneRIF: HDAC6-dependent deacetylation of NGF dictates its
            ubiquitination and maintains primordial follicle dormancy.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1069)
  AUTHORS   Bai,X., Wang,B., Cui,Y., Tian,S., Zhang,Y., You,L., Chang,Y.Z. and
            Gao,G.
  TITLE     Hepcidin deficiency impairs hippocampal neurogenesis and mediates
            brain atrophy and memory decline in mice
  JOURNAL   J Neuroinflammation 21 (1), 15 (2024)
   PUBMED   38195497
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1069)
  AUTHORS   D'Mello,S.R., Jiang,C., Lamberti,C., Martin,S.C. and Heinrich,G.
  TITLE     Differential regulation of the nerve growth factor and
            brain-derived neurotrophic factor genes in L929 mouse fibroblasts
  JOURNAL   J Neurosci Res 33 (4), 519-526 (1992)
   PUBMED   1336558
REFERENCE   6  (bases 1 to 1069)
  AUTHORS   Yamamoto,T., Yamakuni,T., Okabe,N. and Amano,T.
  TITLE     Production and secretion of nerve growth factor by clonal striated
            muscle cell line, G8-1
  JOURNAL   Neurochem Int 21 (2), 251-258 (1992)
   PUBMED   1284621
REFERENCE   7  (bases 1 to 1069)
  AUTHORS   Berkemeier,L.R., Ozcelik,T., Francke,U. and Rosenthal,A.
  TITLE     Human chromosome 19 contains the neurotrophin-5 gene locus and
            three related genes that may encode novel acidic neurotrophins
  JOURNAL   Somat Cell Mol Genet 18 (3), 233-245 (1992)
   PUBMED   1496419
REFERENCE   8  (bases 1 to 1069)
  AUTHORS   Black,M.A., Pope,L., Lefebvre,F.A., Lefebvre,Y.A. and Walker,P.
  TITLE     Thyroid hormones precociously increase nerve growth factor gene
            expression in the submandibular gland of neonatal mice
  JOURNAL   Endocrinology 130 (4), 2083-2090 (1992)
   PUBMED   1547729
REFERENCE   9  (bases 1 to 1069)
  AUTHORS   Selby,M.J., Edwards,R., Sharp,F. and Rutter,W.J.
  TITLE     Mouse nerve growth factor gene: structure and expression
  JOURNAL   Mol Cell Biol 7 (9), 3057-3064 (1987)
   PUBMED   3670305
REFERENCE   10 (bases 1 to 1069)
  AUTHORS   Zabel,B.U., Eddy,R.L., Lalley,P.A., Scott,J., Bell,G.I. and
            Shows,T.B.
  TITLE     Chromosomal locations of the human and mouse genes for precursors
            of epidermal growth factor and the beta subunit of nerve growth
            factor
  JOURNAL   Proc Natl Acad Sci U S A 82 (2), 469-473 (1985)
   PUBMED   3871525
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC108822.9.
            
            On Nov 20, 2013 this sequence version replaced NM_001112698.1.
            
            Transcript Variant: This variant (2) contains a distinct 5' UTR and
            lacks an in-frame portion of the 5' coding region compared to
            variant 1. The resulting isoform (B) has a shorter N-terminus
            compared to isoform A.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BF786523.1, BY334442.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                AC108822.9         97157-97198
            43-166              AC108822.9         141194-141317
            167-1069            AC108822.9         147349-148251
FEATURES             Location/Qualifiers
     source          1..1069
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 45.25 cM"
     gene            1..1069
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /note="nerve growth factor"
                     /db_xref="GeneID:18049"
                     /db_xref="MGI:MGI:97321"
     exon            1..42
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /inference="alignment:Splign:2.1.0"
     exon            43..166
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /inference="alignment:Splign:2.1.0"
     exon            167..1069
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..904
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /note="isoform B precursor is encoded by transcript
                     variant 2; beta-nerve growth factor; nerve growth factor,
                     beta"
                     /codon_start=1
                     /product="beta-nerve growth factor isoform B precursor"
                     /protein_id="NP_001106168.1"
                     /db_xref="CCDS:CCDS51025.1"
                     /db_xref="GeneID:18049"
                     /db_xref="MGI:MGI:97321"
                     /translation="MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSL
                     DTALRRARSAPTAPIAARVTGQTRNITVDPRLFKKRRLHSPRVLFSTQPPPTSSDTLD
                     LDFQAHGTIPFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVL
                     AEVNINNSVFRQYFFETKCRASNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDEKQA
                     AWRFIRIDTACVCVLSRKATRRG"
     regulatory      1040..1045
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /note="hexamer: ATTAAA"
     polyA_site      1063
                     /gene="Ngf"
                     /gene_synonym="beta-NGF; Ngfb"
                     /note="major polyA site"
ORIGIN      
        1 cagcacggca gagagcgcct ggagccggag gggagcgcat cgagttttgg cctgtggtcg
       61 tgcagtccag ggggctggat ggcatgctgg acccaagctc acctcagtgt ctgggcccaa
      121 taaaggtttt gccaaggacg cagctttcta tactggccgc agtgaggtgc atagcgtaat
      181 gtccatgttg ttctacactc tgatcactgc gtttttgatc ggcgtacagg cagaaccgta
      241 cacagatagc aatgtcccag aaggagactc tgtccctgaa gcccactgga ctaaacttca
      301 gcattccctt gacacagccc tccgcagagc ccgcagtgcc cctactgcac caatagctgc
      361 ccgagtgaca gggcagaccc gcaacatcac tgtagacccc agactgttta agaaacggag
      421 actccactca ccccgtgtgc tgttcagcac ccagcctcca cccacctctt cagacactct
      481 ggatctagac ttccaggccc atggtacaat ccctttcaac aggactcacc ggagcaagcg
      541 ctcatccacc cacccagtct tccacatggg ggagttctca gtgtgtgaca gtgtcagtgt
      601 gtgggttgga gataagacca cagccacaga catcaagggc aaggaggtga cagtgctggc
      661 cgaggtgaac attaacaaca gtgtattcag acagtacttt tttgagacca agtgccgagc
      721 ctccaatcct gttgagagtg ggtgccgggg catcgactcc aaacactgga actcatactg
      781 caccacgact cacaccttcg tcaaggcgtt gacaacagat gagaagcagg ctgcctggag
      841 gttcatccgg atagacacag cctgtgtgtg tgtgctcagc aggaaggcta caagaagagg
      901 ctgacttgcc tgcagccccc ttccccacct gccccctcca cactctcctg ggcccctccc
      961 tacctcagcc tgtaaattat tttaaattat aaggactgca tgataattta tcgtttatac
     1021 aattttaaag acattattta ttaaattttc aaagcatcct gtataccga
//
