LOCUS       NM_010914               2552 bp    mRNA    linear   ROD 02-FEB-2024
DEFINITION  Mus musculus nuclear transcription factor-Y beta (Nfyb), mRNA.
ACCESSION   NM_010914
VERSION     NM_010914.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Begum,G., Otsu,M., Ahmed,U., Ahmed,Z., Stevens,A. and Fulton,D.
  TITLE     NF-Y-dependent regulation of glutamate receptor 4 expression and
            cell survival in cells of the oligodendrocyte lineage
  JOURNAL   Glia 66 (9), 1896-1914 (2018)
   PUBMED   29704264
  REMARK    GeneRIF: Study indentifies NF-Yb as a novel transcriptional
            regulator of Gria4 (GluA4 gene), and a controller of excitotoxic
            death in the oligodendroglial lineage; describes a novel regulatory
            region within Gria4 containing CCAAT sequences whose binding by
            NF-Yb is regulated by excitotoxicity. Excitotoxicity-induced
            alterations in NF-Yb binding are associated with changes in Gria4
            transcription.
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Guess,M.G., Barthel,K.K., Harrison,B.C. and Leinwand,L.A.
  TITLE     miR-30 family microRNAs regulate myogenic differentiation and
            provide negative feedback on the microRNA pathway
  JOURNAL   PLoS One 10 (2), e0118229 (2015)
   PUBMED   25689854
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Oldfield,A.J., Yang,P., Conway,A.E., Cinghu,S., Freudenberg,J.M.,
            Yellaboina,S. and Jothi,R.
  TITLE     Histone-fold domain protein NF-Y promotes chromatin accessibility
            for cell type-specific master transcription factors
  JOURNAL   Mol Cell 55 (5), 708-722 (2014)
   PUBMED   25132174
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Gaspard,G.J., MacLean,J., Rioux,D. and Pasumarthi,K.B.
  TITLE     A novel beta-adrenergic response element regulates both basal and
            agonist-induced expression of cyclin-dependent kinase 1 gene in
            cardiac fibroblasts
  JOURNAL   Am J Physiol Cell Physiol 306 (6), C540-C550 (2014)
   PUBMED   24477232
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Reed,G.E., Kirchner,J.E. and Carr,L.G.
  TITLE     NF-Y activates mouse tryptophan hydroxylase transcription
  JOURNAL   Brain Res 682 (1-2), 1-12 (1995)
   PUBMED   7552299
REFERENCE   7  (bases 1 to 2552)
  AUTHORS   Li,X.Y., Hooft van Huijsduijnen,R., Mantovani,R., Benoist,C. and
            Mathis,D.
  TITLE     Intron-exon organization of the NF-Y genes. Tissue-specific
            splicing modifies an activation domain
  JOURNAL   J Biol Chem 267 (13), 8984-8990 (1992)
   PUBMED   1577736
REFERENCE   8  (bases 1 to 2552)
  AUTHORS   Li,X.Y., Mantovani,R., Hooft van Huijsduijnen,R., Andre,I.,
            Benoist,C. and Mathis,D.
  TITLE     Evolutionary variation of the CCAAT-binding transcription factor
            NF-Y
  JOURNAL   Nucleic Acids Res 20 (5), 1087-1091 (1992)
   PUBMED   1549471
  REMARK    Erratum:[Nucleic Acids Res 1992 Apr 11;20(7):1841]
REFERENCE   9  (bases 1 to 2552)
  AUTHORS   Li,X.Y., Mattei,M.G., Zaleska-Rutczynska,Z., Hooft van
            Huijsduijnen,R., Figueroa,F., Nadeau,J., Benoist,C. and Mathis,D.
  TITLE     One subunit of the transcription factor NF-Y maps close to the
            major histocompatibility complex in murine and human chromosomes
  JOURNAL   Genomics 11 (3), 630-634 (1991)
   PUBMED   1774067
REFERENCE   10 (bases 1 to 2552)
  AUTHORS   Hooft van Huijsduijnen,R., Li,X.Y., Black,D., Matthes,H.,
            Benoist,C. and Mathis,D.
  TITLE     Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y
            (CP-1/CBF) subunits
  JOURNAL   EMBO J 9 (10), 3119-3127 (1990)
   PUBMED   1698608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB858171.1, AK079209.1, AK010762.1 and BB031987.1.
            
            [WARNING] On Mar 20, 2024 this sequence was replaced by
            NM_010914.3.
            
            On Jul 16, 2005 this sequence version replaced NM_010914.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.300792.1,
                                           SRR1660815.279664.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-46                BB858171.1         4-49
            47-77               AK079209.1         2-32
            78-165              AK010762.1         58-145
            166-782             AK079209.1         121-737
            783-1247            AK010762.1         763-1227
            1248-2522           AK079209.1         1201-2475
            2523-2552           BB031987.1         232-261
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 40.25 cM"
     gene            1..2552
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /note="nuclear transcription factor-Y beta"
                     /db_xref="GeneID:18045"
                     /db_xref="MGI:MGI:97317"
     exon            1..138
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            139..219
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             214..837
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /note="NF-YB; nuclear transcription factor Y subunit B;
                     CAAT box DNA-binding protein subunit B"
                     /codon_start=1
                     /product="nuclear transcription factor Y subunit beta"
                     /protein_id="NP_035044.1"
                     /db_xref="CCDS:CCDS48654.1"
                     /db_xref="GeneID:18045"
                     /db_xref="MGI:MGI:97317"
                     /translation="MTMDGDSSTTDASQLGISADYIGGSHYVIQPHDDTEDSMNDHED
                     TNGSKESFREQDIYLPIANVARIMKNAIPQTGKIAKDAKECVQECVSEFISFITSEAS
                     ERCHQEKRKTINGEDILFAMSTLGFDSYVEPLKLYLQKFREAMKGEKGIGGAVSATDG
                     LSEELTEEAFTNQLPAGLITADGQQQNVMVYTTSYQQISGVQQIQFS"
     exon            220..313
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            314..444
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            445..642
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            643..724
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            725..804
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /inference="alignment:Splign:2.1.0"
     exon            805..2552
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1225..1230
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /note="putative"
     polyA_site      1247
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /note="putative"
     regulatory      2504..2509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfyb"
                     /gene_synonym="Cbf-A"
                     /note="putative"
ORIGIN      
        1 ggaagcggcc cgcggcggag ggaggggagg ccgagtcctg gaagtggagc tccgcgctgg
       61 gactggttcc ttcgcagcca ttttctgtcc aaccaaacag ccgattggag acgggagcca
      121 accagggctg cattggaggt taaaattata caaggatcca ccaccttttt gacaggtatt
      181 tgagaatacc actgatacac aatacagtat ttcatgacaa tggacggcga cagctccacc
      241 acagatgcct cccagctagg gatttctgca gactacatcg gaggaagtca ttatgtgatc
      301 cagccccatg atgatactga ggacagcatg aatgatcatg aagatacaaa tggttcaaaa
      361 gaaagtttca gagaacaaga tatttatctt ccaattgcaa atgtggctag gataatgaaa
      421 aatgccatac ctcaaacagg aaagatcgca aaagatgcca aagaatgtgt tcaggaatgt
      481 gtgagtgaat ttataagctt catcacgtcg gaagcaagcg aaaggtgtca tcaggagaag
      541 cggaagacaa tcaatgggga ggatattctg tttgccatgt ccactctagg ctttgacagc
      601 tacgtggagc ctctgaaact gtaccttcag aagttcagag aggccatgaa aggagagaag
      661 ggtatcgggg gagcagtctc cgccacagat ggactaagcg aagagctcac ggaagaggca
      721 ttcactaacc agttaccagc tggcttaata actgcagatg gtcaacagca aaacgttatg
      781 gtttacacaa cgtcttacca acagatttct ggtgtccagc aaattcagtt ttcatgatcg
      841 gaaggacgga cggaaccggg cttgtgtgga gagagtctga tggagtctga agcagaggca
      901 tgggcggaag tgagggtgaa gctgcctcct tgtaccataa gtagctgtaa tgtagcttcc
      961 tgatgcttga ctaattgagg tgttaattct gacttgagaa tctttttcat gaatgatttt
     1021 aaaagaaaaa aaaattggat tttaaaggta ttaaaatatt tttgttttgt acgagagttt
     1081 gttgctctgt atgacgcctg tatgcattgt atattgcaat ttattactgt cagagatttg
     1141 tagacagttt cttattttca tattgaatca tgttattttg taattcaagt aagcagctgg
     1201 gttaattcat aatgtttacc ctttaataaa atataagggt agagttcatt ttgaatgaaa
     1261 gttgccttta ttataaattt gagtttgtct tggctatata ctatcttgca tggtaactta
     1321 gctagatgtt ttagcattta tttattgaaa actttttttg ttttgttttg gtaaaacagt
     1381 catagcataa gcaacttcgt tttttaaaaa attttaattg aaaattaagt tggatgcaga
     1441 agcaagtctt gtctggccta ttaaacttgg tgcccttcac tgtctgtggc tgttcaggca
     1501 gcttcagtta ctatcacgcc tgttagcatt catttccctt tgtggaaatg gtccctctct
     1561 tcaagtgtta cagtctcctt cacgaagagg gacttttcag tccattgata gtcattttac
     1621 cttcacaaaa aggtcgggtt cctgttagac cgtgggaact gagcagtggg catggttctg
     1681 tgcagatgct gcaggagaga gtggacaagc aggggagcag tgaccactag gaatcacgtg
     1741 gcacgggagc cttctggttt gctgtcacgc tatctgcagt aaactaacat taggtgatgt
     1801 agcttggtac agcttagtgg tgtgtacttg ggttcctttt ttaaagtgaa gatttctatt
     1861 ttctcatctt ttttttttct ttttagtaat aattactttg aatttttgtg tatgtgctgt
     1921 ggtagttcta gctctatcaa aaatggctta ttgtatagtc tgtccagaag gaaattttgg
     1981 gtactccagt ggacaaaaga tagcagtttc ctaggtccag gctgaacagt aatggccact
     2041 tggccaggag ttttgtggaa cacgcggctg gctatttgga gattaaatag catcctcttc
     2101 ctccaactcc cttttcagta ataacctttc tgtagaaaat gcacatagga aagaacggga
     2161 gatgatggtg aggcaggatc caacagtcat cctgctgtgc tgaaataaca atgttaatat
     2221 tttgataaat tcatttgtcc ttttactttg ctaaatatgt atatttttat aaaagtgggc
     2281 tcgtgttgta cacactgttt tgtaactggt ttttcactta ttatattgtg aacatctccc
     2341 cagtcacgca tggtcttctg catcgttttt actgggtttt tattctgttg tatgattgaa
     2401 tcatgattat ttaatcgcct attgcaaatt ttgacctttt tcatctcttc ttagttataa
     2461 acagcccttc attgaatctt gtgtacatcg taacttttct tgaaataaat tcttagaact
     2521 gctgggttgc cagatacaca gcaggaaggt tt
//
