LOCUS       NM_001110832            3641 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus nuclear transcription factor-Y alpha (Nfya),
            transcript variant 1, mRNA.
ACCESSION   NM_001110832
VERSION     NM_001110832.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3641)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3641)
  AUTHORS   Yamanaka,T., Kurosawa,M., Yoshida,A., Shimogori,T., Hiyama,A.,
            Maity,S.N., Hattori,N., Matsui,H. and Nukina,N.
  TITLE     The transcription factor NF-YA is crucial for neural progenitor
            maintenance during brain development
  JOURNAL   J Biol Chem 300 (2), 105629 (2024)
   PUBMED   38199563
  REMARK    GeneRIF: The transcription factor NF-YA is crucial for neural
            progenitor maintenance during brain development.
REFERENCE   3  (bases 1 to 3641)
  AUTHORS   Cui,M., Bezprozvannaya,S., Hao,T., Elnwasany,A., Szweda,L.I.,
            Liu,N., Bassel-Duby,R. and Olson,E.N.
  TITLE     Transcription factor NFYa controls cardiomyocyte metabolism and
            proliferation during mouse fetal heart development
  JOURNAL   Dev Cell 58 (24), 2867-2880 (2023)
   PUBMED   37972593
  REMARK    GeneRIF: Transcription factor NFYa controls cardiomyocyte
            metabolism and proliferation during mouse fetal heart development.
REFERENCE   4  (bases 1 to 3641)
  AUTHORS   Okada,N., Ueki,C., Shimazaki,M., Tsujimoto,G., Kohno,S.,
            Muranaka,H., Yoshikawa,K. and Takahashi,C.
  TITLE     NFYA promotes malignant behavior of triple-negative breast cancer
            in mice through the regulation of lipid metabolism
  JOURNAL   Commun Biol 6 (1), 596 (2023)
   PUBMED   37268670
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3641)
  AUTHORS   Rigillo,G., Basile,V., Belluti,S., Ronzio,M., Sauta,E.,
            Ciarrocchi,A., Latella,L., Saclier,M., Molinari,S., Vallarola,A.,
            Messina,G., Mantovani,R., Dolfini,D. and Imbriano,C.
  TITLE     The transcription factor NF-Y participates to stem cell fate
            decision and regeneration in adult skeletal muscle
  JOURNAL   Nat Commun 12 (1), 6013 (2021)
   PUBMED   34650038
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3641)
  AUTHORS   Sohn,K.Y., Maity,S.N. and de Crombrugghe,B.
  TITLE     Studies on the structure of the mouse CBF-A gene and properties of
            a truncated CBF-A isoform generated from an alternatively spliced
            RNA
  JOURNAL   Gene 139 (2), 147-153 (1994)
   PUBMED   7509302
REFERENCE   7  (bases 1 to 3641)
  AUTHORS   Li,X.Y., Hooft van Huijsduijnen,R., Mantovani,R., Benoist,C. and
            Mathis,D.
  TITLE     Intron-exon organization of the NF-Y genes. Tissue-specific
            splicing modifies an activation domain
  JOURNAL   J Biol Chem 267 (13), 8984-8990 (1992)
   PUBMED   1577736
REFERENCE   8  (bases 1 to 3641)
  AUTHORS   Li,X.Y., Mantovani,R., Hooft van Huijsduijnen,R., Andre,I.,
            Benoist,C. and Mathis,D.
  TITLE     Evolutionary variation of the CCAAT-binding transcription factor
            NF-Y
  JOURNAL   Nucleic Acids Res 20 (5), 1087-1091 (1992)
   PUBMED   1549471
  REMARK    Erratum:[Nucleic Acids Res 1992 Apr 11;20(7):1841]
REFERENCE   9  (bases 1 to 3641)
  AUTHORS   Li,X.Y., Mattei,M.G., Zaleska-Rutczynska,Z., Hooft van
            Huijsduijnen,R., Figueroa,F., Nadeau,J., Benoist,C. and Mathis,D.
  TITLE     One subunit of the transcription factor NF-Y maps close to the
            major histocompatibility complex in murine and human chromosomes
  JOURNAL   Genomics 11 (3), 630-634 (1991)
   PUBMED   1774067
REFERENCE   10 (bases 1 to 3641)
  AUTHORS   Hooft van Huijsduijnen,R., Li,X.Y., Black,D., Matthes,H.,
            Benoist,C. and Mathis,D.
  TITLE     Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y
            (CP-1/CBF) subunits
  JOURNAL   EMBO J 9 (10), 3119-3127 (1990)
   PUBMED   1698608
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166164.2.
            
            On Oct 31, 2022 this sequence version replaced NM_001110832.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057099.1, AK004729.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-129               AC166164.2         18159-18287
            130-272             AC166164.2         27333-27475
            273-359             AC166164.2         28845-28931
            360-506             AC166164.2         32117-32263
            507-638             AC166164.2         34361-34492
            639-744             AC166164.2         34628-34733
            745-911             AC166164.2         35407-35573
            912-1085            AC166164.2         35864-36037
            1086-1187           AC166164.2         36563-36664
            1188-3641           AC166164.2         38571-41024
FEATURES             Location/Qualifiers
     source          1..3641
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 23.99 cM"
     gene            1..3641
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /note="nuclear transcription factor-Y alpha"
                     /db_xref="GeneID:18044"
                     /db_xref="MGI:MGI:97316"
     exon            1..129
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     exon            130..272
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     CDS             198..1241
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /note="isoform a is encoded by transcript variant 1;
                     nuclear transcription factor Y subunit alpha; nuclear
                     transcription factor Y subunit A; CAAT box DNA-binding
                     protein subunit A"
                     /codon_start=1
                     /product="nuclear transcription factor Y subunit alpha
                     isoform a"
                     /protein_id="NP_001104302.1"
                     /db_xref="CCDS:CCDS50142.1"
                     /db_xref="GeneID:18044"
                     /db_xref="MGI:MGI:97316"
                     /translation="MEQYTTNSNSSTEQIVVQAGQIQQQQQGGVTAVQLQTEAQVASA
                     SGQQVQTLQVVQGQPLMVQVSGGQLITSTGQPIMVQAVPGGQGQTIMQVPVSGTQGLQ
                     QIQLVPPGQIQIQGGQAVQVQGQQGQTQQIIIQQPQTAVTAGQTQTQQQIAVQGQQVA
                     QTAEGQTIVYQPVNADGTILQQVTVPVSGMITIPAASLAGAQIVQTGANTNTTSSGQG
                     TVTVTLPVAGNVVNSGGMVMMVPGAGSVPAIQRIPLPGAEMLEEEPLYVNAKQYHRIL
                     KRRQARAKLEAEGKIPKERRKYLHESRHRHAMARKRGEGGRFFSPKEKDSPHMQDPNQ
                     ADEEAMTQIIRVS"
     exon            273..359
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     exon            360..506
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     exon            507..638
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     exon            639..744
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     exon            745..911
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     exon            912..1085
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1187
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..3641
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3615..3620
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /note="hexamer: AATAAA"
     regulatory      3623..3628
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /note="hexamer: TATAAA"
     polyA_site      3635
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /note="major polyA site"
     polyA_site      3641
                     /gene="Nfya"
                     /gene_synonym="Cbf-b; SEZ-10; SEZ10"
                     /note="major polyA site"
ORIGIN      
        1 gttcagattc gccattttgc gaggcagcgg cagtggcggc ggcagcggcg gctggagcct
       61 ctgattgggt ttcggggtcc ggtactggag ccaatcagcg cgggcagcga accgggggag
      121 cgaggcacgg agtccctacc tggcagctgc ctgggatctg tagagtgaag cttcaggact
      181 cttaacgtgg ccgggccatg gagcagtata cgacaaacag caatagttcc acagagcaga
      241 tcgtggtgca ggccggccag attcagcagc agcagcaggg tggtgtcact gctgtccagc
      301 tgcagactga ggcccaggtg gcatccgcct caggccagca agtccagacc ctccaggtag
      361 tccaggggca gccgttaatg gtgcaagtca gtggaggcca gcttattaca tcaacaggcc
      421 aacccatcat ggtacaggct gtgcctggtg gacaaggcca aaccatcatg caagtacctg
      481 tgtctggaac acaaggttta cagcagatac agttggtgcc tcctggacag atccagattc
      541 agggtgggca ggctgtgcag gtgcaaggcc agcagggtca aacccagcag atcatcatcc
      601 aacagccaca gactgcagtc actgctggcc agactcagac acaacaacag attgctgtcc
      661 agggacagca agtggcccag actgctgaag gacagactat tgtctaccaa ccagttaatg
      721 cagatggcac aattctccag caagttacag tccctgtttc aggcatgatc accatcccag
      781 cagccagttt ggcaggggca cagatcgttc agacaggagc caataccaac acaaccagca
      841 gtggacaagg gacggtcact gtgacactgc ctgtggcagg gaatgtggtc aactcaggag
      901 gaatggtcat gatggtacca ggagctggct ctgtgcctgc tatccaaaga atccctttac
      961 ctggagcaga gatgctggaa gaagagcccc tgtatgtgaa tgccaaacag tatcaccgca
     1021 tccttaagag gagacaagca cgggctaagc tagaggcaga agggaaaatc ccaaaggaac
     1081 gaaggaaata cctccatgag tctcggcatc ggcacgccat ggcacggaag cgtggggaag
     1141 ggggccgctt cttctctcca aaagaaaagg acagtcctca catgcaggat ccaaaccaag
     1201 ctgacgaaga agccatgaca cagatcatcc gagtttccta accacaggag ggtggcagag
     1261 ctgatcagtc acggtcctct ccactgttct ggaaatggac tgacttccag tggggcactg
     1321 acagtctcac tctgcccttt ctcaggacag aaactactta gctcagtatt acagctgcaa
     1381 tgatggctga caaactgaag tggcaagctt ttgtcgcacc ccttcattga ggatctgttt
     1441 cagactgttg gacactgacc ttttgcaaat ttggatgatt aaaaagaggt atttgccagc
     1501 ccagcattac aaacacagca cttatgttga gtggtaaagc catccagtca gccattgcag
     1561 taggggagag cagccttctc aacctggtcc tcagtcgagg cagccacagc ccctgcctcc
     1621 ctgtgggttc tcaacagcat ccatgccctg gtggggtgcc gggctgcctg atgcatagac
     1681 acttggcact caggtggctc ccaagcaaag aagcttcctg ttaggacttg gagcaacaga
     1741 ccaagctgct gtcttctgac ctgtgctgat aagaatctgt ctgcccacat gctaggttgg
     1801 tgtttacttc agccaagaaa gtacaaaaag gatatttgga ctcaggataa aaggatagat
     1861 ggacctaaaa ggtacatttc tagctttgac tgtggtctgc tcatttctat taacagccat
     1921 ctgggtcata gttcatactg tggccacttt agagacagtt tagagagtaa agaacaaaac
     1981 ttcaaaacat ctgtgctgaa gtgttgagga cattcacagt cgttctccaa cagaggcgaa
     2041 cctagggtat tcaatcatgg gctttatgac agcaagtagc aaatggaagg atctgtgcat
     2101 ttcaatctag agagcaaggg ccctgctggc cctagtgctg ctgtagagcg tggttctcca
     2161 gtggatggat agataccagg catgactctt aggctgaaga aaccaagtca catttacatt
     2221 gacaccttct ggcgtgcact aaaagagaat ccttatattg cctgaagaag cactgttgag
     2281 ctagctgtct tggctgcagg ctggagcact gctggagcac agagtggagg agagagatgt
     2341 gcttcatccc tgcctgggtg ctgacccaga gggtgaatgc tcttcccatg gcagctgatt
     2401 ctctggtgcc agtttccact tgttttctcc tttctctgta ggccttgcag caaggtttgc
     2461 tcactgcatc agtgctgtag ggaccaacta cagcctgcaa ggattcctgc agggtcagga
     2521 attgggcctc agaaatgtgt tttctggaca agcactctac cactgagcca cacacacata
     2581 catacacaca cacacacaca cacacaccct tcccctgccc cagccccagc cccaacccca
     2641 gccccagcca atgctgaggt ctggaagaaa agaccaatgt tgatacatca aaagagttgg
     2701 ctgccttctc tgcaatcaaa gtcaaacgca gtcaatccaa agactaaaat acccgtcaag
     2761 tctagagact ggccctttga ctttgttctg tgttaaagat aggaaagact ttaaccttat
     2821 aaagaaatat cgcagggaga ccagtttaat tggagaacca tgaggtaagc catctcttcc
     2881 tgctcccagg aatcttgcca tttctcctgg cttccggagg tcagaggggg ctgatccttt
     2941 tttttataaa ctcactacaa acttctggct cttcacatga gcttccgtgt gttactgaaa
     3001 gccgggagga atttctccct ttgaggtgga caggattcta aggggaggct tcagggattc
     3061 ctccgactta acagtagcgc ttcagccagc agttgtagaa tgctatttat tcgtgtctgt
     3121 aagtttgtac ataaccctaa cctcgtaggc aagtttgagt tttctttcct ttgatgcaga
     3181 tgcttgggtt tccactctgg ctgcattgca gtcggctccc agccctgccg gcgtgggcac
     3241 agaggccaga ggggctcact tggatttatt tttgtttgtt tgtttatttg tttaacttag
     3301 ttctttttac ttgttctcgt gattgtagtg atggcttcaa agacacagag taagtggagg
     3361 agtgggctgc tggtctactg ggcactctac ttcctgttgc aggataactg taaatgtata
     3421 tattttaatt gcactggtct agaccactgc accaacagcc tctcctggct acagggtgcc
     3481 tgataataat gtcttgattt tcctttggga ctcaaccatg tacgtctctc ttcacacccc
     3541 tcacccctca gccccttccc ccagtagggg agtacaggtg atcactgatg tcattgcaat
     3601 tgcttttctt ttttaataaa tttataaaaa tactagaaaa a
//
