LOCUS       NM_001159394            3625 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus nuclear factor of kappa light polypeptide gene
            enhancer in B cells inhibitor, zeta (Nfkbiz), transcript variant 2,
            mRNA.
ACCESSION   NM_001159394
VERSION     NM_001159394.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3625)
  AUTHORS   Swarnkar,G., Naaz,M., Mims,D., Gupta,P., Peterson,T.,
            Christopher,M.J., Singamaneni,S., Mbalaviele,G. and Abu-Amer,Y.
  TITLE     IkBzeta as a Central Modulator of Inflammatory Arthritis
            Pathogenesis
  JOURNAL   Arthritis Rheumatol 77 (2), 124-139 (2025)
   PUBMED   39279148
REFERENCE   2  (bases 1 to 3625)
  AUTHORS   Daly,A.E., Yeh,G., Soltero,S. and Smale,S.T.
  TITLE     Selective regulation of a defined subset of inflammatory and
            immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway
  JOURNAL   Genes Dev 38 (11-12), 536-553 (2024)
   PUBMED   38918046
  REMARK    GeneRIF: Selective regulation of a defined subset of inflammatory
            and immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3625)
  AUTHORS   Fischer,B., Kubelbeck,T., Kolb,A., Ringen,J., Waisman,A.,
            Wittmann,M., Karbach,S., Kolsch,S.M. and Kramer,D.
  TITLE     IL-17A-driven psoriasis is critically dependent on IL-36 signaling
  JOURNAL   Front Immunol 14, 1256133 (2023)
   PUBMED   38162658
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3625)
  AUTHORS   Taylor,T.C., Coleman,B.M., Arunkumar,S.P., Dey,I., Dillon,J.T.,
            Ponde,N.O., Poholek,A.C., Schwartz,D.M., McGeachy,M.J., Conti,H.R.
            and Gaffen,S.L.
  TITLE     IkappaBzeta is an essential mediator of immunity to oropharyngeal
            candidiasis
  JOURNAL   Cell Host Microbe 31 (10), 1700-1713 (2023)
   PUBMED   37725983
REFERENCE   5  (bases 1 to 3625)
  AUTHORS   Terui,H., Yamasaki,K., Wada-Irimada,M., Onodera-Amagai,M.,
            Hatchome,N., Mizuashi,M., Yamashita,R., Kawabe,T., Ishii,N.,
            Abe,T., Asano,Y. and Aiba,S.
  TITLE     Staphylococcus aureus skin colonization promotes SLE-like
            autoimmune inflammation via neutrophil activation and the
            IL-23/IL-17 axis
  JOURNAL   Sci Immunol 7 (76), eabm9811 (2022)
   PUBMED   36306369
REFERENCE   6  (bases 1 to 3625)
  AUTHORS   Shiina,T., Morimatsu,M., Kitamura,H., Ito,T., Kidou,S.,
            Matsubara,K., Matsuda,Y., Saito,M. and Syuto,B.
  TITLE     Genomic organization, chromosomal localization, and promoter
            analysis of the mouse Mail gene
  JOURNAL   Immunogenetics 53 (8), 649-655 (2001)
   PUBMED   11797098
REFERENCE   7  (bases 1 to 3625)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
REFERENCE   8  (bases 1 to 3625)
  AUTHORS   Yamazaki,S., Muta,T. and Takeshige,K.
  TITLE     A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory
            stimuli, negatively regulates nuclear factor-kappaB in the nuclei
  JOURNAL   J Biol Chem 276 (29), 27657-27662 (2001)
   PUBMED   11356851
REFERENCE   9  (bases 1 to 3625)
  AUTHORS   Haruta,H., Kato,A. and Todokoro,K.
  TITLE     Isolation of a novel interleukin-1-inducible nuclear protein
            bearing ankyrin-repeat motifs
  JOURNAL   J Biol Chem 276 (16), 12485-12488 (2001)
   PUBMED   11278262
REFERENCE   10 (bases 1 to 3625)
  AUTHORS   Kitamura,H., Kanehira,K., Okita,K., Morimatsu,M. and Saito,M.
  TITLE     MAIL, a novel nuclear I kappa B protein that potentiates
            LPS-induced IL-6 production
  JOURNAL   FEBS Lett 485 (1), 53-56 (2000)
   PUBMED   11086164
  REMARK    GeneRIF: MAIL localizes in the nucleus, and accelerates IL-6
            production by LPS stimulation in mouse fibroblasts.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AB026551.2 and AK082908.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159917.1, AK159459.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-151               AB026551.2         1-151
            152-3625            AK082908.1         151-3624
FEATURES             Location/Qualifiers
     source          1..3625
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 33.65 cM"
     gene            1..3625
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B cells inhibitor, zeta"
                     /db_xref="GeneID:80859"
                     /db_xref="MGI:MGI:1931595"
     exon            1..371
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..2272
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /note="isoform a is encoded by transcript variant 2;
                     IkappaB-zeta; NF-kappa-B inhibitor zeta; molecule
                     possessing ankyrin-repeats induced by lipopolysaccharide;
                     ikB-zeta; ikappaBzeta; I-kappa-B-zeta; IL-1 inducible
                     nuclear ankyrin-repeat protein"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor zeta isoform a"
                     /protein_id="NP_001152866.1"
                     /db_xref="CCDS:CCDS28216.1"
                     /db_xref="GeneID:80859"
                     /db_xref="MGI:MGI:1931595"
                     /translation="MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPSAP
                     GAGDTGYLSAVPSAPGSPGSDSSDFSSTSSVSSCGAVESRPRGGARAERPQVEPHMGV
                     GRQQRGPFQGVRVKNSVKELLLHIRSNKQKASGQPVDEFKTQSVNIEQLTDLKSAVSA
                     VGKRKGPDPLSDGPVCKRPALLPSHFVTSPQTPTPGESMEDVRHSESKLDSSAALLQN
                     IINIKNECNPVSLNTVQVSWMSPTVPQNSPRDQCQDFHGGQAFSPPQKYQPFQVSGSP
                     QMMDQASMYQYSPQTQNMQQPPPLPPQQQHQQNYPHNSPLQFSPYSRMSQSPKYDSNL
                     FDTHEPQFCTGQSFVSLLTGPGEPESLAVPVPAPTSIPPQTETQLQTFSLMPSNACEA
                     VVGVHDVGSHSLGTSLSLQNIMGSPMNTTQLGKSFFQWQVEQEESKLANIPQDQFLAR
                     DGDGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQD
                     LVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVRSNQFVDLEATNYDGLTPL
                     HCAVVAHNAVVHELQRNRQSHSPEVQDLLLRNKSLVDTIKCLIQMGAAVEAKDRKSGR
                     TALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLL
                     MRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY"
     exon            372..511
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            512..542
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            543..646
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            647..1452
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            1453..1558
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1705
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            1706..1769
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            1770..1939
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2050
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2218
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..3625
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3606..3611
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /note="hexamer: AATAAA"
     polyA_site      3625
                     /gene="Nfkbiz"
                     /gene_synonym="INAP; Mail"
                     /note="major polyA site"
ORIGIN      
        1 acgtactagt cgctctgccg cagccaaccg cgtagccatc cggtggcgca ggtgtctggg
       61 gaccccgagc gcctagcctg ggagcatgat cgtggacaag ctgctggacg acagccgcgg
      121 cggagagggg ctgctggacg cggccggcga ctgcggcctc atgaccagcc cgctcaacct
      181 ggcttacttc tacggcgcct cgcctccttc cgcccccggc gccggcgaca ccggctacct
      241 gtccgccgtg ccctccgcgc ccggctcgcc cggctccgac tcctccgatt tctcctccac
      301 ttcctccgtg tcctcctgcg gggccgtgga gtcccgtccc agaggtggcg cccgcgccga
      361 gcgccctcaa gttgagcccc acatgggggt tggcaggcag cagagaggcc cctttcaagg
      421 tgttcgcgtg aagaactcgg tgaaggagct cctgctacac atccgaagca acaagcagaa
      481 ggcttccggc cagcccgtgg atgagtttaa gacacagagt gtgaacattg agcagctgac
      541 agacctgaag agtgcagtgt ccgcagtggg gaaaagaaag ggacccgatc ctctgtccga
      601 tggaccggtt tgcaagaggc cagctctgtt gccttctcac ttcgtgacat caccgcaaac
      661 gcctacacct ggggagagca tggaagatgt tcgccacagc gaatccaagc tggatagcag
      721 cgctgccctg cttcagaata ttataaacat caagaatgag tgcaacccag tttcactaaa
      781 cactgttcag gttagctgga tgagccccac ggttccccag aactcgccaa gagaccagtg
      841 ccaggatttc catggaggcc aggccttctc tccacctcag aaataccaac cgttccaagt
      901 cagtggctct ccacagatga tggaccaggc gtcaatgtac cagtattcgc cacaaacaca
      961 gaacatgcag cagccgccgc cgctgccacc acagcagcaa catcaacaga attatcccca
     1021 caactcaccc ctgcagttca gtccttactc cagaatgtcc cagtctccca agtatgattc
     1081 caacctcttt gatactcacg agccacagtt ctgcacgggc caaagttttg tgtctttact
     1141 gactggcccg ggggaacccg agtctcttgc tgttcccgtt ccggctccca ccagcattcc
     1201 accccaaact gagactcagc tgcagacctt cagcctgatg ccaagcaatg cctgcgaggc
     1261 cgtcgtcggg gtgcacgatg tgggctcgca ctctttgggc acgtccctgt cactccagaa
     1321 catcatggga agcccgatga ataccaccca gctggggaag tcattttttc agtggcaggt
     1381 agagcaggaa gaaagcaaat tggcaaatat tccccaggac cagttcctcg ctagggacgg
     1441 agatggtgac acgtttctcc atattgctgt tgcccaaggg aggcgagcgc tctcgtatgt
     1501 ccttgcaaga aagatgaacg ctcttcacat gctggacatt aaggagcaca atggacagag
     1561 tgcctttcag gtggcggtag ctgccaatca gcacctcatt gtgcaagatc tggtaaacct
     1621 tggtgcccag gtgaacacca cggattgctg gggaaggaca cctctgcatg tctgtgcgga
     1681 gaagggccac tcccaggtgc tccaggccat ccagaaggga gctgtgagga gcaatcagtt
     1741 tgtggatctt gaggcaacga actatgatgg cctgactccc ctacattgcg cggtcgtggc
     1801 tcacaatgcg gtggtgcacg aactgcagag gaatcggcag tctcattcgc ccgaagtgca
     1861 ggacctctta ctaaggaata agagcctggt agacaccatt aagtgtctga ttcagatggg
     1921 agccgcagtg gaggcaaagg atcgtaagag tggccgcaca gccctgcact tggcagcgga
     1981 agaagcaaat ctggaactca ttcgcctctt tttggagttg cccagttgcc tgtctttcgt
     2041 gaatgccaag gcttacaatg gaaacaccgc cctccatgtt gctgccagcc tgcagtatcg
     2101 ggtgacacag ttggacgcag tccgcctgtt gatgaggaag ggagctgacc ccagtactcg
     2161 gaacttggag aatgaacagc ccgtgcattt ggtccccgat ggcccagtgg gagaacagat
     2221 ccgacgtatc ctgaagggga agtccattca gcagcgagca ccaccatact aggtccactg
     2281 gcgtggagcc tggttcagcg acactcactg tcagttaggc agtcctgatg tatctgtaca
     2341 tagaccattt gccctgtatt ggcaaatgta agttgtttct atgaaacaaa cccatttagt
     2401 tcactattat atagtggatt atattaaaag aaaagaagac agatatctaa ttttcttggc
     2461 agatttgcgt atttcatacc caggtatctg ggatctatat atctgaattt gatcttgaat
     2521 ggtaaaatta ccttcgataa ccagtagctt tcaggtaggg aaaaaaaaaa agactcatgg
     2581 gaaaagactt gatctgtggc ataaagcctt gctcatgtag agattgccag gtccagatta
     2641 ggtgggcttg aaacatgagg tgaaaaatga aagcatttga aaggggacag aaatttggat
     2701 gtgaggttga tgtgcacttt gctgtcatcg atgcttcttt ggtcagatgc aggacctggt
     2761 gtttaataat gctctctctc taggtgaggg aggcctcttg ataggatgtg atctttgaag
     2821 ctgtatataa ttctcatttt taccttttaa aatgttgtac atatttgatt tgaaccacgg
     2881 acatttgaaa tgtgtaagtc aatcaagtag aaaagagcta gtgaattgtt caccactttc
     2941 aaggttgtgc acccacaaag caacttgtac tgtgtaatcg tccagctaga gtttttacag
     3001 ataaagcaaa tggggaagtg ggtcccaacg ttgctgtggt agcaggcggg tttctcttgc
     3061 attggaaaca gacacgtttg taggcatttg cgtattcttg aagagactgt tttatgaatc
     3121 acctcttaga tttatgtaat ttacctaagt tgttgaagtt tctgtttctc cttaagagaa
     3181 attacaaaaa ttcaacattg aagcatagtt tcttgttttc tgttgtcaaa tagtaataat
     3241 gtgctgtgat gtttatgctt attcataaag atgttttact ttttagtgta atgttagttc
     3301 ttttaacatt attttgctta aatttgataa tgcccgacaa gaatatattt tgctttgatt
     3361 tatacactga ttctttgtga caaatatgac ccattaaaaa tgccttttaa tagactaact
     3421 taccttttgt agctaggtac tcatgttctt ttttaaaaga tgccctttgg attggattgg
     3481 attgatcatg tttaactcag cgtattttat ggatgaaagc taaatacaga tatttggcat
     3541 ctctaaggtg gaatgagccc actccacaca ctgataaaat tcatgcatag ttttaaatga
     3601 acattaataa actcatgttg tctta
//
