LOCUS       NM_010909               1441 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus nuclear factor of kappa light polypeptide gene
            enhancer in B cells inhibitor like 1 (Nfkbil1), transcript variant
            1, mRNA.
ACCESSION   NM_010909 XM_001000143
VERSION     NM_010909.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1441)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1441)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1441)
  AUTHORS   McIntyre,R.E., Nicod,J., Robles-Espinoza,C.D., Maciejowski,J.,
            Cai,N., Hill,J., Verstraten,R., Iyer,V., Rust,A.G., Balmus,G.,
            Mott,R., Flint,J. and Adams,D.J.
  TITLE     A Genome-Wide Association Study for Regulators of Micronucleus
            Formation in Mice
  JOURNAL   G3 (Bethesda) 6 (8), 2343-2354 (2016)
   PUBMED   27233670
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1441)
  AUTHORS   Chiba,T., Miyashita,K., Sugoh,T., Warita,T., Inoko,H., Kimura,M.
            and Sato,T.
  TITLE     IkappaBL, a novel member of the nuclear IkappaB family, inhibits
            inflammatory cytokine expression
  JOURNAL   FEBS Lett 585 (22), 3577-3581 (2011)
   PUBMED   22024480
REFERENCE   5  (bases 1 to 1441)
  AUTHORS   Chiba,T., Matsuzaka,Y., Warita,T., Sugoh,T., Miyashita,K.,
            Tajima,A., Nakamura,M., Inoko,H., Sato,T. and Kimura,M.
  TITLE     NFKBIL1 confers resistance to experimental autoimmune arthritis
            through the regulation of dendritic cell functions
  JOURNAL   Scand J Immunol 73 (5), 478-485 (2011)
   PUBMED   21284685
  REMARK    GeneRIF: NFKBIL-1 affects the pathogenesis of rheumatoid arthritis
            at least in part by the regulation of dendritic cell functions.
REFERENCE   6  (bases 1 to 1441)
  AUTHORS   Allcock,R.J., Martin,A.M. and Price,P.
  TITLE     The mouse as a model for the effects of MHC genes on human disease
  JOURNAL   Immunol Today 21 (7), 328-332 (2000)
   PUBMED   10871872
  REMARK    Review article
REFERENCE   7  (bases 1 to 1441)
  AUTHORS   Handel-Fernandez,M.E., Kurimoto,I., Streilein,J.W. and Vincek,V.
  TITLE     Genetic mapping and physical cloning of UVB susceptibility region
            in mice
  JOURNAL   J Invest Dermatol 113 (2), 224-229 (1999)
   PUBMED   10469308
REFERENCE   8  (bases 1 to 1441)
  AUTHORS   Hotfilder,M., Baxendale,S., Cross,M.A. and Sablitzky,F.
  TITLE     Def-2, -3, -6 and -8, novel mouse genes differentially expressed in
            the haemopoietic system
  JOURNAL   Br J Haematol 106 (2), 335-344 (1999)
   PUBMED   10460589
REFERENCE   9  (bases 1 to 1441)
  AUTHORS   Handel-Fernandez,M.E. and Vincek,V.
  TITLE     Sequence analysis and expression of a mouse homolog of human
            IkappaBL gene
  JOURNAL   Biochim Biophys Acta 1444 (2), 306-310 (1999)
   PUBMED   10023090
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CR974444.18.
            
            On Jul 14, 2018 this sequence version replaced NM_010909.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF095902.1, BC013269.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849387,
                                           SAMN01164134 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-137               CR974444.18        171645-171781       c
            138-417             CR974444.18        170947-171226       c
            418-639             CR974444.18        157132-157353       c
            640-1441            CR974444.18        156170-156971       c
FEATURES             Location/Qualifiers
     source          1..1441
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 18.6 cM"
     gene            1..1441
                     /gene="Nfkbil1"
                     /gene_synonym="Def-7; ikappaBL; IKBL"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B cells inhibitor like 1"
                     /db_xref="GeneID:18038"
                     /db_xref="MGI:MGI:1340031"
     exon            1..137
                     /gene="Nfkbil1"
                     /gene_synonym="Def-7; ikappaBL; IKBL"
                     /inference="alignment:Splign:2.1.0"
     CDS             81..1226
                     /gene="Nfkbil1"
                     /gene_synonym="Def-7; ikappaBL; IKBL"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NF-kappa-B inhibitor-like protein 1; I-kappa-B-like
                     protein; inhibitor of kappa B-like protein"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor-like protein 1 isoform 1"
                     /protein_id="NP_035039.1"
                     /db_xref="CCDS:CCDS28693.1"
                     /db_xref="GeneID:18038"
                     /db_xref="MGI:MGI:1340031"
                     /translation="MSNPSPQAPEEEASTSVCRPQSCSMASASRRHRRERRFRRYLSA
                     GRLVRAQALLQRHPGLDVDAGQPPPLHRACARHDAPALCLLLRLGADPAHQDRHGDTA
                     LHAAARQGPDAYTDFFLPLLSRCPSAMGIKNKDGETPGQILGWGPPWDSAEEEEDEEV
                     SKEREWRQKLQGELEDEWQEVIGRFEDDASRDTQEPESFSAWSERLAREHAQKQRQQL
                     EAEGSCRPPRAEGSSHSWRQHEEEQRLFRERARAKEKELCESRARRAQEAQRDKGPEP
                     PRAGPRAEHPRGAERGSLWRFGDVPWPCPGGGDPEAMAAALVARGPPLEEQGALKRYL
                     RVQQVRWHPDRFLQRFRSQIETWELGRVMGAVTALSQALNRHAEALK"
     exon            138..417
                     /gene="Nfkbil1"
                     /gene_synonym="Def-7; ikappaBL; IKBL"
                     /inference="alignment:Splign:2.1.0"
     exon            418..639
                     /gene="Nfkbil1"
                     /gene_synonym="Def-7; ikappaBL; IKBL"
                     /inference="alignment:Splign:2.1.0"
     exon            640..1441
                     /gene="Nfkbil1"
                     /gene_synonym="Def-7; ikappaBL; IKBL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1418..1423
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfkbil1"
                     /gene_synonym="Def-7; ikappaBL; IKBL"
                     /note="hexamer: AATAAG"
     polyA_site      1441
                     /gene="Nfkbil1"
                     /gene_synonym="Def-7; ikappaBL; IKBL"
                     /note="major polyA site"
ORIGIN      
        1 cctcccttct ccgagcgtct taagcccagg cctccggcct ccgtctctga gggtccttgg
       61 gggggcgggg agcaggtctg atgagtaacc cctcccccca ggccccagag gaagaagcct
      121 ctacgtctgt ctgtcggccc cagagttgtt ccatggcctc cgcttcccgc cggcaccgcc
      181 gagagcgacg cttccggcgg tacttgtctg caggacggct ggtgcgagcc caggctctcc
      241 tccagcgaca tcccgggctt gatgtggacg ctgggcagcc cccgcctctc cacagggcct
      301 gcgcccgcca cgatgcccct gccctgtgcc tgctgctgcg tctcggcgct gaccctgccc
      361 accaggaccg ccatggcgac acggcgctgc acgctgctgc ccgccagggc cctgatgctt
      421 acacggactt cttcctgccg ctgctgagtc gttgcccatc tgccatgggg ataaaaaata
      481 aggatgggga gactcctggg cagattctgg gctggggacc cccctgggat tctgccgaag
      541 aggaagaaga tgaggaagtt tccaaggagc gggaatggcg gcagaagcta caaggcgagc
      601 tggaggatga gtggcaggag gtcatcggga ggtttgaaga tgatgcctcc cgggacacgc
      661 aggagcccga gtccttctca gcctggtcag agcgcctggc tcgggagcat gcccagaagc
      721 agcggcagca gctggaggca gagggatcct gccgacctcc aagggctgag ggctccagtc
      781 acagctggcg acagcacgag gaggaacagc ggcttttccg agagcgagcc cgggccaagg
      841 agaaggaact gtgtgagagc cgagccagga gggctcaaga ggctcaacgg gacaaagggc
      901 cagagcctcc cagggctggg cccagggcag aacacccacg aggggcagag aggggcagcc
      961 tctggcgctt tggcgatgtg ccctggccct gccctggtgg aggggaccca gaggccatgg
     1021 ctgcagcctt ggtggccagg ggcccccctc tggaggaaca gggggctctg aagaggtact
     1081 tgagagtcca acaggtccgg tggcatcctg accgcttcct gcagcgattc cgaagccaga
     1141 ttgagacctg ggagctgggc cgagtgatgg gagctgtgac agccctttct caggccctga
     1201 accgccacgc agaagccctc aagtgaccct agggaataag caagaacctg tggggatgta
     1261 gcctcaagaa tagacggaag gaagcaaggt cgtggatggg gatggacaag aaggggcagc
     1321 tgcggcacag agaggagagg atatgggacg gctaacgtaa tggttgtggg ggtggggtgg
     1381 gggaggctct aaccactgct ctggactgcc atttcctaat aagacttggt tccacacctc
     1441 a
//
