LOCUS       NM_008690               2438 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus nuclear factor of kappa light polypeptide gene
            enhancer in B cells inhibitor, epsilon (Nfkbie), transcript variant
            1, mRNA.
ACCESSION   NM_008690
VERSION     NM_008690.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2438)
  AUTHORS   Bonato,A., Chakraborty,S., Bomben,R., Canarutto,G., Felician,G.,
            Martines,C., Zucchetto,A., Pozzo,F., Vujovikj,M., Polesel,J.,
            Chiarenza,A., Del Principe,M.I., Del Poeta,G., D'Arena,G.,
            Marasca,R., Tafuri,A., Laurenti,L., Piazza,S., Dimovski,A.J.,
            Gattei,V. and Efremov,D.G.
  TITLE     NFKBIE mutations are selected by the tumor microenvironment and
            contribute to immune escape in chronic lymphocytic leukemia
  JOURNAL   Leukemia 38 (7), 1511-1521 (2024)
   PUBMED   38486128
  REMARK    GeneRIF: NFKBIE mutations are selected by the tumor
            microenvironment and contribute to immune escape in chronic
            lymphocytic leukemia.
REFERENCE   2  (bases 1 to 2438)
  AUTHORS   Cheng,Q.J., Ohta,S., Sheu,K.M., Spreafico,R., Adelaja,A., Taylor,B.
            and Hoffmann,A.
  TITLE     NF-kappaB dynamics determine the stimulus specificity of epigenomic
            reprogramming in macrophages
  JOURNAL   Science 372 (6548), 1349-1353 (2021)
   PUBMED   34140389
REFERENCE   3  (bases 1 to 2438)
  AUTHORS   Adelaja,A., Taylor,B., Sheu,K.M., Liu,Y., Luecke,S. and Hoffmann,A.
  TITLE     Six distinct NFkappaB signaling codons convey discrete information
            to distinguish stimuli and enable appropriate macrophage responses
  JOURNAL   Immunity 54 (5), 916-930 (2021)
   PUBMED   33979588
REFERENCE   4  (bases 1 to 2438)
  AUTHORS   Marruecos,L., Bertran,J., Guillen,Y., Gonzalez,J., Batlle,R.,
            Lopez-Arribillaga,E., Garrido,M., Ruiz-Herguido,C., Lisiero,D.,
            Gonzalez-Farre,M., Arce-Gallego,S., Iglesias,M., Nebreda,A.R.,
            Miyamoto,S., Bigas,A. and Espinosa,L.
  TITLE     IkappaBalpha deficiency imposes a fetal phenotype to intestinal
            stem cells
  JOURNAL   EMBO Rep 21 (6), e49708 (2020)
   PUBMED   32270911
REFERENCE   5  (bases 1 to 2438)
  AUTHORS   Xie,T., Chen,H., Shen,S., Huang,T., Huang,B., Hu,G., Li,L. and
            Xu,Y.
  TITLE     Proteasome activator REGgamma promotes inflammation in Leydig cells
            via IkBepsilon signaling
  JOURNAL   Int J Mol Med 43 (5), 1961-1968 (2019)
   PUBMED   30816488
  REMARK    GeneRIF: REGgamma regulates NFkappaB activity by specifically
            degrading IkBepsilon to regulate inflammation in testicular Leydig
            cells.
REFERENCE   6  (bases 1 to 2438)
  AUTHORS   Hoffmann,A., Levchenko,A., Scott,M.L. and Baltimore,D.
  TITLE     The IkappaB-NF-kappaB signaling module: temporal control and
            selective gene activation
  JOURNAL   Science 298 (5596), 1241-1245 (2002)
   PUBMED   12424381
  REMARK    GeneRIF: temporal control of NF-kappaB activation by the
            coordinated degradation and synthesis of IkappaB proteins
REFERENCE   7  (bases 1 to 2438)
  AUTHORS   Memet,S., Laouini,D., Epinat,J.C., Whiteside,S.T., Goudeau,B.,
            Philpott,D., Kayal,S., Sansonetti,P.J., Berche,P., Kanellopoulos,J.
            and Israel,A.
  TITLE     IkappaBepsilon-deficient mice: reduction of one T cell precursor
            subspecies and enhanced Ig isotype switching and cytokine synthesis
  JOURNAL   J Immunol 163 (11), 5994-6005 (1999)
   PUBMED   10570287
REFERENCE   8  (bases 1 to 2438)
  AUTHORS   Hu,Y., Baud,V., Delhase,M., Zhang,P., Deerinck,T., Ellisman,M.,
            Johnson,R. and Karin,M.
  TITLE     Abnormal morphogenesis but intact IKK activation in mice lacking
            the IKKalpha subunit of IkappaB kinase
  JOURNAL   Science 284 (5412), 316-320 (1999)
   PUBMED   10195896
REFERENCE   9  (bases 1 to 2438)
  AUTHORS   Ghosh,S., May,M.J. and Kopp,E.B.
  TITLE     NF-kappa B and Rel proteins: evolutionarily conserved mediators of
            immune responses
  JOURNAL   Annu Rev Immunol 16, 225-260 (1998)
   PUBMED   9597130
  REMARK    Review article
REFERENCE   10 (bases 1 to 2438)
  AUTHORS   Simeonidis,S., Liang,S., Chen,G. and Thanos,D.
  TITLE     Cloning and functional characterization of mouse IkappaBepsilon
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14372-14377 (1997)
   PUBMED   9405619
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008843.1, AK151450.1 and AC163677.2.
            
            On Feb 13, 2015 this sequence version replaced NM_008690.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the shorter isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030923.1, AK008843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AK008843.1         2-4
            4-2435              AK151450.1         2-2433
            2436-2438           AC163677.2         41330-41332         c
FEATURES             Location/Qualifiers
     source          1..2438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.58 cM"
     gene            1..2438
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B cells inhibitor, epsilon"
                     /db_xref="GeneID:18037"
                     /db_xref="MGI:MGI:1194908"
     exon            1..615
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1336
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /note="isoform 1 is encoded by transcript variant 1;
                     NF-kappa-B inhibitor epsilon; ikappaBepsilon"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor epsilon isoform 1"
                     /protein_id="NP_032716.2"
                     /db_xref="CCDS:CCDS28811.1"
                     /db_xref="GeneID:18037"
                     /db_xref="MGI:MGI:1194908"
                     /translation="MSDARKGPDEADDSQCDSGIESLRSLRSLPEPTAAPGSGSSQSG
                     CPQPWRHAPETHKEPEKEDADGERADSTYASSSLTESFPLLERPEAKDPSPPAPGSPL
                     PPAGVLSPQQLEALTYISEDGDTLLHLAVIHEAPSVLFCCLAFLPQEVLDIQNNLYQT
                     ALHLAVHLDQPDVVRALVLKGASRILQDQHGDTALHVACRRQNLACACCLLEEQPEPG
                     RQLSHPLDLQLKNWQGLACLHIATLQRNQPLIELLLQNGADIDVQEGTSGKTALHLAV
                     ETQERSLVQFLLQAGARVDARMLNGCTPLHLAAGRGLNSISSTLCEAGADSLLLNVED
                     ETPQDLAEDLLSYLPFDDLKISGKPLLCTD"
     exon            616..718
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /inference="alignment:Splign:2.1.0"
     exon            719..941
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /inference="alignment:Splign:2.1.0"
     exon            942..1030
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1270
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..2438
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2417..2422
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /note="hexamer: ATTAAA"
     polyA_site      2438
                     /gene="Nfkbie"
                     /gene_synonym="I-kappa-B-epsilon; IkB-E; ikB-epsilon;
                     IKBE; NF-kappa-BIE"
                     /note="major polyA site"
ORIGIN      
        1 agagaagacc taactaggga ccgttcagct gcccaaagca cccgctgcgg tggacctggc
       61 cggcgccctg gacctctcgc ttttctcatc cgctccccgc gcctgcacag gcaggtaatg
      121 aagccgctcg gagagtgact ctggttctgt taggcggtca cacaaacccg gaaaagctcg
      181 cttttgcaca cctcagagtt agatcccgct ggaccctgga ccccgggctg gcgcggccgg
      241 catgtcggat gcgcggaagg ggccggacga ggcggatgat agccagtgtg actctggcat
      301 agagtcgctg cgctctctac gctccctgcc tgaacctact gcggccccag gctccggatc
      361 atcccaaagc ggctgcccac agccttggag acatgctccg gagacccaca aggaaccaga
      421 gaaagaagat gcggatggag agcgagcgga ctccacttat gcctcctcct ctctcactga
      481 atccttcccc ttactggaga gacccgaagc caaggatcca agccctcccg ccccaggatc
      541 gccgctgccc cccgcggggg tgctgagccc tcagcaactc gaggcgctca catacatctc
      601 tgaggatgga gacacgctgc tccacctggc agtgattcac gaagccccgt cggtgctatt
      661 ctgttgcttg gctttcctgc cccaggaagt cctggacatt cagaacaacc tttaccagac
      721 agcactgcat ctggccgttc acctggatca gccagatgtt gtccgggcgc tggtgctgaa
      781 gggggccagc cgaattctgc aggatcagca tggtgacacg gccctgcatg tggcctgtcg
      841 gcgccagaat ctggcctgcg cgtgctgtct gctggaggag cagccagagc caggcagaca
      901 gctttctcat cccctggacc tccaactgaa gaactggcaa ggtctggcct gtctccacat
      961 tgccacattg cagaggaacc aaccgctcat agaactgttg cttcagaatg gagctgacat
     1021 tgatgtacag gagggcacga gtggaaagac tgccctgcac ctggctgtgg aaacccagga
     1081 gcgcagcctg gtgcagtttc tgctccaggc cggtgcccgg gtagatgccc gcatgcttaa
     1141 cgggtgcaca cctttacacc tggcagctgg ccggggcctc aacagcatct catccactct
     1201 gtgtgaggcc ggtgccgact ctctgctgct gaatgtagaa gatgagacac cccaggacct
     1261 ggctgaggac ctcctttctt atttgccctt cgatgacctg aaaatctccg gcaaaccact
     1321 gctatgtact gactgaagct cggatgggtc cccaccgctt cccacctgga agctggatcc
     1381 gcagctgctg cagttgggac ccaagcaatg tcgcccctct gctgatgctg gtcctggggc
     1441 tagcatagtc ctaaaatgag atgaaggatt gcagacgagg aagagccgat ctggaaggaa
     1501 ggacttccca agtggcctgg atggagattc ttgaaagacc ctcgaagcca ctggtatcct
     1561 gaaggaagcc tccttgcttc tgttgaagat ggcatgggct gaaattgcca gctacctgga
     1621 aaatggggat gagcaaactg acccgagggg tctcacctaa aatacctttg tgagtgtgtt
     1681 tggcactggg gtgtgaacct agagcctccc cagcggtagg caagcttact atcatggagc
     1741 tgtgtccccg gccctctttt cattttttat gttgtgatgg gatctcaatg agttgccaga
     1801 gatggcctgg aactcactct atagcccagg cagtcatctt tgaactggga acttcctgtc
     1861 tcagcctcct gagtagctgg gattataggt ctggtggcag cgggccaccg caaagttatc
     1921 taaagacttc aaacataagg ctcccaactg aacctttgca gttattctaa tatgacacta
     1981 aaatggaaga gaggggcttt aaaaaaaaca acaacaacaa cgtttccctt ctacagttgt
     2041 atgcataggc aggcctgact ctcgggtaaa ggcagagaga aggaaacaag ccctgagcaa
     2101 gcacagggcc ttgctgggta tggtaggaga cctaagtggt tcctgccacc acaggcacat
     2161 ctccttcatg tggaaatgcc cagggctgga gagtgaggag gaagaatatg gagacacaca
     2221 cgtgtccctg gagaagtttg aggacattga tcacaagaga gttgcaactt tcctccccca
     2281 cccaaccccc ttagactcca cacactgagg gccctgctag gtcatgcacg aagaaggaga
     2341 agaaataaat caacatactt tccgatgctt agcgcttata agcactaagc aaatgcatcc
     2401 tgtgagtgag acagatatta aaggcataaa caactaaa
//
