LOCUS       NM_001360906            2015 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus nuclear factor of kappa light polypeptide gene
            enhancer in B cells inhibitor, delta (Nfkbid), transcript variant
            1, mRNA.
ACCESSION   NM_001360906 XM_006539953
VERSION     NM_001360906.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2015)
  AUTHORS   Daly,A.E., Yeh,G., Soltero,S. and Smale,S.T.
  TITLE     Selective regulation of a defined subset of inflammatory and
            immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway
  JOURNAL   Genes Dev 38 (11-12), 536-553 (2024)
   PUBMED   38918046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2015)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2015)
  AUTHORS   Schmidt,H., Raj,T., O'Neill,T.J., Muschaweckh,A., Giesert,F.,
            Negraschus,A., Hoefig,K.P., Behrens,G., Esser,L., Baumann,C.,
            Feederle,R., Plaza-Sirvent,C., Geerlof,A., Gewies,A., Isay,S.E.,
            Ruland,J., Schmitz,I., Wurst,W., Korn,T., Krappmann,D. and
            Heissmeyer,V.
  TITLE     Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T
            cell activation and the development of autoimmunity
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2309205120 (2023)
   PUBMED   37988467
REFERENCE   4  (bases 1 to 2015)
  AUTHORS   Adori,M., Khoenkhoen,S., Zhang,J., Dopico,X.C. and Karlsson
            Hedestam,G.B.
  TITLE     Enhanced B Cell Receptor Signaling Partially Compensates for
            Impaired Toll-like Receptor 4 Responses in LPS-Stimulated
            IkappaBNS-Deficient B Cells
  JOURNAL   Cells 12 (9), 1229 (2023)
   PUBMED   37174629
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2015)
  AUTHORS   Frentzel,S., Jeron,A., Pausder,A., Kershaw,O., Volckmar,J.,
            Schmitz,I. and Bruder,D.
  TITLE     IkappaBNS-deficiency protects mice from fatal Listeria
            monocytogenes infection by blunting pro-inflammatory signature in
            Ly6Chigh monocytes and preventing exaggerated innate immune
            responses
  JOURNAL   Front Immunol 13, 1028789 (2022)
   PUBMED   36618344
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2015)
  AUTHORS   Shih,V.F., Kearns,J.D., Basak,S., Savinova,O.V., Ghosh,G. and
            Hoffmann,A.
  TITLE     Kinetic control of negative feedback regulators of NF-kappaB/RelA
            determines their pathogen- and cytokine-receptor signaling
            specificity
  JOURNAL   Proc Natl Acad Sci U S A 106 (24), 9619-9624 (2009)
   PUBMED   19487661
REFERENCE   7  (bases 1 to 2015)
  AUTHORS   Touma,M., Antonini,V., Kumar,M., Osborn,S.L., Bobenchik,A.M.,
            Keskin,D.B., Connolly,J.E., Grusby,M.J., Reinherz,E.L. and
            Clayton,L.K.
  TITLE     Functional role for I kappa BNS in T cell cytokine regulation as
            revealed by targeted gene disruption
  JOURNAL   J Immunol 179 (3), 1681-1692 (2007)
   PUBMED   17641034
  REMARK    GeneRIF: IkappaBNS regulates production of interleukin (IL)-2 and
            other cytokines induced via T-cell receptor ligation.
REFERENCE   8  (bases 1 to 2015)
  AUTHORS   Kuwata,H., Matsumoto,M., Atarashi,K., Morishita,H., Hirotani,T.,
            Koga,R. and Takeda,K.
  TITLE     IkappaBNS inhibits induction of a subset of Toll-like
            receptor-dependent genes and limits inflammation
  JOURNAL   Immunity 24 (1), 41-51 (2006)
   PUBMED   16413922
  REMARK    GeneRIF: IkappaBNS regulates inflammatory responses by inhibiting
            the induction of a subset of TLR-dependent genes through modulation
            of NF-kappaB activity.
REFERENCE   9  (bases 1 to 2015)
  AUTHORS   Hirotani,T., Lee,P.Y., Kuwata,H., Yamamoto,M., Matsumoto,M.,
            Kawase,I., Akira,S. and Takeda,K.
  TITLE     The nuclear IkappaB protein IkappaBNS selectively inhibits
            lipopolysaccharide-induced IL-6 production in macrophages of the
            colonic lamina propria
  JOURNAL   J Immunol 174 (6), 3650-3657 (2005)
   PUBMED   15749903
REFERENCE   10 (bases 1 to 2015)
  AUTHORS   Fiorini,E., Schmitz,I., Marissen,W.E., Osborn,S.L., Touma,M.,
            Sasada,T., Reche,P.A., Tibaldi,E.V., Hussey,R.E., Kruisbeek,A.M.,
            Reinherz,E.L. and Clayton,L.K.
  TITLE     Peptide-induced negative selection of thymocytes activates
            transcription of an NF-kappa B inhibitor
  JOURNAL   Mol Cell 9 (3), 637-648 (2002)
   PUBMED   11931770
  REMARK    GeneRIF: blocks transcription from NF-kappa B reporters, alters
            NF-kappa B electrophoretic mobility shifts, and interacts with
            NF-kappa B proteins in thymic nuclear lysates following TCR
            stimulation.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC149067.3.
            
            [WARNING] On Jan 15, 2025 this sequence was replaced by
            NM_001360906.2.
            
            On Feb 17, 2018 this sequence version replaced XM_006539953.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155969.1, SRR7652917.1269737.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               AC149067.3         230430-230533
            105-205             AC149067.3         232102-232202
            206-266             AC149067.3         232334-232394
            267-478             AC149067.3         232939-233150
            479-666             AC149067.3         233921-234108
            667-772             AC149067.3         234201-234306
            773-919             AC149067.3         234408-234554
            920-971             AC149067.3         234669-234720
            972-1120            AC149067.3         234815-234963
            1121-1237           AC149067.3         235767-235883
            1238-1402           AC149067.3         236125-236289
            1403-2015           AC149067.3         236833-237445
FEATURES             Location/Qualifiers
     source          1..2015
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 17.52 cM"
     gene            1..2015
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B cells inhibitor, delta"
                     /db_xref="GeneID:243910"
                     /db_xref="MGI:MGI:3041243"
     exon            1..104
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            105..205
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            206..266
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            267..478
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     CDS             473..1456
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor delta"
                     /protein_id="NP_001347835.1"
                     /db_xref="GeneID:243910"
                     /db_xref="MGI:MGI:3041243"
                     /translation="MEDSLDTRLYPEPSLSQVGSWRVSSLPSGSPQLPSPTGPSLETA
                     RAHILALGPQQLLAQDEEGDTLLHLFAARGLRWAAYAAAEVLQMYRQLDIREHKGKTP
                     LLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDL
                     EARDFEGLTPLHTAVLALNAAMLPASVCPRMQNSQARDRLTCVQMLLQMGASHTSQEI
                     KSNKTILHLAVQAANPTLVQLLLGLPRGDLRAFVNMKAHGNTALHMAAALPPGPPQEA
                     IVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKRSRTAPPGLSS"
     exon            479..666
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            667..772
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            773..919
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            920..971
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1120
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1237
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1402
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..2015
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1995..2000
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /note="hexamer: ATTAAA"
     polyA_site      2015
                     /gene="Nfkbid"
                     /gene_synonym="I-kappa-B-delta; IkappaBNS; ikB-delta"
                     /note="major polyA site"
ORIGIN      
        1 agatcgggga cccggcggcg gctccgcggg gcaggtagcg aggctggcgc aacgccgagg
       61 ccgcggccct gggggcccac agtctgcatc caagaatcct cgagtgagtc ggcctgagcg
      121 tagtcactgc ccaacacaga cggtaaagaa gcttctggaa gaacagaggc gccgacagca
      181 gcagccagag gctgctgggg tgccgggaca cttctcccct cctctggtcc agccactgac
      241 tccatctgtg aatgaggcag agccaggcca tactcatttc cctgccttcc aagagactgt
      301 ggattccgga cctggcaacc tggctccccc ttcaggcttt gcagactggg accctagcat
      361 ccatgctacc tatacagagg gctctttccc attctctgct tctgaaggct tcctgactcc
      421 tgatttctac cctccgtcag acccaggccg gtcaggccca tttcccctgg tgatggagga
      481 ctctctggat acccggctgt atcctgagcc ttccctgtca caggtagggt cctggagagt
      541 ctctagtctc ccctcaggat ccccacagtt gccttcaccc accggaccgt ccctggagac
      601 agcccgagct cacatattgg ctctggggcc ccaacaactg ctggcccagg atgaggaagg
      661 agacacgctc ctgcacctgt ttgctgcccg ggggctgcgc tgggcagcat atgctgcggc
      721 cgaggtgtta cagatgtacc gacagctgga tattcgtgaa cataaaggca agacgccgct
      781 cctggtggca gctgctgcca accagccact gattgtggaa gacctgctga gcctgggagc
      841 agagcctaac gccactgacc accagggccg ttccgtcttg cacgtggctg ccacctatgg
      901 actcccggga gtcctttcgg ctgtgtttaa gtccggcatt caagtggatc tggaagccag
      961 agacttcgaa ggccttaccc ccctgcacac agccgtcctg gccctcaacg ctgctatgct
     1021 cccagctagt gtgtgtccaa ggatgcagaa ttcccaagcc cgagacagac tgacttgtgt
     1081 gcagatgtta ctgcaaatgg gtgccagtca tacaagccag gagatcaaga gcaacaagac
     1141 cattctgcac ttggctgtac aggctgccaa ccccacgctg gttcagctgc tcctgggact
     1201 gccaaggggg gacctgcggg cctttgttaa tatgaaggcc catggcaaca ctgccctcca
     1261 catggcagcc gccctgcccc ctgggccgcc ccaagaggcc attgtgcggc acctgttggc
     1321 agccggagca gacccgacac tgcgcaacct ggagaacgaa cagcctgttc acttgctgcg
     1381 acccgggccg ggccctgagg ggctccggca gctgttgaag aggagccgca cggcaccccc
     1441 aggcttgtcc tcttaggacc gaaacccaga acctggactg attttccagt ccccaccgtc
     1501 ccgtgggaca gtcagcgtat gctcatgtcg cagattcatg ataatatatg tgtaatatcc
     1561 tgccattagg gtcttacatt aaaactccaa agtggcacgg gggggaggtg agcagtctcc
     1621 aatatttggg gtctgtgaca cctcctcccc ctacaagggg ctttctaggt gatttctgtg
     1681 aaatcgagcc cacttgattg tttctgtgaa acactctaga gacctttaac tttctcctac
     1741 ctggatcagt catgatcacc ccccccagac tgtcgtaccc tgaatcccca ttggagtttc
     1801 catgggattt gaggcatctg agtacctttc ggtcaggatt cctccccagg acccacaccc
     1861 ctgagatgtt ggaaaggccc tctgagatta atgtgtcctg agtcctggct acatcatcat
     1921 ttagaaccca atgtctctga cgctagcatt ccccgtgatt gttccccttg gtctgtgtat
     1981 ccctgtagct accaattaaa ctcaatttgg cctca
//
