LOCUS       NM_001306222            1384 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus nuclear factor of kappa light polypeptide gene
            enhancer in B cells inhibitor, beta (Nfkbib), transcript variant 2,
            mRNA.
ACCESSION   NM_001306222 XM_006539613
VERSION     NM_001306222.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1384)
  AUTHORS   Adelaja,A., Taylor,B., Sheu,K.M., Liu,Y., Luecke,S. and Hoffmann,A.
  TITLE     Six distinct NFkappaB signaling codons convey discrete information
            to distinguish stimuli and enable appropriate macrophage responses
  JOURNAL   Immunity 54 (5), 916-930 (2021)
   PUBMED   33979588
REFERENCE   2  (bases 1 to 1384)
  AUTHORS   Marruecos,L., Bertran,J., Guillen,Y., Gonzalez,J., Batlle,R.,
            Lopez-Arribillaga,E., Garrido,M., Ruiz-Herguido,C., Lisiero,D.,
            Gonzalez-Farre,M., Arce-Gallego,S., Iglesias,M., Nebreda,A.R.,
            Miyamoto,S., Bigas,A. and Espinosa,L.
  TITLE     IkappaBalpha deficiency imposes a fetal phenotype to intestinal
            stem cells
  JOURNAL   EMBO Rep 21 (6), e49708 (2020)
   PUBMED   32270911
REFERENCE   3  (bases 1 to 1384)
  AUTHORS   De Dios,R., Nguyen,L., Ghosh,S., McKenna,S. and Wright,C.J.
  TITLE     CpG-ODN-mediated TLR9 innate immune signalling and calcium
            dyshomeostasis converge on the NFkappaB inhibitory protein
            IkappaBbeta to drive IL1alpha and IL1beta expression
  JOURNAL   Immunology 160 (1), 64-77 (2020)
   PUBMED   32064589
  REMARK    GeneRIF: CpG-ODN-mediated TLR9 innate immune signalling and calcium
            dyshomeostasis converge on the NFkappaB inhibitory protein
            IkappaBbeta to drive IL1alpha and IL1beta expression.
REFERENCE   4  (bases 1 to 1384)
  AUTHORS   McKenna,S., Gossling,M., Bugarini,A., Hill,E., Anderson,A.L.,
            Rancourt,R.C., Balasubramaniyan,N., El Kasmi,K.C. and Wright,C.J.
  TITLE     Endotoxemia Induces IkappaBbeta/NF-kappaB-Dependent Endothelin-1
            Expression in Hepatic Macrophages
  JOURNAL   J Immunol 195 (8), 3866-3879 (2015)
   PUBMED   26342031
  REMARK    GeneRIF: these results mechanistically link the innate immune
            response mediated by IkappaBbeta/NF-kappaB to ET-1 expression and
            potentially reveal therapeutic targets for patients with
            Gram-negative septic shock.
REFERENCE   5  (bases 1 to 1384)
  AUTHORS   Zheng,B., Zhao,D., Zhang,P., Shen,C., Guo,Y., Zhou,T., Guo,X.,
            Zhou,Z. and Sha,J.
  TITLE     Quantitative Proteomics Reveals the Essential Roles of Stromal
            Interaction Molecule 1 (STIM1) in the Testicular Cord Formation in
            Mouse Testis
  JOURNAL   Mol Cell Proteomics 14 (10), 2682-2691 (2015)
   PUBMED   26199344
REFERENCE   6  (bases 1 to 1384)
  AUTHORS   Budde,L.M. and Ghosh,S.
  TITLE     Cloning and characterization of the gene encoding mouse IkappaBbeta
  JOURNAL   Gene 247 (1-2), 279-286 (2000)
   PUBMED   10773467
REFERENCE   7  (bases 1 to 1384)
  AUTHORS   Baeuerle,P.A. and Baltimore,D.
  TITLE     NF-kappa B: ten years after
  JOURNAL   Cell 87 (1), 13-20 (1996)
   PUBMED   8858144
REFERENCE   8  (bases 1 to 1384)
  AUTHORS   Suyang,H., Phillips,R., Douglas,I. and Ghosh,S.
  TITLE     Role of unphosphorylated, newly synthesized I kappa B beta in
            persistent activation of NF-kappa B
  JOURNAL   Mol Cell Biol 16 (10), 5444-5449 (1996)
   PUBMED   8816457
REFERENCE   9  (bases 1 to 1384)
  AUTHORS   Klement,J.F., Rice,N.R., Car,B.D., Abbondanzo,S.J., Powers,G.D.,
            Bhatt,P.H., Chen,C.H., Rosen,C.A. and Stewart,C.L.
  TITLE     IkappaBalpha deficiency results in a sustained NF-kappaB response
            and severe widespread dermatitis in mice
  JOURNAL   Mol Cell Biol 16 (5), 2341-2349 (1996)
   PUBMED   8628301
REFERENCE   10 (bases 1 to 1384)
  AUTHORS   Thompson,J.E., Phillips,R.J., Erdjument-Bromage,H., Tempst,P. and
            Ghosh,S.
  TITLE     I kappa B-beta regulates the persistent response in a biphasic
            activation of NF-kappa B
  JOURNAL   Cell 80 (4), 573-582 (1995)
   PUBMED   7867065
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC171210.1, AK038631.1,
            AK010218.1 and BM899229.1.
            
            On Apr 28, 2015 this sequence version replaced XM_006539613.2.
            
            Summary: This gene encodes an inhibitor of nuclear factor
            kappa-light-chain-enhancer of activated B cells (NF-kappaB). The
            encoded protein prevents NF-kappaB-mediated transcription
            activation by sequestering it in the cytosol. In response to
            signals that induce NF-kappaB, such as cytokines and growth
            factors, the encoded protein undergoes phosphorylation, triggering
            its rapid ubiquitination and proteasomal degradation. Alternative
            splicing results in multiple transcript variants. [provided by
            RefSeq, Apr 2015].
            
            Transcript Variant: This variant (2) differs in the 3' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY176059.1, BC021938.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AC171210.1         123909-124028
            121-169             AK038631.1         1-49
            170-1361            AK010218.1         2-1193
            1362-1384           BM899229.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1384
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.91 cM"
     gene            1..1384
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B cells inhibitor, beta"
                     /db_xref="GeneID:18036"
                     /db_xref="MGI:MGI:104752"
     exon            1..401
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /inference="alignment:Splign:2.1.0"
     CDS             223..1302
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /note="nuclear factor of kappa light chain gene enhancer
                     in B-cells inhibitor, beta"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor beta"
                     /protein_id="NP_001293151.1"
                     /db_xref="CCDS:CCDS21054.1"
                     /db_xref="GeneID:18036"
                     /db_xref="MGI:MGI:104752"
                     /translation="MAGVACLGKTADADEWCDSGLGSLGPDAAAPGGPGLGAELGPEL
                     SWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYLDLQNDLGQTALHLAA
                     ILGEASTVEKLYAAGAGVLVAERGGHTALHLACRVRAHTCACVLLQPRPSHPRDASDT
                     YLTQSQDCTPDTSHAPAAVDSQPNPENEEEPRDEDWRLQLEAENYDGHTPLHVAVIHK
                     DAEMVRLLRDAGADLNKPEPTCGRTPLHLAVEAQAASVLELLLKAGADPTARMYGGRT
                     PLGSALLRPNPILARLLRAHGAPEPEDEDDKLSPCSSSGSDSDSDNRDEGDEYDDIVV
                     HSGRSQNRQPPSPASKPLPDDPNPA"
     exon            402..507
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /inference="alignment:Splign:2.1.0"
     exon            508..841
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /inference="alignment:Splign:2.1.0"
     exon            842..930
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1200
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /inference="alignment:Splign:2.1.0"
     exon            1201..1367
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1336..1341
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /note="hexamer: AATAAA"
     polyA_site      1362
                     /gene="Nfkbib"
                     /gene_synonym="I(Kappa)B(beta); I-kappa-B-beta;
                     IKappaBbeta; IkB; ikB-B; IKB-beta; IkBb; NF-kappa-BIB"
                     /note="major polyA site"
ORIGIN      
        1 cgtctggaaa atgtggggaa actcagcgag cgaatgtcca cctcattttt ctgattggct
       61 gtggtgcagt acaggggcgg ggtgtagcta tttaaaacat tttgattggg tatatgaggg
      121 ggcgtgttgg ggaattcccg atagggcgga agcactggag ctcatcgcag agcccagcga
      181 caggcaggcg accacagggg gccacccgag gtggctgggg ccatggccgg ggtcgcgtgc
      241 ttggggaaaa ctgcggatgc cgatgaatgg tgcgacagcg gcctgggctc tctaggtccc
      301 gacgcagcgg ctcccggagg accaggtctg ggcgcagagc ttggcccaga gctgtcgtgg
      361 gcgcccttag tctttggcta cgtcactgag gatggggaca cagccctgca cttggctgtg
      421 attcatcagc atgagccctt cctggatttc ctcctgggct tctccgccgg caccgagtac
      481 cttgacctgc agaatgacct aggccaaaca gccctgcatc tagcagccat ccttggggag
      541 gcatctacag tagagaagtt gtatgcagcc ggtgcaggag tgttggtggc tgagagaggg
      601 ggccacacgg cattgcactt ggcctgccgg gtcagggcac acacgtgcgc gtgcgtactg
      661 ctccagcccc gtcccagcca cccaagagat gcctcagata cctacctcac tcagagccag
      721 gactgtaccc cagacaccag ccatgcccct gctgccgtgg attcccaacc caacccagag
      781 aacgaagagg agccgcgtga tgaagactgg aggctacaac tagaagctga aaactatgat
      841 ggccataccc cactccatgt agctgtcatc cacaaagatg cagagatggt ccggctgctc
      901 agggatgccg gagccgacct caataaaccg gagcctacgt gtggccggac ccctctgcac
      961 ctggcagtag aagcccaggc agccagcgtg ctggaacttc tcctgaaagc cggtgctgac
     1021 cccaccgccc gcatgtatgg gggccgcacc ccgcttggca gtgccctgct ccggcccaac
     1081 cccatccttg cccgcctcct ccgtgcacat ggggcccctg aacctgagga cgaggacgat
     1141 aagcttagcc cttgcagcag cagcggcagc gacagtgaca gtgacaacag agatgagggc
     1201 gatgaatatg atgacatcgt ggttcacagt ggcaggagcc aaaaccgaca accgccttcc
     1261 ccggcatcca aacctcttcc tgatgacccc aaccctgcct gacttaagtg ctaatattaa
     1321 tataatttcc aacttaataa aattgcagac ctgacaacca gagcccaaaa aaaaaaaaaa
     1381 aaaa
//
