LOCUS       NM_010907               1592 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus nuclear factor of kappa light polypeptide gene
            enhancer in B cells inhibitor, alpha (Nfkbia), mRNA.
ACCESSION   NM_010907
VERSION     NM_010907.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1592)
  AUTHORS   Nie,S., Zhang,W., Jin,X., Li,X., Sun,S., Zhao,Y., Jia,Q., Li,L.,
            Liu,Y., Liu,D. and Gao,Q.
  TITLE     Genetic Screening of Haploid Neural Stem Cells Reveals that Nfkbia
            and Atp2b4 are Key Regulators of Oxidative Stress in Neural
            Precursors
  JOURNAL   Adv Sci (Weinh) 11 (29), e2309292 (2024)
   PUBMED   38666459
  REMARK    GeneRIF: Genetic Screening of Haploid Neural Stem Cells Reveals
            that Nfkbia and Atp2b4 are Key Regulators of Oxidative Stress in
            Neural Precursors.
REFERENCE   2  (bases 1 to 1592)
  AUTHORS   Niu,Z., Qu,S.T., Zhang,L., Dai,J.H., Wang,K., Liu,Y., Chen,L.,
            Song,Y., Sun,R., Xu,Z.H. and Zhang,H.L.
  TITLE     Trim14-IkappaBalpha Signaling Regulates Chronic Inflammatory Pain
            in Rats and Osteoarthritis Patients
  JOURNAL   Neuroscience 548, 39-49 (2024)
   PUBMED   38697463
  REMARK    GeneRIF: Trim14-IkappaBalpha Signaling Regulates Chronic
            Inflammatory Pain in Rats and Osteoarthritis Patients.
REFERENCE   3  (bases 1 to 1592)
  AUTHORS   Thambyrajah,R., Maqueda,M., Fadlullah,M.Z., Proffitt,M., Neo,W.H.,
            Guillen,Y., Casado-Pelaez,M., Herrero-Molinero,P., Brujas,C.,
            Castelluccio,N., Gonzalez,J., Iglesias,A., Marruecos,L.,
            Ruiz-Herguido,C., Esteller,M., Mereu,E., Lacaud,G., Espinosa,L. and
            Bigas,A.
  TITLE     IkappaBalpha controls dormancy in hematopoietic stem cells via
            retinoic acid during embryonic development
  JOURNAL   Nat Commun 15 (1), 4673 (2024)
   PUBMED   38824124
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1592)
  AUTHORS   Lin,Y., Sheng,M., Qin,H., Zhang,P., Wang,C., Fu,W., Meng,X.,
            Wang,D. and Hou,Y.
  TITLE     Caspase 6 promotes innate immune activation by functional crosstalk
            between RIPK1-IkappaBalpha axis in liver inflammation
  JOURNAL   Cell Commun Signal 21 (1), 282 (2023)
   PUBMED   37828624
  REMARK    GeneRIF: Caspase 6 promotes innate immune activation by functional
            crosstalk between RIPK1-IkappaBalpha axis in liver inflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1592)
  AUTHORS   Zhang,Y., Gao,Y., Jiang,Y., Ding,Y., Chen,H., Xiang,Y., Zhan,Z. and
            Liu,X.
  TITLE     Histone demethylase KDM5B licenses macrophage-mediated inflammatory
            responses by repressing Nfkbia transcription
  JOURNAL   Cell Death Differ 30 (5), 1279-1292 (2023)
   PUBMED   36914768
  REMARK    GeneRIF: Histone demethylase KDM5B licenses macrophage-mediated
            inflammatory responses by repressing Nfkbia transcription.
REFERENCE   6  (bases 1 to 1592)
  AUTHORS   Beg,A.A., Sha,W.C., Bronson,R.T. and Baltimore,D.
  TITLE     Constitutive NF-kappa B activation, enhanced granulopoiesis, and
            neonatal lethality in I kappa B alpha-deficient mice
  JOURNAL   Genes Dev 9 (22), 2736-2746 (1995)
   PUBMED   7590249
REFERENCE   7  (bases 1 to 1592)
  AUTHORS   Finco,T.S. and Baldwin,A.S.
  TITLE     Mechanistic aspects of NF-kappa B regulation: the emerging role of
            phosphorylation and proteolysis
  JOURNAL   Immunity 3 (3), 263-272 (1995)
   PUBMED   7552992
  REMARK    Review article
REFERENCE   8  (bases 1 to 1592)
  AUTHORS   Beg,A.A., Sha,W.C., Bronson,R.T., Ghosh,S. and Baltimore,D.
  TITLE     Embryonic lethality and liver degeneration in mice lacking the RelA
            component of NF-kappa B
  JOURNAL   Nature 376 (6536), 167-170 (1995)
   PUBMED   7603567
REFERENCE   9  (bases 1 to 1592)
  AUTHORS   Inoue,J., Kerr,L.D., Kakizuka,A. and Verma,I.M.
  TITLE     I kappa B gamma, a 70 kd protein identical to the C-terminal half
            of p110 NF-kappa B: a new member of the I kappa B family
  JOURNAL   Cell 68 (6), 1109-1120 (1992)
   PUBMED   1339305
REFERENCE   10 (bases 1 to 1592)
  AUTHORS   Kawaichi,M., Oka,C., Shibayama,S., Koromilas,A.E., Matsunami,N.,
            Hamaguchi,Y. and Honjo,T.
  TITLE     Genomic organization of mouse J kappa recombination signal binding
            protein (RBP-J kappa) gene
  JOURNAL   J Biol Chem 267 (6), 4016-4022 (1992)
   PUBMED   1740450
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158398.2, BC046754.1, AI462015.1 and CF379853.1.
            
            On Apr 1, 2009 this sequence version replaced NM_010907.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK161622.1, AK089215.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                AC158398.2         58839-58905         c
            68-1144             BC046754.1         1-1077
            1145-1315           AI462015.1         266-436             c
            1316-1592           CF379853.1         25-301
FEATURES             Location/Qualifiers
     source          1..1592
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 24.0 cM"
     gene            1..1592
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B cells inhibitor, alpha"
                     /db_xref="GeneID:18035"
                     /db_xref="MGI:MGI:104741"
     exon            1..348
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1066
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /note="ikB-alpha; ikappaBalpha; I-kappa-B-alpha; nuclear
                     factor of kappa light polyp gene enhancer in B-cell 1;
                     nuclear factor of kappa light chain gene enhancer in
                     B-cells inhibitor, alpha; I-kappaBalpha; I(Kappa)B(alpha)"
                     /codon_start=1
                     /product="NF-kappa-B inhibitor alpha"
                     /protein_id="NP_035037.2"
                     /db_xref="CCDS:CCDS25918.1"
                     /db_xref="GeneID:18035"
                     /db_xref="MGI:MGI:104741"
                     /translation="MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEEYEQ
                     MVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKPLTMEVIGQVKGDLA
                     FLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASV
                     AVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLAIVEHLVTLGADVNAQEPCNGR
                     TALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLEN
                     LQMLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL"
     exon            349..457
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /inference="alignment:Splign:2.1.0"
     exon            458..668
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /inference="alignment:Splign:2.1.0"
     exon            669..757
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /inference="alignment:Splign:2.1.0"
     exon            758..1018
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1579
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1557..1562
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /note="hexamer: ATTAAA"
     polyA_site      1578
                     /gene="Nfkbia"
                     /gene_synonym="Nfkbi"
                     /note="major polyA site"
ORIGIN      
        1 gagaaatccc ctgccagcgt ttatagggcg ccgcggcggc gctgccgagc ccacaacagt
       61 cagacctcgc cagccagccg ccagcagcct gcagcctgca cccgctcagc cccgcacagc
      121 catgtttcag ccagctgggc acggccagga ctgggccatg gagggcccgc gggatggcct
      181 caagaaggag cgcttggtgg acgatcgcca cgacagcggc ctggactcca tgaaggacga
      241 ggagtacgag caaatggtga aggagctgcg ggagatccgc ctgcagccgc aggaggcgcc
      301 gctggccgcc gagccctgga agcagcagct cacggaggac ggagactcgt tcctgcactt
      361 ggcaatcatc cacgaagaga agccgctgac catggaagtc attggtcagg tgaagggaga
      421 cctggccttc ctcaacttcc agaacaacct gcagcagact ccactccact tggctgtgat
      481 caccaaccag ccaggaattg ctgaggcact tctgaaagct ggctgtgatc ctgagctccg
      541 agactttcga ggaaataccc ctctacatct tgcctgtgag cagggctgcc tggccagtgt
      601 agcagtcttg acgcagacct gcacacccca gcatctccac tccgtcctgc aggccaccaa
      661 ctacaatggc cacacgtgtc tgcacctagc ctctatccac ggctacctgg ccatcgtgga
      721 gcacttggtg actttgggtg ctgatgtcaa cgctcaggag ccctgcaatg gccggacagc
      781 cctccacctt gcggtggacc tgcagaatcc tgacctggtt tcgctcttgt tgaaatgtgg
      841 ggctgatgtc aacagggtaa cctaccaagg ctactccccc taccagctta cctggggccg
      901 cccaagtacc cggatacagc agcagctggg ccagctgacc ctggaaaatc tccagatgct
      961 acccgagagc gaggatgagg agagctatga cacggagtca gaattcacag aggatgagct
     1021 gccctatgat gactgtgtgt ttggaggcca gcgtctgaca ttataagtgg aaagtggcaa
     1081 aaagaatgtg gacttgtata tttgtacaaa tagagtttta tttttctaaa aaaaaaaaaa
     1141 aaaagaaaaa gaaaaaaaat gagaaagggt atacttagca ccacaccaca cagcgcctag
     1201 acccaggcat tttactgggg tgattcggct gttgtctttg tgaaatccgg ggaaacagat
     1261 cactgaaatt caaagaaaat gtctcttaag gttcatgttt gtgggatttt ttttgggggg
     1321 gggggaggtg attttccaga acctaatgaa aggaccacgt tttatttatt gtgcttttga
     1381 ttgaaccacc atagacctag taagtgagcc cagtgtgtcc tcccatgtaa gagccaggtg
     1441 ttcagtggca tgtgcttaaa agtcgccccc aactaaggtc tgtgtcgcct tcttgtaaat
     1501 gttgtatatg ttgtattttg ttggtaatta ttttggtact tctaagatgt atatttatta
     1561 aacagatttt tacagacaga aaaaaaaaaa aa
//
