LOCUS       NM_019408               3205 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus nuclear factor of kappa light polypeptide gene
            enhancer in B cells 2, p49/p100 (Nfkb2), transcript variant 1,
            mRNA.
ACCESSION   NM_019408
VERSION     NM_019408.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3205)
  AUTHORS   Daly,A.E., Yeh,G., Soltero,S. and Smale,S.T.
  TITLE     Selective regulation of a defined subset of inflammatory and
            immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway
  JOURNAL   Genes Dev 38 (11-12), 536-553 (2024)
   PUBMED   38918046
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3205)
  AUTHORS   Lin,L., Yu,H., Li,L., Yang,W., Chen,X., Gong,Y., Lei,Q., Li,Z.,
            Zhou,Z., Dai,L., Zhang,H. and Hu,H.
  TITLE     TRIM55 promotes noncanonical NF-kappaB signaling and B
            cell-mediated immune responses by coordinating p100 ubiquitination
            and processing
  JOURNAL   Sci Signal 16 (806), eabn5410 (2023)
   PUBMED   37816088
  REMARK    GeneRIF: TRIM55 promotes noncanonical NF-kappaB signaling and B
            cell-mediated immune responses by coordinating p100 ubiquitination
            and processing.
REFERENCE   3  (bases 1 to 3205)
  AUTHORS   Luecke,S., Adelaja,A., Guo,X., Sen,S., Spreafico,R., Singh,A.,
            Liu,Y., Taylor,B., Diaz,J., Cheng,Q. and Hoffmann,A.
  TITLE     Tonic TNF conditioning of macrophages safeguards stimulus-specific
            inflammatory responses
  JOURNAL   EMBO Rep 24 (7), e55986 (2023)
   PUBMED   37212045
REFERENCE   4  (bases 1 to 3205)
  AUTHORS   Wang,J., Wu,S., Liu,L., Pang,Y., Li,Z. and Mu,H.
  TITLE     HDAC5-Mediated Acetylation of p100 Suppresses Its Processing
  JOURNAL   Int Dent J 73 (3), 387-394 (2023)
   PUBMED   36156247
  REMARK    GeneRIF: HDAC5-Mediated Acetylation of p100 Suppresses Its
            Processing.
REFERENCE   5  (bases 1 to 3205)
  AUTHORS   Papoutsopoulou,S., Tang,J., Elramli,A.H., Williams,J.M., Gupta,N.,
            Ikuomola,F.I., Sheibani-Tezerji,R., Alam,M.T.,
            Hernandez-Fernaud,J.R., Caamano,J.H., Probert,C.S., Muller,W.,
            Duckworth,C.A. and Pritchard,D.M.
  TITLE     Nfkb2 deficiency and its impact on plasma cells and immunoglobulin
            expression in murine small intestinal mucosa
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 323 (4), G306-G317 (2022)
   PUBMED   35916405
  REMARK    GeneRIF: Nfkb2 deficiency and its impact on plasma cells and
            immunoglobulin expression in murine small intestinal mucosa.
REFERENCE   6  (bases 1 to 3205)
  AUTHORS   Franzoso,G., Carlson,L., Xing,L., Poljak,L., Shores,E.W.,
            Brown,K.D., Leonardi,A., Tran,T., Boyce,B.F. and Siebenlist,U.
  TITLE     Requirement for NF-kappaB in osteoclast and B-cell development
  JOURNAL   Genes Dev 11 (24), 3482-3496 (1997)
   PUBMED   9407039
REFERENCE   7  (bases 1 to 3205)
  AUTHORS   Iotsova,V., Caamano,J., Loy,J., Yang,Y., Lewin,A. and Bravo,R.
  TITLE     Osteopetrosis in mice lacking NF-kappaB1 and NF-kappaB2
  JOURNAL   Nat Med 3 (11), 1285-1289 (1997)
   PUBMED   9359707
REFERENCE   8  (bases 1 to 3205)
  AUTHORS   Ishikawa,H., Carrasco,D., Claudio,E., Ryseck,R.P. and Bravo,R.
  TITLE     Gastric hyperplasia and increased proliferative responses of
            lymphocytes in mice lacking the COOH-terminal ankyrin domain of
            NF-kappaB2
  JOURNAL   J Exp Med 186 (7), 999-1014 (1997)
   PUBMED   9314550
REFERENCE   9  (bases 1 to 3205)
  AUTHORS   Ciana,P., Neri,A., Cappellini,C., Cavallo,F., Pomati,M.,
            Chang,C.C., Maiolo,A.T. and Lombardi,L.
  TITLE     Constitutive expression of lymphoma-associated NFKB-2/Lyt-10
            proteins is tumorigenic in murine fibroblasts
  JOURNAL   Oncogene 14 (15), 1805-1810 (1997)
   PUBMED   9150386
REFERENCE   10 (bases 1 to 3205)
  AUTHORS   Verma,I.M., Stevenson,J.K., Schwarz,E.M., Van Antwerp,D. and
            Miyamoto,S.
  TITLE     Rel/NF-kappa B/I kappa B family: intimate tales of association and
            dissociation
  JOURNAL   Genes Dev 9 (22), 2723-2735 (1995)
   PUBMED   7590248
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY147052.1, CJ134893.1, AK137680.1, AK150012.1 and AC114539.8.
            
            On Apr 7, 2010 this sequence version replaced NM_019408.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Both variants 1 and 2 encode the same isoform (a),
            which is shorter than isoform b.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145312.1, BC027423.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 BY147052.1         1-4
            5-317               CJ134893.1         2-314
            318-2658            AK137680.1         157-2497
            2659-3146           AK150012.1         2487-2974
            3147-3205           AC114539.8         81696-81754
FEATURES             Location/Qualifiers
     source          1..3205
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 38.8 cM"
     gene            1..3205
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /note="nuclear factor of kappa light polypeptide gene
                     enhancer in B cells 2, p49/p100"
                     /db_xref="GeneID:18034"
                     /db_xref="MGI:MGI:1099800"
     exon            1..330
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     CDS             310..3009
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /note="isoform a is encoded by transcript variant 1;
                     nuclear factor NF-kappa-B p100 subunit; DNA-binding factor
                     KBF2; NF kappaB2"
                     /codon_start=1
                     /product="nuclear factor NF-kappa-B p100 subunit isoform
                     a"
                     /protein_id="NP_062281.1"
                     /db_xref="CCDS:CCDS29874.1"
                     /db_xref="GeneID:18034"
                     /db_xref="MGI:MGI:1099800"
                     /translation="MDNCYDPGLDGIPEYDDFEFSPSIVEPKDPAPETADGPYLVIVE
                     QPKQRGFRFRYGCEGPSHGGLPGASSEKGRKTYPTVKICNYEGPAKIEVDLVTHSDPP
                     RAHAHSLVGKQCSELGVCAVSVGPKDMTAQFNNLGVLHVTKKNMMEIMIQKLQRQRLR
                     SKPQGLTEAERRELEQEAKELKKVMDLSIVRLRFSAFLRASDGSFSLPLKPVISQPIH
                     DSKSPGASNLKISRMDKTAGSVRGGDEVYLLCDKVQKDDIEVRFYEDDENGWQAFGDF
                     SPTDVHKQYAIVFRTPPYHKMKIERPVTVFLQLKRKRGGDVSDSKQFTYYPLVEDKEE
                     VQRKRRKALPTFSQPFGGGSHMGGGSGGSAGGYGGAGGGGSLGFFSSSLAYNPYQSGA
                     APMGCYPGGGGGAQMAGSRRDTDAGEGAEEPRTPPEAPQGEPQALDTLQRAREYNARL
                     FGLAQRSARALLDYGVTADARALLAGQRHLLMAQDENGDTPLHLAIIHGQTGVIEQIA
                     HVIYHAQYLGVINLTNHLHQTPLHLAVITGQTRVVSFLLQVGADPTLLDRHGDSALHL
                     ALRAGAAAPELLQALLRSGAHAVPQILHMPDFEGLYPVHLAVHARSPECLDLLVDCGA
                     EVEAPERQGGRTALHLATEMEELGLVTHLVTKLHANVNARTFAGNTPLHLAAGLGSPT
                     LTRLLLKAGADIHAENEEPLCPLPSPSTSGSDSDSEGPERDTQRNFRGHTPLDLTCST
                     KVKTLLLNAAQNTTEPPLAPPSPAGPGLSLGDAALQNLEQLLDGPEAQGSWAELAERL
                     GLRSLVDTYRKTPSPSGSLLRSYKLAGGDLVGLLEALSDMGLHEGVRLLKGPETRDKL
                     PSTEVKEDSAYGSQSVEQEAEKLCPPPEPPGGLCHGHPQPQVH"
     exon            331..412
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            413..453
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            454..552
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            553..704
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            705..811
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            812..970
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            971..1075
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1161
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1300
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1426
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1636
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1778
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1893
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2107
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2277
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2278..2380
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2381..2532
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2533..2602
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2603..2775
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2776..2887
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     exon            2888..3205
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3105..3110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /note="hexamer: AATAAA"
     polyA_site      3138
                     /gene="Nfkb2"
                     /gene_synonym="lyt; NF-kappaB2; p49; p49/p100; p50B; p52"
                     /note="major polyA site"
ORIGIN      
        1 tggtattttc gggactttcc taagcagcac taactttctg cccctttccc gggccagccc
       61 cgctccggat ctcgacctcc accggatctt acccgccacg cccggacggg cggctggagg
      121 agatcggacc ctcccccaga tctgagcccc cctcccctac ccatccctct ccccctgccc
      181 acccctatcc tgatatcttt cactcttccc cctcccacgc ctctcttcac cttaggcggg
      241 cgtccgaaac tctggaaagc tgaaccgggg cccgaagccg caagacacag cagggcctag
      301 cccagagata tggacaattg ctacgatcca ggcctggatg gcatccccga atatgatgat
      361 tttgaattca gcccctccat cgtggagcct aaggatccag cccctgagac agctgatggc
      421 ccctatctgg tgattgtgga acagcccaaa cagcgaggct tcagatttcg atatggctgt
      481 gaaggcccct cccatggagg tttgccaggt gcctccagtg agaagggccg gaagacctat
      541 cctactgtca agatctgtaa ctatgaggga ccggccaaga ttgaggtgga cctggtgaca
      601 cacagtgacc cacctcgtgc gcatgcccac agtctggtgg gcaagcagtg ttcagagttg
      661 ggagtgtgcg ctgtgtctgt aggacccaag gacatgactg ctcaatttaa taatctgggt
      721 gtcctgcatg taaccaagaa gaacatgatg gagattatga tccagaaact tcagaggcag
      781 cgtctccgct ccaagcctca gggccttaca gaggctgagc ggcgggagct agagcaggag
      841 gccaaggagc tgaagaaagt catggatctg agcattgtac ggctgcgctt ctcagctttc
      901 cttcgagcta gcgatggctc cttctccttg cccctgaagc ctgtgatctc ccagcccatc
      961 catgacagca agtctccagg ggcctcgaac ctgaagatct cccgaatgga caagacagcg
     1021 ggttccgtgc gcggtggaga cgaagtttat ttgctctgtg ataaggtgca aaaagacgac
     1081 attgaggttc ggttctatga ggatgatgag aatggatggc aagcctttgg ggacttctct
     1141 cccacagacg ttcataaaca gtatgccatt gtgttccgga caccgcccta tcacaagatg
     1201 aagatcgaga ggcctgtaac ggtgttcctg cagctgaaac gcaagcgtgg gggcgatgtc
     1261 tcggactcca aacagttcac atattaccct ctggtggaag acaaggagga agtgcagagg
     1321 aagcggagaa aggccttgcc caccttctcc cagcccttcg ggggcggatc ccacatgggt
     1381 ggaggttctg ggggctccgc tgggggttat ggaggcgctg gaggaggtgg cagcctcggc
     1441 tttttctcct cctccttggc ctacaacccc taccaatccg gtgcagcccc aatgggctgc
     1501 tatccgggtg ggggaggtgg agcgcagatg gccggttcta gacgggacac cgatgctggc
     1561 gagggggcag aggagcccag gacgcccccg gaggctcccc agggcgaacc acaggccctt
     1621 gacacactgc agcgagctcg cgagtacaac gcgcgcctgt tcggtctggc gcagcgcagc
     1681 gcccgagcgt tgctggacta cggcgtcacc gcagacgcgc gtgctctgct agcgggacag
     1741 cgccacctgc tgatggcaca ggacgagaac ggagacacgc cactgcacct ggccatcatc
     1801 catgggcaga ctggtgtcat tgagcagata gcccacgtca tttatcacgc tcagtacctc
     1861 ggcgtcatca acctcaccaa ccacctgcac cagacgcctc tgcacctggc ggtaatcact
     1921 gggcagacaa gggtggtgag cttcctgctg caggtgggtg cagaccccac gctgctggat
     1981 cggcacggag actccgccct ccacttggct ctccgggcag gtgctgcagc cccagagctg
     2041 ttgcaggcac tgttgcgcag cggagcccat gctgtgcccc aaatattgca catgcctgat
     2101 tttgagggac tataccctgt acacctggca gtccatgccc gaagccctga gtgcctggat
     2161 ctgttagttg actgtggagc tgaagtggag gccccagaga ggcaaggggg ccgaactgcc
     2221 ctgcatctag ccacagagat ggaggagttg gggctggtca cccatctagt caccaagctc
     2281 catgctaatg tgaatgcccg gacctttgct ggaaacacac ccctccacct ggcagctgga
     2341 ctcgggtccc caactcttac tcgcctcctt ctaaaggctg gtgctgacat ccatgcagag
     2401 aatgaggagc ctctgtgccc gctgccctca ccctcgacct ctgggagcga ctccgactct
     2461 gaagggcctg agagggatac ccaaagaaac ttccgaggcc atacccctct tgacctcact
     2521 tgcagtacca aggtgaagac tctgctgcta aatgctgctc agaacaccac ggagccaccc
     2581 ctggccccac ccagccctgc agggccaggg ctgtccctgg gggatgcagc cctgcagaac
     2641 ctggagcaac tgctggatgg tcccgaagcc cagggcagct gggcagagct ggcagagcga
     2701 ctggggttga gaagcctggt ggacacatac aggaagaccc cgtctcccag cggcagtctc
     2761 cttcgtagtt acaagctggc tggtggggac ttggtgggtc tattggaggc cttgtctgac
     2821 atgggtctcc atgagggagt caggctgctg aaaggtcctg agacccgcga caagctgccc
     2881 agcacagagg tgaaagaaga cagtgcctat gggagccagt cagtggagca ggaggcagag
     2941 aagctgtgtc caccccctga gcctccagga gggctctgcc acgggcaccc ccagcctcag
     3001 gtgcactgaa tggccccggt caacttccac ccagatccct ctgtacagca tccctgtcta
     3061 atcgaaatct tatttaaacc tcaagcccac atctcggtgg gtcaaataaa ggggaagacc
     3121 cctccccaac ttacggtaca gcaaccccaa tgtgctgccc atcccagtcc ctgagcgaga
     3181 atagaggagg aggcccagcc agcaa
//
