LOCUS       NP_032715                971 aa            linear   ROD 14-FEB-2025
DEFINITION  nuclear factor NF-kappa-B p105 subunit isoform 1 [Mus musculus].
ACCESSION   NP_032715
VERSION     NP_032715.2
DBSOURCE    REFSEQ: accession NM_008689.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 971)
  AUTHORS   Lin,S., Shu,Y., Shen,R., Zhou,Y., Pan,H., He,L., Fang,F., Zhu,X.,
            Wang,X., Wang,Y., Xu,W. and Ding,J.
  TITLE     The regulation of NFKB1 on CD200R1 expression and their potential
            roles in Parkinson's disease
  JOURNAL   J Neuroinflammation 21 (1), 229 (2024)
   PUBMED   39294682
  REMARK    GeneRIF: The regulation of NFKB1 on CD200R1 expression and their
            potential roles in Parkinson's disease.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 971)
  AUTHORS   Abdollahzadeh,B., Cantale Aeo,N.M., Giordano,N., Orlando,A.,
            Basciani,M., Peruzzi,G., Grazioli,P., Screpanti,I., Felli,M.P. and
            Campese,A.F.
  TITLE     The NF-kappaB1/p50 Subunit Influences the Notch/IL-6-Driven
            Expansion of Myeloid-Derived Suppressor Cells in Murine T-Cell
            Acute Lymphoblastic Leukemia
  JOURNAL   Int J Mol Sci 25 (18), 9882 (2024)
   PUBMED   39337370
  REMARK    GeneRIF: The NF-kappaB1/p50 Subunit Influences the
            Notch/IL-6-Driven Expansion of Myeloid-Derived Suppressor Cells in
            Murine T-Cell Acute Lymphoblastic Leukemia.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 971)
  AUTHORS   Ma,H., Jia,H., Zou,W., Ji,F., Wang,W., Zhao,J., Yuan,C. and Jiao,J.
  TITLE     Gasdermin D Mediated Mitochondrial Metabolism Orchestrate
            Neurogenesis Through LDHA During Embryonic Development
  JOURNAL   Adv Sci (Weinh) 11 (35), e2402285 (2024)
   PUBMED   39033542
REFERENCE   4  (residues 1 to 971)
  AUTHORS   Michalani,M.L.E., Passarelli,M. and Machado,U.F.
  TITLE     Nuclear Factor-Kappa-B Mediates the Advanced Glycation End
            Product-Induced Repression of Slc2a4 Gene Expression in 3T3-L1
            Adipocytes
  JOURNAL   Int J Mol Sci 25 (15), 8242 (2024)
   PUBMED   39125811
  REMARK    GeneRIF: Nuclear Factor-Kappa-B Mediates the Advanced Glycation End
            Product-Induced Repression of Slc2a4 Gene Expression in 3T3-L1
            Adipocytes.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 971)
  AUTHORS   Daly,A.E., Yeh,G., Soltero,S. and Smale,S.T.
  TITLE     Selective regulation of a defined subset of inflammatory and
            immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway
  JOURNAL   Genes Dev 38 (11-12), 536-553 (2024)
   PUBMED   38918046
  REMARK    GeneRIF: Selective regulation of a defined subset of inflammatory
            and immunoregulatory genes by an NF-kappaB p50-IkappaBzeta pathway.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 971)
  AUTHORS   Wulczyn,F.G., Naumann,M. and Scheidereit,C.
  TITLE     Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor
            of transcription factor NF-kappa B
  JOURNAL   Nature 358 (6387), 597-599 (1992)
   PUBMED   1501714
REFERENCE   7  (residues 1 to 971)
  AUTHORS   Inoue,J., Kerr,L.D., Kakizuka,A. and Verma,I.M.
  TITLE     I kappa B gamma, a 70 kd protein identical to the C-terminal half
            of p110 NF-kappa B: a new member of the I kappa B family
  JOURNAL   Cell 68 (6), 1109-1120 (1992)
   PUBMED   1339305
REFERENCE   8  (residues 1 to 971)
  AUTHORS   Ryseck,R.P., Bull,P., Takamiya,M., Bours,V., Siebenlist,U.,
            Dobrzanski,P. and Bravo,R.
  TITLE     RelB, a new Rel family transcription activator that can interact
            with p50-NF-kappa B
  JOURNAL   Mol Cell Biol 12 (2), 674-684 (1992)
   PUBMED   1732739
REFERENCE   9  (residues 1 to 971)
  AUTHORS   Nolan,G.P., Ghosh,S., Liou,H.C., Tempst,P. and Baltimore,D.
  TITLE     DNA binding and I kappa B inhibition of the cloned p65 subunit of
            NF-kappa B, a rel-related polypeptide
  JOURNAL   Cell 64 (5), 961-969 (1991)
   PUBMED   2001591
REFERENCE   10 (residues 1 to 971)
  AUTHORS   Ghosh,S., Gifford,A.M., Riviere,L.R., Tempst,P., Nolan,G.P. and
            Baltimore,D.
  TITLE     Cloning of the p50 DNA binding subunit of NF-kappa B: homology to
            rel and dorsal
  JOURNAL   Cell 62 (5), 1019-1029 (1990)
   PUBMED   2203532
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC101973.7 and AC110164.26.
            
            On Nov 8, 2006 this sequence version replaced NP_032715.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M57999.1, SRR13422586.332543.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..971
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 62.82 cM"
     Protein         1..971
                     /product="nuclear factor NF-kappa-B p105 subunit isoform
                     1"
                     /note="nuclear factor NF-kappa-B p105 subunit; EBP-1;
                     DNA-binding factor KBF1; NF-kappa-B1 p84/NF-kappa-B1 p98;
                     nuclear factor of kappa light chain gene enhancer in
                     B-cells 1, p105; NF kappaB1; NF-kappaB p50; p50 subunit of
                     NF kappaB; nuclear factor kappaB p50"
                     /calculated_mol_wt=105485
     Region          40..241
                     /region_name="RHD-n_NFkB1"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of nuclear factor of kappa B1 (NF-kappa B1);
                     cd07935"
                     /db_xref="CDD:143651"
     Site            order(54,56..57,59..60,63..66,141,143..144,241)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143651"
     Region          248..349
                     /region_name="IPT_NFkappaB"
                     /note="IPT domain of the transcription factor NFkappaB and
                     related transcription factors. NFkappaB is considered a
                     central regulator of stress responses, activated by
                     different stressful conditions, including physical stress,
                     oxidative stress, and exposure to...; cd01177"
                     /db_xref="CDD:238582"
     Site            order(249,251..253,255..257,297..299,312,324,343,346,348)
                     /site_type="other"
                     /note="ankyrin protein binding site [polypeptide binding]"
                     /db_xref="CDD:238582"
     Site            order(251..252,254,267,269,271,304..305,308,310)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:238582"
     Site            order(272,274,305..306)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:238582"
     Site            335
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by PKA. /evidence=ECO:0000255;
                     propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Region          358..363
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000255"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Region          370..392
                     /region_name="GRR. /evidence=ECO:0000250|UniProtKB:P19838"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Site            431..432
                     /site_type="cleavage"
                     /note="Cleavage (when cotranslationally processed).
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          433..971
                     /region_name="Interaction with CFLAR.
                     /evidence=ECO:0000250|UniProtKB:P19838"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Site            438
                     /site_type="acetylation"
                     /note="N6-acetyllysine, by EP300.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          439..470
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Site            447
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          492..765
                     /region_name="ANKYR"
                     /note="Ankyrin repeat [Signal transduction mechanisms];
                     COG0666"
                     /db_xref="CDD:440430"
     Site            order(538,540,544..545,548..550,552..553,557,560,575,577,
                     579,583..584,587..589,591..592,596,599,608,610,612,
                     616..617,620..622,624..625,629,632)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          538..575
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Region          577..608
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            order(646,648,652..653,656..658,660..661,665,668,677,680,
                     682,686..687,690..692,694..695,700,703,712,714,716,
                     720..721,724..726,728)
                     /site_type="other"
                     /note="oligomer interface [polypeptide binding]"
                     /db_xref="CDD:293786"
     Region          646..680
                     /region_name="Essential for interaction with HIF1AN.
                     /evidence=ECO:0000250|UniProtKB:P19838"
                     /note="propagated from UniProtKB/Swiss-Prot (P25799.2)"
     Region          646..677
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            674
                     /site_type="hydroxylation"
                     /note="(3S)-3-hydroxyasparagine, by HIF1AN.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          680..712
                     /region_name="ANK repeat"
                     /note="ANK repeat [structural motif]"
                     /db_xref="CDD:293786"
     Site            755
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q63369; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Region          812..886
                     /region_name="Death_NFkB1_p105"
                     /note="Death domain of the Nuclear Factor-KappaB1
                     precursor protein p105; cd08797"
                     /db_xref="CDD:260063"
     Site            896
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            910
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by GSK3-beta, in vitro.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            926
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            930
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKB.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            935
                     /site_type="phosphorylation"
                     /note="Phosphoserine, by IKKB.
                     /evidence=ECO:0000250|UniProtKB:P19838; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            940
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     Site            946
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P25799.2)"
     CDS             1..971
                     /gene="Nfkb1"
                     /gene_synonym="NF-kappaB; NF-kappaB1; NF-KB1; p105; p50;
                     p50/p105"
                     /coded_by="NM_008689.3:421..3336"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS17858.1"
                     /db_xref="GeneID:18033"
                     /db_xref="MGI:MGI:97312"
ORIGIN      
        1 madddpygtg qmfhlntalt hsifnaelys peiplstdgp ylqileqpkq rgfrfryvce
       61 gpshgglpga sseknkksyp qvkicnyvgp akvivqlvtn gknihlhahs lvgkhcedgv
      121 ctvtagpkdm vvgfanlgil hvtkkkvfet learmteaci rgynpgllvh sdlaylqaeg
      181 ggdrqltdre keiirqaavq qtkemdlsvv rlmftaflpd stgsftrrle pvvsdaiyds
      241 kapnasnlki vrmdrtagcv tggeeiyllc dkvqkddiqi rfyeeeengg vwegfgdfsp
      301 tdvhrqfaiv fktpkykdvn itkpasvfvq lrrksdlets epkpflyype ikdkeevqrk
      361 rqklmpnfsd sfgggsgaga ggggmfgsgg gggstgspgp gygysnygfp pyggitfhpg
      421 vtksnagvth gtintkfkng pkdcaksdde esltlpeket egegpslpma ctktepiala
      481 stmedkeqdm gfqdnlflek alqlarrhan alfdyavtgd vkmllavqrh ltavqdengd
      541 svlhlaiihl haqlvrdlle vtsglisddi inmrndlyqt plhlavitkq edvvedllrv
      601 gadlslldrw gnsvlhlaak eghdrilsil lksrkaapli dhpngeglna ihiavmsnsl
      661 pcllllvaag aevnaqeqks grtalhlave ydnislagcl llegdahvds ttydgttplh
      721 iaagrgstrl aallkaagad plvenfeply dlddswekag edegvvpgtt pldmaanwqv
      781 fdilngkpye pvftsddilp qgdmkqlted trlqlcklle ipdpdknwat laqklglgil
      841 nnafrlspap sktlmdnyev sggtikelme alqqmgytea ieviqaafrt pattasspvt
      901 taqvhclpls ssstrqhide lrdsdsvcds gvetsfrkls ftesltgdsp llslnkmphg
      961 ygqegpiegk i
//
