LOCUS       NM_001371060            5379 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus nuclear factor I/X (Nfix), transcript variant 13,
            mRNA.
ACCESSION   NM_001371060
VERSION     NM_001371060.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5379)
  AUTHORS   Caria,C.A., Faa,V., Porcu,S., Marongiu,M.F., Poddie,D., Perseu,L.,
            Meloni,A., Vaccargiu,S. and Ristaldi,M.S.
  TITLE     Post-GWAS Validation of Target Genes Associated with HbF and HbA2
            Levels
  JOURNAL   Cells 13 (14), 1185 (2024)
   PUBMED   39056767
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5379)
  AUTHORS   Kooblall,K.G., Stevenson,M., Heilig,R., Stewart,M., Wright,B.,
            Lockstone,H., Buck,D., Fischer,R., Wells,S., Lines,K.E., Teboul,L.,
            Hennekam,R.C. and Thakker,R.V.
  TITLE     Identification of cellular retinoic acid binding protein 2 (CRABP2)
            as downstream target of nuclear factor I/X (NFIX): implications for
            skeletal dysplasia syndromes
  JOURNAL   JBMR Plus 8 (7), ziae060 (2024)
   PUBMED   38827116
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5379)
  AUTHORS   Angelini,G., Capra,E., Rossi,F., Mura,G., Saclier,M., Taglietti,V.,
            Rovetta,G., Epis,R., Careccia,G., Bonfanti,C. and Messina,G.
  TITLE     MEK-inhibitors decrease Nfix in muscular dystrophy but induce
            unexpected calcifications, partially rescued with Cyanidin diet
  JOURNAL   iScience 27 (1), 108696 (2023)
   PUBMED   38205246
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5379)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5379)
  AUTHORS   Pan,D., Zhong,J., Zhang,J., Dong,H., Zhao,D., Zhang,H. and Yao,B.
  TITLE     Function and regulation of nuclear factor 1 X-type on chondrocyte
            proliferation and differentiation
  JOURNAL   Gene 881, 147620 (2023)
   PUBMED   37433356
  REMARK    GeneRIF: Function and regulation of nuclear factor 1 X-type on
            chondrocyte proliferation and differentiation.
REFERENCE   6  (bases 1 to 5379)
  AUTHORS   Fletcher,C.F., Lutz,C.M., O'Sullivan,T.N., Shaughnessy,J.D. Jr.,
            Hawkes,R., Frankel,W.N., Copeland,N.G. and Jenkins,N.A.
  TITLE     Absence epilepsy in tottering mutant mice is associated with
            calcium channel defects
  JOURNAL   Cell 87 (4), 607-617 (1996)
   PUBMED   8929530
REFERENCE   7  (bases 1 to 5379)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
REFERENCE   8  (bases 1 to 5379)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
REFERENCE   9  (bases 1 to 5379)
  AUTHORS   Nebl,G. and Cato,A.C.
  TITLE     NFI/X proteins: a class of NFI family of transcription factors with
            positive and negative regulatory domains
  JOURNAL   Cell Mol Biol Res 41 (2), 85-95 (1995)
   PUBMED   8581067
REFERENCE   10 (bases 1 to 5379)
  AUTHORS   Scherthan,H., Seisenberger,C., Greulich,K. and Winnacker,E.L.
  TITLE     Mapping of the murine nuclear factor I/X gene (Nfix) to mouse
            chromosome 8 C1-2 by FISH
  JOURNAL   Genomics 22 (1), 247-249 (1994)
   PUBMED   7959784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155163.4 and AC145556.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7974084.7771.1,
                                           SRR11927935.4025615.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164139 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-97                AC155163.4         124646-124742       c
            98-629              AC155163.4         116444-116975       c
            630-692             AC155163.4         72565-72627         c
            693-767             AC155163.4         72265-72339         c
            768-888             AC155163.4         71784-71904         c
            889-1022            AC155163.4         71129-71262         c
            1023-1145           AC155163.4         68388-68510         c
            1146-1321           AC155163.4         66303-66478         c
            1322-1413           AC155163.4         58426-58517         c
            1414-2056           AC155163.4         52695-53337         c
            2057-5379           AC145556.4         175078-178400       c
FEATURES             Location/Qualifiers
     source          1..5379
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.02 cM"
     gene            1..5379
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="nuclear factor I/X"
                     /db_xref="GeneID:18032"
                     /db_xref="MGI:MGI:97311"
     exon            1..97
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            98..629
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1393
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="isoform 13 is encoded by transcript variant 13;
                     nuclear factor 1 X-type; nuclear factor 1/X; TGGCA-binding
                     protein; CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 X-type isoform 13"
                     /protein_id="NP_001357989.1"
                     /db_xref="GeneID:18032"
                     /db_xref="MGI:MGI:97311"
                     /translation="MSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDF
                     VLTITGKKPPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGER
                     LYKSPQCSNPGLCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPN
                     GHLSFQDCFVTSGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRS
                     ITSPPSTSTKRPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLK
                     KSGKLDFCSALSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSP
                     YFTHPTIRYHHHHGQDSLKEFVQFVCSDGSGQATGQHSQRQAPPLPTGLSASDPGTAT
                     F"
     exon            630..692
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            693..767
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            768..888
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1022
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1023..1145
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..1321
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1413
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..5379
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1548
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="major polyA site"
     regulatory      5359..5364
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="hexamer: AATAAA"
     regulatory      5363..5368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="hexamer: AAGAAA"
     polyA_site      5374
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
     polyA_site      5379
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="major polyA site"
ORIGIN      
        1 acagttttct cttgtgtgtg ctgaatcggg tcatagaggg agacttcccg tgcaaacagt
       61 ttgtgttgga gctggaggac gcagaggggg agagagggat gagttccacc cgtttatcga
      121 ggcgctgctg cctcacgtcc gagccttctc ctacacctgg ttcaacctgc aggcgcggaa
      181 gcgcaagtac ttcaagaagc acgagaagcg gatgtcaaag gacgaggagc gcgcagtgaa
      241 ggacgagctg ctgggcgaga agcctgagat caagcagaag tgggcatccc ggctgttggc
      301 caagctgcgc aaagacatcc ggcccgagtt ccgcgaggac tttgtgctaa ccatcacggg
      361 caagaagccc ccctgctgcg tgctttccaa ccccgaccag aagggcaaga tccggcggat
      421 tgactgcctg cgccaggctg acaaggtgtg gcggctggac ctggtcatgg tgattttgtt
      481 taaagggatc cctttggaaa gtactgatgg ggagcggctc tacaagtcgc cccagtgctc
      541 gaaccccggc ctgtgtgtcc agccacatca cattggagtc acaatcaaag aactggacct
      601 ttatctggct tactttgtcc acactccgga atccggacaa tcagatagtt caaaccagca
      661 aggagatgcg gacatcaaac cactgcccaa cgggcactta agtttccagg actgctttgt
      721 gacgtctggg gtctggaatg tgacagagct ggtgagagta tcacagactc cagttgcgac
      781 tgcatcaggg cccaacttct cactggcgga cctggagagc cccagctact acaacataaa
      841 tcaagtgacc ctgggaaggc ggtccatcac ctcccctcct tccaccagca ccaagcgccc
      901 caagtccatc gacgacagtg agatggagag tccagtagat gatgtgttct atcctgggac
      961 aggccgctct ccggccgctg gcagcagcca gtctagcgga tggcccaatg acgtggatgc
     1021 aggccctgct tctctaaaga agtcaggaaa gctggacttc tgcagcgccc tctcctctca
     1081 gggcagttcc ccacgcatgg ctttcaccca ccacccgctg cctgtgcttg ctggagtcag
     1141 accagggagc ccccgggcca cggcatcagc gctgcacttc ccttccacgt ccatcatcca
     1201 gcagtcgagc ccgtatttca cacacccaac catccgctac caccaccacc atgggcagga
     1261 ctcgctgaag gagtttgtgc agtttgtgtg ctctgacggc tcgggtcagg ccaccggaca
     1321 gcattcacaa cgacaggcgc ctcctctgcc aaccggtttg tcagcatcgg atcccgggac
     1381 ggcaactttc tgaacatccc acagcagtct cagtcctggt tcctctgatt aagatcaaca
     1441 aagaaacaac taaatttaaa aaaggaaaaa aaaaaaagag gttcctcaaa atgggggaga
     1501 agaaattttg agacatggaa atatccccca gcccagcccc accgaaaagc aaaacttaga
     1561 cgtcgtcagc cactcagccc ttccctcctc cagccctggt acccccgcgt tccaaagccg
     1621 cccagttctg ggagtcctcg gaaaggggtc tcagcggagc tgtacaccag cagccaagca
     1681 gaaagaagca tgctaagcgg actctgctaa gcagaggaca aacagaaaga aaggatgcaa
     1741 caagactgcc ttcctcctac tcagcctggc cttcccagga aggagcagcc agctcactgg
     1801 ccggccaccc tggcagttcc tggggacccc accctccgct ggacttaagc ttcccaagga
     1861 gcccagagga acagctcgta acaatagtag acattcgagc tcccctccgg acttcgtctc
     1921 tttccctcac cccacccccc actccccaac ctctcttgcc cttcctggga gcctctgctc
     1981 aggcttctgg ccccagctgc tctggaccag gctagggcgt tcccgggtag gtaagggatg
     2041 cttcttagag ctaactgaat tcagcctgag tccagaatag agggtgttct gccaccccat
     2101 tttgaaccgc ccgggcagtt ctcgggctgg acaccctctg tacagcacac aggaaagtca
     2161 gaatgctctg gactggacgc ccagcccagc ataggcacct tcttccacgc ccgcaggacg
     2221 caagggctgc tgccctctgc cacgccccta gtgaagggag tcggccccag gtcgccccgc
     2281 accccagccc tgcatgcagg tgcccttgct ccgcccctct gccctgcccc tgcccttgct
     2341 gcacacagcc ctccaggggc cggctgagag tggagcagaa agggcccccg gagctgagcg
     2401 aggaggacaa ggcagcctcc acctgcgcta ggtaggcgtc ctgctctcga gactttgagt
     2461 tcctgtggag ggtggggggt gtcatccttt taaaagagtg ttctggagct ttctggtccc
     2521 cttcccttcc caccacgccc cgtggccact tctccctaga ttttagctgt aatgtctttc
     2581 ctctttattt aggggtgggg cagtcattgt ttgggtcttt cgctgtttgc agttgggaac
     2641 tcctctgttt gagcaacttg ggaacaattt cgtaacacac cacaggaagc agttctcctc
     2701 ccagccccct cctccagtaa gggatggcgg aggcttgtcc agagggtctt gagaagcccc
     2761 ctgggaggga ggggaacgcg agcacgccag accccctgca gggtgactgg gcccctctgg
     2821 cttgtctttc tgtgccttag tcctccttcc ctgcatctcc cctcccaggc ccgttctcaa
     2881 ggccatgcgc ctctctccgg tatgaaaaca caaagcacag gtcaggatct tccgaaagtc
     2941 ggtccaacat tgcaccacgt gggggtgggt tgtgggcttt atttattgag aatctagttg
     3001 gtgaggctgc ggccctgaac aggagaatgg ccgctagcag ggagctcggg gctgcgaggc
     3061 ggctgtccct gcgttctgtg tggaagttga gcgaagccct cccctgcggc gtcgagggcc
     3121 aggccggggt ggacgtccag cggggggagg cctccctgtg cgaggggagg gagccccagg
     3181 gtggggggcc gggcgggccg ggcgtgacgc gcggtcaaag tgcaatgatt tttcagttcg
     3241 gttggctaaa cagggtcaga gctaagagct agcgaaagag ggtccctgcc cggccgcgtg
     3301 cgcctcttcg gtcggtcgag gacagtcggg ctgtgggcgc tgtgggattg cggggcacac
     3361 gccccgggcg aggtcagaag ctgcaggcca gctgggccgg ggcccaaggt gcccgagaga
     3421 ggtaccctcg ggaggactgg ggtgggggtg gtgctccttt cccaagtggt ggtgtgaggg
     3481 gcaggcaggc agggacgatg agggcgacag atgtggggac gtgtttagga gaggaaacaa
     3541 cccacaaaaa aatatagggg aaattaacct tttttttttt attgaaccaa gtgcaatgca
     3601 tcagagagtt ttcctatctt tgtatgttaa gagattaaga aaaaaaattc tatttttgtt
     3661 gtaatgtcct cgcggctctg gggacgctaa aagaactggg cctgccctgc ccttagcggg
     3721 gatgaaagct gagtgttttc cttttttttg tttttttttt tgtttgtttt cctttttgat
     3781 agttttctgg gtttttgttt gttggtttgg ttggttggtt ttttttttgt tttttttttt
     3841 ttgttttgcc ttttttcctg cgttgacgag gataatctgg ggtttaaatt tgtttcgtcg
     3901 ttcggtttcg gtgggagggc tgaagaaaac gtttaaaaac acctcgacat taaaaaaaaa
     3961 aaaccaacac aagatcaaaa ggaaaaggac gagagaaaat tatttttaag ataattaaac
     4021 ataaaaaccc tggtgcttat tacattataa agtacgtttt taaaaaccca caaactatta
     4081 tacatacgtt tatgaatcaa ttaaatactc tgcacttgtt aggaacacgc atatcccttc
     4141 tttgttgagt ttaacggaac gggacagcgg cgtgcgcccc gcggctgggc tgctctggcc
     4201 gcgggtctcc ccaggcgctc cccccttcct cgccccctcc ccctccgggc actggggcgc
     4261 ggcgggggtc cccggccccc tcccccgcag aggtcaatgc caacgaacaa acgtcccttt
     4321 tccctccctc cccactccga gcgcccttct ttgagccaga cgccaacttg accctcacca
     4381 gcattaatca ggagcgcgct cagcaagttg gtagtttcct ccccgacccc ttcccacgta
     4441 acaccactat tccccctccc tccgggaggt tcgatgctcc aggacaggtc cagccacgct
     4501 gacaggtcga tttgcccagg cccgcgcccg cacgcacgca cgcacatagc ccggcacaca
     4561 cccccaccct accccgcaac cagccctgtc gactgcctta cacacccgcc cccgcgctgg
     4621 ccggccgacc tagtgccttg ttctcacccc cgtgctggcg gagcggacgc cgcgctctgg
     4681 gtcccagagg ggccgggtgg ctcagacgac ccaccgtttc ccccaacccg accgtactga
     4741 acggaccccc cacgagagaa aaaaaaaagg agcaataaag ttatgagaac tttgtccccc
     4801 aatcgagagc cctaggggca ccccagcccc acctctgctc cctcccaccc catccaccct
     4861 cggggcgtcc cactctgcgc aagccagctg gggccaaccc ctgctttggc ccctcttggg
     4921 agatccgtgc gccccatcag caccagcatc gcggaccgca aaggccgccc gtcccgtcaa
     4981 acaagtttct tcttaggcta agaaacgcag tatatacgag tatctctata tatatatagt
     5041 actaatggat ttggtgtgct tcccccttag cgtcccttcc ctctgctcct ctttcagcct
     5101 ggtctccctt ctctgccctc caattcccct cccccgtctc tgcactgaga tacataagaa
     5161 acaagggtag tttactgtct gttttgtttt ctgggttttc agtgtcctag cggaatgcaa
     5221 gtaggcagcc agcccgtctg tcccctctcc gcccgccccg ccccgcccca ccccagtcac
     5281 tgcgcttctg ttataccatc tttgcctgac tctcttcggc ttctccattg aatggctaat
     5341 gtgtatgtga aataaagaaa taaagaaaaa caaatgcaa
//
