LOCUS       NM_001371057            5342 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus nuclear factor I/X (Nfix), transcript variant 10,
            mRNA.
ACCESSION   NM_001371057
VERSION     NM_001371057.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5342)
  AUTHORS   Caria,C.A., Faa,V., Porcu,S., Marongiu,M.F., Poddie,D., Perseu,L.,
            Meloni,A., Vaccargiu,S. and Ristaldi,M.S.
  TITLE     Post-GWAS Validation of Target Genes Associated with HbF and HbA2
            Levels
  JOURNAL   Cells 13 (14), 1185 (2024)
   PUBMED   39056767
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5342)
  AUTHORS   Kooblall,K.G., Stevenson,M., Heilig,R., Stewart,M., Wright,B.,
            Lockstone,H., Buck,D., Fischer,R., Wells,S., Lines,K.E., Teboul,L.,
            Hennekam,R.C. and Thakker,R.V.
  TITLE     Identification of cellular retinoic acid binding protein 2 (CRABP2)
            as downstream target of nuclear factor I/X (NFIX): implications for
            skeletal dysplasia syndromes
  JOURNAL   JBMR Plus 8 (7), ziae060 (2024)
   PUBMED   38827116
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5342)
  AUTHORS   Angelini,G., Capra,E., Rossi,F., Mura,G., Saclier,M., Taglietti,V.,
            Rovetta,G., Epis,R., Careccia,G., Bonfanti,C. and Messina,G.
  TITLE     MEK-inhibitors decrease Nfix in muscular dystrophy but induce
            unexpected calcifications, partially rescued with Cyanidin diet
  JOURNAL   iScience 27 (1), 108696 (2023)
   PUBMED   38205246
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5342)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5342)
  AUTHORS   Pan,D., Zhong,J., Zhang,J., Dong,H., Zhao,D., Zhang,H. and Yao,B.
  TITLE     Function and regulation of nuclear factor 1 X-type on chondrocyte
            proliferation and differentiation
  JOURNAL   Gene 881, 147620 (2023)
   PUBMED   37433356
  REMARK    GeneRIF: Function and regulation of nuclear factor 1 X-type on
            chondrocyte proliferation and differentiation.
REFERENCE   6  (bases 1 to 5342)
  AUTHORS   Fletcher,C.F., Lutz,C.M., O'Sullivan,T.N., Shaughnessy,J.D. Jr.,
            Hawkes,R., Frankel,W.N., Copeland,N.G. and Jenkins,N.A.
  TITLE     Absence epilepsy in tottering mutant mice is associated with
            calcium channel defects
  JOURNAL   Cell 87 (4), 607-617 (1996)
   PUBMED   8929530
REFERENCE   7  (bases 1 to 5342)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
REFERENCE   8  (bases 1 to 5342)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
REFERENCE   9  (bases 1 to 5342)
  AUTHORS   Nebl,G. and Cato,A.C.
  TITLE     NFI/X proteins: a class of NFI family of transcription factors with
            positive and negative regulatory domains
  JOURNAL   Cell Mol Biol Res 41 (2), 85-95 (1995)
   PUBMED   8581067
REFERENCE   10 (bases 1 to 5342)
  AUTHORS   Scherthan,H., Seisenberger,C., Greulich,K. and Winnacker,E.L.
  TITLE     Mapping of the murine nuclear factor I/X gene (Nfix) to mouse
            chromosome 8 C1-2 by FISH
  JOURNAL   Genomics 22 (1), 247-249 (1994)
   PUBMED   7959784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155163.4 and AC145556.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1077403.1,
                                           SRR11927936.3492790.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                AC155163.4         118014-118070       c
            58-589              AC155163.4         116444-116975       c
            590-652             AC155163.4         72565-72627         c
            653-727             AC155163.4         72265-72339         c
            728-848             AC155163.4         71784-71904         c
            849-985             AC155163.4         71129-71265         c
            986-1108            AC155163.4         68388-68510         c
            1109-1284           AC155163.4         66303-66478         c
            1285-1376           AC155163.4         58426-58517         c
            1377-2019           AC155163.4         52695-53337         c
            2020-5342           AC145556.4         175078-178400       c
FEATURES             Location/Qualifiers
     source          1..5342
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.02 cM"
     gene            1..5342
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="nuclear factor I/X"
                     /db_xref="GeneID:18032"
                     /db_xref="MGI:MGI:97311"
     exon            1..57
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1356
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="isoform 10 is encoded by transcript variant 10;
                     nuclear factor 1 X-type; nuclear factor 1/X; TGGCA-binding
                     protein; CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 X-type isoform 10"
                     /protein_id="NP_001357986.1"
                     /db_xref="GeneID:18032"
                     /db_xref="MGI:MGI:97311"
                     /translation="MDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRMSKDE
                     ERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLSNPDQ
                     KGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQPHHI
                     GVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVWNVTE
                     LVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSSTKRPKSIDDS
                     EMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQGSSP
                     RMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHGQDSL
                     KEFVQFVCSDGSGQATGQHSQRQAPPLPTGLSASDPGTATF"
     exon            58..589
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            590..652
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            653..727
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            728..848
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            849..985
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            986..1108
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1284
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1376
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1377..5342
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1511
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="major polyA site"
     regulatory      5322..5327
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="hexamer: AATAAA"
     regulatory      5326..5331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="hexamer: AAGAAA"
     polyA_site      5337
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
     polyA_site      5342
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="major polyA site"
ORIGIN      
        1 gttgagccca gaatctcaga atcaggcgtt ggctttgccg ggtgcttcag atcaatggat
       61 gagttccacc cgtttatcga ggcgctgctg cctcacgtcc gagccttctc ctacacctgg
      121 ttcaacctgc aggcgcggaa gcgcaagtac ttcaagaagc acgagaagcg gatgtcaaag
      181 gacgaggagc gcgcagtgaa ggacgagctg ctgggcgaga agcctgagat caagcagaag
      241 tgggcatccc ggctgttggc caagctgcgc aaagacatcc ggcccgagtt ccgcgaggac
      301 tttgtgctaa ccatcacggg caagaagccc ccctgctgcg tgctttccaa ccccgaccag
      361 aagggcaaga tccggcggat tgactgcctg cgccaggctg acaaggtgtg gcggctggac
      421 ctggtcatgg tgattttgtt taaagggatc cctttggaaa gtactgatgg ggagcggctc
      481 tacaagtcgc cccagtgctc gaaccccggc ctgtgtgtcc agccacatca cattggagtc
      541 acaatcaaag aactggacct ttatctggct tactttgtcc acactccgga atccggacaa
      601 tcagatagtt caaaccagca aggagatgcg gacatcaaac cactgcccaa cgggcactta
      661 agtttccagg actgctttgt gacgtctggg gtctggaatg tgacagagct ggtgagagta
      721 tcacagactc cagttgcgac tgcatcaggg cccaacttct cactggcgga cctggagagc
      781 cccagctact acaacataaa tcaagtgacc ctgggaaggc ggtccatcac ctcccctcct
      841 tccaccagca gcaccaagcg ccccaagtcc atcgacgaca gtgagatgga gagtccagta
      901 gatgatgtgt tctatcctgg gacaggccgc tctccggccg ctggcagcag ccagtctagc
      961 ggatggccca atgacgtgga tgcaggccct gcttctctaa agaagtcagg aaagctggac
     1021 ttctgcagcg ccctctcctc tcagggcagt tccccacgca tggctttcac ccaccacccg
     1081 ctgcctgtgc ttgctggagt cagaccaggg agcccccggg ccacggcatc agcgctgcac
     1141 ttcccttcca cgtccatcat ccagcagtcg agcccgtatt tcacacaccc aaccatccgc
     1201 taccaccacc accatgggca ggactcgctg aaggagtttg tgcagtttgt gtgctctgac
     1261 ggctcgggtc aggccaccgg acagcattca caacgacagg cgcctcctct gccaaccggt
     1321 ttgtcagcat cggatcccgg gacggcaact ttctgaacat cccacagcag tctcagtcct
     1381 ggttcctctg attaagatca acaaagaaac aactaaattt aaaaaaggaa aaaaaaaaaa
     1441 gaggttcctc aaaatggggg agaagaaatt ttgagacatg gaaatatccc ccagcccagc
     1501 cccaccgaaa agcaaaactt agacgtcgtc agccactcag cccttccctc ctccagccct
     1561 ggtacccccg cgttccaaag ccgcccagtt ctgggagtcc tcggaaaggg gtctcagcgg
     1621 agctgtacac cagcagccaa gcagaaagaa gcatgctaag cggactctgc taagcagagg
     1681 acaaacagaa agaaaggatg caacaagact gccttcctcc tactcagcct ggccttccca
     1741 ggaaggagca gccagctcac tggccggcca ccctggcagt tcctggggac cccaccctcc
     1801 gctggactta agcttcccaa ggagcccaga ggaacagctc gtaacaatag tagacattcg
     1861 agctcccctc cggacttcgt ctctttccct caccccaccc cccactcccc aacctctctt
     1921 gcccttcctg ggagcctctg ctcaggcttc tggccccagc tgctctggac caggctaggg
     1981 cgttcccggg taggtaaggg atgcttctta gagctaactg aattcagcct gagtccagaa
     2041 tagagggtgt tctgccaccc cattttgaac cgcccgggca gttctcgggc tggacaccct
     2101 ctgtacagca cacaggaaag tcagaatgct ctggactgga cgcccagccc agcataggca
     2161 ccttcttcca cgcccgcagg acgcaagggc tgctgccctc tgccacgccc ctagtgaagg
     2221 gagtcggccc caggtcgccc cgcaccccag ccctgcatgc aggtgccctt gctccgcccc
     2281 tctgccctgc ccctgccctt gctgcacaca gccctccagg ggccggctga gagtggagca
     2341 gaaagggccc ccggagctga gcgaggagga caaggcagcc tccacctgcg ctaggtaggc
     2401 gtcctgctct cgagactttg agttcctgtg gagggtgggg ggtgtcatcc ttttaaaaga
     2461 gtgttctgga gctttctggt ccccttccct tcccaccacg ccccgtggcc acttctccct
     2521 agattttagc tgtaatgtct ttcctcttta tttaggggtg gggcagtcat tgtttgggtc
     2581 tttcgctgtt tgcagttggg aactcctctg tttgagcaac ttgggaacaa tttcgtaaca
     2641 caccacagga agcagttctc ctcccagccc cctcctccag taagggatgg cggaggcttg
     2701 tccagagggt cttgagaagc cccctgggag ggaggggaac gcgagcacgc cagaccccct
     2761 gcagggtgac tgggcccctc tggcttgtct ttctgtgcct tagtcctcct tccctgcatc
     2821 tcccctccca ggcccgttct caaggccatg cgcctctctc cggtatgaaa acacaaagca
     2881 caggtcagga tcttccgaaa gtcggtccaa cattgcacca cgtgggggtg ggttgtgggc
     2941 tttatttatt gagaatctag ttggtgaggc tgcggccctg aacaggagaa tggccgctag
     3001 cagggagctc ggggctgcga ggcggctgtc cctgcgttct gtgtggaagt tgagcgaagc
     3061 cctcccctgc ggcgtcgagg gccaggccgg ggtggacgtc cagcgggggg aggcctccct
     3121 gtgcgagggg agggagcccc agggtggggg gccgggcggg ccgggcgtga cgcgcggtca
     3181 aagtgcaatg atttttcagt tcggttggct aaacagggtc agagctaaga gctagcgaaa
     3241 gagggtccct gcccggccgc gtgcgcctct tcggtcggtc gaggacagtc gggctgtggg
     3301 cgctgtggga ttgcggggca cacgccccgg gcgaggtcag aagctgcagg ccagctgggc
     3361 cggggcccaa ggtgcccgag agaggtaccc tcgggaggac tggggtgggg gtggtgctcc
     3421 tttcccaagt ggtggtgtga ggggcaggca ggcagggacg atgagggcga cagatgtggg
     3481 gacgtgttta ggagaggaaa caacccacaa aaaaatatag gggaaattaa cctttttttt
     3541 tttattgaac caagtgcaat gcatcagaga gttttcctat ctttgtatgt taagagatta
     3601 agaaaaaaaa ttctattttt gttgtaatgt cctcgcggct ctggggacgc taaaagaact
     3661 gggcctgccc tgcccttagc ggggatgaaa gctgagtgtt ttcctttttt ttgttttttt
     3721 ttttgtttgt tttccttttt gatagttttc tgggtttttg tttgttggtt tggttggttg
     3781 gttttttttt tgtttttttt tttttgtttt gccttttttc ctgcgttgac gaggataatc
     3841 tggggtttaa atttgtttcg tcgttcggtt tcggtgggag ggctgaagaa aacgtttaaa
     3901 aacacctcga cattaaaaaa aaaaaaccaa cacaagatca aaaggaaaag gacgagagaa
     3961 aattattttt aagataatta aacataaaaa ccctggtgct tattacatta taaagtacgt
     4021 ttttaaaaac ccacaaacta ttatacatac gtttatgaat caattaaata ctctgcactt
     4081 gttaggaaca cgcatatccc ttctttgttg agtttaacgg aacgggacag cggcgtgcgc
     4141 cccgcggctg ggctgctctg gccgcgggtc tccccaggcg ctcccccctt cctcgccccc
     4201 tccccctccg ggcactgggg cgcggcgggg gtccccggcc ccctcccccg cagaggtcaa
     4261 tgccaacgaa caaacgtccc ttttccctcc ctccccactc cgagcgccct tctttgagcc
     4321 agacgccaac ttgaccctca ccagcattaa tcaggagcgc gctcagcaag ttggtagttt
     4381 cctccccgac cccttcccac gtaacaccac tattccccct ccctccggga ggttcgatgc
     4441 tccaggacag gtccagccac gctgacaggt cgatttgccc aggcccgcgc ccgcacgcac
     4501 gcacgcacat agcccggcac acacccccac cctaccccgc aaccagccct gtcgactgcc
     4561 ttacacaccc gcccccgcgc tggccggccg acctagtgcc ttgttctcac ccccgtgctg
     4621 gcggagcgga cgccgcgctc tgggtcccag aggggccggg tggctcagac gacccaccgt
     4681 ttcccccaac ccgaccgtac tgaacggacc ccccacgaga gaaaaaaaaa aggagcaata
     4741 aagttatgag aactttgtcc cccaatcgag agccctaggg gcaccccagc cccacctctg
     4801 ctccctccca ccccatccac cctcggggcg tcccactctg cgcaagccag ctggggccaa
     4861 cccctgcttt ggcccctctt gggagatccg tgcgccccat cagcaccagc atcgcggacc
     4921 gcaaaggccg cccgtcccgt caaacaagtt tcttcttagg ctaagaaacg cagtatatac
     4981 gagtatctct atatatatat agtactaatg gatttggtgt gcttccccct tagcgtccct
     5041 tccctctgct cctctttcag cctggtctcc cttctctgcc ctccaattcc cctcccccgt
     5101 ctctgcactg agatacataa gaaacaaggg tagtttactg tctgttttgt tttctgggtt
     5161 ttcagtgtcc tagcggaatg caagtaggca gccagcccgt ctgtcccctc tccgcccgcc
     5221 ccgccccgcc ccaccccagt cactgcgctt ctgttatacc atctttgcct gactctcttc
     5281 ggcttctcca ttgaatggct aatgtgtatg tgaaataaag aaataaagaa aaacaaatgc
     5341 aa
//
