LOCUS       NM_001371054            5559 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus nuclear factor I/X (Nfix), transcript variant 7, mRNA.
ACCESSION   NM_001371054 XM_006530762
VERSION     NM_001371054.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5559)
  AUTHORS   Caria,C.A., Faa,V., Porcu,S., Marongiu,M.F., Poddie,D., Perseu,L.,
            Meloni,A., Vaccargiu,S. and Ristaldi,M.S.
  TITLE     Post-GWAS Validation of Target Genes Associated with HbF and HbA2
            Levels
  JOURNAL   Cells 13 (14), 1185 (2024)
   PUBMED   39056767
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5559)
  AUTHORS   Kooblall,K.G., Stevenson,M., Heilig,R., Stewart,M., Wright,B.,
            Lockstone,H., Buck,D., Fischer,R., Wells,S., Lines,K.E., Teboul,L.,
            Hennekam,R.C. and Thakker,R.V.
  TITLE     Identification of cellular retinoic acid binding protein 2 (CRABP2)
            as downstream target of nuclear factor I/X (NFIX): implications for
            skeletal dysplasia syndromes
  JOURNAL   JBMR Plus 8 (7), ziae060 (2024)
   PUBMED   38827116
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5559)
  AUTHORS   Angelini,G., Capra,E., Rossi,F., Mura,G., Saclier,M., Taglietti,V.,
            Rovetta,G., Epis,R., Careccia,G., Bonfanti,C. and Messina,G.
  TITLE     MEK-inhibitors decrease Nfix in muscular dystrophy but induce
            unexpected calcifications, partially rescued with Cyanidin diet
  JOURNAL   iScience 27 (1), 108696 (2023)
   PUBMED   38205246
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5559)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5559)
  AUTHORS   Pan,D., Zhong,J., Zhang,J., Dong,H., Zhao,D., Zhang,H. and Yao,B.
  TITLE     Function and regulation of nuclear factor 1 X-type on chondrocyte
            proliferation and differentiation
  JOURNAL   Gene 881, 147620 (2023)
   PUBMED   37433356
  REMARK    GeneRIF: Function and regulation of nuclear factor 1 X-type on
            chondrocyte proliferation and differentiation.
REFERENCE   6  (bases 1 to 5559)
  AUTHORS   Fletcher,C.F., Lutz,C.M., O'Sullivan,T.N., Shaughnessy,J.D. Jr.,
            Hawkes,R., Frankel,W.N., Copeland,N.G. and Jenkins,N.A.
  TITLE     Absence epilepsy in tottering mutant mice is associated with
            calcium channel defects
  JOURNAL   Cell 87 (4), 607-617 (1996)
   PUBMED   8929530
REFERENCE   7  (bases 1 to 5559)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
REFERENCE   8  (bases 1 to 5559)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
REFERENCE   9  (bases 1 to 5559)
  AUTHORS   Nebl,G. and Cato,A.C.
  TITLE     NFI/X proteins: a class of NFI family of transcription factors with
            positive and negative regulatory domains
  JOURNAL   Cell Mol Biol Res 41 (2), 85-95 (1995)
   PUBMED   8581067
REFERENCE   10 (bases 1 to 5559)
  AUTHORS   Scherthan,H., Seisenberger,C., Greulich,K. and Winnacker,E.L.
  TITLE     Mapping of the murine nuclear factor I/X gene (Nfix) to mouse
            chromosome 8 C1-2 by FISH
  JOURNAL   Genomics 22 (1), 247-249 (1994)
   PUBMED   7959784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155163.4 and AC145556.4.
            
            On Jun 26, 2019 this sequence version replaced XM_006530762.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.2424646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-126               AC155163.4         117410-117535       c
            127-658             AC155163.4         116444-116975       c
            659-721             AC155163.4         72565-72627         c
            722-796             AC155163.4         72265-72339         c
            797-917             AC155163.4         71784-71904         c
            918-1054            AC155163.4         71129-71265         c
            1055-1177           AC155163.4         68388-68510         c
            1178-1353           AC155163.4         66303-66478         c
            1354-1501           AC155163.4         60801-60948         c
            1502-1593           AC155163.4         58426-58517         c
            1594-2236           AC155163.4         52695-53337         c
            2237-5559           AC145556.4         175078-178400       c
FEATURES             Location/Qualifiers
     source          1..5559
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.02 cM"
     gene            1..5559
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="nuclear factor I/X"
                     /db_xref="GeneID:18032"
                     /db_xref="MGI:MGI:97311"
     exon            1..126
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     CDS             112..1608
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="isoform 7 is encoded by transcript variant 7;
                     nuclear factor 1 X-type; nuclear factor 1/X; TGGCA-binding
                     protein; CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 X-type isoform 7"
                     /protein_id="NP_001357983.1"
                     /db_xref="GeneID:18032"
                     /db_xref="MGI:MGI:97311"
                     /translation="MDMSWDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKHEKRM
                     SKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPCCVLS
                     NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPGLCVQ
                     PHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVTSGVW
                     NVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSSTKRPKS
                     IDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSALSSQ
                     GSSPRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYHHHHG
                     QDSLKEFVQFVCSDGSGQATGQPNGSGQGKVPGSFLLPPPPPVARPVPLPMPDSKTTS
                     TAPDGAALTPPSPSFTTTGASSANRFVSIGSRDGNFLNIPQQSQSWFL"
     exon            127..658
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            659..721
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            722..796
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            797..917
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1054
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1177
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1353
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1501
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..1593
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..5559
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1728
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="major polyA site"
     regulatory      5539..5544
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="hexamer: AATAAA"
     regulatory      5543..5548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="hexamer: AAGAAA"
     polyA_site      5554
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
     polyA_site      5559
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="major polyA site"
ORIGIN      
        1 acattggcca gtccggacaa ggcagttctt gcatgccctt tggtctgcac cctcaggggc
       61 agcaggacac tactggaacc agctgaccct agttcacagc tgctgtagaa catggacatg
      121 tcatgggatg agttccaccc gtttatcgag gcgctgctgc ctcacgtccg agccttctcc
      181 tacacctggt tcaacctgca ggcgcggaag cgcaagtact tcaagaagca cgagaagcgg
      241 atgtcaaagg acgaggagcg cgcagtgaag gacgagctgc tgggcgagaa gcctgagatc
      301 aagcagaagt gggcatcccg gctgttggcc aagctgcgca aagacatccg gcccgagttc
      361 cgcgaggact ttgtgctaac catcacgggc aagaagcccc cctgctgcgt gctttccaac
      421 cccgaccaga agggcaagat ccggcggatt gactgcctgc gccaggctga caaggtgtgg
      481 cggctggacc tggtcatggt gattttgttt aaagggatcc ctttggaaag tactgatggg
      541 gagcggctct acaagtcgcc ccagtgctcg aaccccggcc tgtgtgtcca gccacatcac
      601 attggagtca caatcaaaga actggacctt tatctggctt actttgtcca cactccggaa
      661 tccggacaat cagatagttc aaaccagcaa ggagatgcgg acatcaaacc actgcccaac
      721 gggcacttaa gtttccagga ctgctttgtg acgtctgggg tctggaatgt gacagagctg
      781 gtgagagtat cacagactcc agttgcgact gcatcagggc ccaacttctc actggcggac
      841 ctggagagcc ccagctacta caacataaat caagtgaccc tgggaaggcg gtccatcacc
      901 tcccctcctt ccaccagcag caccaagcgc cccaagtcca tcgacgacag tgagatggag
      961 agtccagtag atgatgtgtt ctatcctggg acaggccgct ctccggccgc tggcagcagc
     1021 cagtctagcg gatggcccaa tgacgtggat gcaggccctg cttctctaaa gaagtcagga
     1081 aagctggact tctgcagcgc cctctcctct cagggcagtt ccccacgcat ggctttcacc
     1141 caccacccgc tgcctgtgct tgctggagtc agaccaggga gcccccgggc cacggcatca
     1201 gcgctgcact tcccttccac gtccatcatc cagcagtcga gcccgtattt cacacaccca
     1261 accatccgct accaccacca ccatgggcag gactcgctga aggagtttgt gcagtttgtg
     1321 tgctctgacg gctcgggtca ggccaccgga cagcccaacg gtagcggcca gggcaaagtc
     1381 ccggggtcat ttttgctacc gccgccgcct ccagtggcca gacctgtgcc ccttcctatg
     1441 cctgattcca aaaccaccag cacggcccca gacggcgccg ccttgactcc tccatcacct
     1501 tcattcacaa cgacaggcgc ctcctctgcc aaccggtttg tcagcatcgg atcccgggac
     1561 ggcaactttc tgaacatccc acagcagtct cagtcctggt tcctctgatt aagatcaaca
     1621 aagaaacaac taaatttaaa aaaggaaaaa aaaaaaagag gttcctcaaa atgggggaga
     1681 agaaattttg agacatggaa atatccccca gcccagcccc accgaaaagc aaaacttaga
     1741 cgtcgtcagc cactcagccc ttccctcctc cagccctggt acccccgcgt tccaaagccg
     1801 cccagttctg ggagtcctcg gaaaggggtc tcagcggagc tgtacaccag cagccaagca
     1861 gaaagaagca tgctaagcgg actctgctaa gcagaggaca aacagaaaga aaggatgcaa
     1921 caagactgcc ttcctcctac tcagcctggc cttcccagga aggagcagcc agctcactgg
     1981 ccggccaccc tggcagttcc tggggacccc accctccgct ggacttaagc ttcccaagga
     2041 gcccagagga acagctcgta acaatagtag acattcgagc tcccctccgg acttcgtctc
     2101 tttccctcac cccacccccc actccccaac ctctcttgcc cttcctggga gcctctgctc
     2161 aggcttctgg ccccagctgc tctggaccag gctagggcgt tcccgggtag gtaagggatg
     2221 cttcttagag ctaactgaat tcagcctgag tccagaatag agggtgttct gccaccccat
     2281 tttgaaccgc ccgggcagtt ctcgggctgg acaccctctg tacagcacac aggaaagtca
     2341 gaatgctctg gactggacgc ccagcccagc ataggcacct tcttccacgc ccgcaggacg
     2401 caagggctgc tgccctctgc cacgccccta gtgaagggag tcggccccag gtcgccccgc
     2461 accccagccc tgcatgcagg tgcccttgct ccgcccctct gccctgcccc tgcccttgct
     2521 gcacacagcc ctccaggggc cggctgagag tggagcagaa agggcccccg gagctgagcg
     2581 aggaggacaa ggcagcctcc acctgcgcta ggtaggcgtc ctgctctcga gactttgagt
     2641 tcctgtggag ggtggggggt gtcatccttt taaaagagtg ttctggagct ttctggtccc
     2701 cttcccttcc caccacgccc cgtggccact tctccctaga ttttagctgt aatgtctttc
     2761 ctctttattt aggggtgggg cagtcattgt ttgggtcttt cgctgtttgc agttgggaac
     2821 tcctctgttt gagcaacttg ggaacaattt cgtaacacac cacaggaagc agttctcctc
     2881 ccagccccct cctccagtaa gggatggcgg aggcttgtcc agagggtctt gagaagcccc
     2941 ctgggaggga ggggaacgcg agcacgccag accccctgca gggtgactgg gcccctctgg
     3001 cttgtctttc tgtgccttag tcctccttcc ctgcatctcc cctcccaggc ccgttctcaa
     3061 ggccatgcgc ctctctccgg tatgaaaaca caaagcacag gtcaggatct tccgaaagtc
     3121 ggtccaacat tgcaccacgt gggggtgggt tgtgggcttt atttattgag aatctagttg
     3181 gtgaggctgc ggccctgaac aggagaatgg ccgctagcag ggagctcggg gctgcgaggc
     3241 ggctgtccct gcgttctgtg tggaagttga gcgaagccct cccctgcggc gtcgagggcc
     3301 aggccggggt ggacgtccag cggggggagg cctccctgtg cgaggggagg gagccccagg
     3361 gtggggggcc gggcgggccg ggcgtgacgc gcggtcaaag tgcaatgatt tttcagttcg
     3421 gttggctaaa cagggtcaga gctaagagct agcgaaagag ggtccctgcc cggccgcgtg
     3481 cgcctcttcg gtcggtcgag gacagtcggg ctgtgggcgc tgtgggattg cggggcacac
     3541 gccccgggcg aggtcagaag ctgcaggcca gctgggccgg ggcccaaggt gcccgagaga
     3601 ggtaccctcg ggaggactgg ggtgggggtg gtgctccttt cccaagtggt ggtgtgaggg
     3661 gcaggcaggc agggacgatg agggcgacag atgtggggac gtgtttagga gaggaaacaa
     3721 cccacaaaaa aatatagggg aaattaacct tttttttttt attgaaccaa gtgcaatgca
     3781 tcagagagtt ttcctatctt tgtatgttaa gagattaaga aaaaaaattc tatttttgtt
     3841 gtaatgtcct cgcggctctg gggacgctaa aagaactggg cctgccctgc ccttagcggg
     3901 gatgaaagct gagtgttttc cttttttttg tttttttttt tgtttgtttt cctttttgat
     3961 agttttctgg gtttttgttt gttggtttgg ttggttggtt ttttttttgt tttttttttt
     4021 ttgttttgcc ttttttcctg cgttgacgag gataatctgg ggtttaaatt tgtttcgtcg
     4081 ttcggtttcg gtgggagggc tgaagaaaac gtttaaaaac acctcgacat taaaaaaaaa
     4141 aaaccaacac aagatcaaaa ggaaaaggac gagagaaaat tatttttaag ataattaaac
     4201 ataaaaaccc tggtgcttat tacattataa agtacgtttt taaaaaccca caaactatta
     4261 tacatacgtt tatgaatcaa ttaaatactc tgcacttgtt aggaacacgc atatcccttc
     4321 tttgttgagt ttaacggaac gggacagcgg cgtgcgcccc gcggctgggc tgctctggcc
     4381 gcgggtctcc ccaggcgctc cccccttcct cgccccctcc ccctccgggc actggggcgc
     4441 ggcgggggtc cccggccccc tcccccgcag aggtcaatgc caacgaacaa acgtcccttt
     4501 tccctccctc cccactccga gcgcccttct ttgagccaga cgccaacttg accctcacca
     4561 gcattaatca ggagcgcgct cagcaagttg gtagtttcct ccccgacccc ttcccacgta
     4621 acaccactat tccccctccc tccgggaggt tcgatgctcc aggacaggtc cagccacgct
     4681 gacaggtcga tttgcccagg cccgcgcccg cacgcacgca cgcacatagc ccggcacaca
     4741 cccccaccct accccgcaac cagccctgtc gactgcctta cacacccgcc cccgcgctgg
     4801 ccggccgacc tagtgccttg ttctcacccc cgtgctggcg gagcggacgc cgcgctctgg
     4861 gtcccagagg ggccgggtgg ctcagacgac ccaccgtttc ccccaacccg accgtactga
     4921 acggaccccc cacgagagaa aaaaaaaagg agcaataaag ttatgagaac tttgtccccc
     4981 aatcgagagc cctaggggca ccccagcccc acctctgctc cctcccaccc catccaccct
     5041 cggggcgtcc cactctgcgc aagccagctg gggccaaccc ctgctttggc ccctcttggg
     5101 agatccgtgc gccccatcag caccagcatc gcggaccgca aaggccgccc gtcccgtcaa
     5161 acaagtttct tcttaggcta agaaacgcag tatatacgag tatctctata tatatatagt
     5221 actaatggat ttggtgtgct tcccccttag cgtcccttcc ctctgctcct ctttcagcct
     5281 ggtctccctt ctctgccctc caattcccct cccccgtctc tgcactgaga tacataagaa
     5341 acaagggtag tttactgtct gttttgtttt ctgggttttc agtgtcctag cggaatgcaa
     5401 gtaggcagcc agcccgtctg tcccctctcc gcccgccccg ccccgcccca ccccagtcac
     5461 tgcgcttctg ttataccatc tttgcctgac tctcttcggc ttctccattg aatggctaat
     5521 gtgtatgtga aataaagaaa taaagaaaaa caaatgcaa
//
