LOCUS       NM_001371053            5804 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus nuclear factor I/X (Nfix), transcript variant 6, mRNA.
ACCESSION   NM_001371053 XM_006530761
VERSION     NM_001371053.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5804)
  AUTHORS   Caria,C.A., Faa,V., Porcu,S., Marongiu,M.F., Poddie,D., Perseu,L.,
            Meloni,A., Vaccargiu,S. and Ristaldi,M.S.
  TITLE     Post-GWAS Validation of Target Genes Associated with HbF and HbA2
            Levels
  JOURNAL   Cells 13 (14), 1185 (2024)
   PUBMED   39056767
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5804)
  AUTHORS   Kooblall,K.G., Stevenson,M., Heilig,R., Stewart,M., Wright,B.,
            Lockstone,H., Buck,D., Fischer,R., Wells,S., Lines,K.E., Teboul,L.,
            Hennekam,R.C. and Thakker,R.V.
  TITLE     Identification of cellular retinoic acid binding protein 2 (CRABP2)
            as downstream target of nuclear factor I/X (NFIX): implications for
            skeletal dysplasia syndromes
  JOURNAL   JBMR Plus 8 (7), ziae060 (2024)
   PUBMED   38827116
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5804)
  AUTHORS   Angelini,G., Capra,E., Rossi,F., Mura,G., Saclier,M., Taglietti,V.,
            Rovetta,G., Epis,R., Careccia,G., Bonfanti,C. and Messina,G.
  TITLE     MEK-inhibitors decrease Nfix in muscular dystrophy but induce
            unexpected calcifications, partially rescued with Cyanidin diet
  JOURNAL   iScience 27 (1), 108696 (2023)
   PUBMED   38205246
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5804)
  AUTHORS   Dali,O., D'Cruz,S., Legoff,L., Diba Lahmidi,M., Heitz,C.,
            Merret,P.E., Kernanec,P.Y., Pakdel,F. and Smagulova,F.
  TITLE     Transgenerational epigenetic effects imposed by neonicotinoid
            thiacloprid exposure
  JOURNAL   Life Sci Alliance 7 (2), e202302237 (2023)
   PUBMED   37973188
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5804)
  AUTHORS   Pan,D., Zhong,J., Zhang,J., Dong,H., Zhao,D., Zhang,H. and Yao,B.
  TITLE     Function and regulation of nuclear factor 1 X-type on chondrocyte
            proliferation and differentiation
  JOURNAL   Gene 881, 147620 (2023)
   PUBMED   37433356
  REMARK    GeneRIF: Function and regulation of nuclear factor 1 X-type on
            chondrocyte proliferation and differentiation.
REFERENCE   6  (bases 1 to 5804)
  AUTHORS   Fletcher,C.F., Lutz,C.M., O'Sullivan,T.N., Shaughnessy,J.D. Jr.,
            Hawkes,R., Frankel,W.N., Copeland,N.G. and Jenkins,N.A.
  TITLE     Absence epilepsy in tottering mutant mice is associated with
            calcium channel defects
  JOURNAL   Cell 87 (4), 607-617 (1996)
   PUBMED   8929530
REFERENCE   7  (bases 1 to 5804)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
REFERENCE   8  (bases 1 to 5804)
  AUTHORS   Qian,F., Kruse,U., Lichter,P. and Sippel,A.E.
  TITLE     Chromosomal localization of the four genes (NFIA, B, C, and X) for
            the human transcription factor nuclear factor I by FISH
  JOURNAL   Genomics 28 (1), 66-73 (1995)
   PUBMED   7590749
REFERENCE   9  (bases 1 to 5804)
  AUTHORS   Nebl,G. and Cato,A.C.
  TITLE     NFI/X proteins: a class of NFI family of transcription factors with
            positive and negative regulatory domains
  JOURNAL   Cell Mol Biol Res 41 (2), 85-95 (1995)
   PUBMED   8581067
REFERENCE   10 (bases 1 to 5804)
  AUTHORS   Scherthan,H., Seisenberger,C., Greulich,K. and Winnacker,E.L.
  TITLE     Mapping of the murine nuclear factor I/X gene (Nfix) to mouse
            chromosome 8 C1-2 by FISH
  JOURNAL   Genomics 22 (1), 247-249 (1994)
   PUBMED   7959784
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155163.4 and AC145556.4.
            
            On Jun 26, 2019 this sequence version replaced XM_006530761.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.1888954.1,
                                           SRR7652917.47288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-371               AC155163.4         144658-145028       c
            372-903             AC155163.4         116444-116975       c
            904-966             AC155163.4         72565-72627         c
            967-1041            AC155163.4         72265-72339         c
            1042-1162           AC155163.4         71784-71904         c
            1163-1299           AC155163.4         71129-71265         c
            1300-1422           AC155163.4         68388-68510         c
            1423-1598           AC155163.4         66303-66478         c
            1599-1746           AC155163.4         60801-60948         c
            1747-1838           AC155163.4         58426-58517         c
            1839-2481           AC155163.4         52695-53337         c
            2482-5804           AC145556.4         175078-178400       c
FEATURES             Location/Qualifiers
     source          1..5804
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 41.02 cM"
     gene            1..5804
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="nuclear factor I/X"
                     /db_xref="GeneID:18032"
                     /db_xref="MGI:MGI:97311"
     exon            1..371
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     CDS             345..1853
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="isoform 6 is encoded by transcript variant 6;
                     nuclear factor 1 X-type; nuclear factor 1/X; TGGCA-binding
                     protein; CCAAT-box-binding transcription factor"
                     /codon_start=1
                     /product="nuclear factor 1 X-type isoform 6"
                     /protein_id="NP_001357982.1"
                     /db_xref="GeneID:18032"
                     /db_xref="MGI:MGI:97311"
                     /translation="MYSPYCLTQDEFHPFIEALLPHVRAFSYTWFNLQARKRKYFKKH
                     EKRMSKDEERAVKDELLGEKPEIKQKWASRLLAKLRKDIRPEFREDFVLTITGKKPPC
                     CVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLYKSPQCSNPG
                     LCVQPHHIGVTIKELDLYLAYFVHTPESGQSDSSNQQGDADIKPLPNGHLSFQDCFVT
                     SGVWNVTELVRVSQTPVATASGPNFSLADLESPSYYNINQVTLGRRSITSPPSTSSTK
                     RPKSIDDSEMESPVDDVFYPGTGRSPAAGSSQSSGWPNDVDAGPASLKKSGKLDFCSA
                     LSSQGSSPRMAFTHHPLPVLAGVRPGSPRATASALHFPSTSIIQQSSPYFTHPTIRYH
                     HHHGQDSLKEFVQFVCSDGSGQATGQPNGSGQGKVPGSFLLPPPPPVARPVPLPMPDS
                     KTTSTAPDGAALTPPSPSFTTTGASSANRFVSIGSRDGNFLNIPQQSQSWFL"
     exon            372..903
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            904..966
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1041
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1162
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1299
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1422
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1423..1598
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1599..1746
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1838
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     exon            1839..5804
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1973
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="major polyA site"
     regulatory      5784..5789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="hexamer: AATAAA"
     regulatory      5788..5793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="hexamer: AAGAAA"
     polyA_site      5799
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
     polyA_site      5804
                     /gene="Nfix"
                     /gene_synonym="CTF; NF-I/X; NF1-X; NFI-X"
                     /note="major polyA site"
ORIGIN      
        1 gtctaaactt tcactttcac agcgcggcgg cggcggcggc ggcggcggtg gcgggcgagg
       61 gcgagcggcc gagcggcggc ggcatggagt agacgcgcgg cggcggcggc ggcggcggcg
      121 gacgcgagag gcagcggcga gcgcggcggc ggcccggagc ccgcggggcc gagcctgtga
      181 gcgcggagcg gcggcgggcc gagcggggcc gcgggccggg cgggcgccgc gcggcagagg
      241 ccggagcagc ggagccggag cccgagcgcc agccagcgcg acgccgcctg ccgggcctgc
      301 cctcgccgcg gccggcctcc gcgctcgcgc ccgggcgccc agcgatgtac tccccgtact
      361 gcctcaccca ggatgagttc cacccgttta tcgaggcgct gctgcctcac gtccgagcct
      421 tctcctacac ctggttcaac ctgcaggcgc ggaagcgcaa gtacttcaag aagcacgaga
      481 agcggatgtc aaaggacgag gagcgcgcag tgaaggacga gctgctgggc gagaagcctg
      541 agatcaagca gaagtgggca tcccggctgt tggccaagct gcgcaaagac atccggcccg
      601 agttccgcga ggactttgtg ctaaccatca cgggcaagaa gcccccctgc tgcgtgcttt
      661 ccaaccccga ccagaagggc aagatccggc ggattgactg cctgcgccag gctgacaagg
      721 tgtggcggct ggacctggtc atggtgattt tgtttaaagg gatccctttg gaaagtactg
      781 atggggagcg gctctacaag tcgccccagt gctcgaaccc cggcctgtgt gtccagccac
      841 atcacattgg agtcacaatc aaagaactgg acctttatct ggcttacttt gtccacactc
      901 cggaatccgg acaatcagat agttcaaacc agcaaggaga tgcggacatc aaaccactgc
      961 ccaacgggca cttaagtttc caggactgct ttgtgacgtc tggggtctgg aatgtgacag
     1021 agctggtgag agtatcacag actccagttg cgactgcatc agggcccaac ttctcactgg
     1081 cggacctgga gagccccagc tactacaaca taaatcaagt gaccctggga aggcggtcca
     1141 tcacctcccc tccttccacc agcagcacca agcgccccaa gtccatcgac gacagtgaga
     1201 tggagagtcc agtagatgat gtgttctatc ctgggacagg ccgctctccg gccgctggca
     1261 gcagccagtc tagcggatgg cccaatgacg tggatgcagg ccctgcttct ctaaagaagt
     1321 caggaaagct ggacttctgc agcgccctct cctctcaggg cagttcccca cgcatggctt
     1381 tcacccacca cccgctgcct gtgcttgctg gagtcagacc agggagcccc cgggccacgg
     1441 catcagcgct gcacttccct tccacgtcca tcatccagca gtcgagcccg tatttcacac
     1501 acccaaccat ccgctaccac caccaccatg ggcaggactc gctgaaggag tttgtgcagt
     1561 ttgtgtgctc tgacggctcg ggtcaggcca ccggacagcc caacggtagc ggccagggca
     1621 aagtcccggg gtcatttttg ctaccgccgc cgcctccagt ggccagacct gtgccccttc
     1681 ctatgcctga ttccaaaacc accagcacgg ccccagacgg cgccgccttg actcctccat
     1741 caccttcatt cacaacgaca ggcgcctcct ctgccaaccg gtttgtcagc atcggatccc
     1801 gggacggcaa ctttctgaac atcccacagc agtctcagtc ctggttcctc tgattaagat
     1861 caacaaagaa acaactaaat ttaaaaaagg aaaaaaaaaa aagaggttcc tcaaaatggg
     1921 ggagaagaaa ttttgagaca tggaaatatc ccccagccca gccccaccga aaagcaaaac
     1981 ttagacgtcg tcagccactc agcccttccc tcctccagcc ctggtacccc cgcgttccaa
     2041 agccgcccag ttctgggagt cctcggaaag gggtctcagc ggagctgtac accagcagcc
     2101 aagcagaaag aagcatgcta agcggactct gctaagcaga ggacaaacag aaagaaagga
     2161 tgcaacaaga ctgccttcct cctactcagc ctggccttcc caggaaggag cagccagctc
     2221 actggccggc caccctggca gttcctgggg accccaccct ccgctggact taagcttccc
     2281 aaggagccca gaggaacagc tcgtaacaat agtagacatt cgagctcccc tccggacttc
     2341 gtctctttcc ctcaccccac cccccactcc ccaacctctc ttgcccttcc tgggagcctc
     2401 tgctcaggct tctggcccca gctgctctgg accaggctag ggcgttcccg ggtaggtaag
     2461 ggatgcttct tagagctaac tgaattcagc ctgagtccag aatagagggt gttctgccac
     2521 cccattttga accgcccggg cagttctcgg gctggacacc ctctgtacag cacacaggaa
     2581 agtcagaatg ctctggactg gacgcccagc ccagcatagg caccttcttc cacgcccgca
     2641 ggacgcaagg gctgctgccc tctgccacgc ccctagtgaa gggagtcggc cccaggtcgc
     2701 cccgcacccc agccctgcat gcaggtgccc ttgctccgcc cctctgccct gcccctgccc
     2761 ttgctgcaca cagccctcca ggggccggct gagagtggag cagaaagggc ccccggagct
     2821 gagcgaggag gacaaggcag cctccacctg cgctaggtag gcgtcctgct ctcgagactt
     2881 tgagttcctg tggagggtgg ggggtgtcat ccttttaaaa gagtgttctg gagctttctg
     2941 gtccccttcc cttcccacca cgccccgtgg ccacttctcc ctagatttta gctgtaatgt
     3001 ctttcctctt tatttagggg tggggcagtc attgtttggg tctttcgctg tttgcagttg
     3061 ggaactcctc tgtttgagca acttgggaac aatttcgtaa cacaccacag gaagcagttc
     3121 tcctcccagc cccctcctcc agtaagggat ggcggaggct tgtccagagg gtcttgagaa
     3181 gccccctggg agggagggga acgcgagcac gccagacccc ctgcagggtg actgggcccc
     3241 tctggcttgt ctttctgtgc cttagtcctc cttccctgca tctcccctcc caggcccgtt
     3301 ctcaaggcca tgcgcctctc tccggtatga aaacacaaag cacaggtcag gatcttccga
     3361 aagtcggtcc aacattgcac cacgtggggg tgggttgtgg gctttattta ttgagaatct
     3421 agttggtgag gctgcggccc tgaacaggag aatggccgct agcagggagc tcggggctgc
     3481 gaggcggctg tccctgcgtt ctgtgtggaa gttgagcgaa gccctcccct gcggcgtcga
     3541 gggccaggcc ggggtggacg tccagcgggg ggaggcctcc ctgtgcgagg ggagggagcc
     3601 ccagggtggg gggccgggcg ggccgggcgt gacgcgcggt caaagtgcaa tgatttttca
     3661 gttcggttgg ctaaacaggg tcagagctaa gagctagcga aagagggtcc ctgcccggcc
     3721 gcgtgcgcct cttcggtcgg tcgaggacag tcgggctgtg ggcgctgtgg gattgcgggg
     3781 cacacgcccc gggcgaggtc agaagctgca ggccagctgg gccggggccc aaggtgcccg
     3841 agagaggtac cctcgggagg actggggtgg gggtggtgct cctttcccaa gtggtggtgt
     3901 gaggggcagg caggcaggga cgatgagggc gacagatgtg gggacgtgtt taggagagga
     3961 aacaacccac aaaaaaatat aggggaaatt aacctttttt tttttattga accaagtgca
     4021 atgcatcaga gagttttcct atctttgtat gttaagagat taagaaaaaa aattctattt
     4081 ttgttgtaat gtcctcgcgg ctctggggac gctaaaagaa ctgggcctgc cctgccctta
     4141 gcggggatga aagctgagtg ttttcctttt ttttgttttt ttttttgttt gttttccttt
     4201 ttgatagttt tctgggtttt tgtttgttgg tttggttggt tggttttttt tttgtttttt
     4261 tttttttgtt ttgccttttt tcctgcgttg acgaggataa tctggggttt aaatttgttt
     4321 cgtcgttcgg tttcggtggg agggctgaag aaaacgttta aaaacacctc gacattaaaa
     4381 aaaaaaaacc aacacaagat caaaaggaaa aggacgagag aaaattattt ttaagataat
     4441 taaacataaa aaccctggtg cttattacat tataaagtac gtttttaaaa acccacaaac
     4501 tattatacat acgtttatga atcaattaaa tactctgcac ttgttaggaa cacgcatatc
     4561 ccttctttgt tgagtttaac ggaacgggac agcggcgtgc gccccgcggc tgggctgctc
     4621 tggccgcggg tctccccagg cgctcccccc ttcctcgccc cctccccctc cgggcactgg
     4681 ggcgcggcgg gggtccccgg ccccctcccc cgcagaggtc aatgccaacg aacaaacgtc
     4741 ccttttccct ccctccccac tccgagcgcc cttctttgag ccagacgcca acttgaccct
     4801 caccagcatt aatcaggagc gcgctcagca agttggtagt ttcctccccg accccttccc
     4861 acgtaacacc actattcccc ctccctccgg gaggttcgat gctccaggac aggtccagcc
     4921 acgctgacag gtcgatttgc ccaggcccgc gcccgcacgc acgcacgcac atagcccggc
     4981 acacaccccc accctacccc gcaaccagcc ctgtcgactg ccttacacac ccgcccccgc
     5041 gctggccggc cgacctagtg ccttgttctc acccccgtgc tggcggagcg gacgccgcgc
     5101 tctgggtccc agaggggccg ggtggctcag acgacccacc gtttccccca acccgaccgt
     5161 actgaacgga ccccccacga gagaaaaaaa aaaggagcaa taaagttatg agaactttgt
     5221 cccccaatcg agagccctag gggcacccca gccccacctc tgctccctcc caccccatcc
     5281 accctcgggg cgtcccactc tgcgcaagcc agctggggcc aacccctgct ttggcccctc
     5341 ttgggagatc cgtgcgcccc atcagcacca gcatcgcgga ccgcaaaggc cgcccgtccc
     5401 gtcaaacaag tttcttctta ggctaagaaa cgcagtatat acgagtatct ctatatatat
     5461 atagtactaa tggatttggt gtgcttcccc cttagcgtcc cttccctctg ctcctctttc
     5521 agcctggtct cccttctctg ccctccaatt cccctccccc gtctctgcac tgagatacat
     5581 aagaaacaag ggtagtttac tgtctgtttt gttttctggg ttttcagtgt cctagcggaa
     5641 tgcaagtagg cagccagccc gtctgtcccc tctccgcccg ccccgccccg ccccacccca
     5701 gtcactgcgc ttctgttata ccatctttgc ctgactctct tcggcttctc cattgaatgg
     5761 ctaatgtgta tgtgaaataa agaaataaag aaaaacaaat gcaa
//
