LOCUS       NM_017373               2019 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus nuclear factor, interleukin 3, regulated (Nfil3),
            mRNA.
ACCESSION   NM_017373 XM_915798
VERSION     NM_017373.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2019)
  AUTHORS   Lin,Y.N., Hsu,J.R., Wang,C.L., Huang,Y.C., Wang,J.Y., Wu,C.Y. and
            Wu,L.L.
  TITLE     Nuclear factor interleukin 3 and metabolic dysfunction-associated
            fatty liver disease development
  JOURNAL   Commun Biol 7 (1), 897 (2024)
   PUBMED   39048678
  REMARK    GeneRIF: Nuclear factor interleukin 3 and metabolic
            dysfunction-associated fatty liver disease development.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2019)
  AUTHORS   Kajimura,Y., Taguchi,A., Nagao,Y., Yamamoto,K., Masuda,K.,
            Shibata,K., Asaoka,Y., Furutani-Seiki,M., Tanizawa,Y. and Ohta,Y.
  TITLE     E4BP4 in macrophages induces an anti-inflammatory phenotype that
            ameliorates the severity of colitis
  JOURNAL   Commun Biol 7 (1), 527 (2024)
   PUBMED   38714733
  REMARK    GeneRIF: E4BP4 in macrophages induces an anti-inflammatory
            phenotype that ameliorates the severity of colitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2019)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2019)
  AUTHORS   Park,J., Cho,Y., Yang,D., Yang,H., Lee,D., Kubo,M. and Kang,S.J.
  TITLE     The transcription factor NFIL3/E4BP4 regulates the developmental
            stage-specific acquisition of basophil function
  JOURNAL   J Allergy Clin Immunol 153 (1), 132-145 (2024)
   PUBMED   37783432
  REMARK    GeneRIF: The transcription factor NFIL3/E4BP4 regulates the
            developmental stage-specific acquisition of basophil function.
REFERENCE   5  (bases 1 to 2019)
  AUTHORS   Lin,L., Huang,Y., Wang,J., Guo,X., Yu,F., He,D., Wu,C., Guo,L. and
            Wu,B.
  TITLE     CRY1/2 regulate rhythmic CYP2A5 in mouse liver through repression
            of E4BP4
  JOURNAL   Biochem Pharmacol 217, 115843 (2023)
   PUBMED   37797722
  REMARK    GeneRIF: CRY1/2 regulate rhythmic CYP2A5 in mouse liver through
            repression of E4BP4.
REFERENCE   6  (bases 1 to 2019)
  AUTHORS   Yu,Y.L., Chiang,Y.J. and Yen,J.J.
  TITLE     GATA factors are essential for transcription of the survival gene
            E4bp4 and the viability response of interleukin-3 in Ba/F3
            hematopoietic cells
  JOURNAL   J Biol Chem 277 (30), 27144-27153 (2002)
   PUBMED   12023274
  REMARK    GeneRIF: the GATA factors play an important role in transducing the
            survival signal of IL-3, and one of their cellular targets is E4bp4
REFERENCE   7  (bases 1 to 2019)
  AUTHORS   Nishimura,Y. and Tanaka,T.
  TITLE     Calcium-dependent activation of nuclear factor regulated by
            interleukin 3/adenovirus E4 promoter-binding protein gene
            expression by calcineurin/nuclear factor of activated T cells and
            calcium/calmodulin-dependent protein kinase signaling
  JOURNAL   J Biol Chem 276 (23), 19921-19928 (2001)
   PUBMED   11262393
REFERENCE   8  (bases 1 to 2019)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   9  (bases 1 to 2019)
  AUTHORS   Ikushima,S., Inukai,T., Inaba,T., Nimer,S.D., Cleveland,J.L. and
            Look,A.T.
  TITLE     Pivotal role for the NFIL3/E4BP4 transcription factor in
            interleukin 3-mediated survival of pro-B lymphocytes
  JOURNAL   Proc Natl Acad Sci U S A 94 (6), 2609-2614 (1997)
   PUBMED   9122243
REFERENCE   10 (bases 1 to 2019)
  AUTHORS   Wallace,A.D., Wheeler,T.T. and Young,D.A.
  TITLE     Inducibility of E4BP4 suggests a novel mechanism of negative gene
            regulation by glucocorticoids
  JOURNAL   Biochem Biophys Res Commun 232 (2), 403-406 (1997)
   PUBMED   9125190
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK087541.1, BB872092.1, BQ899715.1 and BC031377.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_915798.1, NM_017373.2.
            
            Summary: The protein encoded by this gene is a transcriptional
            regulator that binds as a homodimer to activating transcription
            factor (ATF) sites in many cellular and viral promoters. The
            encoded protein represses Per1 and Per2 expression and therefore
            plays a role in the regulation of circadian rhythm. [provided by
            RefSeq, Feb 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031377.1, AK087541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN02415135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               AK087541.1         2-572
            572-748             BB872092.1         174-350
            749-1322            BQ899715.1         127-700
            1323-2019           BC031377.1         1167-1863
FEATURES             Location/Qualifiers
     source          1..2019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 27.68 cM"
     gene            1..2019
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /note="nuclear factor, interleukin 3, regulated"
                     /db_xref="GeneID:18030"
                     /db_xref="MGI:MGI:109495"
     exon            1..179
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /inference="alignment:Splign:2.1.0"
     exon            180..1992
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             335..1723
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /note="embryo implantation-related NFIL3/E4BP4-like
                     transcription factor; E4 promoter-binding protein 4"
                     /codon_start=1
                     /product="nuclear factor interleukin-3-regulated protein"
                     /protein_id="NP_059069.1"
                     /db_xref="CCDS:CCDS26519.1"
                     /db_xref="GeneID:18030"
                     /db_xref="MGI:MGI:109495"
                     /translation="MQLRKMQTIKKEPAPLDPTSSSDKMLLLNSALAEVAEDLASGED
                     LLLNEGSMGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLE
                     NKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKAAVS
                     SFVDEHEPAMVAGSCISVIKHSPQSSLSDVSEVSSVEHTQESPAQGGCRSPENKFPVI
                     KQEPVELESFAREAREERGTYSTSIYQSYMGSSFSTYSHSPPLLQVHGSTSNSPRTSE
                     ADEGVVGKSSDGEDEQQVPKGPIHSPVELQRVHATVVKVPEVNPSALPHKLRIKAKAM
                     QVKVEALDSEFEGMQKLSSPADAIAKRHFDLEKHGTSGMAHSSLPPFSVQVTNIQDWS
                     LKSEHWHHKELSSKTQSSFKTGVVEVKDGGYKVSEAENLYLKQGIANLSAEVVSLKRF
                     IATQPISASDSR"
     regulatory      1969..1974
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /note="hexamer: AATAAA"
     polyA_site      1992
                     /gene="Nfil3"
                     /gene_synonym="E4BP4"
                     /note="major polyA site"
ORIGIN      
        1 acacatctct cggcgcggcc acggcgcccg cggacccggc gcgcccgctc gtctcccgcg
       61 ccgcgccctc gccaccgccc gctgagggcc cggcggagct tgaatcgcgc cccggcgccg
      121 ccagcccggt tacagccgcc ctttcttttc cccctcacgg accagggagc agaaccacga
      181 taacccatga aaggctcctg acagatttac cctgtgccgg acaacagaag gacccattga
      241 tggatgagag gctgaagtcc ttaagacctg aaagaagact ggggaagtga tttgtctcct
      301 ccatccggtc tgtaggacga ggaggtcctt tctgatgcag ctgagaaaaa tgcagaccat
      361 caaaaaggag cccgcacccc tagatcctac cagcagctca gacaagatgc tgctgctgaa
      421 ctctgcctta gctgaggtgg ccgaggacct agcctcaggt gaagatttgc tcctgaacga
      481 agggagcatg gggaaaaaca aatcctcggc gtgtcggaga aaacgggaat tcattccgga
      541 cgagaagaaa gacgccatgt attgggagaa acggcggaaa aacaacgaag ctgccaaaag
      601 atctcgggag aagcgccgcc tcaatgacct ggttttggag aacaagctga tcgccctggg
      661 agaagaaaat gccactttaa aagctgagct gctctccctg aaattaaagt ttggtttaat
      721 tagctccacg gcgtatgccc aagaaatcca gaaactcagt aattccacag ctgtctactt
      781 tcaggactac cagacatcca aggctgccgt gagctctttt gtggacgagc atgagcctgc
      841 gatggtagcc ggaagttgca tctcagtcat caagcactct ccccagagct cgctctccga
      901 tgtgtcagag gtgtcctcgg tggagcacac tcaggaaagc cccgcacagg gaggctgccg
      961 gagccctgag aacaagttcc ctgtgatcaa gcaggagccc gtggagttgg agagctttgc
     1021 cagggaggcc agggaggagc ggggcacgta ttccacctcc atctaccaga gctacatggg
     1081 aagctctttc tccacttact cccactcccc acccctcttg caggtccatg ggtccactag
     1141 caactcccca agaacctcag aggccgatga gggtgtagtg ggcaagtctt ctgatgggga
     1201 agacgaacaa caggtcccta agggccccat ccattctcca gtggagctgc aacgggtcca
     1261 cgccacggtg gtgaaggttc cggaagtgaa cccttctgcc ttaccgcaca agcttcggat
     1321 taaagccaag gccatgcagg tcaaagtgga ggctttggac agcgagtttg aaggcatgca
     1381 gaaactctct tcacccgccg atgcgatcgc caaaagacat tttgacctgg agaaacatgg
     1441 aacctcgggt atggcccatt cctccctccc tcctttctca gtgcaggtga cgaacattca
     1501 agattggtcc ctcaaatcgg aacactggca tcacaaagaa ctgagcagca aaactcagag
     1561 tagcttcaaa acaggtgtgg tggaagtcaa agacggtggc tataaggttt ccgaagctga
     1621 gaatttgtat ttgaagcagg gaatagcaaa cttatctgca gaggtggtct cgctcaagag
     1681 attcatagcc acacaaccga tctcggcttc ggactccagg taaatggctg ctgaccgagc
     1741 tatgcatgga ggaggaggct gttggtacca tactgaattt ccactggacc tctaaagtca
     1801 tttcactgta gtgtgcacaa cggcgtctgt ctgggtgtcc ttgtgtgcac gcgctgaaga
     1861 cttgatgccc tcactctgcc tggcgtgtag tcagatagcc ccccacagag gctgtacata
     1921 ctgaacgtta tttttgctct attataaagt gtgtatgttg ccagtttcaa taaaggattg
     1981 gtggcaagca caaaaaaaaa aaaaaaaaaa aaaaaaaaa
//
