LOCUS       NM_008688               6295 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus nuclear factor I/C (Nfic), transcript variant 1, mRNA.
ACCESSION   NM_008688
VERSION     NM_008688.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6295)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    GeneRIF: NFIC regulates ribosomal biology and ER stress in
            pancreatic acinar cells and restrains PDAC initiation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6295)
  AUTHORS   Jia,P., Zhang,W. and Shi,Y.
  TITLE     NFIC attenuates rheumatoid arthritis-induced inflammatory response
            in mice by regulating PTEN/SENP8 transcription
  JOURNAL   Tissue Cell 81, 102013 (2023)
   PUBMED   36669387
  REMARK    GeneRIF: NFIC attenuates rheumatoid arthritis-induced inflammatory
            response in mice by regulating PTEN/SENP8 transcription.
REFERENCE   3  (bases 1 to 6295)
  AUTHORS   Huang,W., Huang,T., Liu,Y., Fu,J., Wei,X., Liu,D., Ma,W., Gu,H. and
            Yuan,Z.
  TITLE     Nuclear factor I-C disrupts cellular homeostasis between autophagy
            and apoptosis via miR-200b-Ambra1 in neural tube defects
  JOURNAL   Cell Death Dis 13 (1), 17 (2021)
   PUBMED   34930914
  REMARK    GeneRIF: Nuclear factor I-C disrupts cellular homeostasis between
            autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6295)
  AUTHORS   Zhang,L., Zhang,L., Li,S., Zhang,Q., Luo,Y., Zhang,C., Huan,Q. and
            Zhang,C.
  TITLE     Overexpression of mm9_circ_013935 alleviates renal inflammation and
            fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis
  JOURNAL   Can J Physiol Pharmacol 99 (11), 1199-1206 (2021)
   PUBMED   34197715
  REMARK    GeneRIF: Overexpression of mm9_circ_013935 alleviates renal
            inflammation and fibrosis in diabetic nephropathy via the
            miR-153-3p/NFIC axis.
REFERENCE   5  (bases 1 to 6295)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6295)
  AUTHORS   Behrens,M., Venkatraman,G., Gronostajski,R.M., Reed,R.R. and
            Margolis,F.L.
  TITLE     NFI in the development of the olfactory neuroepithelium and the
            regulation of olfactory marker protein gene expression
  JOURNAL   Eur J Neurosci 12 (4), 1372-1384 (2000)
   PUBMED   10762365
REFERENCE   7  (bases 1 to 6295)
  AUTHORS   Wattler,F., Wattler,S., Kelly,M., Skinner,H.B. and Nehls,M.
  TITLE     Cloning, chromosomal location, and expression analysis of murine
            Smarce1-related, a new member of the high-mobility 365 group gene
            family
  JOURNAL   Genomics 60 (2), 172-178 (1999)
   PUBMED   10486208
REFERENCE   8  (bases 1 to 6295)
  AUTHORS   Fletcher,C.F., Jenkins,N.A., Copeland,N.G., Chaudhry,A.Z. and
            Gronostajski,R.M.
  TITLE     Exon structure of the nuclear factor I DNA-binding domain from C.
            elegans to mammals
  JOURNAL   Mamm Genome 10 (4), 390-396 (1999)
   PUBMED   10087299
REFERENCE   9  (bases 1 to 6295)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   10 (bases 1 to 6295)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY226699.1, AK087539.1 and AC155937.4.
            
            On Jan 5, 2006 this sequence version replaced NM_008688.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes a longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155258.1, SRR7974084.17014.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-98                BY226699.1         3-100
            99-1582             AK087539.1         84-1567
            1583-6295           AC155937.4         120982-125694       c
FEATURES             Location/Qualifiers
     source          1..6295
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..6295
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /note="nuclear factor I/C"
                     /db_xref="GeneID:18029"
                     /db_xref="MGI:MGI:109591"
     exon            1..98
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1388
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /note="isoform a is encoded by transcript variant 1;
                     nuclear factor 1 C-type; CTF; NFI-C; NF-I/C; nuclear
                     factor 1/C; TGGCA-binding protein; CCAAT-box-binding
                     transcription factor; nuclear factor 1-C2"
                     /codon_start=1
                     /product="nuclear factor 1 C-type isoform a"
                     /protein_id="NP_032714.1"
                     /db_xref="CCDS:CCDS24058.1"
                     /db_xref="GeneID:18029"
                     /db_xref="MGI:MGI:109591"
                     /translation="MYSSPLCLTQDEFHPFIEALLPHVRAFAYTWFNLQARKRKYFKK
                     HEKRMSKDEERAVKDELLGEKAEVKQKWASRLLAKLRKDIRPECREDFVLAVTGKKAP
                     GCVLSNPDQKGKMRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLVKAAACAHP
                     VLCVQPHHIGVAVKELDLYLAYFVRERDAEQSSSPRTGVGSDQEDSKPITLDTTDFQE
                     SFVTSGVFSVTELIQVSRTPVVTGTGPNFSLGELQGHLAYDLNPASAGMRRTLPSTSS
                     SGSKRHKSGSMEEDVDTSPGGDYYTSPNSPTSSSRNWTEDIEGGISSPVKKTEMDKSP
                     FNSPSPQDSPRLSSFTQHHRPVIAVHSGIARSPHPTSALHFPATPILPQTASTYFPHT
                     AIRYPPHLNPQDPLKDLVSLACDPATQQPGPPALRPTRPLQTVPLWD"
     exon            99..630
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            631..702
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            703..777
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            778..901
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            902..1026
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1027..1152
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1337
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1414
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     exon            1415..6295
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3506..3511
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /note="hexamer: AATAAA"
     polyA_site      3526
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /note="major polyA site"
ORIGIN      
        1 gctgcaaaaa tgactcagta agttcggcgg ccgctcggcc tctgcgcctc cggtgccagc
       61 gccccgggat gtattcctcc ccgctctgcc tgacccagga tgagttccac ccgttcatcg
      121 aggcgctgct gccgcatgtg cgcgccttcg cctacacctg gttcaacctg caggcgcgca
      181 agcgcaagta cttcaagaag cacgagaagc gcatgtccaa ggacgaggag cgcgcggtga
      241 aggatgagct gctgggtgaa aaggccgaag tgaagcagaa gtgggcgtcg cggctgctgg
      301 ccaagctgcg caaggacatc cggcccgagt gccgtgaaga cttcgtactg gctgtgactg
      361 gcaagaaggc gccaggctgt gtgctgtcca acccggacca gaagggcaag atgcggcgca
      421 tcgactgcct gcgccaggcc gacaaagtgt ggcgtctgga cctggtcatg gtcatcctgt
      481 tcaagggcat cccactggag agcacagatg gtgagcggct ggtgaaggcg gctgcctgtg
      541 cgcacccggt gctgtgtgtg cagccgcacc atattggcgt ggccgtcaag gagctggacc
      601 tgtacctggc ctactttgtg cgggagcgcg atgcggagca gagcagcagc ccccggacag
      661 gtgtgggctc agaccaggag gacagcaagc ccataacgct ggacaccaca gacttccagg
      721 agagctttgt cacgtcaggt gtgttcagtg tcacggagct gatccaagtg tctcggacac
      781 ctgtggtgac cggaaccgga cccaacttct cactgggaga gctgcagggt cacctggcat
      841 atgacctgaa cccggccagc gccggcatga gaaggactct acccagcacc tcctccagtg
      901 ggagcaagcg gcacaagtcg ggctcgatgg aagaggacgt ggacacgagc cccggcggcg
      961 actactacac gtcgcccaac tcacccacga gtagcagccg caactggacg gaagacatag
     1021 aaggaggcat ctcatccccg gtgaagaaga cagagatgga caaatctcca ttcaacagcc
     1081 cgtcccccca ggactccccc cggctctcca gcttcacaca acaccacagg ccggtcatcg
     1141 cggtacacag tggcatcgcg cggagccccc acccgacctc ggccctgcac ttccctgcca
     1201 cgcccatcct gccacagaca gcctccacct acttccccca tacggccatc cggtacccgc
     1261 cacatctcaa cccccaggac ccgctcaagg atctggtgtc cctggcctgt gacccggcca
     1321 cccagcagcc tggaccgcct gctctccgcc cgacacgtcc cctgcaaaca gtccctttgt
     1381 gggattagga cggagggatc ctcttgcggg acagtcctgg tacctggggt agccgaggtt
     1441 gccttcccat ccctccttca tcaccggtgg agtcccaggg tgacagtccc agcctgcatt
     1501 tttggtggaa aattagatgg agtgagaagc cccctgcgga ctcccagctg gatggaaaag
     1561 acaggaggag aaaaggacaa agacaaacag gaaaaaaaaa acaaaccctt cccaaccaag
     1621 atgacaacag atgggagctg tgggtctctg gcacctgctg ctgatggacg gctgcctgca
     1681 gcccttctgc gccctgaggg ctctgccatc acccacagac caggcaatcc tggcctggta
     1741 cctgcgccca gcaccaacag atgggcagaa tggacggggt gggccaccca gccaggccac
     1801 ctctccccag acccctgctg ccagccacca gcgccagcct cggggacctc cggccgtccc
     1861 taccgacagt gtttgccaaa gacaggaggc tggaggtgga cagaccgcac ggtgggcaga
     1921 agaggctcga gggagccgcc cagcgctggc cctgctgggg acagacatgc catacaggta
     1981 ctttgggacc cctgggaggg tcctacgtcc agcctccatc tcggtcctct ggccccttct
     2041 ccttgcggac ctcatttgga aggacacatc tctctatgca atttgtcccc accccacccc
     2101 ggcatgagag gccacgcagc tcccgaccct ccggcctcct ctcgcacatg gaaggtatca
     2161 gcactttgag aaacagaggt gggggaaccg ggggcccccc acgccgaggt tcctggaggc
     2221 gggaggtgcc gcgatctaag tgcctagccc ttccacccac ccgccgtcca cctcgtccat
     2281 cggggacaca gagtggccag ggcaccccac ccttgtctcc gtgtacccta gctccccatc
     2341 actgcgcgcc ctccaagcta gagagatggg accccagggg gggttagagc tgggtgtccc
     2401 gaaaacccag gctggggcta tgcgccgtcc ccctacactt ctgccagtgc cttacttcct
     2461 ggagacccac cctggggtac cccactgcag gggggtaccc cctttgcact ttgaccctcc
     2521 tgatgacgtg gggcccagca cagggaccaa gaaggctggt ggaagtgcac tcagacccca
     2581 ggtgggaggg ctctgggagt gatggggtga cagggtggac tgatggctgg ggtcccccat
     2641 ctgctatgcg tacttcactg acctataaac actaagatgg ggtgcaaggg cccagcccca
     2701 gctccacagc ccccatatgc acccaccctg tcgctatctt ggatggcccg ctctgggaga
     2761 tgttgggtgt tttaaggtta ctgaacctac aaaggcccct cctccctgac cacccatctt
     2821 ggcccgtcat acctagcgct gtcatgtccc ctccccgcag aggccgcagg ccatcacccc
     2881 agcagagccc ccagggccag gccccaccca cctgccacct gtcctccctg ggacacttgt
     2941 aagtacaaag ctccccagcc tttgaggcct caacccccca ccatctgtct gtcctcaggg
     3001 accctccagt agggggacca ttggggacat cacagaagcc actgtccaga tggggctcag
     3061 gccagtgggt gtgggatggg ccatctgcag gatagacctg gcaagtcccc tctgataccc
     3121 ccaagccagc cagccgggtc ccccaggggt caggacagaa ccaactattt acctaactgc
     3181 atggtgctta aggccccgcg acacccaaga gccccctccc ctgccgggct gctgtgtgca
     3241 tgacaggtcc acctacctgc ccacttccct caccgcctct attaaaaaag gaaagaaaaa
     3301 aaaaggatac acaaaatata tatataaata tatatatata tccttaccaa aaaaaaaaaa
     3361 atccattatt tccaaatttg cacgaacttt ttaccacaac atgtgccttg ctctcccgag
     3421 gacaagtatt aacttttaaa taatatccgc gcacacagac gcatgccctg cacgcatagt
     3481 tacaaacaga caaatgatta catgaaataa aaaataaaat ccaaaagggt ggtatttcta
     3541 tttgtaaaga aaagaaaaat caaatgaaag caagattttt tttttttaaa tataagaagg
     3601 ctgggcgtgg tggcgcacgc ctgtgatcct agcccttggg aggctgaggc aggaggattg
     3661 ctctgagttc caggtcaagt ctgggctaca gagtgagacg ctgcctcaag aaaaggggag
     3721 gggggaccaa atcatagaaa caaacaagaa aaataacact attaaggaag tcacaattgg
     3781 ccatggtttt tgatcccagc tcgcccacag ccctggcccc acctcacccc atagtggggg
     3841 actggagtcg ccttggtgct cattccctga gccccccaat cctcctctgt cttccagcca
     3901 acccacaaag ctgaatatat gcaatatccg tccgtctgtc tgggtcaagc tcagctgtgg
     3961 ggagtcccag tggtggaggg gacacagcgg gcccgttccc aagtccgtga tttcagtttt
     4021 tcttttatgg tttcattgtt tgtagttgcc tttgggtttt tgtctttgtt tttctgtctt
     4081 ttgttaaatc tgctcttaaa gttcaccaaa gctaagacag ttgccagggc agacaggagt
     4141 ccaggctcca agctatcccc ttgcctcttt ctgcccccag ccccaccccc caaccagtct
     4201 gcctgttgcc ccactcagcc ctgagtgtta ggcactggca gagaggcaat ggcaggctca
     4261 ccttgatgga gggactgggg tgggtgggac taccgccccg cccacctgtc tgcactcctg
     4321 tcacttgtag gcctggctga cttacagatt tttccttccc cagcttgtgt ccacccctgt
     4381 gccaggagag gtagcaccat ctcctgggac catcaaagag tgggctggag tggggacagt
     4441 ggacagagca tacctggtgg caggttggga ggggccactc agcgtccccc ccatttctca
     4501 gaaaatctcc agtcccaccc agggacccca ccctggccca gtcctcaggt ggatgactga
     4561 cgcacggcag gagatttttg tttttgtttt cctgtatatg aaatgttttt caaaccatcc
     4621 tctcctcagg ccaccacccc ttaccctaac ccatcacgcc ctggtgaagc ccccaaggcc
     4681 tgctgctttg gggtgtggcc tgtgactgtg tttcccaggt ggggaccaga agatgtctga
     4741 ggtcctcctg agccctgaaa tcttgataat caggaatacc cagggtggtg ggactgacat
     4801 caggggagtg gcgtctgccc accccccacc ctgtccctcc gggggtgaac cagccaggct
     4861 gcactacaat gtccacaggc aagaggcccc caggccacca gcaaatgtcc cgcccctggg
     4921 gacagtgcgc ccgctcgccc ttggttgtgc tgggcagcat ttgtacatac atgcgcgcat
     4981 ttagtttgca gttaattcct gctgcgctgc ccacagtggc ttcctccctt cagtttgtcc
     5041 ctgagacccc tgagtggcct ttgcttctcc agggtactgg gttgaagatc cagccactta
     5101 atttcccctc tgattgtttt gatatctgag agacagaaag gtctccccag gctggtctcc
     5161 aactcctggc aatcctcctg cctctgtttc tcagttgctc tgacaacagg tgtgtaccac
     5221 cactcctgac ttccctgccc aaacttcata tcctacttgt taatagccgt cttctccctc
     5281 tgtcatctac ccagagcatt cagcttggga ctgtcgtcca gtgcagggcc caggtgagag
     5341 gagactgcca gcgagtccct agatcttgta gccatgatac cacacagtca tttcccaatc
     5401 agtgcctcac acatctatct gatggtgcag ttttggggtc tgtccccact cccctcagtc
     5461 cctacccctg ctcccctcag acatggggca ggaaacagca ggtgcgctgg gcaggaggaa
     5521 ggcatgtgct tcctccccag ccaccacccc tcccacagca cccagcctca ctaccccagc
     5581 atggggtacc cagctggata ctcccaaaat gtcacatccc atccaacctc agatctgatg
     5641 cagtcatctg tgtcccccaa ccaaagccca tttgggtctg agggttccag cgtaaatgcc
     5701 tgccctgcag cgcctggcaa ctggcaagca tcgggtctga gggactacac agggcgcagc
     5761 acaaggcgct catgggtttc agggagtggg agggactgtt tttctccgtt gctcttcctc
     5821 cttgttttct gggtgttttc ctgcagagat cttttgggtt tattttgaga ttcctccccc
     5881 caaccccacc ccattcagcc actttgtatt ttactcctgg gtcgatgcac ctccgacctt
     5941 cagcttttcc taactgcact tacgtggtct gcagcaacct ctgccccctc ctcccagagc
     6001 agatggggtc tggatgggga gcagagggca ccccaggccc ttcttgctcc acagtccccc
     6061 gcccgcagca tactccactc ataaccgtat attacaaact cattttggtt tctggctttt
     6121 tgttttgttt tgtggacccg cctgagcacc attgactgcc tgctgttccg tttctcccta
     6181 tgcaaacaaa caaaaacagt gagggggtcc ataaaagatt caataaaagg caaaaaaaaa
     6241 gaaaaaaaaa agaaaaaaga aaaaaatgta taaaaattaa ataagcttaa gcttc
//
