LOCUS       NP_032714                439 aa            linear   ROD 25-APR-2025
DEFINITION  nuclear factor 1 C-type isoform a [Mus musculus].
ACCESSION   NP_032714
VERSION     NP_032714.1
DBSOURCE    REFSEQ: accession NM_008688.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 439)
  AUTHORS   Lahti,L., Volakakis,N., Gillberg,L., Yaghmaeian Salmani,B.,
            Tiklova,K., Kee,N., Lunden-Miguel,H., Werkman,M., Piper,M.,
            Gronostajski,R. and Perlmann,T.
  TITLE     Sox9 and nuclear factor I transcription factors regulate the timing
            of neurogenesis and ependymal maturation in dopamine progenitors
  JOURNAL   Development 152 (6) (2025)
   PUBMED   39995267
REFERENCE   2  (residues 1 to 439)
  AUTHORS   Cobo,I., Paliwal,S., Bodas,C., Felipe,I., Melia-Aloma,J.,
            Torres,A., Martinez-Villarreal,J., Malumbres,M., Garcia,F.,
            Millan,I., Del Pozo,N., Park,J.C., MacDonald,R.J., Munoz,J.,
            Mendez,R. and Real,F.X.
  TITLE     NFIC regulates ribosomal biology and ER stress in pancreatic acinar
            cells and restrains PDAC initiation
  JOURNAL   Nat Commun 14 (1), 3761 (2023)
   PUBMED   37353485
  REMARK    GeneRIF: NFIC regulates ribosomal biology and ER stress in
            pancreatic acinar cells and restrains PDAC initiation.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 439)
  AUTHORS   Jia,P., Zhang,W. and Shi,Y.
  TITLE     NFIC attenuates rheumatoid arthritis-induced inflammatory response
            in mice by regulating PTEN/SENP8 transcription
  JOURNAL   Tissue Cell 81, 102013 (2023)
   PUBMED   36669387
  REMARK    GeneRIF: NFIC attenuates rheumatoid arthritis-induced inflammatory
            response in mice by regulating PTEN/SENP8 transcription.
REFERENCE   4  (residues 1 to 439)
  AUTHORS   Huang,W., Huang,T., Liu,Y., Fu,J., Wei,X., Liu,D., Ma,W., Gu,H. and
            Yuan,Z.
  TITLE     Nuclear factor I-C disrupts cellular homeostasis between autophagy
            and apoptosis via miR-200b-Ambra1 in neural tube defects
  JOURNAL   Cell Death Dis 13 (1), 17 (2021)
   PUBMED   34930914
  REMARK    GeneRIF: Nuclear factor I-C disrupts cellular homeostasis between
            autophagy and apoptosis via miR-200b-Ambra1 in neural tube defects.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 439)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 439)
  AUTHORS   Behrens,M., Venkatraman,G., Gronostajski,R.M., Reed,R.R. and
            Margolis,F.L.
  TITLE     NFI in the development of the olfactory neuroepithelium and the
            regulation of olfactory marker protein gene expression
  JOURNAL   Eur J Neurosci 12 (4), 1372-1384 (2000)
   PUBMED   10762365
REFERENCE   7  (residues 1 to 439)
  AUTHORS   Wattler,F., Wattler,S., Kelly,M., Skinner,H.B. and Nehls,M.
  TITLE     Cloning, chromosomal location, and expression analysis of murine
            Smarce1-related, a new member of the high-mobility 365 group gene
            family
  JOURNAL   Genomics 60 (2), 172-178 (1999)
   PUBMED   10486208
REFERENCE   8  (residues 1 to 439)
  AUTHORS   Fletcher,C.F., Jenkins,N.A., Copeland,N.G., Chaudhry,A.Z. and
            Gronostajski,R.M.
  TITLE     Exon structure of the nuclear factor I DNA-binding domain from C.
            elegans to mammals
  JOURNAL   Mamm Genome 10 (4), 390-396 (1999)
   PUBMED   10087299
REFERENCE   9  (residues 1 to 439)
  AUTHORS   Chaudhry,A.Z., Lyons,G.E. and Gronostajski,R.M.
  TITLE     Expression patterns of the four nuclear factor I genes during mouse
            embryogenesis indicate a potential role in development
  JOURNAL   Dev Dyn 208 (3), 313-325 (1997)
   PUBMED   9056636
REFERENCE   10 (residues 1 to 439)
  AUTHORS   Kulkarni,S. and Gronostajski,R.M.
  TITLE     Altered expression of the developmentally regulated NFI gene family
            during phorbol ester-induced differentiation of human leukemic
            cells
  JOURNAL   Cell Growth Differ 7 (4), 501-510 (1996)
   PUBMED   9052991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY226699.1, AK087539.1 and AC155937.4.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes a longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK155258.1, SRR7974084.17014.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     Protein         1..439
                     /product="nuclear factor 1 C-type isoform a"
                     /note="nuclear factor 1 C-type; CTF; NFI-C; NF-I/C;
                     nuclear factor 1/C; TGGCA-binding protein;
                     CCAAT-box-binding transcription factor; nuclear factor
                     1-C2"
                     /calculated_mol_wt=48637
     Site            1
                     /site_type="acetylation"
                     /note="N-acetylmethionine.
                     /evidence=ECO:0000250|UniProtKB:P08651; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Region          10..47
                     /region_name="NfI_DNAbd_pre-N"
                     /note="Nuclear factor I protein pre-N-terminus; pfam10524"
                     /db_xref="CDD:463134"
     Region          68..169
                     /region_name="MH1"
                     /note="N-terminal Mad Homology 1 (MH1) domain; cl00055"
                     /db_xref="CDD:469592"
     Site            194
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08651; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Region          217..>424
                     /region_name="CTF_NFI"
                     /note="CTF/NF-I family transcription modulation region;
                     pfam00859"
                     /db_xref="CDD:459967"
     Region          265..348
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70255.1)"
     Site            294
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:P08651; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Site            300
                     /site_type="phosphorylation"
                     /note="Phosphotyrosine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Site            302
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Site            305
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Site            323
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Site            333
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Site            337
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Site            339
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079;
                     propagated from UniProtKB/Swiss-Prot (P70255.1)"
     Site            343
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:17242355,
                     ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Site            365
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P08651;
                     Omega-N-methylarginine, alternate.
                     /evidence=ECO:0000250|UniProtKB:P08651; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Site            395
                     /site_type="methylation"
                     /note="Asymmetric dimethylarginine.
                     /evidence=ECO:0000250|UniProtKB:P08651; propagated from
                     UniProtKB/Swiss-Prot (P70255.1)"
     Region          404..412
                     /region_name="9aaTAD.
                     /evidence=ECO:0000250|UniProtKB:P08651"
                     /note="propagated from UniProtKB/Swiss-Prot (P70255.1)"
     Region          415..439
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70255.1)"
     CDS             1..439
                     /gene="Nfic"
                     /gene_synonym="1110019L22Rik; 1500041O16Rik; NF1-C"
                     /coded_by="NM_008688.3:69..1388"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS24058.1"
                     /db_xref="GeneID:18029"
                     /db_xref="MGI:MGI:109591"
ORIGIN      
        1 myssplcltq defhpfieal lphvrafayt wfnlqarkrk yfkkhekrms kdeeravkde
       61 llgekaevkq kwasrllakl rkdirpecre dfvlavtgkk apgcvlsnpd qkgkmrridc
      121 lrqadkvwrl dlvmvilfkg iplestdger lvkaaacahp vlcvqphhig vavkeldlyl
      181 ayfvrerdae qsssprtgvg sdqedskpit ldttdfqesf vtsgvfsvte liqvsrtpvv
      241 tgtgpnfslg elqghlaydl npasagmrrt lpstsssgsk rhksgsmeed vdtspggdyy
      301 tspnsptsss rnwtediegg isspvkktem dkspfnspsp qdsprlssft qhhrpviavh
      361 sgiarsphpt salhfpatpi lpqtastyfp htairypphl npqdplkdlv slacdpatqq
      421 pgppalrptr plqtvplwd
//
