LOCUS       NM_010903               2549 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus nuclear factor, erythroid derived 2, like 3 (Nfe2l3),
            mRNA.
ACCESSION   NM_010903
VERSION     NM_010903.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2549)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2549)
  AUTHORS   Munz,M., Bharioke,A., Kosche,G., Moreno-Juan,V., Brignall,A.,
            Rodrigues,T.M., Graff-Meyer,A., Ulmer,T., Haeuselmann,S.,
            Pavlinic,D., Ledergerber,N., Gross-Scherf,B., Rozsa,B., Krol,J.,
            Picelli,S., Cowan,C.S. and Roska,B.
  TITLE     Pyramidal neurons form active, transient, multilayered circuits
            perturbed by autism-associated mutations at the inception of
            neocortex
  JOURNAL   Cell 186 (9), 1930-1949 (2023)
   PUBMED   37071993
REFERENCE   3  (bases 1 to 2549)
  AUTHORS   Waku,T., Iwami,T., Masuda,H., Hirose,S., Aketa,I. and Kobayashi,A.
  TITLE     Nrf3 Functions Reversely as a Tumorigenic to an Antitumorigenic
            Transcription Factor in Obese Mice
  JOURNAL   Tohoku J Exp Med 259 (1), 1-8 (2022)
   PUBMED   36328531
  REMARK    GeneRIF: Nrf3 Functions Reversely as a Tumorigenic to an
            Antitumorigenic Transcription Factor in Obese Mice.
REFERENCE   4  (bases 1 to 2549)
  AUTHORS   Du,H., Wang,Z., Guo,R., Yang,L., Liu,G., Zhang,Z., Xu,Z., Tian,Y.,
            Yang,Z., Li,X. and Chen,B.
  TITLE     Transcription factors Bcl11a and Bcl11b are required for the
            production and differentiation of cortical projection neurons
  JOURNAL   Cereb Cortex 32 (17), 3611-3632 (2022)
   PUBMED   34963132
REFERENCE   5  (bases 1 to 2549)
  AUTHORS   Saliba,J., Coutaud,B., Makhani,K., Epstein Roth,N., Jackson,J.,
            Park,J.Y., Gagnon,N., Costa,P., Jeyakumar,T., Bury,M.,
            Beauchemin,N., Mann,K.K. and Blank,V.
  TITLE     Loss of NFE2L3 protects against inflammation-induced colorectal
            cancer through modulation of the tumor microenvironment
  JOURNAL   Oncogene 41 (11), 1563-1575 (2022)
   PUBMED   35091681
  REMARK    GeneRIF: Loss of NFE2L3 protects against inflammation-induced
            colorectal cancer through modulation of the tumor microenvironment.
REFERENCE   6  (bases 1 to 2549)
  AUTHORS   Zhang,Y., Kobayashi,A., Yamamoto,M. and Hayes,J.D.
  TITLE     The Nrf3 transcription factor is a membrane-bound glycoprotein
            targeted to the endoplasmic reticulum through its N-terminal
            homology box 1 sequence
  JOURNAL   J Biol Chem 284 (5), 3195-3210 (2009)
   PUBMED   19047052
  REMARK    GeneRIF: data are presented suggesting that the NHB2 sequence in
            mouse Nrf3 may regulate the topology of the transcription factor
            within the ER membrane
REFERENCE   7  (bases 1 to 2549)
  AUTHORS   Sankaranarayanan,K. and Jaiswal,A.K.
  TITLE     Nrf3 negatively regulates antioxidant-response element-mediated
            expression and antioxidant induction of NAD(P)H:quinone
            oxidoreductase1 gene
  JOURNAL   J Biol Chem 279 (49), 50810-50817 (2004)
   PUBMED   15385560
REFERENCE   8  (bases 1 to 2549)
  AUTHORS   Funatsu,N., Inoue,T. and Nakamura,S.
  TITLE     Gene expression analysis of the late embryonic mouse cerebral
            cortex using DNA microarray: identification of several region- and
            layer-specific genes
  JOURNAL   Cereb Cortex 14 (9), 1031-1044 (2004)
   PUBMED   15142957
REFERENCE   9  (bases 1 to 2549)
  AUTHORS   Derjuga,A., Gourley,T.S., Holm,T.M., Heng,H.H., Shivdasani,R.A.,
            Ahmed,R., Andrews,N.C. and Blank,V.
  TITLE     Complexity of CNC transcription factors as revealed by gene
            targeting of the Nrf3 locus
  JOURNAL   Mol Cell Biol 24 (8), 3286-3294 (2004)
   PUBMED   15060151
  REMARK    GeneRIF: Data show that Nrf3 null mice develop normally with no
            obvious phenotypic differences compared to wild-type animals, that
            they are fertile, and that gross anatomy as well as behavior appear
            normal.
REFERENCE   10 (bases 1 to 2549)
  AUTHORS   Kobayashi,A., Ito,E., Toki,T., Kogame,K., Takahashi,S.,
            Igarashi,K., Hayashi,N. and Yamamoto,M.
  TITLE     Molecular cloning and functional characterization of a new Cap'n'
            collar family transcription factor Nrf3
  JOURNAL   J Biol Chem 274 (10), 6443-6452 (1999)
   PUBMED   10037736
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ045939.1, AK133935.1, AC154011.3 and AV237858.1.
            
            On Feb 25, 2018 this sequence version replaced NM_010903.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC005416.1, AB013852.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                CJ045939.1         2-54
            54-987              AK133935.1         2-935
            988-988             AC154011.3         124109-124109
            989-2545            AK133935.1         937-2493
            2546-2549           AV237858.1         250-253
FEATURES             Location/Qualifiers
     source          1..2549
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 24.84 cM"
     gene            1..2549
                     /gene="Nfe2l3"
                     /gene_synonym="Nrf3"
                     /note="nuclear factor, erythroid derived 2, like 3"
                     /db_xref="GeneID:18025"
                     /db_xref="MGI:MGI:1339958"
     exon            1..745
                     /gene="Nfe2l3"
                     /gene_synonym="Nrf3"
                     /inference="alignment:Splign:2.1.0"
     exon            746..922
                     /gene="Nfe2l3"
                     /gene_synonym="Nrf3"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1006
                     /gene="Nfe2l3"
                     /gene_synonym="Nrf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..2549
                     /gene="Nfe2l3"
                     /gene_synonym="Nrf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2524..2529
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfe2l3"
                     /gene_synonym="Nrf3"
                     /note="hexamer: AATAAA"
     polyA_site      2546
                     /gene="Nfe2l3"
                     /gene_synonym="Nrf3"
                     /note="major polyA site"
ORIGIN      
        1 gccaggcaat ggggcgggtt ctgagagctg ggtgttgcag gtgtctcctc cgcctctctg
       61 ggtccccggc cgcgccaggc actgtgtggg cagccgaggg agcgcctttg tgcctggctg
      121 gggtgaggct gcaacggccc cttgtacgcc ctggtccatt gtcttttcgg ctggtgccac
      181 aggggcggct gtagtgccaa gccgggtgga cacaggcatc cccggcgcac cgtgggagat
      241 gaagctcccg aagccttggt gggcgggcgg cggcctcctg caactcacga ttctgttgag
      301 cttggtaggg ctccgtgtgg acctggacct cttcctgccg ccgccggccg ccgcactttg
      361 ggaagagctg ctcccactct gccccacccg ccccgcctcg gcttctaacc ccttctcggc
      421 ttcggaaggc tgggaacgca cccccctgct acctgccaaa ggccggctgc tgcacgaagt
      481 gcgcgcgctc ggggtcccct tcattccccg cacccgcgtg gacgcgtggc tagtgcacag
      541 cgtggcgact gggaacgcag acggggccca cgggctgctc ggcaccgccg cctcgtcggc
      601 cgtgggagac ggcggccagt cagcatccgc gggcggcggg gacccccgag cggctcatag
      661 cagccctctg gccgctgagg aagaggagga gaaggcggcc gaaccgacgg cgcaggtgcc
      721 agatgcaggc ggatgcggga gccaggagaa cgggatgcta agagaaaaga gcgaagctgt
      781 ggatcacagt tcccagcagg aggaaaacga ggaaggggtg tcagcccagg caaaatcgcg
      841 acagcagagt aagacggagg aacacaaaat ggcgtgtgcc tctgccaggg aagccgagaa
      901 gatcaccgag gctaggaacg agagccatct acattggtca gatacatctt tctctttgga
      961 agatttattc caactacttt catcacagcc tgaacattct ctggagggca tctcagtgga
     1021 agacattcca ccttttctga gcagtgtctg tgaaagtgtt aattcctcag cacagaacat
     1081 aaatttgagc caagctataa gccatgatgt caatcttcat gaagccatgc tgttgtaccc
     1141 caacaacaca tttagaagag atccatcagc aaggtcttca caggcacaag aaccatttct
     1201 gcagttaaat cctcatacaa atcctgagca agccactcct gcaatgtctc ttccaccgtt
     1261 tgacaatcaa atgaggaacc taacaagcca agatctcctg tatgacctgg attcaaatat
     1321 atttgatgga ataaacctaa tgtcattggc cacaggtttc agtccattgg aagtttctca
     1381 actttttgaa gaaccagatt ccgggctctc attaaattca agttacaaca gcacctctct
     1441 cacaaattct taccgtattt atgatgggac tgtaggttac aatagcgacc tacagtctct
     1501 ttgtcatgat ttaggtgctg taggaggctg ctacccagaa ccccataaac attgtcatat
     1561 ggaccatagg actatagctg gctttcatgt gtcccttgaa tgtcagcaag tatttcatga
     1621 ccacacttac catttacagt caggtgcatc agagcccaca tctgaatctt ttgcatggtc
     1681 tgagaagtcg cagaaaacca gtggatgcct tgataaccca gatagaaact tgagccgtga
     1741 tgaacagcgt gctaaagctc tgcacattcc cttttctgta gatgaaattg tccgtatgcc
     1801 tgttgactct ttcaacagca tgttaagcag atactacctg acagacttac aagtgtctct
     1861 catccgtgat atcaggcgaa gaggaaaaaa taaagttgct gctcagaact gccgtaaacg
     1921 taaactagac atcattttga atctagagga tgatatatgt aacttgcaag caaagaaaga
     1981 agcccttaaa aatgagcaaa ctcaatgtag caaagctatt gacataatga ggcagaagct
     2041 acatggcctt caccaggatg tttttaatag attaagagat gaccaaggta ggccagtcaa
     2101 tccaagccaa tatgcacttc agtacagcca tgatggaact gttttgattg tacccaaaga
     2161 actcatctca tcaggccaca aaaaggaagc cccaaaggga aagagagaga gaagaaactg
     2221 aatagctcca gtgaccagca tcacaaactg tccaactatt ttaagatttt aaaagtactg
     2281 gtacttgaat cattcagtta attctgatgt ttaggaatca agattatgct tctgtgaagt
     2341 tgggagaatc cacatgttcc tgcacaattc ataaatatct atgtgaagta atctccaaga
     2401 actacagcca ccttataata cagtggtcac ctgaaaaaaa tgctttaaga ccttatggct
     2461 taaaattgaa acagccttag tgttttctga aggttatttt taaatattta acttgtgtgt
     2521 aaaaataaaa ttttgtattt aaactatta
//
