LOCUS       NM_010902               2347 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus nuclear factor, erythroid derived 2, like 2 (Nfe2l2),
            transcript variant 1, mRNA.
ACCESSION   NM_010902
VERSION     NM_010902.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2347)
  AUTHORS   Greenwood,H.E., Barber,A.R., Edwards,R.S., Tyrrell,W.E.,
            George,M.E., Dos Santos,S.N., Baark,F., Tanc,M., Khalil,E.,
            Falzone,A., Ward,N.P., DeBlasi,J.M., Torrente,L., Soni,P.N.,
            Pearce,D.R., Firth,G., Smith,L.M., Vilhelmsson Timmermand,O.,
            Huebner,A., Swanton,C., Hynds,R.E., DeNicola,G.M. and Witney,T.H.
  TITLE     Imaging NRF2 activation in non-small cell lung cancer with positron
            emission tomography
  JOURNAL   Nat Commun 15 (1), 10484 (2024)
   PUBMED   39690148
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2347)
  AUTHORS   Hashimoto,H., Okazaki,T., Honkura,Y., Ren,Y., Ngamsnae,P.,
            Hisaoka,T., Koshiba,Y., Suzuki,J., Ebihara,S. and Katori,Y.
  TITLE     Nrf2 Deficiency Exacerbates the Decline in Swallowing and
            Respiratory Muscle Mass and Function in Mice with Aspiration
            Pneumonia
  JOURNAL   Int J Mol Sci 25 (21), 11829 (2024)
   PUBMED   39519380
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2347)
  AUTHORS   McBride,M.A., Caja,K.R., Patil,T.K., Owen,A.M., Luan,L.,
            Bohannon,J.K., Hernandez,A., Stothers,C.L., Trenary,I.A., Rahim,M.,
            Young,J.D., Calcutt,M.W., Stephens,V.R., Davis,X., Oliver,M.A.,
            Hao,D., Si,C., McRae,M., Nguyen,K.K., Davis,N.S., Wang,J.,
            Patil,N.K. and Sherwood,E.R.
  TITLE     Immunoresponsive Gene 1 Facilitates TLR4-agonist-Induced
            Augmentation of Innate Antimicrobial Immunity
  JOURNAL   J Leukoc Biol (2024) In press
   PUBMED   39351765
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   4  (bases 1 to 2347)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2347)
  AUTHORS   Romeo,P.H., Conquet,L., Messiaen,S., Pascal,Q., Moreno,S.G.,
            Bravard,A., Bernardino-Sgherri,J., Dereuddre-Bosquet,N.,
            Montagutelli,X., Le Grand,R., Petit,V. and Ferri,F.
  TITLE     Multiple Mechanisms of Action of Sulfodyne(R), a Natural
            Antioxidant, against Pathogenic Effects of SARS-CoV-2 Infection
  JOURNAL   Antioxidants (Basel) 13 (9), 1083 (2024)
   PUBMED   39334742
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2347)
  AUTHORS   Yehiely,F., Bamborough,P., Da Costa,M., Perry,B.J., Thinakaran,G.,
            Cohen,F.E., Carlson,G.A. and Prusiner,S.B.
  TITLE     Identification of candidate proteins binding to prion protein
  JOURNAL   Neurobiol Dis 3 (4), 339-355 (1997)
   PUBMED   9173930
  REMARK    Erratum:[Neurobiol Dis 2002 Jun;10(1):67-8]
REFERENCE   7  (bases 1 to 2347)
  AUTHORS   Chan,K., Lu,R., Chang,J.C. and Kan,Y.W.
  TITLE     NRF2, a member of the NFE2 family of transcription factors, is not
            essential for murine erythropoiesis, growth, and development
  JOURNAL   Proc Natl Acad Sci U S A 93 (24), 13943-13948 (1996)
   PUBMED   8943040
REFERENCE   8  (bases 1 to 2347)
  AUTHORS   Oyake,T., Itoh,K., Motohashi,H., Hayashi,N., Hoshino,H.,
            Nishizawa,M., Yamamoto,M. and Igarashi,K.
  TITLE     Bach proteins belong to a novel family of BTB-basic leucine zipper
            transcription factors that interact with MafK and regulate
            transcription through the NF-E2 site
  JOURNAL   Mol Cell Biol 16 (11), 6083-6095 (1996)
   PUBMED   8887638
REFERENCE   9  (bases 1 to 2347)
  AUTHORS   Shivdasani,R.A. and Orkin,S.H.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   10 (bases 1 to 2347)
  AUTHORS   Chui,D.H., Tang,W. and Orkin,S.H.
  TITLE     cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related
            transcription factor
  JOURNAL   Biochem Biophys Res Commun 209 (1), 40-46 (1995)
   PUBMED   7726861
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL772404.5.
            
            On Feb 25, 2022 this sequence version replaced NM_010902.4.
            
            Summary: This gene encodes a transcription factor which is a member
            of a small family of basic leucine zipper (bZIP) proteins. The
            encoded transcription factor regulates genes which contain
            antioxidant response elements (ARE) in their promoters; many of
            these genes encode proteins involved in response to injury and
            inflammation which includes the production of free radicals.
            [provided by RefSeq, Sep 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026943.1, AK142347.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164133
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-153               AL772404.5         53273-53425         c
            154-420             AL772404.5         28072-28338         c
            421-510             AL772404.5         27397-27486         c
            511-678             AL772404.5         26454-26621         c
            679-2347            AL772404.5         24425-26093         c
FEATURES             Location/Qualifiers
     source          1..2347
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 44.75 cM"
     gene            1..2347
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /note="nuclear factor, erythroid derived 2, like 2"
                     /db_xref="GeneID:18024"
                     /db_xref="MGI:MGI:108420"
     exon            1..153
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1902
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor erythroid 2-related factor 2; NFE2-related
                     factor 2; NF-E2-related factor 2"
                     /codon_start=1
                     /product="nuclear factor erythroid 2-related factor 2
                     isoform 1"
                     /protein_id="NP_035032.1"
                     /db_xref="CCDS:CCDS16150.1"
                     /db_xref="GeneID:18024"
                     /db_xref="MGI:MGI:108420"
                     /translation="MMDLELPPPGLQSQQDMDLIDILWRQDIDLGVSREVFDFSQRQK
                     DYELEKQKKLEKERQEQLQKEQEKAFFAQFQLDEETGEFLPIQPAQHIQTDTSGSASY
                     SQVAHIPKQDALYFEDCMQLLAETFPFVDDHESLALDIPSHAESSVFTAPHQAQSLNS
                     SLEAAMTDLSSIEQDMEQVWQELFSIPELQCLNTENKQLADTTAVPSPEATLTEMDSN
                     YHFYSSISSLEKEVGNCGPHFLHGFEDSFSSILSTDDASQLTSLDSNPTLNTDFGDEF
                     YSAFIAEPSDGGSMPSSAAISQSLSELLDGTIEGCDLSLCKAFNPKHAEGTMEFNDSD
                     SGISLNTSPSRASPEHSVESSIYGDPPPGFSDSEMEELDSAPGSVKQNGPKAQPAHSP
                     GDTVQPLSPAQGHSAPMRESQCENTTKKEVPVSPGHQKAPFTKDKHSSRLEAHLTRDE
                     LRAKALHIPFPVEKIINLPVDDFNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRK
                     RKLENIVELEQDLGHLKDEREKLLREKGENDRNLHLLKRRLSTLYLEVFSMLRDEDGK
                     PYSPSEYSLQQTRDGNVFLVPKSKKPDTKKN"
     exon            154..420
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..510
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            511..678
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /inference="alignment:Splign:2.1.0"
     exon            679..2347
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2324..2329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /note="hexamer: AATAAA"
     polyA_site      2347
                     /gene="Nfe2l2"
                     /gene_synonym="Nrf2"
                     /note="major polyA site"
ORIGIN      
        1 aggctatctc ctagttctcc gctgctcgga ctagccattg ccgccgcctc acctctgctg
       61 caagtagcct cgccgtcggg gagccctacc acagcgtccg ccctcagcat gatggacttg
      121 gagttgccac cgccaggact acagtcccag caggacatgg atttgattga catcctttgg
      181 aggcaagaca tagatcttgg agtaagtcga gaagtgtttg actttagtca gcgacagaag
      241 gactatgagc tggaaaaaca gaaaaaactc gaaaaggaaa gacaagagca actccagaag
      301 gaacaggaga aggccttttt tgctcagttt caactggatg aagaaacagg agaattcctc
      361 ccaattcagc cggcccagca catccagaca gacaccagtg gatccgccag ctactcccag
      421 gttgcccaca ttcccaaaca agatgccttg tactttgaag actgtatgca gcttttggca
      481 gagacattcc catttgtaga tgaccatgag tcgcttgccc tggatatccc cagccacgct
      541 gaaagttcag tcttcactgc ccctcatcag gcccagtccc tcaatagctc tctggaggca
      601 gccatgactg atttaagcag catagagcag gacatggagc aagtttggca ggagctattt
      661 tccattcccg aattacagtg tcttaatacc gaaaacaagc agctggctga tactaccgct
      721 gttcccagcc cagaagccac actgacagaa atggacagca attaccattt ttactcatcg
      781 atctcctcgc tggaaaaaga agtgggcaac tgtggtccac atttccttca tggttttgag
      841 gattctttca gcagcatcct ctccactgat gatgccagcc agctgacctc cttagactca
      901 aatcccacct taaacacaga ttttggcgat gaattttatt ctgctttcat agcagagccc
      961 agtgacggtg gcagcatgcc ttcctccgct gccatcagtc agtcactctc tgaactcctg
     1021 gacgggacta ttgaaggctg tgacctgtca ctgtgtaaag ctttcaaccc gaagcacgct
     1081 gaaggcacaa tggaattcaa tgactctgac tctggcattt cactgaacac gagtcccagc
     1141 cgagcgtccc cagagcactc cgtggagtct tccatttacg gagacccacc gcctgggttc
     1201 agtgactcgg aaatggagga gctagatagt gcccctggaa gtgtcaaaca gaacggccct
     1261 aaagcacagc cagcacattc tcctggagac acagtacagc ctctgtcacc agctcaaggg
     1321 cacagtgctc ctatgcgtga atcccaatgt gaaaatacaa caaaaaaaga agttcccgtg
     1381 agtcctggtc atcaaaaagc cccattcaca aaagacaaac attcaagccg cttagaggct
     1441 catctcacac gagatgagct tagggcaaaa gctctccata ttccattccc tgtcgaaaaa
     1501 atcattaacc tccctgttga tgacttcaat gaaatgatgt ccaaggagca attcaatgaa
     1561 gctcagctcg cattgatccg agatatacgc aggagaggta agaataaagt cgccgcccag
     1621 aactgtagga aaaggaagct ggagaacatt gtcgagctgg agcaagactt gggccactta
     1681 aaagacgaga gagaaaaact actcagagaa aagggagaaa acgacagaaa cctccatcta
     1741 ctgaaaaggc ggctcagcac cttgtatctt gaagtcttca gcatgttacg tgatgaggat
     1801 ggaaagcctt actctcccag tgaatactct ctgcagcaaa ccagagatgg caatgtgttc
     1861 cttgttccca aaagcaagaa gccagataca aagaaaaact aggttcggga ggatggagcc
     1921 ttttctgagc tagtgtttgt tttgtactgc taaaacttcc tactgtgatg tgaaatgcag
     1981 aaacacttta taagtaacta tgcagaatta tagccaaagc tagtatagca ataatatgaa
     2041 actttacaaa gcattaaagt ctcaatgttg aatcagtttc attttaactc tcaagttaat
     2101 ttcttaggca ccatttggga gagtttctgt ttaagtgtaa atactacaga acttatttat
     2161 actgttctca cttgttacag tcatagactt atatgacatc tggctaaaag caaactattg
     2221 aaaactaacc agaccactat acttttttat atactgtatg aacaggaaat gacattttta
     2281 tattaaattg tttagctcat aaaaattaaa aggagctagc actaataaaa gaatatcatg
     2341 acttaaa
//
