LOCUS       NM_008686               4654 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus nuclear factor, erythroid derived 2,-like 1 (Nfe2l1),
            transcript variant 1, mRNA.
ACCESSION   NM_008686
VERSION     NM_008686.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4654)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4654)
  AUTHORS   Bairos,J.A., Njoku,U., Zafar,M., Akl,M.G., Li,L., Parlakgul,G.,
            Arruda,A.P. and Widenmaier,S.B.
  TITLE     Sterol O-acyltransferase (SOAT/ACAT) activity is required to form
            cholesterol crystals in hepatocyte lipid droplets
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (6), 159512 (2024)
   PUBMED   38761895
REFERENCE   3  (bases 1 to 4654)
  AUTHORS   Akl,M.G., Li,L. and Widenmaier,S.B.
  TITLE     Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2,
            against MASLD Progression
  JOURNAL   Int J Mol Sci 25 (15), 8046 (2024)
   PUBMED   39125617
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4654)
  AUTHORS   Shen,W., Ren,S., Hou,Y., Zuo,Z., Liu,S., Liu,Z., Fu,J., Wang,H.,
            Yang,B., Zhao,R., Chen,Y., Yamamoto,M., Xu,Y., Zhang,Q. and Pi,J.
  TITLE     Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor
            determining the thermogenesis and cellular heterogeneity and
            dynamics of brown adipose tissues in mice
  JOURNAL   Redox Biol 67, 102879 (2023)
   PUBMED   37716088
  REMARK    GeneRIF: Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key
            factor determining the thermogenesis and cellular heterogeneity and
            dynamics of brown adipose tissues in mice.
REFERENCE   5  (bases 1 to 4654)
  AUTHORS   Trites,M.J., Stebbings,B.M., Aoki,H., Phanse,S., Akl,M.G., Li,L.,
            Babu,M. and Widenmaier,S.B.
  TITLE     HDL functionality is dependent on hepatocyte stress defense factors
            Nrf1 and Nrf2
  JOURNAL   Front Physiol 14, 1212785 (2023)
   PUBMED   37501930
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4654)
  AUTHORS   Johnsen,O., Skammelsrud,N., Luna,L., Nishizawa,M., Prydz,H. and
            Kolsto,A.B.
  TITLE     Small Maf proteins interact with the human transcription factor
            TCF11/Nrf1/LCR-F1
  JOURNAL   Nucleic Acids Res 24 (21), 4289-4297 (1996)
   PUBMED   8932385
REFERENCE   7  (bases 1 to 4654)
  AUTHORS   McKie,J. and Scambler,P.J.
  TITLE     The Nfe2l1 gene maps to distal mouse chromosome 11
  JOURNAL   Mamm Genome 7 (1), 89 (1996)
   PUBMED   8903741
REFERENCE   8  (bases 1 to 4654)
  AUTHORS   Shivdasani,R.A. and Orkin,S.H.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   9  (bases 1 to 4654)
  AUTHORS   Chui,D.H., Tang,W. and Orkin,S.H.
  TITLE     cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related
            transcription factor
  JOURNAL   Biochem Biophys Res Commun 209 (1), 40-46 (1995)
   PUBMED   7726861
REFERENCE   10 (bases 1 to 4654)
  AUTHORS   McKie,J., Johnstone,K., Mattei,M.G. and Scambler,P.
  TITLE     Cloning and mapping of murine Nfe2l1
  JOURNAL   Genomics 25 (3), 716-719 (1995)
   PUBMED   7759107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY301848.1, AK152040.1, BC043063.1 and AK038187.1.
            
            On Jul 24, 2008 this sequence version replaced NM_008686.2.
            
            Summary: This gene encodes a protein that is involved in globin
            gene expression in erythrocytes. Confusion has occurred in
            bibliographic databases from the use of NRF1 for this gene, NFE2L1,
            and for 'nuclear respiratory factor 1' which has an official symbol
            of NRF1. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1). Variants 1 and 5
            encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660815.64186.1, BC099895.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                BY301848.1         2-20
            20-1411             AK152040.1         1-1392
            1412-4637           BC043063.1         994-4219
            4638-4654           AK038187.1         3163-3179
FEATURES             Location/Qualifiers
     source          1..4654
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.12 cM"
     gene            1..4654
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="nuclear factor, erythroid derived 2,-like 1"
                     /db_xref="GeneID:18023"
                     /db_xref="MGI:MGI:99421"
     exon            1..150
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /inference="alignment:Splign:2.1.0"
     exon            151..1176
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /inference="alignment:Splign:2.1.0"
     CDS             667..2892
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor erythroid 2-related factor 1; NFE2-related
                     factor 1; NF-E2-related factor 1; locus control
                     region-factor 1; endoplasmic reticulum membrane sensor
                     NFE2L1"
                     /codon_start=1
                     /product="endoplasmic reticulum membrane sensor NFE2L1
                     isoform 1"
                     /protein_id="NP_032712.2"
                     /db_xref="CCDS:CCDS25304.1"
                     /db_xref="GeneID:18023"
                     /db_xref="MGI:MGI:99421"
                     /translation="MLSLKKYLTEGLLQFTILLSLIGVRVDVDTYLTSQLPPLREIIL
                     GPSSAYTQTQFHNLRNTLDGYGIHPKSIDLDNYFTARRLLSQVRALDRFQVPTTEVNA
                     WLVHRDPEGSVSGSQPNSGLALESSSGLQDVTGPDNGVRESETEQGFGEDLEDLGAVA
                     PPVSGDLTKEDIDLIDILWRQDIDLGAGREVFDYSHRQKEQDVDKELQDGREREDTWS
                     GEGAEALARDLLVDGETGESFPAQFPADVSSIPEAVPSESESPALQNSLLSPLLTGTE
                     SPFDLEQQWQDLMSIMEMQAMEVNTSASEILYNAPPGDPLSTNYSLAPNTPINQNVSL
                     HQASLGGCSQDFSLFSPEVESLPVASSSTLLPLVPSNSTSLNSTFGSTNLAGLFFPSQ
                     LNGTANDTSGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDSGL
                     SLDSSHSPSSLSSSEGSSSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEEAE
                     GAVGYQPEYSKFCRMSYQDPSQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSTLKK
                     GSKEKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLSLI
                     RDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMKQK
                     VQSLYQEVFGRLRDEHGRPYSPSQYALQYAGDGSVLLIPRTMADQQARRQERKPKDRR
                     K"
     exon            1177..1392
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1393..1551
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1552..4654
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4617..4622
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="hexamer: AATAAA"
     regulatory      4627..4632
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="hexamer: AATAAA"
     polyA_site      4637
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="major polyA site"
     polyA_site      4650
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
ORIGIN      
        1 gagtgcagtg gaaggagggg gcggggaggg aagccgaggc tgggcgctcc aggccggccg
       61 gaggtggcgg cgacggcggc ggtggcgagg ccgggacttg ggctgagggc ctgctgtggc
      121 ggcagcgaca gactgtgacc tcagcagcgg ggttctctgg aaacccccct ggtaagtgca
      181 gaggaggcgg gacactctga cccaagacaa agacctgtag ctccagccaa agaaaataaa
      241 ccttaggaag gagaaggggg ggaaaaaaaa aaggaggaaa gaaagactcc atcagctgtt
      301 ggtgtgagca gcctgcagtg gatctccata gaggacaact aatgtgaatc cgaaagtgac
      361 tgtgtatggg ctgtggtgaa gtaagttgag ggccctgagc gcctggactg tgttaggaac
      421 gatcgaacgg ctcaactttg cgaggtgagg tgtcaaaaag ggaaaagtga atgtggcttt
      481 cgctccacgg ggtgtgctgt cgtctggggc cgtcagggag ctcagccctt gtgttgtgcc
      541 agggtggggt ccagggtctg gcactgagga gggtagcctg ctggctgaag tggcagagca
      601 gtggccttga tttgtcttgt ggaagattta aaaacaaaaa agcataaata ttctggtcct
      661 tcagcaatgc tttctctgaa gaaatattta acggaaggac ttctccagtt caccatcctg
      721 ctgagtctga ttggggttcg ggtggacgtg gatacttacc tgacctcaca gctcccccct
      781 ctccgggaga tcatcctggg gcccagctct gcctataccc agacccagtt ccacaacctg
      841 aggaatacct tggatggcta tgggatccac cccaagagca tagacctgga caattacttc
      901 actgcccggc ggctccttag tcaggtgagg gccctggata ggttccaggt gcctaccact
      961 gaggtcaatg cttggctggt ccaccgagac ccggaggggt ctgtctctgg cagccagccc
     1021 aactcaggcc tcgccctcga gagttccagt ggcctccaag atgtgacagg cccagacaac
     1081 ggggtgagag aaagcgaaac ggagcaggga ttcggtgaag atttggagga cctgggggct
     1141 gtagcccctc ctgtcagtgg agacttaacc aaagaggata tagatctgat tgacatcctt
     1201 tggcgacagg atattgatct gggggctggg cgtgaggttt ttgactacag tcatcgccag
     1261 aaggagcagg atgtggataa ggaactgcaa gatggacgag aacgagagga cacctggtca
     1321 ggcgagggtg cggaagctct ggcccgagac ctgctagtag atggagagac tggggagagc
     1381 ttccctgcac agttcccagc tgacgtttcc agcatcccag aagcagtgcc tagtgagagt
     1441 gagtcccccg cccttcagaa cagccttcta tctcctcttc tgacggggac agaatcacca
     1501 tttgatttgg aacagcagtg gcaagatctc atgtccatca tggaaatgca ggctatggaa
     1561 gtaaatacat cagcaagtga gattctgtac aatgcccctc ctggagaccc tcttagcacc
     1621 aactacagcc ttgcacccaa cactcccatc aatcagaatg tcagcctgca tcaggcgtcc
     1681 ctggggggct gcagtcagga cttctccctc ttcagccccg aggtggagag cctgcctgtg
     1741 gctagcagct ccacactgct tccactcgtc cccagcaact ccaccagtct caactccacc
     1801 tttggctcta ccaacctagc agggcttttc tttccatccc agctcaatgg cacagccaat
     1861 gacacatcag gccctgagct acctgacccc cttgggggcc tgttagacga agctatgctg
     1921 gatgagatca gcctgatgga cctggccatt gaggagggct tcaacccggt gcaggcttcc
     1981 cagctcgaag aggagtttga ctctgactca ggcctctcct tggactccag ccatagccct
     2041 tcctctctga gcagctctga agggagctct tcttcttcct cctcctcctc ttcctcttct
     2101 gcttcctcct ctgcctcttc ttccttctct gaggagggtg ctgttggtta cagctctgac
     2161 tctgagaccc tagacctaga agaggctgag ggtgcagtgg gctaccagcc ggaatactcc
     2221 aagttctgcc gcatgagcta tcaggatcct tctcagctct cttgccttcc ctacttagag
     2281 catgtgggcc acaatcatac atacaatatg gcacccagtg cccttgactc tgctgatcta
     2341 ccaccaccca gcaccctcaa gaaaggtagc aaggaaaagc aggctgactt cctggacaag
     2401 cagatgagcc gagatgagca cagagcccga gccatgaaga tcccattcac caatgacaag
     2461 atcatcaacc tgcctgtaga agaattcaat gagctgctgt ccaaatacca gctgagcgag
     2521 gcccagctca gcctcatccg ggatatccgg cgccggggca aaaacaagat ggctgcacag
     2581 aactgccgca agcgcaagtt ggacaccatc ctaaacctag aacgtgatgt ggaggacttg
     2641 cagcgagata aggcccgatt gcttcgagaa aaggtagagt tccttcggtc tctgcgacag
     2701 atgaagcaga aggtccaaag cttataccag gaggtgtttg ggcggctgcg ggatgagcat
     2761 gggaggccct actcacccag tcagtatgcc cttcagtatg ctggggatgg cagtgtcctc
     2821 ctcattcctc gcacgatggc tgaccagcag gctcggcgac aggagagaaa gccaaaggac
     2881 cggaggaagt gagcctgggg aggcaggggg tggacgctca ctaagaccga aactggagaa
     2941 gggctgggcc tggacctaac attggggact taaatgcctt cttatccaat atatcttctc
     3001 agatgggatg actgcgggtc agtgcaccga agaggcgggc gcaggcgctg tctggctcag
     3061 ctgccccctt ggggtgggca gggaggacca gactgcttgg gtgattgggg tccccagcct
     3121 attccctttc tcttgagggg agggtagtgt cggcatgctg gaagtagagg agctgtgtgg
     3181 agtgaaggag agaaagtgtg ggagatctca ttgctggaag gagaaaagga aggaatcccc
     3241 cgaaaatcaa agcagtcaga aaaaccagag cgactgttaa gggctttggc cagctttcta
     3301 ggcagcgagt gcaggtgaca acggtggtct agggagagtt actggtatgg aacacagaca
     3361 tggcggggcc ccagaaggcc tttgtaactg tttcttcaac tcttgcatcc ctgaagggaa
     3421 gatgctcttg gatgcacctg taatatctta gttactgaat gggaagctgt aggggccgag
     3481 gagggcagag ggtataggaa gtgagaacga ggcctgtgtc gcagcagccc agcatcaagc
     3541 atgtcacaca ctgccctgcc acagccacct ccctccctgg ccatcccaga gccgaggctc
     3601 ccactgtcct cagagagcct gcatggaaat gctgtcctct tccactctcc tcctcttttt
     3661 gatacccacc ctcactagct gcctccagct ctggagtggg gtgctattct ggcagtatct
     3721 ggaacttggc ctacagcttc ctctgcaggg tctaaacagg gaaggcacgt gtggaggagt
     3781 ggtcccagtg acatccaggc accattcagc acaacactgg gaagtgattc ttccctcagg
     3841 cccctctgcc taccaacacc tgggctcctc actgggggaa acaaaagcct ataaacccca
     3901 gcaacaaaac ctagtcctct tagacgttct tgcgctttga tttttttagg gcgtgtgccc
     3961 tgttacactt atagggccta ggatgcttgt gttgagtaaa aaggagatgc cccaatattc
     4021 aaagctgcta aatgttctct ttgccataaa gactccgtgt taactgtgta aacacttggg
     4081 atttttctcc tatgtcccga ggtctggtct tgatttcttt tttgggtttc tttctaggaa
     4141 aatgagaagt gcatgcaagg ggcaggagat gaccctcccc taggctttca gcttcaggca
     4201 gcttcttcac agcctgttca gcctgggctc ctggaggaca gccctggggg aggcagtgag
     4261 gggcagcgcc aagatagcca ggtggttggt tccaggacca cagtgtcttt tttttgttgt
     4321 tggttttttg ttgttgttgt ttgtttgttt gttttttaac tgccactgcc gccccctgac
     4381 ccccaatctt ggtcagctct ggagtactgc ctgccccaga cgagcagggg ttggggggga
     4441 gcactgatcc tcctccctgg gcagggcaga gggctttcct aaccgagcag tagggataga
     4501 aagcgtgagc ctgggagtgc tttttataaa ttattttcct tgtagatttt atttttaatt
     4561 tatctctgtg acctgccagg gagaggagag aaagaaatgc tgtgagcaca tgacaaaata
     4621 aaatcaaata aaatggatga ttcagcttaa gtgc
//
