LOCUS       NM_001130452            3497 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus nuclear factor, erythroid derived 2,-like 1 (Nfe2l1),
            transcript variant 6, mRNA.
ACCESSION   NM_001130452
VERSION     NM_001130452.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3497)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3497)
  AUTHORS   Bairos,J.A., Njoku,U., Zafar,M., Akl,M.G., Li,L., Parlakgul,G.,
            Arruda,A.P. and Widenmaier,S.B.
  TITLE     Sterol O-acyltransferase (SOAT/ACAT) activity is required to form
            cholesterol crystals in hepatocyte lipid droplets
  JOURNAL   Biochim Biophys Acta Mol Cell Biol Lipids 1869 (6), 159512 (2024)
   PUBMED   38761895
REFERENCE   3  (bases 1 to 3497)
  AUTHORS   Akl,M.G., Li,L. and Widenmaier,S.B.
  TITLE     Protective Effects of Hepatocyte Stress Defenders, Nrf1 and Nrf2,
            against MASLD Progression
  JOURNAL   Int J Mol Sci 25 (15), 8046 (2024)
   PUBMED   39125617
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3497)
  AUTHORS   Shen,W., Ren,S., Hou,Y., Zuo,Z., Liu,S., Liu,Z., Fu,J., Wang,H.,
            Yang,B., Zhao,R., Chen,Y., Yamamoto,M., Xu,Y., Zhang,Q. and Pi,J.
  TITLE     Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor
            determining the thermogenesis and cellular heterogeneity and
            dynamics of brown adipose tissues in mice
  JOURNAL   Redox Biol 67, 102879 (2023)
   PUBMED   37716088
  REMARK    GeneRIF: Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key
            factor determining the thermogenesis and cellular heterogeneity and
            dynamics of brown adipose tissues in mice.
REFERENCE   5  (bases 1 to 3497)
  AUTHORS   Trites,M.J., Stebbings,B.M., Aoki,H., Phanse,S., Akl,M.G., Li,L.,
            Babu,M. and Widenmaier,S.B.
  TITLE     HDL functionality is dependent on hepatocyte stress defense factors
            Nrf1 and Nrf2
  JOURNAL   Front Physiol 14, 1212785 (2023)
   PUBMED   37501930
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3497)
  AUTHORS   Johnsen,O., Skammelsrud,N., Luna,L., Nishizawa,M., Prydz,H. and
            Kolsto,A.B.
  TITLE     Small Maf proteins interact with the human transcription factor
            TCF11/Nrf1/LCR-F1
  JOURNAL   Nucleic Acids Res 24 (21), 4289-4297 (1996)
   PUBMED   8932385
REFERENCE   7  (bases 1 to 3497)
  AUTHORS   McKie,J. and Scambler,P.J.
  TITLE     The Nfe2l1 gene maps to distal mouse chromosome 11
  JOURNAL   Mamm Genome 7 (1), 89 (1996)
   PUBMED   8903741
REFERENCE   8  (bases 1 to 3497)
  AUTHORS   Shivdasani,R.A. and Orkin,S.H.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   9  (bases 1 to 3497)
  AUTHORS   Chui,D.H., Tang,W. and Orkin,S.H.
  TITLE     cDNA cloning of murine Nrf 2 gene, coding for a p45 NF-E2 related
            transcription factor
  JOURNAL   Biochem Biophys Res Commun 209 (1), 40-46 (1995)
   PUBMED   7726861
REFERENCE   10 (bases 1 to 3497)
  AUTHORS   McKie,J., Johnstone,K., Mattei,M.G. and Scambler,P.
  TITLE     Cloning and mapping of murine Nfe2l1
  JOURNAL   Genomics 25 (3), 716-719 (1995)
   PUBMED   7759107
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ152359.1 and AK038187.1.
            
            Summary: This gene encodes a protein that is involved in globin
            gene expression in erythrocytes. Confusion has occurred in
            bibliographic databases from the use of NRF1 for this gene, NFE2L1,
            and for 'nuclear respiratory factor 1' which has an official symbol
            of NRF1. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (6) has multiple differences in
            the 5' UTR and 5' coding region which cause translation initiation
            to occur at a downstream in-frame ATG, compared to variant 1. The
            encoded protein (isoform 2) has a shorter N-terminus, compared to
            isoform 1. Variants 2 and 6 encode the same isoform.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660811.180447.1, CJ152359.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-427               CJ152359.1         22-448
            428-3497            AK038187.1         110-3179
FEATURES             Location/Qualifiers
     source          1..3497
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.12 cM"
     gene            1..3497
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="nuclear factor, erythroid derived 2,-like 1"
                     /db_xref="GeneID:18023"
                     /db_xref="MGI:MGI:99421"
     exon            1..52
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /inference="alignment:Splign:2.1.0"
     exon            53..235
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /inference="alignment:Splign:2.1.0"
     exon            236..394
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1735
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="isoform 2 is encoded by transcript variant 6;
                     nuclear factor erythroid 2-related factor 1; NFE2-related
                     factor 1; NF-E2-related factor 1; locus control
                     region-factor 1; endoplasmic reticulum membrane sensor
                     NFE2L1"
                     /codon_start=1
                     /product="endoplasmic reticulum membrane sensor NFE2L1
                     isoform 2"
                     /protein_id="NP_001123924.1"
                     /db_xref="CCDS:CCDS48893.1"
                     /db_xref="GeneID:18023"
                     /db_xref="MGI:MGI:99421"
                     /translation="MSIMEMQAMEVNTSASEILYNAPPGDPLSTNYSLAPNTPINQNV
                     SLHQASLGGCSQDFSLFSPEVESLPVASSSTLLPLVPSNSTSLNSTFGSTNLAGLFFP
                     SQLNGTANDTSGPELPDPLGGLLDEAMLDEISLMDLAIEEGFNPVQASQLEEEFDSDS
                     GLSLDSSHSPSSLSSSEGSSSSSSSSSSSSASSSASSSFSEEGAVGYSSDSETLDLEE
                     AEGAVGYQPEYSKFCRMSYQDPSQLSCLPYLEHVGHNHTYNMAPSALDSADLPPPSTL
                     KKGSKEKQADFLDKQMSRDEHRARAMKIPFTNDKIINLPVEEFNELLSKYQLSEAQLS
                     LIRDIRRRGKNKMAAQNCRKRKLDTILNLERDVEDLQRDKARLLREKVEFLRSLRQMK
                     QKVQSLYQEVFGRLRDEHGRPYSPSQYALQYAGDGSVLLIPRTMADQQARRQERKPKD
                     RRK"
     exon            395..3497
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3460..3465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="hexamer: AATAAA"
     regulatory      3470..3475
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="hexamer: AATAAA"
     polyA_site      3480
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
                     /note="major polyA site"
     polyA_site      3493
                     /gene="Nfe2l1"
                     /gene_synonym="LCR-F1; Lcrf1; NRF1; TCF-11; TCF11"
ORIGIN      
        1 agtgacctgc ggggtgggag ggggagggga ttggctcctt gcggcagcct aggatattga
       61 tctgggggct gggcgtgagg tttttgacta cagtcatcgc cagaaggagc aggatgtgga
      121 taaggaactg caagatggac gagaacgaga ggacacctgg tcaggcgagg gtgcggaagc
      181 tctggcccga gacctgctag tagatggaga gactggggag agcttccctg cacagttccc
      241 agctgacgtt tccagcatcc cagaagcagt gcctagtgag agtgagtccc ccgcccttca
      301 gaacagcctt ctatctcctc ttctgacggg gacagaatca ccatttgatt tggaacagca
      361 gtggcaagat ctcatgtcca tcatggaaat gcaggctatg gaagtaaata catcagcaag
      421 tgagattctg tacaatgccc ctcctggaga ccctcttagc accaactaca gccttgcacc
      481 caacactccc atcaatcaga atgtcagcct gcatcaggcg tccctggggg gctgcagtca
      541 ggacttctcc ctcttcagcc ccgaggtgga gagcctgcct gtggctagca gctccacact
      601 gcttccactc gtccccagca actccaccag tctcaactcc acctttggct ctaccaacct
      661 agcagggctt ttctttccat cccagctcaa tggcacagcc aatgacacat caggccctga
      721 gctacctgac ccccttgggg gcctgttaga cgaagctatg ctggatgaga tcagcctgat
      781 ggacctggcc attgaggagg gcttcaaccc ggtgcaggct tcccagctcg aagaggagtt
      841 tgactctgac tcaggcctct ccttggactc cagccatagc ccttcctctc tgagcagctc
      901 tgaagggagc tcttcttctt cctcctcctc ctcttcctct tctgcttcct cctctgcctc
      961 ttcttccttc tctgaggagg gtgctgttgg ttacagctct gactctgaga ccctagacct
     1021 agaagaggct gagggtgcag tgggctacca gccggaatac tccaagttct gccgcatgag
     1081 ctatcaggat ccttctcagc tctcttgcct tccctactta gagcatgtgg gccacaatca
     1141 tacatacaat atggcaccca gtgcccttga ctctgctgat ctaccaccac ccagcaccct
     1201 caagaaaggt agcaaggaaa agcaggctga cttcctggac aagcagatga gccgagatga
     1261 gcacagagcc cgagccatga agatcccatt caccaatgac aagatcatca acctgcctgt
     1321 agaagaattc aatgagctgc tgtccaaata ccagctgagc gaggcccagc tcagcctcat
     1381 ccgggatatc cggcgccggg gcaaaaacaa gatggctgca cagaactgcc gcaagcgcaa
     1441 gttggacacc atcctaaacc tagaacgtga tgtggaggac ttgcagcgag ataaggcccg
     1501 attgcttcga gaaaaggtag agttccttcg gtctctgcga cagatgaagc agaaggtcca
     1561 aagcttatac caggaggtgt ttgggcggct gcgggatgag catgggaggc cctactcacc
     1621 cagtcagtat gcccttcagt atgctgggga tggcagtgtc ctcctcattc ctcgcacgat
     1681 ggctgaccag caggctcggc gacaggagag aaagccaaag gaccggagga agtgagcctg
     1741 gggaggcagg gggtggacgc tcactaagac cgaaactgga gaagggctgg gcctggacct
     1801 aacattgggg acttaaatgc cttcttatcc aatatatctt ctcagatggg atgactgcgg
     1861 gtcagtgcac cgaagaggcg ggcgcaggcg ctgtctggct cagctgcccc cttggggtgg
     1921 gcagggagga ccagactgct tgggtgattg gggtccccag cctattccct ttctcttgag
     1981 gggagggtag tgtcggcatg ctggaagtag aggagctgtg tggagtgaag gagagaaagt
     2041 gtgggagatc tcattgctgg aaggagaaaa ggaaggaatc ccccgaaaat caaagcagtc
     2101 agaaaaacca gagcgactgt taagggcttt ggccagcttt ctaggcagcg agtgcaggtg
     2161 acaacggtgg tctagggaga gttactggta tggaacacag acatggcggg gccccagaag
     2221 gcctttgtaa ctgtttcttc aactcttgca tccctgaagg gaagatgctc ttggatgcac
     2281 ctgtaatatc ttagttactg aatgggaagc tgtaggggcc gaggagggca gagggtatag
     2341 gaagtgagaa cgaggcctgt gtcgcagcag cccagcatca agcatgtcac acactgccct
     2401 gccacagcca cctccctccc tggccatccc agagccgagg ctcccactgt cctcagagag
     2461 cctgcatgga aatgctgtcc tcttccactc tcctcctctt tttgataccc accctcacta
     2521 gctgcctcca gctctggagt ggggtgctat tctggcagta tctggaactt ggcctacagc
     2581 ttcctctgca gggtctaaac agggaaggca cgtgtggagg agtggtccca gtgacatcca
     2641 ggcaccattc agcacaacac tgggaagtga ttcttccctc aggcccctct gcctaccaac
     2701 acctgggctc ctcactgggg gaaacaaaag cctataaacc ccagcaacaa aacctagtcc
     2761 tcttagacgt tcttgcgctt tgattttttt agggcgtgtg ccctgttaca cttatagggc
     2821 ctaggatgct tgtgttgagt aaaaaggaga tgccccaata ttcaaagctg ctaaatgttc
     2881 tctttgccat aaagactccg tgttaactgt gtaaacactt gggatttttc tcctatgtcc
     2941 cgaggtctgg tcttgatttc ttttttgggt ttctttctag gaaaatgaga agtgcatgca
     3001 aggggcagga gatgaccctc ccctaggctt tcagcttcag gcagcttctt cacagcctgt
     3061 tcagcctggg ctcctggagg acagccctgg gggaggcagt gaggggcagc gccaagatag
     3121 ccaggtggtt ggttccagga ccacagtgtc ttttttttgt tgttggtttt ttgttgttgt
     3181 tgtttgtttg tttgtttttt aactgccact gccgccccct gacccccaat cttggtcagc
     3241 tctggagtac tgcctgcccc agacgagcag gggttggggg ggagcactga tcctcctccc
     3301 tgggcagggc agagggcttt cctaaccgag cagtagggat agaaagcgtg agcctgggag
     3361 tgctttttat aaattatttt ccttgtagat tttattttta atttatctct gtgacctgcc
     3421 agggagagga gagaaagaaa tgctgtgagc acatgacaaa ataaaatcaa ataaaatgga
     3481 tgattcagct taagtgc
//
