LOCUS       NM_001302343            1603 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus nuclear factor, erythroid derived 2 (Nfe2), transcript
            variant 6, mRNA.
ACCESSION   NM_001302343 XM_030248375
VERSION     NM_001302343.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1603)
  AUTHORS   Staehle,A.M., Peeken,J.C., Vladimirov,G., Hoeness,M.E., Bojtine
            Kovacs,S., Karantzelis,N., Gruender,A., Koellerer,C., Jutzi,J.S.,
            Pahl,H.L. and Staehle,H.F.
  TITLE     The histone demethylase JMJD2C constitutes a novel NFE2 target gene
            that is required for the survival of JAK2V617F mutated cells
  JOURNAL   Leukemia 37 (4), 919-923 (2023)
   PUBMED   36709354
  REMARK    GeneRIF: The histone demethylase JMJD2C constitutes a novel NFE2
            target gene that is required for the survival of JAK2[V617F]
            mutated cells.
REFERENCE   2  (bases 1 to 1603)
  AUTHORS   Potts,K.S., Farley,A., Dawson,C.A., Rimes,J., Biben,C., de
            Graaf,C., Potts,M.A., Stonehouse,O.J., Carmagnac,A.,
            Gangatirkar,P., Josefsson,E.C., Anttila,C., Amann-Zalcenstein,D.,
            Naik,S., Alexander,W.S., Hilton,D.J., Hawkins,E.D. and Taoudi,S.
  TITLE     Membrane budding is a major mechanism of in vivo platelet
            biogenesis
  JOURNAL   J Exp Med 217 (9) (2020)
   PUBMED   32706855
REFERENCE   3  (bases 1 to 1603)
  AUTHORS   Jutzi,J.S., Basu,T., Pellmann,M., Kaiser,S., Steinemann,D.,
            Sanders,M.A., Hinai,A.S.A., Zeilemaker,A., Bojtine Kovacs,S.,
            Koellerer,C., Ostendorp,J., Aumann,K., Wang,W., Raffoux,E.,
            Cassinat,B., Bullinger,L., Schlegelberger,B., Valk,P.J.M. and
            Pahl,H.L.
  TITLE     Altered NFE2 activity predisposes to leukemic transformation and
            myelosarcoma with AML-specific aberrations
  JOURNAL   Blood 133 (16), 1766-1777 (2019)
   PUBMED   30755419
  REMARK    GeneRIF: mutations in NFE2 predispose to the acquisition of
            secondary changes promoting the development of myelosarcoma and/or
            AML
REFERENCE   4  (bases 1 to 1603)
  AUTHORS   Gudmundsdottir,B., Gudmundsson,K.O., Klarmann,K.D., Singh,S.K.,
            Sun,L., Singh,S., Du,Y., Coppola,V., Stockwin,L., Nguyen,N.,
            Tessarollo,L., Thorsteinsson,L., Sigurjonsson,O.E., Gudmundsson,S.,
            Rafnar,T., Tisdale,J.F. and Keller,J.R.
  TITLE     POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin
            and Human Fetal Hemoglobin Expression
  JOURNAL   Cell Rep 23 (11), 3236-3248 (2018)
   PUBMED   29898395
REFERENCE   5  (bases 1 to 1603)
  AUTHORS   Tan,L.H., Bahmed,K., Lin,C.R., Marchetti,N., Bolla,S., Criner,G.J.,
            Kelsen,S., Madesh,M. and Kosmider,B.
  TITLE     The cytoprotective role of DJ-1 and p45 NFE2 against human primary
            alveolar type II cell injury and emphysema
  JOURNAL   Sci Rep 8 (1), 3555 (2018)
   PUBMED   29476075
  REMARK    GeneRIF: We detected that cigarette smoke significantly increased
            p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our
            results indicate that p45 NFE2 expression is induced by exposure to
            cigarette smoke, has a cytoprotective activity against cell injury,
            and its downregulation in human primary ATII cells may contribute
            to emphysema pathogenesis
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1603)
  AUTHORS   Shivdasani,R.A. and Orkin,S.H.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   7  (bases 1 to 1603)
  AUTHORS   Kotkow,K.J. and Orkin,S.H.
  TITLE     Dependence of globin gene expression in mouse erythroleukemia cells
            on the NF-E2 heterodimer
  JOURNAL   Mol Cell Biol 15 (8), 4640-4647 (1995)
   PUBMED   7623856
REFERENCE   8  (bases 1 to 1603)
  AUTHORS   Raja,K.B., Gerard,B., McKie,A., Beaumont,C., Simpson,R.J.,
            Grandchamp,B. and Peters,T.J.
  TITLE     Duodenal expression of NF-E2 in mouse models of altered iron
            metabolism
  JOURNAL   Biochem Soc Trans 23 (2), 326S (1995)
   PUBMED   7672357
REFERENCE   9  (bases 1 to 1603)
  AUTHORS   Igarashi,K., Itoh,K., Motohashi,H., Hayashi,N., Matuzaki,Y.,
            Nakauchi,H., Nishizawa,M. and Yamamoto,M.
  TITLE     Activity and expression of murine small Maf family protein MafK
  JOURNAL   J Biol Chem 270 (13), 7615-7624 (1995)
   PUBMED   7706310
REFERENCE   10 (bases 1 to 1603)
  AUTHORS   Kreimer-Birnbaum,M., Bannerman,R.M., Russell,E.S. and
            Bernstein,S.E.
  TITLE     Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W
            v, ha-ha, nb-nb, mk-mk, f-f and sla-Y)
  JOURNAL   Comp Biochem Physiol A Comp Physiol 43 (1), 21-30 (1972)
   PUBMED   4404581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164069.9.
            
            On or before Jan 21, 2022 this sequence version replaced
            XM_030248375.2, NM_001302343.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR13861889.26369.1,
                                           SRR13862062.219850.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AC164069.9         88260-88348
            90-201              AC164069.9         90344-90455
            202-371             AC164069.9         92400-92569
            372-1603            AC164069.9         94050-95281
FEATURES             Location/Qualifiers
     source          1..1603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.62 cM"
     gene            1..1603
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="nuclear factor, erythroid derived 2"
                     /db_xref="GeneID:18022"
                     /db_xref="MGI:MGI:97308"
     exon            1..89
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     exon            90..201
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     exon            202..371
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             258..1379
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="leucine zipper protein NF-E2; nuclear factor,
                     erythroid-derived 2 45 kDa subunit; nuclear factor,
                     erythroid derived 2, 45 kDa"
                     /codon_start=1
                     /product="transcription factor NF-E2 45 kDa subunit"
                     /protein_id="NP_001289272.1"
                     /db_xref="CCDS:CCDS27900.1"
                     /db_xref="GeneID:18022"
                     /db_xref="MGI:MGI:97308"
                     /translation="MPPCPPQQNRNRLSQLPVGELGEMELTWQEIMSITELQGLNVPS
                     ETSFEPQAPTPYPGPLPPPTYCPCSIHPDAGFSLPPPSYELPASTPHVPELPYSYGNV
                     AIPVSKPLTLSGLLNEPLPDHLALLDIGLPVGQPKPQEDPESDSGLSLNYSDAESLEL
                     EGMEAGRRRSEYADMYPVEYPYSLMPNSLAHPNYTLPPTETPLALESSSGPVRAKPAV
                     RGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLAQYPLTESQLALVRDIRRRGKN
                     KVAAQNCRKRKLETIVQLERELERLSSERERLLRARGEADRTLEVMRQQLAELYHDIF
                     QHLRDESGNSYSPEEYVLQQAADGAIFLVPRGTKMEATD"
     exon            372..1603
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1584..1589
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="hexamer: CATAAA"
     polyA_site      1599
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="major polyA site"
     polyA_site      1603
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="major polyA site"
ORIGIN      
        1 gtcagctctg acccagcctc tcagggacac tacccgcagc ctcatctctc tcctcgccgg
       61 gcttggaatc cgccacaggt gcctgaaagc tggaaactgt gatgcaattt gtccaaggcc
      121 atacatcttg aaggctggag aatcttgcct actagggcaa gatctttgta tagtacctca
      181 gattcagatc caggaagaca ggttgcagga atcctttgtg cttgtggaga cctggggcca
      241 tcagctggca cagtaggatg cccccgtgtc ctcctcagca gaacaggaac aggttatcac
      301 agctgcctgt tggggagctt ggagagatgg aactgacttg gcaagagatc atgtccatta
      361 ctgagctgca gggtctaaat gttccaagtg agacatcttt tgagcctcaa gcacccaccc
      421 cataccctgg gccactgcca cctccaacat attgcccctg ttcaattcat ccagatgcag
      481 gcttctccct tcccccacca tcttatgagc tcccagcatc tactccccat gtcccagaac
      541 taccatactc ctatggtaat gtagccatac cagtgtcaaa gccacttacc ctttcaggcc
      601 tgctcaatga gcccctccca gaccacttag ctctcctgga cattgggctg ccagtggggc
      661 aacccaagcc ccaagaagac ccagaatctg actcaggatt atccctcaac tacagtgatg
      721 cagaatctct tgagctagag ggtatggagg ctggcaggcg gaggagcgag tacgcggaca
      781 tgtacccagt ggagtatcct tactcactta tgcccaattc tttggcccat cccaactata
      841 ctcttccacc cactgagaca cccttggcct tagagtcatc ctccggtcca gttcgggcta
      901 agcctgctgt ccgtggggag gcagggagtc gggacgagcg gcgagccctg gccatgaaga
      961 ttcctttccc tacggacaag atagttaact tgccggtaga tgactttaat gagttgttgg
     1021 cacagtatcc gctaacggag agccagctgg ctctagttcg ggacatccgt cgacggggca
     1081 agaacaaggt ggcagcccaa aactgtcgca agagaaaact ggaaaccatt gtgcagctgg
     1141 agcgagagct ggagcggctg agcagtgaaa gggagcggct tctcagagcc cgaggggagg
     1201 ctgaccgcac tctggaggtc atgcgccaac agctggcaga gctgtaccat gatattttcc
     1261 agcatcttcg ggatgaatct ggcaacagtt actcaccaga ggaatatgta ctgcaacagg
     1321 ctgctgatgg tgccatcttt ctggtacccc gtggaaccaa aatggaggct acagattgag
     1381 ctggtctaga gagtggacac tggtgctaga gactccctca ttcccttctg atgaaggcac
     1441 ttcttaatcc cacaagactc agagtcctcc agaccaaaag gcagatgtaa ccatatcacc
     1501 tgggagtatt tggtgaggtt tgcctggagg ccaggtgttg gcttctcagg tcctcaaccc
     1561 cacctcttgt ccaagctttg gttcataaag agctgtgtgg aaa
//
