LOCUS       NM_001302340            1445 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus nuclear factor, erythroid derived 2 (Nfe2), transcript
            variant 4, mRNA.
ACCESSION   NM_001302340 XM_006520571
VERSION     NM_001302340.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1445)
  AUTHORS   Staehle,A.M., Peeken,J.C., Vladimirov,G., Hoeness,M.E., Bojtine
            Kovacs,S., Karantzelis,N., Gruender,A., Koellerer,C., Jutzi,J.S.,
            Pahl,H.L. and Staehle,H.F.
  TITLE     The histone demethylase JMJD2C constitutes a novel NFE2 target gene
            that is required for the survival of JAK2V617F mutated cells
  JOURNAL   Leukemia 37 (4), 919-923 (2023)
   PUBMED   36709354
  REMARK    GeneRIF: The histone demethylase JMJD2C constitutes a novel NFE2
            target gene that is required for the survival of JAK2[V617F]
            mutated cells.
REFERENCE   2  (bases 1 to 1445)
  AUTHORS   Potts,K.S., Farley,A., Dawson,C.A., Rimes,J., Biben,C., de
            Graaf,C., Potts,M.A., Stonehouse,O.J., Carmagnac,A.,
            Gangatirkar,P., Josefsson,E.C., Anttila,C., Amann-Zalcenstein,D.,
            Naik,S., Alexander,W.S., Hilton,D.J., Hawkins,E.D. and Taoudi,S.
  TITLE     Membrane budding is a major mechanism of in vivo platelet
            biogenesis
  JOURNAL   J Exp Med 217 (9) (2020)
   PUBMED   32706855
REFERENCE   3  (bases 1 to 1445)
  AUTHORS   Jutzi,J.S., Basu,T., Pellmann,M., Kaiser,S., Steinemann,D.,
            Sanders,M.A., Hinai,A.S.A., Zeilemaker,A., Bojtine Kovacs,S.,
            Koellerer,C., Ostendorp,J., Aumann,K., Wang,W., Raffoux,E.,
            Cassinat,B., Bullinger,L., Schlegelberger,B., Valk,P.J.M. and
            Pahl,H.L.
  TITLE     Altered NFE2 activity predisposes to leukemic transformation and
            myelosarcoma with AML-specific aberrations
  JOURNAL   Blood 133 (16), 1766-1777 (2019)
   PUBMED   30755419
  REMARK    GeneRIF: mutations in NFE2 predispose to the acquisition of
            secondary changes promoting the development of myelosarcoma and/or
            AML
REFERENCE   4  (bases 1 to 1445)
  AUTHORS   Gudmundsdottir,B., Gudmundsson,K.O., Klarmann,K.D., Singh,S.K.,
            Sun,L., Singh,S., Du,Y., Coppola,V., Stockwin,L., Nguyen,N.,
            Tessarollo,L., Thorsteinsson,L., Sigurjonsson,O.E., Gudmundsson,S.,
            Rafnar,T., Tisdale,J.F. and Keller,J.R.
  TITLE     POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin
            and Human Fetal Hemoglobin Expression
  JOURNAL   Cell Rep 23 (11), 3236-3248 (2018)
   PUBMED   29898395
REFERENCE   5  (bases 1 to 1445)
  AUTHORS   Tan,L.H., Bahmed,K., Lin,C.R., Marchetti,N., Bolla,S., Criner,G.J.,
            Kelsen,S., Madesh,M. and Kosmider,B.
  TITLE     The cytoprotective role of DJ-1 and p45 NFE2 against human primary
            alveolar type II cell injury and emphysema
  JOURNAL   Sci Rep 8 (1), 3555 (2018)
   PUBMED   29476075
  REMARK    GeneRIF: We detected that cigarette smoke significantly increased
            p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our
            results indicate that p45 NFE2 expression is induced by exposure to
            cigarette smoke, has a cytoprotective activity against cell injury,
            and its downregulation in human primary ATII cells may contribute
            to emphysema pathogenesis
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1445)
  AUTHORS   Shivdasani,R.A. and Orkin,S.H.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   7  (bases 1 to 1445)
  AUTHORS   Kotkow,K.J. and Orkin,S.H.
  TITLE     Dependence of globin gene expression in mouse erythroleukemia cells
            on the NF-E2 heterodimer
  JOURNAL   Mol Cell Biol 15 (8), 4640-4647 (1995)
   PUBMED   7623856
REFERENCE   8  (bases 1 to 1445)
  AUTHORS   Raja,K.B., Gerard,B., McKie,A., Beaumont,C., Simpson,R.J.,
            Grandchamp,B. and Peters,T.J.
  TITLE     Duodenal expression of NF-E2 in mouse models of altered iron
            metabolism
  JOURNAL   Biochem Soc Trans 23 (2), 326S (1995)
   PUBMED   7672357
REFERENCE   9  (bases 1 to 1445)
  AUTHORS   Igarashi,K., Itoh,K., Motohashi,H., Hayashi,N., Matuzaki,Y.,
            Nakauchi,H., Nishizawa,M. and Yamamoto,M.
  TITLE     Activity and expression of murine small Maf family protein MafK
  JOURNAL   J Biol Chem 270 (13), 7615-7624 (1995)
   PUBMED   7706310
REFERENCE   10 (bases 1 to 1445)
  AUTHORS   Kreimer-Birnbaum,M., Bannerman,R.M., Russell,E.S. and
            Bernstein,S.E.
  TITLE     Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W
            v, ha-ha, nb-nb, mk-mk, f-f and sla-Y)
  JOURNAL   Comp Biochem Physiol A Comp Physiol 43 (1), 21-30 (1972)
   PUBMED   4404581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164069.9.
            
            On Jan 21, 2022 this sequence version replaced NM_001302340.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AA268651.1, BB844413.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                AC164069.9         91825-91867
            44-213              AC164069.9         92400-92569
            214-1445            AC164069.9         94050-95281
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.62 cM"
     gene            1..1445
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="nuclear factor, erythroid derived 2"
                     /db_xref="GeneID:18022"
                     /db_xref="MGI:MGI:97308"
     exon            1..43
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     exon            44..213
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             100..1221
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="leucine zipper protein NF-E2; nuclear factor,
                     erythroid-derived 2 45 kDa subunit; nuclear factor,
                     erythroid derived 2, 45 kDa"
                     /codon_start=1
                     /product="transcription factor NF-E2 45 kDa subunit"
                     /protein_id="NP_001289269.1"
                     /db_xref="CCDS:CCDS27900.1"
                     /db_xref="GeneID:18022"
                     /db_xref="MGI:MGI:97308"
                     /translation="MPPCPPQQNRNRLSQLPVGELGEMELTWQEIMSITELQGLNVPS
                     ETSFEPQAPTPYPGPLPPPTYCPCSIHPDAGFSLPPPSYELPASTPHVPELPYSYGNV
                     AIPVSKPLTLSGLLNEPLPDHLALLDIGLPVGQPKPQEDPESDSGLSLNYSDAESLEL
                     EGMEAGRRRSEYADMYPVEYPYSLMPNSLAHPNYTLPPTETPLALESSSGPVRAKPAV
                     RGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLAQYPLTESQLALVRDIRRRGKN
                     KVAAQNCRKRKLETIVQLERELERLSSERERLLRARGEADRTLEVMRQQLAELYHDIF
                     QHLRDESGNSYSPEEYVLQQAADGAIFLVPRGTKMEATD"
     exon            214..1445
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1426..1431
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="hexamer: CATAAA"
     polyA_site      1441
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="major polyA site"
     polyA_site      1445
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="major polyA site"
ORIGIN      
        1 ctctaagcac tcacttcttg ggaagaaagg gctgaaatac taggttgcag gaatcctttg
       61 tgcttgtgga gacctggggc catcagctgg cacagtagga tgcccccgtg tcctcctcag
      121 cagaacagga acaggttatc acagctgcct gttggggagc ttggagagat ggaactgact
      181 tggcaagaga tcatgtccat tactgagctg cagggtctaa atgttccaag tgagacatct
      241 tttgagcctc aagcacccac cccataccct gggccactgc cacctccaac atattgcccc
      301 tgttcaattc atccagatgc aggcttctcc cttcccccac catcttatga gctcccagca
      361 tctactcccc atgtcccaga actaccatac tcctatggta atgtagccat accagtgtca
      421 aagccactta ccctttcagg cctgctcaat gagcccctcc cagaccactt agctctcctg
      481 gacattgggc tgccagtggg gcaacccaag ccccaagaag acccagaatc tgactcagga
      541 ttatccctca actacagtga tgcagaatct cttgagctag agggtatgga ggctggcagg
      601 cggaggagcg agtacgcgga catgtaccca gtggagtatc cttactcact tatgcccaat
      661 tctttggccc atcccaacta tactcttcca cccactgaga cacccttggc cttagagtca
      721 tcctccggtc cagttcgggc taagcctgct gtccgtgggg aggcagggag tcgggacgag
      781 cggcgagccc tggccatgaa gattcctttc cctacggaca agatagttaa cttgccggta
      841 gatgacttta atgagttgtt ggcacagtat ccgctaacgg agagccagct ggctctagtt
      901 cgggacatcc gtcgacgggg caagaacaag gtggcagccc aaaactgtcg caagagaaaa
      961 ctggaaacca ttgtgcagct ggagcgagag ctggagcggc tgagcagtga aagggagcgg
     1021 cttctcagag cccgagggga ggctgaccgc actctggagg tcatgcgcca acagctggca
     1081 gagctgtacc atgatatttt ccagcatctt cgggatgaat ctggcaacag ttactcacca
     1141 gaggaatatg tactgcaaca ggctgctgat ggtgccatct ttctggtacc ccgtggaacc
     1201 aaaatggagg ctacagattg agctggtcta gagagtggac actggtgcta gagactccct
     1261 cattcccttc tgatgaaggc acttcttaat cccacaagac tcagagtcct ccagaccaaa
     1321 aggcagatgt aaccatatca cctgggagta tttggtgagg tttgcctgga ggccaggtgt
     1381 tggcttctca ggtcctcaac cccacctctt gtccaagctt tggttcataa agagctgtgt
     1441 ggaaa
//
