LOCUS       NM_001302338            1878 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus nuclear factor, erythroid derived 2 (Nfe2), transcript
            variant 1, mRNA.
ACCESSION   NM_001302338 XM_006520574
VERSION     NM_001302338.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1878)
  AUTHORS   Staehle,A.M., Peeken,J.C., Vladimirov,G., Hoeness,M.E., Bojtine
            Kovacs,S., Karantzelis,N., Gruender,A., Koellerer,C., Jutzi,J.S.,
            Pahl,H.L. and Staehle,H.F.
  TITLE     The histone demethylase JMJD2C constitutes a novel NFE2 target gene
            that is required for the survival of JAK2V617F mutated cells
  JOURNAL   Leukemia 37 (4), 919-923 (2023)
   PUBMED   36709354
  REMARK    GeneRIF: The histone demethylase JMJD2C constitutes a novel NFE2
            target gene that is required for the survival of JAK2[V617F]
            mutated cells.
REFERENCE   2  (bases 1 to 1878)
  AUTHORS   Potts,K.S., Farley,A., Dawson,C.A., Rimes,J., Biben,C., de
            Graaf,C., Potts,M.A., Stonehouse,O.J., Carmagnac,A.,
            Gangatirkar,P., Josefsson,E.C., Anttila,C., Amann-Zalcenstein,D.,
            Naik,S., Alexander,W.S., Hilton,D.J., Hawkins,E.D. and Taoudi,S.
  TITLE     Membrane budding is a major mechanism of in vivo platelet
            biogenesis
  JOURNAL   J Exp Med 217 (9) (2020)
   PUBMED   32706855
REFERENCE   3  (bases 1 to 1878)
  AUTHORS   Jutzi,J.S., Basu,T., Pellmann,M., Kaiser,S., Steinemann,D.,
            Sanders,M.A., Hinai,A.S.A., Zeilemaker,A., Bojtine Kovacs,S.,
            Koellerer,C., Ostendorp,J., Aumann,K., Wang,W., Raffoux,E.,
            Cassinat,B., Bullinger,L., Schlegelberger,B., Valk,P.J.M. and
            Pahl,H.L.
  TITLE     Altered NFE2 activity predisposes to leukemic transformation and
            myelosarcoma with AML-specific aberrations
  JOURNAL   Blood 133 (16), 1766-1777 (2019)
   PUBMED   30755419
  REMARK    GeneRIF: mutations in NFE2 predispose to the acquisition of
            secondary changes promoting the development of myelosarcoma and/or
            AML
REFERENCE   4  (bases 1 to 1878)
  AUTHORS   Gudmundsdottir,B., Gudmundsson,K.O., Klarmann,K.D., Singh,S.K.,
            Sun,L., Singh,S., Du,Y., Coppola,V., Stockwin,L., Nguyen,N.,
            Tessarollo,L., Thorsteinsson,L., Sigurjonsson,O.E., Gudmundsson,S.,
            Rafnar,T., Tisdale,J.F. and Keller,J.R.
  TITLE     POGZ Is Required for Silencing Mouse Embryonic beta-like Hemoglobin
            and Human Fetal Hemoglobin Expression
  JOURNAL   Cell Rep 23 (11), 3236-3248 (2018)
   PUBMED   29898395
REFERENCE   5  (bases 1 to 1878)
  AUTHORS   Tan,L.H., Bahmed,K., Lin,C.R., Marchetti,N., Bolla,S., Criner,G.J.,
            Kelsen,S., Madesh,M. and Kosmider,B.
  TITLE     The cytoprotective role of DJ-1 and p45 NFE2 against human primary
            alveolar type II cell injury and emphysema
  JOURNAL   Sci Rep 8 (1), 3555 (2018)
   PUBMED   29476075
  REMARK    GeneRIF: We detected that cigarette smoke significantly increased
            p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our
            results indicate that p45 NFE2 expression is induced by exposure to
            cigarette smoke, has a cytoprotective activity against cell injury,
            and its downregulation in human primary ATII cells may contribute
            to emphysema pathogenesis
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1878)
  AUTHORS   Shivdasani,R.A. and Orkin,S.H.
  TITLE     Erythropoiesis and globin gene expression in mice lacking the
            transcription factor NF-E2
  JOURNAL   Proc Natl Acad Sci U S A 92 (19), 8690-8694 (1995)
   PUBMED   7567998
REFERENCE   7  (bases 1 to 1878)
  AUTHORS   Kotkow,K.J. and Orkin,S.H.
  TITLE     Dependence of globin gene expression in mouse erythroleukemia cells
            on the NF-E2 heterodimer
  JOURNAL   Mol Cell Biol 15 (8), 4640-4647 (1995)
   PUBMED   7623856
REFERENCE   8  (bases 1 to 1878)
  AUTHORS   Raja,K.B., Gerard,B., McKie,A., Beaumont,C., Simpson,R.J.,
            Grandchamp,B. and Peters,T.J.
  TITLE     Duodenal expression of NF-E2 in mouse models of altered iron
            metabolism
  JOURNAL   Biochem Soc Trans 23 (2), 326S (1995)
   PUBMED   7672357
REFERENCE   9  (bases 1 to 1878)
  AUTHORS   Igarashi,K., Itoh,K., Motohashi,H., Hayashi,N., Matuzaki,Y.,
            Nakauchi,H., Nishizawa,M. and Yamamoto,M.
  TITLE     Activity and expression of murine small Maf family protein MafK
  JOURNAL   J Biol Chem 270 (13), 7615-7624 (1995)
   PUBMED   7706310
REFERENCE   10 (bases 1 to 1878)
  AUTHORS   Kreimer-Birnbaum,M., Bannerman,R.M., Russell,E.S. and
            Bernstein,S.E.
  TITLE     Pyrrole pigments in normal and congenitally anaemic mice (+:+, W-W
            v, ha-ha, nb-nb, mk-mk, f-f and sla-Y)
  JOURNAL   Comp Biochem Physiol A Comp Physiol 43 (1), 21-30 (1972)
   PUBMED   4404581
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164069.9.
            
            On Jan 21, 2022 this sequence version replaced NM_001302338.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156702.1, BY751522.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-476               AC164069.9         91825-92300
            477-646             AC164069.9         92400-92569
            647-1878            AC164069.9         94050-95281
FEATURES             Location/Qualifiers
     source          1..1878
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 58.62 cM"
     gene            1..1878
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="nuclear factor, erythroid derived 2"
                     /db_xref="GeneID:18022"
                     /db_xref="MGI:MGI:97308"
     exon            1..476
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     exon            477..646
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     CDS             533..1654
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="leucine zipper protein NF-E2; nuclear factor,
                     erythroid-derived 2 45 kDa subunit; nuclear factor,
                     erythroid derived 2, 45 kDa"
                     /codon_start=1
                     /product="transcription factor NF-E2 45 kDa subunit"
                     /protein_id="NP_001289267.1"
                     /db_xref="CCDS:CCDS27900.1"
                     /db_xref="GeneID:18022"
                     /db_xref="MGI:MGI:97308"
                     /translation="MPPCPPQQNRNRLSQLPVGELGEMELTWQEIMSITELQGLNVPS
                     ETSFEPQAPTPYPGPLPPPTYCPCSIHPDAGFSLPPPSYELPASTPHVPELPYSYGNV
                     AIPVSKPLTLSGLLNEPLPDHLALLDIGLPVGQPKPQEDPESDSGLSLNYSDAESLEL
                     EGMEAGRRRSEYADMYPVEYPYSLMPNSLAHPNYTLPPTETPLALESSSGPVRAKPAV
                     RGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLAQYPLTESQLALVRDIRRRGKN
                     KVAAQNCRKRKLETIVQLERELERLSSERERLLRARGEADRTLEVMRQQLAELYHDIF
                     QHLRDESGNSYSPEEYVLQQAADGAIFLVPRGTKMEATD"
     exon            647..1878
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1859..1864
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="hexamer: CATAAA"
     polyA_site      1874
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="major polyA site"
     polyA_site      1878
                     /gene="Nfe2"
                     /gene_synonym="NF-E2; NF-E2/P45; p45; p45nf-e2; p45NFE2"
                     /note="major polyA site"
ORIGIN      
        1 ctctaagcac tcacttcttg ggaagaaagg gctgaaatac taggtgtggt ggtacatgcc
       61 tttaattcca gcacttggga ggcagaggca gtcggatctc tgtgagctag aagccagcct
      121 ggtctacata gcaagttcta ggacacagcc agggacacat agcgagacct tgttttaaaa
      181 aacaacaatg aaagggttag accctacgct gaggacacaa gaagaaggca agggtgactc
      241 ttgatgtttt cttccagaat ggaaaatgaa atttcaatcc ccaaacctga gaaagactgg
      301 attttgtctc tggacaggaa taccattttt agggagtaag agaaggcaac ttgctgagaa
      361 aaagtaagga tacctactct gtgtccagag gactgactat ggtcagatca ggtgaggtag
      421 agagtactcc actgaagaaa agaacattac agttcatagg gtggttgatg gcacctgttg
      481 caggaatcct ttgtgcttgt ggagacctgg ggccatcagc tggcacagta ggatgccccc
      541 gtgtcctcct cagcagaaca ggaacaggtt atcacagctg cctgttgggg agcttggaga
      601 gatggaactg acttggcaag agatcatgtc cattactgag ctgcagggtc taaatgttcc
      661 aagtgagaca tcttttgagc ctcaagcacc caccccatac cctgggccac tgccacctcc
      721 aacatattgc ccctgttcaa ttcatccaga tgcaggcttc tcccttcccc caccatctta
      781 tgagctccca gcatctactc cccatgtccc agaactacca tactcctatg gtaatgtagc
      841 cataccagtg tcaaagccac ttaccctttc aggcctgctc aatgagcccc tcccagacca
      901 cttagctctc ctggacattg ggctgccagt ggggcaaccc aagccccaag aagacccaga
      961 atctgactca ggattatccc tcaactacag tgatgcagaa tctcttgagc tagagggtat
     1021 ggaggctggc aggcggagga gcgagtacgc ggacatgtac ccagtggagt atccttactc
     1081 acttatgccc aattctttgg cccatcccaa ctatactctt ccacccactg agacaccctt
     1141 ggccttagag tcatcctccg gtccagttcg ggctaagcct gctgtccgtg gggaggcagg
     1201 gagtcgggac gagcggcgag ccctggccat gaagattcct ttccctacgg acaagatagt
     1261 taacttgccg gtagatgact ttaatgagtt gttggcacag tatccgctaa cggagagcca
     1321 gctggctcta gttcgggaca tccgtcgacg gggcaagaac aaggtggcag cccaaaactg
     1381 tcgcaagaga aaactggaaa ccattgtgca gctggagcga gagctggagc ggctgagcag
     1441 tgaaagggag cggcttctca gagcccgagg ggaggctgac cgcactctgg aggtcatgcg
     1501 ccaacagctg gcagagctgt accatgatat tttccagcat cttcgggatg aatctggcaa
     1561 cagttactca ccagaggaat atgtactgca acaggctgct gatggtgcca tctttctggt
     1621 accccgtgga accaaaatgg aggctacaga ttgagctggt ctagagagtg gacactggtg
     1681 ctagagactc cctcattccc ttctgatgaa ggcacttctt aatcccacaa gactcagagt
     1741 cctccagacc aaaaggcaga tgtaaccata tcacctggga gtatttggtg aggtttgcct
     1801 ggaggccagg tgttggcttc tcaggtcctc aaccccacct cttgtccaag ctttggttca
     1861 taaagagctg tgtggaaa
//
