LOCUS       NM_023699               3284 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus nuclear factor of activated T cells, cytoplasmic,
            calcineurin dependent 4 (Nfatc4), transcript variant 1, mRNA.
ACCESSION   NM_023699
VERSION     NM_023699.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3284)
  AUTHORS   Mackiewicz,J., Tomczak,J., Lisek,M., Sakowicz,A., Guo,F. and
            Boczek,T.
  TITLE     NFATc4 Knockout Promotes Neuroprotection and Retinal Ganglion Cell
            Regeneration After Optic Nerve Injury
  JOURNAL   Mol Neurobiol 61 (11), 9383-9401 (2024)
   PUBMED   38639863
  REMARK    GeneRIF: NFATc4 Knockout Promotes Neuroprotection and Retinal
            Ganglion Cell Regeneration After Optic Nerve Injury.
REFERENCE   2  (bases 1 to 3284)
  AUTHORS   Yu,S., Sun,Z., Ju,T., Liu,Y., Mei,Z., Wang,C., Qu,Z., Li,N., Wu,F.,
            Liu,K., Lu,M., Huang,M., Pang,X., Jia,Y., Li,Y., Zhang,Y., Dou,S.,
            Jiang,J., Dong,X., Huang,C., Li,W., Zhang,Y., Yuan,Y., Yang,B. and
            Du,W.
  TITLE     The m7G Methyltransferase Mettl1 Drives Cardiac Hypertrophy by
            Regulating SRSF9-Mediated Splicing of NFATc4
  JOURNAL   Adv Sci (Weinh) 11 (29), e2308769 (2024)
   PUBMED   38810124
  REMARK    GeneRIF: The m7G Methyltransferase Mettl1 Drives Cardiac
            Hypertrophy by Regulating SRSF9-Mediated Splicing of NFATc4.
REFERENCE   3  (bases 1 to 3284)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3284)
  AUTHORS   Ahuja,N., Hiltabidle,M.S., Rajasekhar,H., Voss,S., Lu,S.Z.,
            Barlow,H.R., Cowdin,M.A., Daniel,E., Vaddaraju,V., Anandakumar,T.,
            Black,E., Cleaver,O. and Maynard,C.
  TITLE     Endothelial Cyp26b1 restrains murine heart valve growth during
            development
  JOURNAL   Dev Biol 486, 81-95 (2022)
   PUBMED   35364055
REFERENCE   5  (bases 1 to 3284)
  AUTHORS   Ypsilanti,A.R., Pattabiraman,K., Catta-Preta,R., Golonzhka,O.,
            Lindtner,S., Tang,K., Jones,I.R., Abnousi,A., Juric,I., Hu,M.,
            Shen,Y., Dickel,D.E., Visel,A., Pennachio,L.A., Hawrylycz,M.,
            Thompson,C.L., Zeng,H., Barozzi,I., Nord,A.S. and Rubenstein,J.L.
  TITLE     Transcriptional network orchestrating regional patterning of
            cortical progenitors
  JOURNAL   Proc Natl Acad Sci U S A 118 (51) (2021)
   PUBMED   34921112
REFERENCE   6  (bases 1 to 3284)
  AUTHORS   Bushdid,P.B., Osinska,H., Waclaw,R.R., Molkentin,J.D. and
            Yutzey,K.E.
  TITLE     NFATc3 and NFATc4 are required for cardiac development and
            mitochondrial function
  JOURNAL   Circ Res 92 (12), 1305-1313 (2003)
   PUBMED   12750314
REFERENCE   7  (bases 1 to 3284)
  AUTHORS   Wilkins,B.J., De Windt,L.J., Bueno,O.F., Braz,J.C., Glascock,B.J.,
            Kimball,T.F. and Molkentin,J.D.
  TITLE     Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic
            defect in calcineurin-mediated cardiac hypertrophic growth
  JOURNAL   Mol Cell Biol 22 (21), 7603-7613 (2002)
   PUBMED   12370307
  REMARK    GeneRIF: NFATc4 is not regulated by calcineurin and is not
            essential for hypertrophic growth
REFERENCE   8  (bases 1 to 3284)
  AUTHORS   Yang,T.T., Xiong,Q., Enslen,H., Davis,R.J. and Chow,C.W.
  TITLE     Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases
  JOURNAL   Mol Cell Biol 22 (11), 3892-3904 (2002)
   PUBMED   11997522
  REMARK    GeneRIF: Phosphorylation of NFATc4 by p38 mitogen-activated protein
            kinases.
REFERENCE   9  (bases 1 to 3284)
  AUTHORS   Graef,I.A., Chen,F., Chen,L., Kuo,A. and Crabtree,G.R.
  TITLE     Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the
            developing vasculature
  JOURNAL   Cell 105 (7), 863-875 (2001)
   PUBMED   11439183
REFERENCE   10 (bases 1 to 3284)
  AUTHORS   Graef,I.A., Gastier,J.M., Francke,U. and Crabtree,G.R.
  TITLE     Evolutionary relationships among Rel domains indicate functional
            diversification by recombination
  JOURNAL   Proc Natl Acad Sci U S A 98 (10), 5740-5745 (2001)
   PUBMED   11344309
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ067971.1, AK159078.1 and AW493556.1.
            
            On Dec 2, 2009 this sequence version replaced NM_023699.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC028928.1, AK159078.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-154               CJ067971.1         2-155
            155-3265            AK159078.1         1-3111
            3266-3284           AW493556.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..3284
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 28.19 cM"
     gene            1..3284
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /note="nuclear factor of activated T cells, cytoplasmic,
                     calcineurin dependent 4"
                     /db_xref="GeneID:73181"
                     /db_xref="MGI:MGI:1920431"
     exon            1..342
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     CDS             243..2948
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     nuclear factor of activated T-cells, cytoplasmic 4;
                     transcription complex subunit NF-ATc4; NF-AT3; T-cell
                     transcription factor NFAT3"
                     /codon_start=1
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     4 isoform 1"
                     /protein_id="NP_076188.3"
                     /db_xref="CCDS:CCDS27132.1"
                     /db_xref="GeneID:73181"
                     /db_xref="MGI:MGI:1920431"
                     /translation="MGAASCEDEELEFKLVFGEEKEPPPLGPGGPGEELDSEDTPPCC
                     RLALGEPLPYGAAPIGIPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGNA
                     GGAGGGRVLECPSIRITSISPTPDPPTSLEDTSETWGDGSPRDYPPPEGFGGYREAGG
                     QGGGAFFSPSPGSSSLSSWSFFSDASDEAALYAACDEVESELNEAASRFGLSSPLPSP
                     RASPRPWTPEDPWSLYGPSSGGRAPEDSWLLLSAPGPVPASPRPASPCGKRRYSSSGT
                     PSSASPALSRRGSLGEEGPEPPPPPPLPLVRDPSSPGPFDYVGAPPTESIPQKTRRTS
                     SEQAVALPRSEEPPSCNGKLPSGTEDSVAAPGALRKEVAGMDYLAVPSPLAWSKARIG
                     GHSPIFRTSALPPLDWPLPSQYEQLELRIEVQPRAHHRAHYETEGSRGAVKAAPGGHP
                     VVKLLGYSEKPLTLQMFIGTADERSLRPHAFYQVHRITGKMVATASYEAVVSGTKVLE
                     MTLLPENNMAANIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHVPQGGGKVV
                     SVQAASVPIECSQRSAQELPQVETYSPSACSVRGGEELVLTGSNFLPDSKVVFIERGP
                     DGKLQWEEEAAVNRLQSSEVTLTLTIPEYSNKRVSRPVQVYFYVSNGRRKRSPTQSFK
                     FLPVVFKEEPLPDSSLRGFPSTSGPPFGPDVDFSPPRPPYPSYPHEDPAYETPYLSEG
                     FGYSTPALYPQTGPPPSYRSGLRMFPETGGTTGCARLPSVSFLPRPFPGDQYGGQGSS
                     FALGLPFSPPAPFRPPLPSSPPLEDPFHPQSAIHPLPPEGYNEVGPGYTPGEGASEQE
                     KARGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPARPGEEPPA"
     exon            343..1438
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1601
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1801
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1974
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..2115
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2171
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2298
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..2880
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     exon            2881..3267
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3245..3250
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /note="hexamer: AATAAA"
     polyA_site      3267
                     /gene="Nfatc4"
                     /gene_synonym="3110041H08Rik; Nfat3"
                     /note="major polyA site"
ORIGIN      
        1 ggtgcatccc gggtaaccaa tcagagacag gctggggggg ggccgctttg aagaagtttg
       61 ggagaaaaaa gtttggaaaa gtttctataa taacgagggg gcgtccggag ggaggcggca
      121 gcgacagaag agggggcgtc tcagagaaag ggagggaggg agctaccctc gcgtgaagct
      181 acagcagcgt ccagagcttc cccctcccac ccaggcggga cctgggggct ccggccggat
      241 ccatgggggc cgcaagctgc gaggatgagg agctggaatt taagctggtg ttcggagagg
      301 aaaaggagcc ccccccgctg ggccctgggg gtcctgggga agagctggac tcagaggata
      361 cccctccatg ctgtcgtttg gccctggggg aaccccttcc ttatggtgct gcccctattg
      421 ggattccccg acccccaccc cctcggccag ggatgcactc accaccgccc cgtcccgccc
      481 cttcacctgg cacctgggag agccagccag ctaggtcggt gaggctgggg ggcccaggag
      541 gtaatgcagg gggtgctggg ggtggtcgtg ttcttgagtg tcccagcatc cggattacct
      601 ccatctctcc cacgcctgac ccgccgacct cgctagagga cacatctgaa acttgggggg
      661 acggctctcc tagagattac cctccaccag aaggctttgg gggctatcga gaggctggag
      721 gtcagggcgg aggcgctttc ttcagcccga gccctggcag cagcagcctg tcttcgtgga
      781 gcttcttctc ggacgcctcc gacgaggcag ccctgtatgc agcgtgcgac gaggtggagt
      841 ctgaacttaa tgaagcagcc tcccgttttg gcttgagctc tccgctgccc tcgccccggg
      901 cttctcctag gccatggacc ccggaggatc cctggagcct atacggtcca agctcgggag
      961 gccgagcgcc agaggatagc tggctactcc tcagcgctcc tgggcccgtc ccagcctccc
     1021 ctcggcctgc ttctccctgc ggcaagcggc gctattccag ttccggaacc ccatcttcgg
     1081 cctccccagc tttgtcccgc cgaggcagcc ttggggaaga aggtccagag ccacctccac
     1141 cacccccgtt gcctctggtc cgggacccta gttcccctgg cccttttgac tatgtgggtg
     1201 ctccaccaac cgagagcatc cctcagaaaa ctcggaggac ttctagcgag caagcagtgg
     1261 ccctgcctcg gtctgaagag cctccctcgt gcaatgggaa gctaccctcc ggtacagagg
     1321 actctgtggc tgctccgggg gctctgcgga aagaggtggc cggcatggat tacctagcag
     1381 tgccttctcc ccttgcttgg tccaaggccc ggattggggg acacagcccc atcttcagga
     1441 cctctgccct acctcccctg gactggcctt tacccagcca gtatgagcag ctggagctga
     1501 ggatcgaggt acagcctaga gcacaccacc gagctcacta tgagactgag ggcagccggg
     1561 gggctgtcaa ggctgctcct ggaggccacc ctgtggtcaa gctcctaggc tacagtgaga
     1621 agccattgac tctgcagatg ttcattggca ctgcagatga gaggagcctg cggccccatg
     1681 ccttctacca ggtgcaccgg attactggca agatggtggc tacagccagc tatgaagctg
     1741 tagtcagtgg taccaaagtg ttggagatga ccttactccc agagaacaac atggctgcca
     1801 acattgactg tgctggaatc ctgaagcttc gaaattcaga cattgagcta cggaagggtg
     1861 agacagacat cgggcgcaaa aacacgcgtg tgcggctggt gttccgtgtg cacgtgcctc
     1921 agggcggcgg gaaggtcgtg tctgtgcagg cagcatcagt gcccatcgag tgctcccagc
     1981 gctcggccca ggagctgccc caggtggaga cctacagccc cagtgcctgc tctgtgagag
     2041 gaggggagga gctagtgttg actggttcca acttcctgcc agactctaaa gtggtgttca
     2101 ttgagagggg tcctgatgga aaactgcagt gggaggaaga ggcagcggtg aaccgactgc
     2161 agagcagtga ggtgacattg actctcacca tccccgagta cagcaacaag cgggtgtccc
     2221 gaccagtcca ggtctacttt tacgtctcca atggacggag gaagcgcagt cctacccaaa
     2281 gtttcaagtt cctacctgtg gtcttcaagg aggagcccct accagactca tctctccggg
     2341 gcttcccttc cacatcgggt cccccctttg gccctgacgt ggacttctca ccgcccaggc
     2401 ccccttaccc ctcctatccc catgaagacc ctgcttatga gactccttat ctgtcagaag
     2461 gctttggtta tagcacaccc gctctgtacc cccagacggg gcccccaccg tcctatagat
     2521 ctggcctgcg gatgttccct gagactgggg gtaccacagg ttgtgcccgc ctaccttcag
     2581 tctctttcct tccgcgcccc tttcctggtg atcaatatgg aggacagggc tcctcttttg
     2641 ccctggggct tccattctcc cctccagccc cctttaggcc gccactgcct tcctccccac
     2701 cactcgaaga ccccttccat ccccagagtg ccatccaccc cttacctcct gagggctaca
     2761 atgaggtggg gccaggctat acccctgggg agggggcttc ggagcaggag aaagccaggg
     2821 gtggctacag cagcggcttc agagacagtg tacctatcca gggtatcacc ctggaggaag
     2881 tgagtgagat cattggccga gacctgagtg gcttccctgc acgtcctgga gaagagcctc
     2941 ctgcctgaac cacatgtagt ggtccccgaa gccccaccgc cttgccctct taactggggt
     3001 gctggctcca gaagcttggg gccaactcta gtttctccta gcccagcttc tagcttcctg
     3061 ttttcccttt ctctcccagc aaaggtgtga cccccaggcc tggtgctgcc ttggaaggga
     3121 ctaagggtgt gggggacagg ggatgagggt ggagcctgag gctggaggcc agaactgact
     3181 gggctgaaca tgatgtcctg atcgtgcagg ccgtgatgct aacaggctgg acaggttgat
     3241 gggtaataaa ctgctcgctg accagtgaaa aaaaaaaaaa aaaa
//
