LOCUS       NM_010900               3389 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus nuclear factor of activated T cells, cytoplasmic,
            calcineurin dependent 2 interacting protein (Nfatc2ip), transcript
            variant 1, mRNA.
ACCESSION   NM_010900
VERSION     NM_010900.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3389)
  AUTHORS   Koch,S., Knipfer,L., Kolle,J., Mirzakhani,H., Graser,A.,
            Zimmermann,T., Kiefer,A., Melichar,V.O., Rascher,W.,
            Papadopoulos,N.G., Rieker,R.J., Raby,B.A., Weiss,S.T., Wirtz,S. and
            Finotto,S.
  TITLE     Targeted deletion of NFAT-Interacting-Protein-(NIP) 45 resolves
            experimental asthma by inhibiting Innate Lymphoid Cells group 2
            (ILC2)
  JOURNAL   Sci Rep 9 (1), 15695 (2019)
   PUBMED   31666531
  REMARK    GeneRIF: Targeted deletion of NFAT-Interacting-Protein-(NIP) 45
            resolves experimental asthma by inhibiting Innate Lymphoid Cells
            group 2 (ILC2).
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3389)
  AUTHORS   Lucitti,J.L., Sealock,R., Buckley,B.K., Zhang,H., Xiao,L.,
            Dudley,A.C. and Faber,J.E.
  TITLE     Variants of Rab GTPase-Effector Binding Protein-2 Cause Variation
            in the Collateral Circulation and Severity of Stroke
  JOURNAL   Stroke 47 (12), 3022-3031 (2016)
   PUBMED   27811335
REFERENCE   4  (bases 1 to 3389)
  AUTHORS   Hashiguchi,K., Ozaki,M., Kuraoka,I. and Saitoh,H.
  TITLE     Establishment of a human cell line stably overexpressing mouse
            Nip45 and characterization of Nip45 subcellular localization
  JOURNAL   Biochem Biophys Res Commun 430 (1), 72-77 (2013)
   PUBMED   23159618
  REMARK    GeneRIF: Under standard, non-stressful conditions, FLAG-mNip45
            diffusely distributed in the nucleus.
REFERENCE   5  (bases 1 to 3389)
  AUTHORS   Shanmugarajan,S., Haycraft,C.J., Reddy,S.V. and Ries,W.L.
  TITLE     NIP45 negatively regulates RANK ligand induced osteoclast
            differentiation
  JOURNAL   J Cell Biochem 113 (4), 1274-1281 (2012)
   PUBMED   22105856
  REMARK    GeneRIF: results indicate that RANKL signaling down regulates NIP45
            expression and that NIP45 is a negative regulator of osteoclast
            differentiation
REFERENCE   6  (bases 1 to 3389)
  AUTHORS   Bettelli,E., Dastrange,M. and Oukka,M.
  TITLE     Foxp3 interacts with nuclear factor of activated T cells and
            NF-kappa B to repress cytokine gene expression and effector
            functions of T helper cells
  JOURNAL   Proc Natl Acad Sci U S A 102 (14), 5138-5143 (2005)
   PUBMED   15790681
REFERENCE   7  (bases 1 to 3389)
  AUTHORS   Mowen,K.A., Schurter,B.T., Fathman,J.W., David,M. and Glimcher,L.H.
  TITLE     Arginine methylation of NIP45 modulates cytokine gene expression in
            effector T lymphocytes
  JOURNAL   Mol Cell 15 (4), 559-571 (2004)
   PUBMED   15327772
  REMARK    GeneRIF: Data report a role for arginine methylation of NIP45 in
            regulating cytokine gene transcription in the T helper lymphocyte.
REFERENCE   8  (bases 1 to 3389)
  AUTHORS   Lieberson,R., Mowen,K.A., McBride,K.D., Leautaud,V., Zhang,X.,
            Suh,W.K., Wu,L. and Glimcher,L.H.
  TITLE     Tumor necrosis factor receptor-associated factor (TRAF)2 represses
            the T helper cell type 2 response through interaction with
            NFAT-interacting protein (NIP45)
  JOURNAL   J Exp Med 194 (1), 89-98 (2001)
   PUBMED   11435475
REFERENCE   9  (bases 1 to 3389)
  AUTHORS   Rengarajan,J., Mittelstadt,P.R., Mages,H.W., Gerth,A.J.,
            Kroczek,R.A., Ashwell,J.D. and Glimcher,L.H.
  TITLE     Sequential involvement of NFAT and Egr transcription factors in
            FasL regulation
  JOURNAL   Immunity 12 (3), 293-300 (2000)
   PUBMED   10755616
REFERENCE   10 (bases 1 to 3389)
  AUTHORS   Hodge,M.R., Chun,H.J., Rengarajan,J., Alt,A., Lieberson,R. and
            Glimcher,L.H.
  TITLE     NF-AT-Driven interleukin-4 transcription potentiated by NIP45
  JOURNAL   Science 274 (5294), 1903-1905 (1996)
   PUBMED   8943202
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC125322.4.
            
            On Oct 14, 2022 this sequence version replaced NM_010900.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK030107.1, BC113761.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-382               AC125322.4         54913-55294         c
            383-455             AC125322.4         54499-54571         c
            456-579             AC125322.4         49828-49951         c
            580-660             AC125322.4         49220-49300         c
            661-847             AC125322.4         48943-49129         c
            848-992             AC125322.4         46169-46313         c
            993-1102            AC125322.4         45959-46068         c
            1103-3389           AC125322.4         41410-43696         c
FEATURES             Location/Qualifiers
     source          1..3389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.01 cM"
     gene            1..3389
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /note="nuclear factor of activated T cells, cytoplasmic,
                     calcineurin dependent 2 interacting protein"
                     /db_xref="GeneID:18020"
                     /db_xref="MGI:MGI:1329015"
     exon            1..382
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            383..455
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            456..579
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            580..660
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            661..847
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            848..992
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1102
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..3389
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3364..3369
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /note="hexamer: AATAAA"
     polyA_site      3389
                     /gene="Nfatc2ip"
                     /gene_synonym="D7Ertd304e; NIP45"
                     /note="major polyA site"
ORIGIN      
        1 gtttgtggaa gcagtgtggg agatggcgga accactgagg ggacgtggtc cgaggtcccg
       61 cggtggccga ggcgctcgga gagcccgagg cgcccgtggc cggtgtcctc gcgcccggca
      121 gtctccggct aggctcattc cagacaccgt gcttgtggac ttggtcagtg acagcgacga
      181 agaggtcttg gaagtcgcag acccagtaga ggtgccggtc gcccgcctcc ccgcgccggc
      241 taaacctgag caggacagcg acagtgacag tgaaggggcg gccgaggggc ctgcgggagc
      301 cccgcgtaca ttggtgcgac ggcggcggcg gcggctgctg gatcccggag aggcgccggt
      361 ggtcccagtg tactccggga aggtacagag cagcctcaac ctcattccag ataattcatc
      421 cctcttgaaa ctgtgccctt cagagcctga agatgaggca gatctgacaa attctggcag
      481 ttctccctct gaggatgatg ccctgccttc aggttctccc tggagaaaga agctcagaaa
      541 gaagtgtgag aaagaagaaa agaaaatgga agagtttccg gaccaggaca tctctccttt
      601 gccccaacct tcgtcaagga acaaaagcag aaagcatacg gaggcgctcc agaagctaag
      661 ggaagtgaac aagcgtctcc aagatctccg ctcctgcctg agccccaagc agcaccagag
      721 tccagccctt cagagcacag atgatgaggt ggtcctagtg gaagggcctg tcttgccaca
      781 gagctctcga ctctttacac tcaagatccg gtgccgggct gacctagtga gactgcctgt
      841 caggatgtcg gagccccttc agaatgtggt ggatcacatg gccaatcatc ttggggtgtc
      901 tccaaacagg attcttttgc tttttggaga gagtgaactg tctcctactg ccacccctag
      961 taccctaaag cttggagtgg ctgacatcat tgattgtgtg gtgctagcaa gctcttcaga
     1021 ggccacagag acatcccagg agctccggct ccgggtgcag gggaaggaga aacaccagat
     1081 gttggagatc tcactgtctc ctgattctcc tcttaaggtt ctcatgtcac actatgagga
     1141 agccatggga ctctctggac acaagctctc cttcttcttt gatgggacaa agctttcagg
     1201 caaggagctg ccagctgatc tgggcctgga atccggagat ctcatcgaag tctggggctg
     1261 aagctctcac cctgttcgga cgcaaagcca agacatggag acaatagctc ccaattttat
     1321 tattgtgatt tttcgcccca taagggctaa cagaaactga attagaactt gtttacttat
     1381 ttatttctgg tgctggggat tgaaccccag actatgcaca tgctaaggat gtatgaagtg
     1441 gaggcaaaac caaggcatta cctttagcca gcctctagta gactgtagtg tcaagcaagt
     1501 ggctacttgg tagttgtgtg gctctgtgta tgtttgtgct gtatttggca gcccctgggg
     1561 cacatagaag ggaccttggc ttccctacca tttcacgttc gctggtgccc tttccttcat
     1621 cagatgactt ctgtgaagct gcctatgttg agtgtgttga actaaatgag ctctgctttg
     1681 ggtgtccagg cctggggttt gtgccgcagt tggagccagc agtgacttca ctctgacttg
     1741 ggactgagaa tgcatttcct ggtggagaca ctcgggtgca gaaatataac agaaggtgac
     1801 atacatgctg aagctgagga ctaggtcgaa agttaacgac gttgcatttt cagccttggg
     1861 tatcctctct gcctgccagg actctagcca gtgtctggta cacacttctt ggcatggaca
     1921 cctagccata atcaaataca tagagccgtt gagtgttaga tcactctagt tctcggtctt
     1981 cctccctcac gctctctctc tccagttagt acctatctgg gatattggta cctttggata
     2041 tgaatgtcct tataagaaaa tattctgaac acatgtggtt ttactgtata cacacggagt
     2101 tgtgcaatag atagtctgtc ttcagtcaga atgagtaaca gtctagccat gttagcgcct
     2161 tctaggtccg tcgttgcttg gatctctgtg ggtgccacat agtggcatta gatgctttta
     2221 ctcacacatt gccttaaggg ggatgcccaa gtctccagct ccttgggacc atattccagg
     2281 ccacagcaaa catctttcat gtgtcccctt tgggcctggg taggtctttc tttggtgtgc
     2341 ttgtccaggc tgggactgtg gcttatacag gttctttttt cttggggctt ctctttcctt
     2401 atctttacca gcatttggcg ctgttgaaat cctgattttg gcagtcagtg tgtataaagc
     2461 accacatatc ttaatatccc tttatctgaa gaccatttct tacgcatggc caccttctgg
     2521 tttttctttg tcagctgctg tattctcggg aggcggcttc ctcttgcttg tgtttccttt
     2581 ccttgaggag ttgcttgtgt tctgggcggt tgcaaaaacc ctcagaacag cactttgtgt
     2641 atccagggga ttttcaccaa acatacattc ttaattttaa tgtatacagt tggcttttgt
     2701 taggaagttt tgttttgatt ttttgttttt aagggaaaat acaaaggagc ttccagagtg
     2761 ggggcggggg gtggggtggg ggtgggggcg gtagtggaga atctcaggat tgatacgttt
     2821 gggtttccaa gctagtttaa gagactttga ttttcttctt ttagctccat agttttttgt
     2881 tcttttgttt ttttttgttt ttgttttgtt ttgttttgtt ttgttttgtt ttgttttttt
     2941 ctctcatatt gagaccacta gatgagacta gagttctaac tggtctactc tggtgtaggt
     3001 agattgttct gagccctcta cccaggttct cactggttgc tgctgggctc ctgactattg
     3061 tgtgttactt ataaactgtc taaaatgcac ctttgtgccg gagaacaagt tgtattttgt
     3121 ttttaattat aacgagccag ttttctaagc tttgtctact aaaacaaaat aaaaacatta
     3181 tagtctgatt ttcacaaaag tatgccaact cccttttttt gtgagaatat atgccattcc
     3241 tttgactttt gtaacatttt taaaaatcca tgatatagta tagcttccag gtttttcagc
     3301 tcttgtatgc ccattggtta gtaagtctga acacactatt atgtatccat ccaatctcaa
     3361 ctgaataaag ggagatgcct tttggagca
//
