LOCUS       NM_001164111            4315 bp    mRNA    linear   ROD 04-MAR-2025
DEFINITION  Mus musculus nuclear factor of activated T cells, cytoplasmic,
            calcineurin dependent 1 (Nfatc1), transcript variant 6, mRNA.
ACCESSION   NM_001164111
VERSION     NM_001164111.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4315)
  AUTHORS   Feng,W., Hong,N., Wu,Y., Huang,J., Zhang,Q., Liu,G., Qian,Z.,
            Chen,Y., Jin,L., Ding,X., Zhao,P., Chen,A.F. and Yu,Y.
  TITLE     Deficiency of Sox7 leads to congenital aortic stenosis via abnormal
            valve remodeling
  JOURNAL   J Mol Cell Cardiol 199, 81-94 (2025)
   PUBMED   39746830
REFERENCE   2  (bases 1 to 4315)
  AUTHORS   Yamashita,Y., Hayashi,M., Liu,A., Sasaki,F., Tsuchiya,Y.,
            Takayanagi,H., Saito,M. and Nakashima,T.
  TITLE     Fam102a translocates Runx2 and Rbpjl to facilitate Osterix
            expression and bone formation
  JOURNAL   Nat Commun 16 (1), 9 (2025)
   PUBMED   39747056
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4315)
  AUTHORS   Komatsu,K., Ideno,H., Nakashima,K., Udagawa,N., Kobayashi,Y.,
            Kimura,H., Tachibana,M., Yamashita,T. and Nifuji,A.
  TITLE     The G9a histone methyltransferase represses osteoclastogenesis and
            bone resorption by regulating NFATc1 function
  JOURNAL   FASEB J 38 (13), e23779 (2024)
   PUBMED   38967255
  REMARK    GeneRIF: The G9a histone methyltransferase represses
            osteoclastogenesis and bone resorption by regulating NFATc1
            function.
REFERENCE   4  (bases 1 to 4315)
  AUTHORS   Kim,J.M., Kim,H.K., Cho,H.J., Moon,S.A., Kim,Y., Hong,J.Y.,
            Lee,S.H., Kim,K. and Koh,J.M.
  TITLE     Extracellular C1qbp inhibits myogenesis by suppressing NFATc1
  JOURNAL   Sci Rep 14 (1), 15678 (2024)
   PUBMED   38977785
  REMARK    GeneRIF: Extracellular C1qbp inhibits myogenesis by suppressing
            NFATc1.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4315)
  AUTHORS   Jagga,S., Hughes,A., Manoochehri Arash,N., Sorsby,M., Brooks,D.J.,
            Divieti Pajevic,P. and Liu,E.S.
  TITLE     NFATc1 Is Required for Vitamin D- and Phosphate-Mediated Regulation
            of Osteocyte Lacuno-Canalicular Remodeling
  JOURNAL   Endocrinology 165 (8) (2024)
   PUBMED   39024412
  REMARK    GeneRIF: NFATc1 Is Required for Vitamin D- and Phosphate-Mediated
            Regulation of Osteocyte Lacuno-Canalicular Remodeling.
REFERENCE   6  (bases 1 to 4315)
  AUTHORS   Pan,S., Koyano-Nakagawa,N., Tsuruta,L., Amasaki,Y., Yokota,T.,
            Mori,S., Arai,N. and Arai,K.
  TITLE     Molecular cloning and functional characterization of murine cDNA
            encoding transcription factor NFATc
  JOURNAL   Biochem Biophys Res Commun 240 (2), 314-323 (1997)
   PUBMED   9388475
REFERENCE   7  (bases 1 to 4315)
  AUTHORS   Liu,J., Koyano-Nakagawa,N., Amasaki,Y., Saito-Ohara,F., Ikeuchi,T.,
            Imai,S., Takano,T., Arai,N., Yokota,T. and Arai,K.
  TITLE     Calcineurin-dependent nuclear translocation of a murine
            transcription factor NFATx: molecular cloning and functional
            characterization
  JOURNAL   Mol Biol Cell 8 (1), 157-170 (1997)
   PUBMED   9017603
REFERENCE   8  (bases 1 to 4315)
  AUTHORS   Xanthoudakis,S., Viola,J.P., Shaw,K.T., Luo,C., Wallace,J.D.,
            Bozza,P.T., Luk,D.C., Curran,T. and Rao,A.
  TITLE     An enhanced immune response in mice lacking the transcription
            factor NFAT1
  JOURNAL   Science 272 (5263), 892-895 (1996)
   PUBMED   8629027
  REMARK    Erratum:[Science 1996 Sep 6;273(5280):1325]
REFERENCE   9  (bases 1 to 4315)
  AUTHORS   Ho,S.N., Thomas,D.J., Timmerman,L.A., Li,X., Francke,U. and
            Crabtree,G.R.
  TITLE     NFATc3, a lymphoid-specific NFATc family member that is
            calcium-regulated and exhibits distinct DNA binding specificity
  JOURNAL   J Biol Chem 270 (34), 19898-19907 (1995)
   PUBMED   7650004
REFERENCE   10 (bases 1 to 4315)
  AUTHORS   Li,X., Ho,S.N., Luna,J., Giacalone,J., Thomas,D.J., Timmerman,L.A.,
            Crabtree,G.R. and Francke,U.
  TITLE     Cloning and chromosomal localization of the human and murine genes
            for the T-cell transcription factors NFATc and NFATp
  JOURNAL   Cytogenet Cell Genet 68 (3-4), 185-191 (1995)
   PUBMED   7842733
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB647702.1 and EU887569.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: EU887569.1, SRR13422601.213332.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                BB647702.1         2-56
            56-4315             EU887569.1         1-4260
FEATURES             Location/Qualifiers
     source          1..4315
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 53.66 cM"
     gene            1..4315
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /note="nuclear factor of activated T cells, cytoplasmic,
                     calcineurin dependent 1"
                     /db_xref="GeneID:18018"
                     /db_xref="MGI:MGI:102469"
     exon            1..140
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..2497
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /note="isoform 6 is encoded by transcript variant 6;
                     transcription factor NF-ATc; NF-ATc1; NFAT transcription
                     complex cytosolic component; nuclear factor of activated
                     T-cells, cytoplasmic 1"
                     /codon_start=1
                     /product="nuclear factor of activated T-cells, cytoplasmic
                     1 isoform 6"
                     /protein_id="NP_001157583.1"
                     /db_xref="CCDS:CCDS89286.1"
                     /db_xref="GeneID:18018"
                     /db_xref="MGI:MGI:102469"
                     /translation="MTGLEQDPEFDFDFLFEFDQSGGGAAAAEHYSYVSPSVTSTLPL
                     PTAHSALPAACHDLQTSTPGISAVPSANHPPSYGGAVDSGPSGYFLSSGNTRPNGAPT
                     LESPRIEITSYLGLHHGSGQFFHDVEVEDVLPSCKRSPSTATLHLPSLEAYRDPSCLS
                     PASSLSSRSCNSEASSYESNYSYPYASPQTSPWQSPCVSPKTTDPEEGFPRSLGACHL
                     LGSPRHSPSTSPRASITEESWLGARGSRPTSPCNKRKYSLNGRQPSCSPHHSPTPSPH
                     GSPRVSVTEDTWLGNTTQYTSSAIVAAINALTTDSTLDLGDGVPIKSRKTALEHAPSV
                     ALKVEPAGEDLGTTPPTSDFPPEEYTFQHLRKGAFCEQYLSVPQASYQWAKPKSLSPT
                     SYMSPSLPALDWQLPSHSGPYELRIEVQPKSHHRAHYETEGSRGAVKASAGGHPIVQL
                     HGYLENEPLTLQLFIGTADDRLLRPHAFYQVHRITGKTVSTTSHEIILSNTKVLEIPL
                     LPENNMRAIIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPNGRTLSLQ
                     VASNPIECSQRSAQELPLVEKQSTDSYPVIGGKKMVLSGHNFLQDSKVIFVEKAPDGH
                     HVWEMEAKTDRDLCKPNSLVVEIPPFRNQRITSPVQVSFYVCNGKRKRSQYQRFTYLP
                     ANVPIIKTEPTDDFEPALTCGPMSQGISPLPRPYYSQQLTMPPDPGSCLVAGFAPCSQ
                     RNTLMPTPPNASPKLHDLSSPAYTKGLTNPGHSGHLGLQPPASEAPTMQEVPRPMAIQ
                     PNSPEQPPSARLQPQ"
     exon            141..1242
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1402
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1605
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..1778
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1779..1919
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..1975
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2108
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2109..2494
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     exon            2495..4315
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2972..2977
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /note="hexamer: ATTAAA"
     polyA_site      2993
                     /gene="Nfatc1"
                     /gene_synonym="2210017P03Rik; NF-ATc; NFAT2; NFATc;
                     Nfatcb"
                     /note="major polyA site"
ORIGIN      
        1 gtcacgccgg ggacgcgcgc gagcgccggg cgcaccagtg ccgcgcgacc ccgacatgac
       61 ggggctggag caggacccgg agttcgactt cgatttcctc ttcgagttcg atcagagcgg
      121 cgggggcgcc gcggccgcag aacactacag ttatgtgtcc cctagtgtca cctcgaccct
      181 gccccttccc acagcacact ctgccttgcc agcagcatgc cacgacctcc agacgtccac
      241 cccgggtatc tcagctgttc cttcagccaa tcatcccccc agttacggag gggctgtgga
      301 cagcgggcct tcgggatact tcctgtcctc tggcaacacc agacccaacg gggccccgac
      361 tctggagagt ccgagaatcg agatcacctc ctacctgggc ctacaccatg gcagcggcca
      421 gtttttccac gacgtggagg tggaagacgt acttcctagc tgcaagcgct caccgtctac
      481 agcaaccctg cacctgccca gcctggaagc ctacagagac ccctcctgcc tgagcccagc
      541 cagcagtctc tcctccagaa gctgtaactc tgaggcctcc tcctacgagt ccaactactc
      601 ctacccatac gcgtcccccc agacctctcc gtggcagtca ccctgcgtgt ctcccaagac
      661 cacggacccg gaggagggtt ttccccgaag cctgggtgcc tgccacctgc taggatcgcc
      721 caggcactcc ccatccacct ctcctcgggc aagcatcacg gaggagagct ggctcggtgc
      781 ccgcggctcc cggcccacgt ccccctgcaa caagcgcaag tacagtctca atggccggca
      841 gccctcctgc tcaccccacc actcacccac accatccccc catggctccc ctcgggtcag
      901 tgtgaccgaa gatacctggc tcggtaacac cacccagtat accagctctg ccattgtggc
      961 agccatcaac gccctgacca ccgatagcac tctggacctg ggtgatgggg tccctatcaa
     1021 gtctcgaaag acagcactgg agcatgcgcc ctctgtggcc ctcaaagtag agccagctgg
     1081 ggaagacctg ggcaccactc cacccacttc tgacttccca cccgaggagt acaccttcca
     1141 gcaccttcgg aagggtgcct tttgcgagca gtatctgtcg gtgccacagg cctcgtatca
     1201 gtgggcgaag cccaagtctc tttccccgac atcatatatg agcccatcct tgcctgccct
     1261 tgactggcag ctcccgtcac attctggtcc atacgagctt cggatcgagg tgcagcccaa
     1321 gtctcaccac agggctcact atgagacgga aggcagccgg ggggctgtga aggcttcagc
     1381 tggaggacac cccattgtgc agctacacgg ttacttggag aatgaacctc tcacgctaca
     1441 gctgttcatt gggacggctg acgaccgcct gctgaggccc cacgccttct accaggtcca
     1501 ccggatcacg gggaagactg tctccaccac cagccacgag atcatcctgt ccaacaccaa
     1561 agtcctggag atcccgttgc ttccagaaaa taacatgcga gccatcatcg actgtgctgg
     1621 gatcctgaag ctcagaaact ctgatattga gctgaggaaa ggggagacag acatcgggag
     1681 gaagaacacc agggtgaggc tggtcttccg agttcacatc ccacagccca atggccggac
     1741 gctgtctctc caggtggcct cgaaccctat cgagtgttcc cagcggtcag cccaggagct
     1801 gcccctcgtg gagaagcaga gcacagacag ctacccagtc atcggcggga agaagatggt
     1861 gctgtctggc cataactttc tgcaagactc caaagtcatt ttcgtggaga aggctccaga
     1921 tggccaccac gtctgggaga tggaagcaaa gactgaccgg gacctgtgca agccaaattc
     1981 cctggtggtt gagataccac ctttccgcaa ccagaggata accagccccg tccaagtcag
     2041 tttctatgtc tgcaacggga aacggaagag aagccagtac cagcgtttca cgtaccttcc
     2101 tgccaatgtt ccaattataa agacagaacc cacggacgac tttgagccag ctctgacctg
     2161 tggaccaatg agccagggga ttagtcctct gccgaggcct tactacagcc aacagctcac
     2221 catgcctccc gaccccggct cctgcctcgt ggctggcttc gccccctgct cccagaggaa
     2281 cacgctgatg cccacgcctc ccaacgcaag cccgaagctc cacgaccttt cctctcctgc
     2341 ctacaccaag ggcctcacca acccgggcca cagtggtcac cttggacttc agccacccgc
     2401 ttcggaggcc cccaccatgc aggaagtgcc gagacccatg gccatccaac ccaactcgcc
     2461 tgagcagccc ccatccgcca ggctacagcc gcagtaaatg agatcatacg taacgacctc
     2521 tccagcacga tcccccactc ctaattcagc acatcggagc tggcagaagc tgtgaggagt
     2581 tggctcagtg cagacaaccg cgcttcagca agcgagactt tgatgagata aactggaccc
     2641 acatctggta ccactcagaa atcccaactt accgaacgaa cggaacgcta ggagcttatg
     2701 tctgaagaag tagctctcca acagggacgg aggagcagga gagggcccac tgcatctcct
     2761 gaaagaaaca ccatctcaag gaacgagaag ggctggtcag tgaggccagg ggcagacgct
     2821 ggtccaccgt gtggcagact gtccccaagc ctgaccctcc tgcccactgg atcaaaacac
     2881 tggaagtgcc ttatttagtc tgaccacacc agggcatatg gaagtgagca ctgaattttc
     2941 taccatgaga gtatttgtgg gagccaaagc tattaaagaa cacttcctta ggaggtttta
     3001 tcttttgtat taattgatag gattctgaag agcctcctgc gtatctctag cttttctggc
     3061 tgccctacac aatttgcctg ccttatccag tgcattttag aggtcttcca gcctgtcttc
     3121 ttggctctct catagtcagc cccctcctct gtgtgactga aaccacaggt ctgttaataa
     3181 tagcatgcta ggattcttgt tctcaatcca gcttcgaaca tagtgaagga agtcgaacag
     3241 cacaaggcag ggtcctggac agaacaaaac ctgcctgcta caggacagag cttgtgtttg
     3301 catgcatgta catataggca tatatttatg tatagatatc caaggacaga ggtggcaatg
     3361 agcagtctgt gcccaccagg ggccttcctt ccatgttagc aataaccagt atccaccttg
     3421 agagtgcacc tcagagtcca gaaccggctt cccaccatca tggtctttcc ttccatcagg
     3481 gtctacctct ggacaggcag gtggcctttt cttgcctcac gcagtgactg agcactccag
     3541 agctgtgctc aaatgcccat cagctaccaa atggcaaaat ctgaaagtgg ttgtaaataa
     3601 ccattacaga atgagtgtag tatatttgtt caattataag attattcttt cacagaagcc
     3661 ttatagctct ctgcttcatc taagaaaaca attaccaaaa aaaacaacgt ttctaactgc
     3721 aatctgtgaa ctgtgcgttt tcagattggt tactggtaac agataagctg gtgtctgctc
     3781 tgtgtaatta gctgcttact tcagttacta gcagtgacct attatttctt ataaccaaaa
     3841 aaagcatggt ttaattaaaa catgtttaat gatcgtgcct taggagttaa tgccccctta
     3901 tggaacacgc ctgaattgca cctgtggctg gaagttttaa gttactccca gacagatgga
     3961 ctcatgacag gaaaagctct ctcacaggaa gatgcatctt taaaattttt gtcagtctgt
     4021 atgatggtgg cttacctttc ccaacgcaca gaaagaaaca actgtctgaa agcatactga
     4081 atgatttcgc acgactgtga agagctggcg cgaactgcct tgtacacaca tagctcctgg
     4141 ccgcctgcag gctgcctccc gcctgcctct cgtctgtacc ccatgtttat tagcatcatg
     4201 gagttgcatg aaccattctt agtagactgt catctgaaag caagcgtttg atatttgtgt
     4261 cagctatctt tgtagttagg agatgaatcc aataaagcag tatttttttt ctttt
//
