LOCUS       NM_018823              13389 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus nuclear factor of activated T cells 5 (Nfat5),
            transcript variant b, mRNA.
ACCESSION   NM_018823
VERSION     NM_018823.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 13389)
  AUTHORS   Xu,F., Bian,N. and Li,X.
  TITLE     SNHG14 Elevates NFAT5 Expression Through Sequestering miR-375-3p to
            Promote MPP + -Induced Neuronal Apoptosis, Inflammation, and
            Oxidative Stress in Parkinson's Disease
  JOURNAL   Neurochem Res 49 (5), 1212-1225 (2024)
   PUBMED   38381247
  REMARK    GeneRIF: SNHG14 Elevates NFAT5 Expression Through Sequestering
            miR-375-3p to Promote MPP + -Induced Neuronal Apoptosis,
            Inflammation, and Oxidative Stress in Parkinson's Disease.
REFERENCE   2  (bases 1 to 13389)
  AUTHORS   Couasnay,G., Garcia,H. and Elefteriou,F.
  TITLE     A comparative analysis of TonEBP conditional knockout mouse models
            reveals inter-dependency between compartments of the intervertebral
            disc
  JOURNAL   Development 151 (6) (2024)
   PUBMED   38421307
  REMARK    GeneRIF: A comparative analysis of TonEBP conditional knockout
            mouse models reveals inter-dependency between compartments of the
            intervertebral disc.
REFERENCE   3  (bases 1 to 13389)
  AUTHORS   Li,M., Kim,Y.M., Koh,J.H., Park,J., Kwon,H.M., Park,J.H., Jin,J.,
            Park,Y., Kim,D. and Kim,W.U.
  TITLE     Serum amyloid A expression in liver promotes synovial macrophage
            activation and chronic arthritis via NFAT5
  JOURNAL   J Clin Invest 134 (5), e167835 (2024)
   PUBMED   38426494
  REMARK    GeneRIF: Serum amyloid A expression in liver promotes synovial
            macrophage activation and chronic arthritis via NFAT5.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 13389)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 13389)
  AUTHORS   Palahati,A., Luo,Y., Qin,L., Duan,Y., Zhang,M., Gan,H. and Zhai,X.
  TITLE     TonEBP: A Key Transcription Factor in Microglia Following
            Intracerebral Hemorrhage Induced-Neuroinflammation
  JOURNAL   Int J Mol Sci 25 (3), 1438 (2024)
   PUBMED   38338716
  REMARK    GeneRIF: TonEBP: A Key Transcription Factor in Microglia Following
            Intracerebral Hemorrhage Induced-Neuroinflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 13389)
  AUTHORS   Stroud,J.C., Lopez-Rodriguez,C., Rao,A. and Chen,L.
  TITLE     Structure of a TonEBP-DNA complex reveals DNA encircled by a
            transcription factor
  JOURNAL   Nat Struct Biol 9 (2), 90-94 (2002)
   PUBMED   11780147
  REMARK    GeneRIF: Structure of the NFAT5/TonEBP DNA binding domain bound to
            a TonE DNA element. The structure shows DNA encirclement by two
            dimerization interfaces: (1) at the TIG domain similar to NF-kappaB
            family members, and (2) at the DNA recognition domain.
REFERENCE   7  (bases 1 to 13389)
  AUTHORS   Tian,W. and Cohen,D.M.
  TITLE     Urea inhibits hypertonicity-inducible TonEBP expression and action
  JOURNAL   Am J Physiol Renal Physiol 280 (5), F904-F912 (2001)
   PUBMED   11292634
REFERENCE   8  (bases 1 to 13389)
  AUTHORS   Pan,S., Tsuruta,R., Masuda,E.S., Imamura,R., Bazan,F., Arai,K.,
            Arai,N. and Miyatake,S.
  TITLE     NFATz: a novel rel similarity domain containing protein
  JOURNAL   Biochem Biophys Res Commun 272 (3), 765-776 (2000)
   PUBMED   10860829
REFERENCE   9  (bases 1 to 13389)
  AUTHORS   Hebinck,A., Dalski,A., Engel,H., Mattei,M., Hawken,R., Schwinger,E.
            and Zuhlke,C.
  TITLE     Assignment of transcription factor NFAT5 to human chromosome
            16q22.1, murine chromosome 8D and porcine chromosome 6p1.4 and
            comparison of the polyglutamine domains
  JOURNAL   Cytogenet Cell Genet 90 (1-2), 68-70 (2000)
   PUBMED   11060450
REFERENCE   10 (bases 1 to 13389)
  AUTHORS   Lopez-Rodriguez,C., Aramburu,J., Rakeman,A.S., Copeland,N.G.,
            Gilbert,D.J., Thomas,S., Disteche,C., Jenkins,N.A. and Rao,A.
  TITLE     NF-AT5: the NF-AT family of transcription factors expands in a new
            direction
  JOURNAL   Cold Spring Harb Symp Quant Biol 64, 517-526 (1999)
   PUBMED   11233530
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK045123.1, AF200687.1, AF369980.1, AC158364.4 and BE633760.1.
            
            On Dec 27, 2007 this sequence version replaced NM_018823.1.
            
            Transcript Variant: This variant (b) encodes the longest isoform
            (b).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849375,
                              SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-395               AK045123.1         2-396
            396-5018            AF200687.1         31-4653
            5019-5033           AF369980.1         4720-4734
            5034-13159          AC158364.4         150719-158844
            13160-13389         BE633760.1         1-230
FEATURES             Location/Qualifiers
     source          1..13389
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 53.93 cM"
     gene            1..13389
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /note="nuclear factor of activated T cells 5"
                     /db_xref="GeneID:54446"
                     /db_xref="MGI:MGI:1859333"
     exon            1..429
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..5015
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /note="isoform b is encoded by transcript variant b;
                     tonicity-responsive enhancer binding protein; T-cell
                     transcription factor NFAT5; rel domain-containing
                     transcription factor NFAT5"
                     /codon_start=1
                     /product="nuclear factor of activated T-cells 5 isoform b"
                     /protein_id="NP_061293.2"
                     /db_xref="CCDS:CCDS22648.2"
                     /db_xref="GeneID:54446"
                     /db_xref="MGI:MGI:1859333"
                     /translation="MPSDFISLLSADLDLESPKSLYSRDSLKLHPSQTFHRAGLLEES
                     VYDLLPKELQLPPPRETSVASMSQTSGGEAGSPPPAVVAADASSAPSSSSMGGACSSF
                     TTSSSPTIYSTSVTDSKAMQVESCSSAVGVSNRGVSEKQLTGNTVQQHPSTPKRHTVL
                     YISPPPEDLLDNSRMSCQDEGCGLESEQSCSMWMEDSPSNFSNMSTSSYNDNTEVPRK
                     SRKRNPKQRPGVKRRDCEESNMDIFDADSAKAPHYVLSQLTTDNKGNSKAGNGTLDSQ
                     KGTGVKKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGFPTV
                     KLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIEGTTVIEVGLDP
                     SNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARLVFRVNITRKDGSTLTLQTP
                     SSPILCTQPAGVPEILKKSLHSCSVKGEEEVFLIGKNFLKGTKVIFQENVSDENSWKS
                     EAEIDMELFHQNHLIVKVPPYHDQHITLPVSVGIYVVTNAGRSHDVQPFTYTPDPAAG
                     ALNVNVKKEISSPARPCSFEEAMKAMKTTGCNVDKVTILPNALITPLISSSMIKTEDV
                     TPMEVTSEKRSSPIFQTTKSIGSTQQTLETISNIAGGAPFSSPSSSSHLTPESENQQQ
                     LQPKAYNPETLTTIQTQDISQPGTFPAVSAASQLPSSDALLQQATQFQTREAQSRDTI
                     QSDTVVNLSQLTEASQQQQSPLQEQAQTLQQQIPSNIFPSPSSVSQLQSTIQQLQAGS
                     FTGSAAGGRSGSVDLVQQVLEAQQQLSSVLFSTPDGNENVQEQLNADIFQVSQIQNSV
                     SPGMFSSAESAVHTRPDNLLPGRADSVHQQTENTLSNQQQQQQQQQQVMESSAAMVME
                     MQQSICQAAAQIQSELFPSAASASGSLQQSPVYQQPSHMMSALPTNEDMQMQCELFSS
                     PPAASGNETSTTTTPQVATPGSTMFQTPSSGDGEETGAQAKQIQNSVFQTMVQMQRSG
                     DSQPQVNLFSSTKNIMSVQNNGTQQQGNSLFQQGSEMMSLQSGNFLQQSSHSQAQLFH
                     PQNPIADAQNLSQETQGSIFHSPNPIVHSQTSTASSEQLQPSMFHSQNTIAVLQGSSV
                     PQDQQSPNIFLSQSSINNLQTNTVAQEEQISFFAAQNSISPLQSTSNTEQQAAFQQQP
                     PISHIQTPILSQEQAQPSQQGLFQPQVALGSLPPNPMPQNQQGPIFQTQRPIVGMQSN
                     SPSQEQQQQQQQQQQQQQQQQQQQQSILFSNQNAMATMASQKQPPPNMMFSPNQNPMA
                     SQEQQNQSIFHQQSNMAPMNQEQQPMQFQNQPTVSSLQNPGPTQSESPQTSLFHSSPQ
                     IQLVQGSPSSQDQQVTLFLSPASMSALQTSINQPDMQQSPLYSPQNNIPGIQGSTSSP
                     QPQATLFHNTTGGTINQIQNSPGSSQQTSGMFLFGIQNNCSQLLTSGPATLPDQLMAI
                     NQQGQPQNEGQSSVTTLLSQQMPETSPLASSVNSSQNMEKIDLLVSLQSQGNNLTGSF
                     "
     exon            430..483
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            484..609
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            610..1168
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1361
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1362..1552
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1725
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1860
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..1913
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2046
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2127
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2128..2276
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            2277..4779
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            4780..5021
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     exon            5022..13381
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      13353..13358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /note="hexamer: AATAAA"
     polyA_site      13374
                     /gene="Nfat5"
                     /gene_synonym="B130038B15Rik; CAG-8; CAG80; mKIAA0827;
                     NFATL1; nfatz; OREBP; TonEBP"
                     /note="major polyA site"
ORIGIN      
        1 agattcctgt cagcggcgcc ggcggtggcg gcggccgtca gtgtgcgctg aggagaagcc
       61 cgaaacggac ccgtttggct ctccctcttc ccctttcccc ggtccgaagc ttctggtctc
      121 tggactcacc gggagtcagt tctccactcc gcagagctgt tccctccact ccgccgccct
      181 tctcatcgct cggccgggtg ggaagtgact gccctcgagg aggaggagga ggcagcggct
      241 gccgccctcg cctcaccgcc cccggttcgg tgcccgcgga tcccggagag gaggtgccgc
      301 cgccaccgcc gctccccccc tcccgctgcc ctcgggccgg gctgggtcga gctgcgatgc
      361 cctcggactt catctcattg ctcagcgcgg acctagacct ggaatcgccc aagtccctgt
      421 actcgcgaga ttctctgaag ttacacccat cacagacttt tcatagagct ggactattgg
      481 aagaatctgt ctatgatctt ctcccaaagg agttacagtt acctccacct agagaaacat
      541 ctgtagcatc aatgagtcag acaagcggtg gtgaggcagg ctcgcctcct ccagctgtag
      601 ttgctgctga tgcttcttca gctccctcct cttcctccat gggcggtgct tgcagctcct
      661 ttaccacctc ttccagccct accatttatt ctacctcagt caccgacagc aaggctatgc
      721 aagtggagag ctgctcctca gccgtggggg taagtaacag aggggtaagt gaaaagcagt
      781 taaccggtaa cacagttcag cagcatccat caaccccgaa gaggcacaca gttttgtaca
      841 tctcaccacc acctgaggac ttgctggata acagtcggat gtcctgccag gatgaggggt
      901 gtggattgga atctgagcag agctgcagta tgtggatgga ggattccccc tccaacttca
      961 gtaacatgag caccagttcc tacaatgata acactgaggt acctcgtaaa tcacgaaaac
     1021 gaaatccaaa gcagaggccg ggggtcaaac gacgagattg tgaagaatct aatatggata
     1081 tatttgatgc cgacagtgcc aaagcacctc actatgtgct ttctcagctt accacggaca
     1141 acaaaggcaa ctcaaaagct ggaaatggaa cattggacag ccaaaaggga actggagtaa
     1201 agaagagccc tatgttgtgc ggacagtatc cggttaaaag tgaggggaag gagctgaaga
     1261 tagtggtaca gcctgaaacc caacaccgag cccggtacct gacagagggc agccgaggct
     1321 ctgtaaaaga cagaacacag caaggctttc ctacggtgaa gctggaaggc cataatgaac
     1381 cagtggtgtt gcaggtattt gtgggcaatg attctggtcg agtaaaacca catggattct
     1441 atcaggcctg tagagtaact gggcgaaata caactccctg caaagaagtg gacattgaag
     1501 gtaccactgt tatagaagtt ggtcttgatc ctagcaacaa catgacactg gcggtggact
     1561 gtgttggaat attgaagctg aggaatgccg atgttgaagc cagaattgga attgctggat
     1621 ctaagaaaaa gagcactcgt gccagattgg tttttcgagt taatatcaca aggaaagatg
     1681 gctctactct gacattgcag acaccttctt cccccatttt atgcactcag ccagcaggag
     1741 ttcctgagat cttaaagaaa agcttgcata gctgttcagt gaaaggagag gaagaagtat
     1801 ttttaattgg gaaaaacttt ctgaaaggaa ctaaagttat tttccaggaa aatgtttctg
     1861 atgaaaactc ttggaaatca gaagctgaaa ttgacatgga gttattccat cagaaccatc
     1921 ttattgtgaa ggttcctccg tatcatgacc aacatataac tttgcctgta tcagtgggaa
     1981 tatatgttgt gaccaatgct ggaagatctc atgatgttca gccatttacg tacactccgg
     2041 atccagcagc tggtgctttg aatgtaaatg tgaaaaagga gatatctagt ccagcaagac
     2101 cttgctcttt tgaagaagcc atgaaagcaa tgaaaacgac tggatgtaac gtagataagg
     2161 tgactatcct tcctaatgcc ctgatcactc cactcatatc aagcagtatg attaagactg
     2221 aagatgttac tccaatggaa gtaacttcag aaaaaagatc ttccccaatt tttcagacta
     2281 caaagagcat tggatcaacc cagcaaacct tagaaactat ttctaacata gcggggggtg
     2341 cacccttctc ctcaccgtcg tcatcttccc acttaactcc tgaaagtgag aatcagcagc
     2401 agcttcagcc caaggcatac aacccagaga ccctgacaac tatccagaca caggacatct
     2461 cacagcccgg gacctttccc gcagtttctg ctgctagtca gctgcccagc agcgatgcac
     2521 tactgcagca ggcaacacag tttcagacaa gagaagctca gtccagagac acaatacagt
     2581 cagatacagt ggttaacttg tcacagttaa ctgaagcatc acagcagcag caatccccac
     2641 tacaagaaca agcacaaacg ttacagcagc agataccatc aaatattttt ccatcgccaa
     2701 gcagtgtcag ccagctccag agtactattc agcagctgca agcaggaagt ttcacaggca
     2761 gcgctgctgg cggcaggagt ggaagcgttg atttggtcca gcaggtttta gaggcacaac
     2821 agcagttatc gtctgttctg ttttctactc cagatgggaa tgagaatgtt caagaacagc
     2881 ttaatgcaga cattttccaa gtcagtcaaa ttcaaaatag tgtaagccct ggaatgtttt
     2941 cttcagcgga gtctgcagtt cacactagac cagataactt actacctggg agggctgaca
     3001 gcgtccatca acagactgaa aatacactgt ctaatcagca gcagcagcaa cagcagcagc
     3061 agcaagtgat ggagtcatca gctgcaatgg tgatggagat gcagcagagc atttgccaag
     3121 cagctgccca gatccagtca gagctgtttc cttcagctgc ttcagcaagt ggaagccttc
     3181 agcagtctcc agtttaccag cagccttctc acatgatgag tgcactgcct accaacgagg
     3241 acatgcagat gcagtgtgag ctgttctcgt ctccccctgc agcttctgga aacgaaactt
     3301 ccacaaccac cacgccacag gtggcaaccc ctggctccac catgtttcag acaccaagtt
     3361 caggagatgg agaagaaact ggagcacaag caaaacagat tcagaacagc gtctttcaga
     3421 caatggtcca aatgcagcgc agtggtgaca gccaacctca agtaaacctc ttttcatcta
     3481 caaaaaatat aatgagtgtt cagaataatg gtacccagca acaagggaat agcttgttcc
     3541 agcaagggag cgagatgatg tcacttcagt ctgggaactt tttgcagcag tcctctcatt
     3601 cacaggctca gctctttcat cctcaaaatc ctattgctga tgctcagaac ctttcccagg
     3661 aaactcaagg ttcaattttt catagtccaa atcctattgt ccacagtcaa acttccacag
     3721 catcctctga acaactgcag ccttcaatgt ttcactctca gaataccatt gctgtgttac
     3781 agggctcttc agttcctcaa gaccagcagt cacccaacat atttctttcc caaagttcta
     3841 tcaataatct tcaaactaac acagtagccc aagaagagca gatttcattt tttgcagcac
     3901 agaactcaat ttctccactt cagtcaacat caaacactga gcagcaagct gctttccaac
     3961 agcagcctcc aatctcacac atccagaccc ctattctttc ccaggaacag gcacaaccct
     4021 ctcagcaagg gttatttcag cctcaggtgg cccttggctc cctgcctcct aatccaatgc
     4081 ctcaaaacca gcaaggtcca attttccaaa cacagcgccc aatagttggc atgcagagta
     4141 actctccatc ccaggagcag cagcagcagc aacagcagca acagcagcag cagcaacagc
     4201 aacaacaaca gcaacagagc attttattca gtaatcagaa tgccatggct acaatggcct
     4261 cccagaagca gccaccacca aacatgatgt ttagcccaaa ccagaaccca atggctagtc
     4321 aggagcagca gaaccagtca atttttcacc agcaaagtaa tatggcccca atgaaccaag
     4381 agcagcagcc catgcaattt cagaatcagc ctacggtttc ctcacttcag aacccaggtc
     4441 ctacgcagtc tgagtcacca cagacctcct tgttccatag ctctcctcag atccagttgg
     4501 ttcaagggtc acctagttct caagatcagc aagtaacact cttcctctct ccagcatcca
     4561 tgtctgcatt gcaaaccagt ataaaccaac cagacatgca gcagtctcct ctttattccc
     4621 cgcagaacaa catccctgga atccaaggaa gcacttcttc accccagcca caggctactt
     4681 tatttcacaa cactacagga ggcacaataa accaaataca aaattctcct ggctcatctc
     4741 agcagacttc aggaatgttc ttatttggca ttcaaaataa ttgtagtcag cttttaacct
     4801 ccggaccagc tacattgcca gatcagctga tggccataaa tcagcagggc caaccacaaa
     4861 atgagggcca atcttctgtg acaacacttc tttctcagca aatgccagag acttccccac
     4921 tggcctcctc tgtgaacagc agtcagaaca tggaaaagat tgatttgctt gtttcattgc
     4981 aaagccaagg gaacaattta accggctcct tttagtgaga taaattccat gaagaattct
     5041 gtaacagtga ttccaagata tcctgagaac tgtggttcca taaagattat tgaactctgg
     5101 tgaagaacta tgtttgagta aatggataga tttcctggct ataagagtac acccatgctg
     5161 cctgttgcag tgatttgcca ccaatgtgct ttttgtttct aataacagtg atgactgaga
     5221 gcctgttaga ttttccagct gacagcattg ttgcttgtgt cctctgtttg taactgcaag
     5281 gctgggcctc tcagttatta ttgctattag gaaatcatat ttgtcatgtt tacttatatt
     5341 cttacttcct ttcctgcatt attttaatca agtagtggct taggacaacg taaagtccag
     5401 tagtgactaa ggctgtgctt ttgttgatgt aaaaaacgtg gctgttggcc aaagtgaagg
     5461 agtttctttt agttttcatg gagaagctga aggagtaatt tagctgtatt aggaactctg
     5521 cagatctgag gactcctcct cacacacaca agcagatgac atgcctgcaa aactggttac
     5581 agctgggaag ttattgagtt catttttcag agagttgtta gttctctgta tttctactaa
     5641 gggatttagc cataactgca taaaaatatt ttgttctatg aaaatgaagg gggtgatata
     5701 tgatgtgtta cgttctcata gtctcctccg gtagcttaaa ctgacagtac tttgagcctg
     5761 ttgtcttctt gcccagcgtt aggctagtat tcccttctta tgtgcatcac ctgtattgtg
     5821 ttgtctgcat tttttcttcg tagttttatt aatattctac tggctttctg accctgtagg
     5881 aattagagaa ggcagccaca ttgatccagt gacctggcag tcagcagcac aggccaggaa
     5941 tactctttta ggagttattg ggatttgatt cctgggaaaa aaccattctc tttttttctt
     6001 ccatgaacgg tgctgttctg aagtcttcaa aattctccct ctgctgataa atagcagtat
     6061 acattttaat tttacaaaca aggcaaacaa acatttctca aactattact tctccccacg
     6121 ctgcagtgac tgtttacatg tcagtcagct cagtgcttta cagttgaagt ggtcacttac
     6181 atgatggttc ccacagcctt gggctccaca gggtcatagc attgatttaa aaggaagagt
     6241 taactgtgtt gcatctacag agagcaaaat tacacactcc agaacttgca tttgtagcat
     6301 tagttgtaga gttttgggtg tccttaccac ccgtgggatg cctgcttctc actaccacct
     6361 acatctggac acgtgcttat gtctcattta tctttggcat gtgggaagtg tcaatgcagc
     6421 gttagcccat catgtatgca gcttctatat gttgacatgc tttggtttcc tgttcaattc
     6481 ttttactttc taagctttta aaaattagcc agttcatggt tgttgccttt ttccttactt
     6541 ttcctttcag tttttctccc cctatcctcc acatgtgttg aactgtgtgg agcttggtgt
     6601 tggtttagtt tatatggcca gatcctgctt tgggactctt cctttgttat ttgactgtgg
     6661 ttcttgtcat ctgtttcttc tctttgtcct tctccctctg ccctggccct tcctttccct
     6721 ctctgagagg cattggatta cgttttcagt agtacaggct tcttgccaat atgaagggaa
     6781 ctttccagaa agagacctac tctggtcatt taattttgaa aacagttttc aatcgttcaa
     6841 gttttggatg gtttatatct aatgtgtgtt tcattttttt ggaaagctat attttatatt
     6901 taggaaatgg tatactattt tgctatttgt actaagtgag tacattggca taaatataga
     6961 aatttatata tatatatata tatacatata taaactattc ttttttgcca cacatttttg
     7021 tggtaaattt gtgagtttgt ctgatgttct accacaacgt ggcgtctgat aacagtgagg
     7081 ggggtttgtt atgtctttct tgagtattta agcacctttt gaagcaaatg gcctgtttat
     7141 ctgtagccat tccatcaggc agttcctcga tgttattagg gagctgaagg gcgactgact
     7201 gtgtgtttgc tggatcttca ctcagtgaga tgttaaagcg caaggaaatt catttgaggc
     7261 agtgtgtcaa atggtgtttg acaagaatga gccactctgt ctttgttcac tatatattta
     7321 atattttatt attgttgttg ttgttgttat taattggctt tctgtatcct atgcctttta
     7381 tttataaaga cactaaaaaa aaaccatgtt tgtaatttta ataacatttc cccatctttt
     7441 aatatccaga gctactttat aaattctcta aaccaaaagt atttcctcaa gatctccttt
     7501 ctccccccag ttcctatagg gaaaaatcac ccaacatagt tcgggttaca agaagggtca
     7561 gccacacaat tcagtgcttc agttttaaaa gtaaaacaga cagacactag agtgttgtcc
     7621 agagcatcat agaaagcaga cctagcagat ttaggaaaaa cagaagtcaa agtttaatac
     7681 cacatttact tctgagtttt ctgaattact ttgtgagatc atgtagaaga ctcaggaaat
     7741 ctgtttcttc accaagatca agttagaatg tttgacactg ccatgctggg gatgacgtgg
     7801 cagcaggaag cctggctcgt gtggtggctt ctggtcgttc tggactagca gcttatcctt
     7861 ataaaatgct gattggcaat gccaagtcac cgggaccaat ttctgtttta taatgtttaa
     7921 gtttagaaca gaacatcacc tgaactgtag tgctttgaga ggatggaggt ggaaaccccc
     7981 attttcagtc tcatcacttc tgtggttatt tatacaaggg ctgtgctgtg ctaccatatt
     8041 cctgctcgaa tatgatggag tttgtttatt ttctcgcatt gttaaatgtt ccttgcccct
     8101 aaaggtccat gttaagaaca atgttctgaa tatatgattt ggttacaaaa agtatgtctt
     8161 cttattgaag agttagctca gtggttgata tttgtgctaa gatgcagctt cccagttact
     8221 gttacaagtt acagctgcca atgggaagac tcaataagcc agcaaaggcc ttgaaaatca
     8281 tgatttatta aatttatatc tggcagaagg acctaaataa actgtgaact acattgtatt
     8341 cctttgttac atttggctct tgctttcagc aattcacaga aatgcttgga gctctctctc
     8401 tctctctctc tctctctctc tctctctctc tctctctctc tctctctgtc tctcccctcc
     8461 cttcctctct ccctttccct ctccctctct gtccccctcc ctctctccct ccctctacat
     8521 cctttccttc ctctctccct ttccctctcc ctttccctct ctctctccct ctctccctcc
     8581 ctctctactc tcccactaca tccttccctt tctctctccc tctttccctc ccttcctctt
     8641 tccatccaca cacacctctg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     8701 tgtgtgtatg tgtgtgtgtg tgtatgcaag ttattccttc ttgtcatttc acaccaagga
     8761 gaagatatta catacttttt tcctaagcat tgctgtggac ttttctgatt ctagcatcat
     8821 gttgctattt ggtatttagc cattgtagac ctgtcttacc cttagaccaa gtgttaaaag
     8881 ggcttttatt aatagaagca gtattaacaa gaggcctctt tctttccctc ccattctccc
     8941 atcctttctt gccccctctt tgtataatat tgtgagttat aatttataat tgcattatag
     9001 tagatttatt gcctatcaga attttgacta atgtacccag aaaaaataga aggaagaaat
     9061 tgtgcatctg tcccttcaga attaaaggga caattccttt tgaccttttg agtgtttgtt
     9121 tttatttttt cagcaaggtt gcagtatcct gcccaagtcc tgggcctgct ggtatgaagc
     9181 accttaccgg gacccctttt ttaaaccagt ataaatgctt gttttgggaa aatgaaatct
     9241 gtcagcaaat aagaaccaaa actgaataat tctttttttt taattattat tatttttgta
     9301 ttttttctgt acattgacac tgtcttcaga caccagagga gggcattgga tcccattaca
     9361 aatggttttg agccagcaag tggttgctgg gaattgaact caggacctct gggaaagcaa
     9421 tcagttctct taaccactgt gccatctctt cggctcctga ataattctta aattcagcag
     9481 agttatactt actcacaggg gttagcctga gaatttttca ttttcctagt aaaatttttt
     9541 gttatcccta tttcctgatt gttaattagt tgaaagttat gggagaactt gtggctttac
     9601 tttgcatctc tagcacaggc tctatctcta accaaaatga ccactttata tctgggtcct
     9661 ttgggttacc tggaggggct cagtgaaaga gaaaaactaa ttcaatagac atacgagaaa
     9721 aataacccag gccttgagga gtggctcaga ggtagagagt ttatgtagca tgcgcaaggc
     9781 cctgaatttg gtccccagca ccaccaaaag ggagagagag atcttgggta cacgtgctag
     9841 caagaggatt agcactcacc cattcatcac acatactgag agctttccca ttctgcctac
     9901 ttttgtcact agagctaaac tgaaggtgac attcatgatg caggagattg actctcttca
     9961 gtatatgtaa attatcccaa taccctaatt actttctaac tgtctgtcta ttttcatgcc
    10021 atgctaagcc tcatattaat aaagttctgt ttttactgct cttgctcttc aggcaatttt
    10081 ttacattaat attttatatg tagattaaat gttatggaaa agtgcctttt taccatgcca
    10141 gtgccccctt ctttagtata tgtgctgcca aagcaagcac cgtgccccct tcttaaaaac
    10201 ttcaccttcc actattgcca aaattctgtg aacaactggt tttatcaggt cccaacttgt
    10261 actttttcca tgtgaccatt attttctcca tttcttggtc accataggag ataaccttgt
    10321 cagttccttt gacttaaaaa taatagagaa agtgctttgg cagaattgct tgggaaagta
    10381 agtgcacact gttcaggctt gtgtgaatct aatttcctca tcccaacaaa ttatagatgg
    10441 ctatcacctg aataagaaca aaaataaaca tttggctgtc tgtgagactt catgcacaaa
    10501 aatgtgtgtt aaatgttata aaggcactac tcaacagcct cttctcagat cctaattagc
    10561 tgggggtggg ggggaacagt cactaaaact taggttttgt aaggcctgga ggtaacattg
    10621 ggtttttttc cttaattaaa tgtgacaaag tagtttattt cttatctatc tgaacttcag
    10681 ttaattgact ttagaaaact taatgtcaga aaaaacttag aagtcatttg agtggggggg
    10741 gggggagagc taaagtaatg ttttagtctc agatacagtt gggttgagtg tcctggtttt
    10801 gtccattttg tttctgatcc aactctttat ggtggtgctt gaagaaagag acatcagcat
    10861 caaattcagg acagtagtaa cttaaactcc acaacaaagg tgtgttcccc atgcaagtat
    10921 gattgtaact gttggtggac tgaagatagc atagttatgc agtatttgta atactctatt
    10981 gtgcacttta atcattccaa aaaaagccaa gaatacatct taactattca gaatactgca
    11041 tatttatttt ggatatatgg cttggtgtgt taggttcctg cttaattaaa gtaacttaca
    11101 ataagtttga aattactatt ttctaaagga cttaagacct tgaaatgtag ctgtagggaa
    11161 atgactatat tttgcagacc attttagaaa tagtaaaatt tgactggctg atgagtatgt
    11221 cggagagcta cttagaacca ttccccttcc ttcgtgtccc ttatataaga atgctatagt
    11281 gtatagtttc tacccctgtg gtttatgcaa accagtatgg tcctctgccc agcagctagc
    11341 tgatgcagta tgagcaggga actagttaaa ggtgcacatt cttgggcagt agcccaggca
    11401 tactgaatta gatctgaagt ggggcccagc agtctgtcta acccaagtcc ccagtgagtc
    11461 cagtgcatcc ttagtttcag agccactcta acggatgagt tctatctagt gaaagccaga
    11521 gaatttcttc ccacttttaa gagataatta tttcttcttt gtgtatattc agccttacct
    11581 ggttatctgt gatcatttct caacaataat aatttattct cagtactgcc taagaaatgc
    11641 atgtgtttta tgtatataca gtgtagttat tgataattca tttaacttag tttggcattt
    11701 ccctaccact gactaaaaag tttacattaa ctgactgatt tcaatatata ggtgcaatgt
    11761 tctgtatttc tttaattgtt gtgacactta cttagctaaa ataattgatg ggtgctacag
    11821 tctcctgttt atgcataaca tgggtacatt gtgggcagtg taatacaagc tttctctttg
    11881 ttgcctctta atttaccagc aggccatggt tttgctcttg gctagaccag ctctcagaac
    11941 agaattgcca ttccatacca tttttcttgt atctgagatc tcagatagat ggctagccag
    12001 gccaacatag caccttattt aatttcttct cttaatagat tcttttcaag tagcttactt
    12061 ggcatttgaa cagtgcagtc aagtgatggt tctccttgga actcacactt caggtgaagt
    12121 acttaacaaa atgataagac agtgcatttt ataatttggg tatccccttt ctcagttgtg
    12181 tgcatcttaa taaatacaag ctaagcaggt ttattttttt cctttagaat tcagcacttc
    12241 catcatcctt ccactgttta caaatcgctg atgagttaac tcatgataga gagattcact
    12301 tttcagaata aaactaactg aatacttgct ttctgagaat cactgcttct gtaccacact
    12361 agcagtgcta agtggcttac tctacaaact ggtgctggaa agtaagtagg caagctgttg
    12421 ggatgctgta gagaccccct cccttcccct tctgtcactg gatacagagc attctacaca
    12481 atttatttaa ccaaggtttg taacacctcc tttaaagatc ctgcattcaa cccatgtcac
    12541 ccctacctgc tctctcacat tggtccttcc ctttcccagg aacccacccc agcagtaata
    12601 atatgcatgg tttgtagggg tggcctattg ttactatttt agctagtgag cctcaggaaa
    12661 gcttacactc acacataacc ccagacgctt gcaagtgagt tgagaatcaa acttctgtga
    12721 cctggctgga gttagagttc agcgacagag cctttgtaca cacaaggccc aaggtaggtg
    12781 taatccctgg taccaaagag agacagacag acagacagag ctgtcctgta tcgaagtgat
    12841 cacaatttca ctcattagag accttctgca gtgcaattga actaacccct tctctctaat
    12901 gaatgtatct gttcaccttg ttccctctaa ggataagctc caagtgattg ctgctttcct
    12961 ggcaacttga ctgagtttca ctctcttctt ttacttcctg ttttaatgag taacttggaa
    13021 tatttcatta acatgttctc aagtgattta gctgccattc tgccattttg agttttgttt
    13081 aattttatct gcttgagcac actgatcaac cactgacctg ccttcttgca ttgtcctgca
    13141 gtgacgtaag agtgacattg tgtatacggc ttcatagttg gaatttcaga gcactgacac
    13201 cagatattct cagtttgttc tctgggggaa tttcatttgc atctatgttt ttagctatct
    13261 gtgataactt gttaaatatt aaaaagatat tttgcttcta ttggaacatt tgtatactcg
    13321 caattatatt tctgtaaaca gctgcagtca aaaataaaac attgaaagtt ttcattttgc
    13381 aaaaaaaaa
//
