LOCUS       NM_001271411            3962 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus Nfat activating molecule with ITAM motif 1 (Nfam1),
            transcript variant 1, mRNA.
ACCESSION   NM_001271411
VERSION     NM_001271411.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3962)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3962)
  AUTHORS   Gupta,N., Soriano-Ubeda,C., Stein,P., Savy,V., Papas,B.N.,
            Ardestani,G., Carvacho,I., Alfandari,D., Williams,C.J. and
            Fissore,R.A.
  TITLE     Essential role of Mg2+ in mouse preimplantation embryo development
            revealed by TRPM7 chanzyme-deficient gametes
  JOURNAL   Cell Rep 42 (10), 113232 (2023)
   PUBMED   37824328
REFERENCE   3  (bases 1 to 3962)
  AUTHORS   Zhu,J., Chen,Z., Peng,X., Zheng,Z., Le,A., Guo,J., Ma,L., Shi,H.,
            Yao,K., Zhang,S., Ge,J., Zheng,Z. and Wang,Q.
  TITLE     Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell
            Maturation and Cardiac Inflammation via miR-342-3p/NFAM1
  JOURNAL   Oxid Med Cell Longev 2022, 8392313 (2022)
   PUBMED   35615580
  REMARK    GeneRIF: Extracellular Vesicle-Derived circITGB1 Regulates
            Dendritic Cell Maturation and Cardiac Inflammation via
            miR-342-3p/NFAM1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3962)
  AUTHORS   Juchem,K.W., Gounder,A.P., Gao,J.P., Seccareccia,E., Yeddula,N.,
            Huffmaster,N.J., Cote-Martin,A., Fogal,S.E., Souza,D., Wang,S.S.,
            Glynn,E.R.A., Yung,I., Ritchie,J., Li,L., Zheng,J., Mbow,M.L.,
            Li,J. and Chanda,S.K.
  TITLE     NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and
            Human Monocytes
  JOURNAL   Front Immunol 12, 773445 (2022)
   PUBMED   35095847
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3962)
  AUTHORS   Ray,J.P., Staron,M.M., Shyer,J.A., Ho,P.C., Marshall,H.D.,
            Gray,S.M., Laidlaw,B.J., Araki,K., Ahmed,R., Kaech,S.M. and
            Craft,J.
  TITLE     The Interleukin-2-mTORc1 Kinase Axis Defines the Signaling,
            Differentiation, and Metabolism of T Helper 1 and Follicular B
            Helper T Cells
  JOURNAL   Immunity 43 (4), 690-702 (2015)
   PUBMED   26410627
REFERENCE   6  (bases 1 to 3962)
  AUTHORS   Ohtsuka,M., Arase,H., Takeuchi,A., Yamasaki,S., Shiina,R.,
            Suenaga,T., Sakurai,D., Yokosuka,T., Arase,N., Iwashima,M.,
            Kitamura,T., Moriya,H. and Saito,T.
  TITLE     NFAM1, an immunoreceptor tyrosine-based activation motif-bearing
            molecule that regulates B cell development and signaling
  JOURNAL   Proc Natl Acad Sci U S A 101 (21), 8126-8131 (2004)
   PUBMED   15143214
  REMARK    GeneRIF: NFAM1 modulates B cell signaling through its
            immunoreceptor tyrosine-based activation motif, which regulates B
            cell development
REFERENCE   7  (bases 1 to 3962)
  AUTHORS   Yang,J., Hu,G., Wang,S.W., Li,Y., Martin,R., Li,K. and Yao,Z.
  TITLE     Calcineurin/nuclear factors of activated T cells (NFAT)-activating
            and immunoreceptor tyrosine-based activation motif
            (ITAM)-containing protein (CNAIP), a novel ITAM-containing protein
            that activates the calcineurin/NFAT-signaling pathway
  JOURNAL   J Biol Chem 278 (19), 16797-16801 (2003)
   PUBMED   12615919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133880.7 and AK150635.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK151187.1, AK150635.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-91                AC133880.7         66715-66805
            92-3962             AK150635.1         1-3871
FEATURES             Location/Qualifiers
     source          1..3962
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 39.01 cM"
     gene            1..3962
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /note="Nfat activating molecule with ITAM motif 1"
                     /db_xref="GeneID:74039"
                     /db_xref="MGI:MGI:1921289"
     exon            1..285
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /inference="alignment:Splign:2.1.0"
     CDS             168..962
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; calcineurin/NFAT-activating ITAM-containing
                     protein; NFAT activation molecule 1"
                     /codon_start=1
                     /product="NFAT activation molecule 1 isoform a precursor"
                     /protein_id="NP_001258340.1"
                     /db_xref="CCDS:CCDS70652.1"
                     /db_xref="GeneID:74039"
                     /db_xref="MGI:MGI:1921289"
                     /translation="MESWLLRRGARVRCLHPPSWLPAWCFLCLLPVPQTLQLTGLVSL
                     THTSLPIMVSLANTDVFFSCRIEDFTRLQRDLPVKLFHTDIHGRRRWEKQINCQHRPG
                     MENHTRDCMVKLSQANTSATGIYYFIVEGEETYQSDGVVILVRDTVYQPPAFKVQEAL
                     MLGFTSLMSVLGVLGTALLLWKKKQISVLGKHTAKTCSGLKSTVGTTKPPAESVYTSL
                     QRRETEVYACMKEETGSPVFSQSPATKEKLNRFEDDNEFNLVYENL"
     exon            286..603
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /inference="alignment:Splign:2.1.0"
     exon            604..716
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /inference="alignment:Splign:2.1.0"
     exon            717..815
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /inference="alignment:Splign:2.1.0"
     exon            816..902
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /inference="alignment:Splign:2.1.0"
     exon            903..3962
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2935..2940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /note="hexamer: AATAAA"
     polyA_site      2977
                     /gene="Nfam1"
                     /gene_synonym="4921501M20Rik; Cnaip"
                     /note="major polyA site"
ORIGIN      
        1 ggtttctgag aggaaccgcc ttgaggaagc agaagggtgt ccagaggagg aacttatggg
       61 gacacaaaag ggaactctag ctgccagcag gggccttagt ctgcagtgac ctgaagcgga
      121 aggaggaaca ggctttgata agtgtccagc ttggcgcacg gtattccatg gagagctggc
      181 ttctgcgacg tggggcccga gtgcgatgcc tgcacccacc cagctggctc ccagcctggt
      241 gcttcctctg tttgctgccg gtgccccaga ccctgcagct aacaggattg gtatcattga
      301 cccataccag ccttcctatc atggtgtccc tggcaaacac cgatgtgttc ttcagctgca
      361 gaatcgagga cttcacaaga cttcaaagag atttgcctgt taagttgttt catacggata
      421 tccatggccg gagacgctgg gagaagcaga ttaactgcca acacagacct ggcatggaga
      481 accataccag ggattgcatg gttaaactca gccaggcaaa cacatcagcc acaggcattt
      541 actacttcat agtcgaagga gaggaaacat atcagagcga tggcgttgtc attctggtca
      601 gagacacagt gtaccagcca cctgcattca aggtccagga ggctctgatg cttggcttta
      661 ccagcctgat gagcgtcctg ggtgtgctgg gcacagcgct actgctttgg aagaagaaac
      721 agatatcagt tctgggcaag cacactgcta agacttgttc tggtctcaaa tccaccgtcg
      781 gaaccacaaa gcctccagca gaatctgtct acacgtccct acagcgtcga gagacggagg
      841 tctacgcctg tatgaaggaa gagactggaa gccctgtctt cagccaaagc ccagccacca
      901 aggagaagct gaatagattt gaggatgaca acgaatttaa ccttgtctat gaaaatctct
      961 agaaattcta caggctccga gacttgtctt gaattaggac cccagagcca cagctcttgt
     1021 ctaaggacct gctttgggtc aggagtaggg ccttcaggac aggccatcat caccttacct
     1081 gcacagcagg gctttcccca tcttggcctg gtctgctctc acattctgca tcccagcctg
     1141 aactgttaat gtctctggga ttttgcccag gctgtttctt ccatcaggaa agccattcct
     1201 cccctggcca tttctccatg gacaaagtgg tcctcagtcc cacggggctc ttgtggatcg
     1261 catctctttc ctcttcaccc cttactgcca cccctgcaga gctgtgtatg tggctgtcgt
     1321 ggcatcggcc tcccaatttg gtccccaggc agacgtggtc ctgtgaggac atagcaggac
     1381 ccctgttagg gctctgcctg gccactgagt cactccagct cctcggctag cccagaagct
     1441 tgtacagggt gggcacatgc tgagtggact ggctaaggag agatgaagaa tgggcatcaa
     1501 agaactgcac caaagctgac tggcccaggg ccagatatgg aggctgcgga tatggcaagc
     1561 agagatgaac caggaccagg agcagggagg ttccatacat gctggtgaga gaggagaatc
     1621 tcggagcgcc cctcccccaa cgagaaccct gagctagttt ccaacatcag catgtgtggg
     1681 cacacacctc accgtgcctc accctaagct ctacaggcct ctctgttcct tattctactc
     1741 ttagacccag ttcccccagt tcctctttgt ggcctactct gaccccacca cctgcagctt
     1801 catgttcttt tcctctgtct ttattaattt gcttttggcc catctcgcct cccctgaaga
     1861 cagagagcag cctagctgtc tttcctcagt ggttcagctg tgtggcttgc tgctgggcca
     1921 cccctgggta agtgggcgag tctctgtgct ggagaaactt gagccagggt ggaccaaagc
     1981 ttcccaatgc ctctcagcct ttctggcctt ccaggaactc attcagggga cccctcattc
     2041 actctccaga cacccctata aggaagctgt ctccttggaa gacagggact gaagggctcc
     2101 tctcctaccc tactccccct cctcttagcc tgcctttcct tcagctttcc cagagcttcc
     2161 aatttagctg tggaagatag gccgatctac ctccccatcc caggctgctt ccaaagttcc
     2221 tgagatgttc tcataccaaa atccgcatgc acgcaaggaa tacggaggtg tccacgagca
     2281 gacacaccta gcctggccca agcagtgttg agcagcagag gggtgcagag gaaggcacag
     2341 atgcttcagg acatgaagtt cagaagctcc tgtgtccttg gacagtggcg ccaggctttt
     2401 ctgggcccag tgggtggctt gtcacctaca aacctagttc caggctctcc tctcgaacat
     2461 ccaacaatca gagctcctca gaggctgcca ggatgaatga aggccgagct cctggaggct
     2521 ggcttgatga attccagggc tgtgaggacg gggaactgtt tggcacagag ctgcctccag
     2581 gctcctggct ccagcggtct gagatgaagc ttagcgctta gtgcgcactg gggtgaaagc
     2641 cttaaccagc aagaacttgc cgtttcctct cctacctcct gagctttaca ttcggtctct
     2701 ggatgacctg gctgggactg aggtttcttt taaccctttt caggggagtg agggaagcca
     2761 gatgggactt catattgtgc cctggctcag gacgaaggac ccaggtctcc cagcagccat
     2821 cccgtttgtt cccactgcct cttccctaca aagcagctgg aggaacctga taaaacatgc
     2881 attgttttgt ccctttccca tgaaaatgcc ttccgtagtt tctactttac ttggaataaa
     2941 atctcagctc cttgctgtgg cctaggagac ccaggaagac tgacccattg cctgccctgg
     3001 agacacagac aatgccagag tggtggctgc tgagtggtgg gggtaaagat gcgcagtggg
     3061 gaggccagag gttacccagg gctctggtga tcaagaagag agactgggaa ggaaaagagg
     3121 aagagaagga cagtttgggg tgaagggtgg gctaaaagaa gggtttccat attagggaag
     3181 gtagggaaga atattttagg gctctcagta gtcaacaaag aagactgagc acccagtaca
     3241 ccccccagcc ctgagagcct gcagagggga actgatgcaa ggatgagggg tgcagatggc
     3301 agtgacaaga agggaccccc gaatatgaac cccttgggga gaggctctga gtgggaagga
     3361 agaggagagg caggctgggt ggccatagga cctcccttaa gaggtccact tcctagcagc
     3421 agctcagact tgactaagtg tcactgcctg cttgccttag cctaagtttc cagccacaac
     3481 ccagaccact cagagtattg tagtacaggc tggtgcggag gtccctgagc cctgctgagg
     3541 gtcagtcgat gagtgcgtgt ttctttgaga atcaaactgc tagagcaatg ggcaaagcct
     3601 gcagagagag agagagagag agagagagag agagagagag agatttcctt agaaaaacaa
     3661 aagtattaac agttgtgtag cagcttagtc ttcttgtggg gactcctaac aactggagca
     3721 ggggctgtct ctgaccctat tacctgcctt tgggatccat tccccctcct gcatcgtcca
     3781 acattagtag aagaggaggt gcctagtctt actgcaactt gatatgccat ggctggttga
     3841 tatccatcaa ggcctgccct tctctgaaga gaaacagagg aggagtggag gagggaggag
     3901 gggtgtggag gagggactgg gaggagagga gggaggggaa actacagtca ggatgtaaaa
     3961 tg
//
