LOCUS       NM_010898               4732 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus neurofibromin 2 (Nf2), transcript variant 3, mRNA.
ACCESSION   NM_010898
VERSION     NM_010898.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4732)
  AUTHORS   Warren,R., Klinkhammer,K., Lyu,H., Knopp,J., Yuan,T., Yao,C.,
            Stripp,B. and De Langhe,S.P.
  TITLE     Cell competition drives bronchiolization and pulmonary fibrosis
  JOURNAL   Nat Commun 15 (1), 10624 (2024)
   PUBMED   39639058
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4732)
  AUTHORS   Li,Q., Jiang,S., Lei,K., Han,H., Chen,Y., Lin,W., Xiong,Q., Qi,X.,
            Gan,X., Sheng,R., Wang,Y., Zhang,Y., Ma,J., Li,T., Lin,S., Zhou,C.,
            Chen,D. and Yuan,Q.
  TITLE     Metabolic rewiring during bone development underlies tRNA
            m7G-associated primordial dwarfism
  JOURNAL   J Clin Invest 134 (20), e177220 (2024)
   PUBMED   39255038
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4732)
  AUTHORS   Yamaguchi,I. and Katoh,H.
  TITLE     Merlin/NF2 regulates SLC7A11/xCT expression and cell viability
            under glucose deprivation at high cell density in glioblastoma
            cells
  JOURNAL   J Biochem 175 (3), 313-322 (2024)
   PUBMED   38102738
  REMARK    GeneRIF: Merlin/NF2 regulates SLC7A11/xCT expression and cell
            viability under glucose deprivation at high cell density in
            glioblastoma cells.
REFERENCE   4  (bases 1 to 4732)
  AUTHORS   Warren,R., Lyu,H., Klinkhammer,K. and De Langhe,S.P.
  TITLE     Hippo signaling impairs alveolar epithelial regeneration in
            pulmonary fibrosis
  JOURNAL   Elife 12, e85092 (2023)
   PUBMED   37166104
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4732)
  AUTHORS   Gerardo-Ramirez,M., Giam,V., Becker,D., Groth,M., Hartmann,N.,
            Morrison,H., May-Simera,H.L., Radsak,M.P., Marquardt,J.U.,
            Galle,P.R., Herrlich,P., Straub,B.K. and Hartmann,M.
  TITLE     Deletion of Cd44 Inhibits Metastasis Formation of Liver Cancer in
            Nf2-Mutant Mice
  JOURNAL   Cells 12 (9), 1257 (2023)
   PUBMED   37174657
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4732)
  AUTHORS   MacCollin,M., Ramesh,V., Jacoby,L.B., Louis,D.N., Rubio,M.P.,
            Pulaski,K., Trofatter,J.A., Short,M.P., Bove,C., Eldridge,R. et al.
  TITLE     Mutational analysis of patients with neurofibromatosis 2
  JOURNAL   Am J Hum Genet 55 (2), 314-320 (1994)
   PUBMED   7913580
REFERENCE   7  (bases 1 to 4732)
  AUTHORS   Takeuchi,K., Kawashima,A., Nagafuchi,A. and Tsukita,S.
  TITLE     Structural diversity of band 4.1 superfamily members
  JOURNAL   J Cell Sci 107 (Pt 7), 1921-1928 (1994)
   PUBMED   7983158
REFERENCE   8  (bases 1 to 4732)
  AUTHORS   Huynh,D.P., Nechiporuk,T. and Pulst,S.M.
  TITLE     Alternative transcripts in the mouse neurofibromatosis type 2 (NF2)
            gene are conserved and code for schwannomins with distinct
            C-terminal domains
  JOURNAL   Hum Mol Genet 3 (7), 1075-1079 (1994)
   PUBMED   7981675
REFERENCE   9  (bases 1 to 4732)
  AUTHORS   Haase,V.H., Trofatter,J.A., MacCollin,M., Tarttelin,E.,
            Gusella,J.F. and Ramesh,V.
  TITLE     The murine NF2 homologue encodes a highly conserved merlin protein
            with alternative forms
  JOURNAL   Hum Mol Genet 3 (3), 407-411 (1994)
   PUBMED   8012352
REFERENCE   10 (bases 1 to 4732)
  AUTHORS   Hara,T., Bianchi,A.B., Seizinger,B.R. and Kley,N.
  TITLE     Molecular cloning and characterization of alternatively spliced
            transcripts of the mouse neurofibromatosis 2 gene
  JOURNAL   Cancer Res 54 (2), 330-335 (1994)
   PUBMED   7506121
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645603.12, L27090.1, AK167685.1, AL606521.24 and BX638106.1.
            
            On Nov 9, 2011 this sequence version replaced NM_010898.3.
            
            Transcript Variant: This variant (3) lacks an internal exon in the
            3' region, compared to variant 1.  The resulting isoform (2) is
            shorter and has a distinct C-terminus, compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X74671.1, L27090.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-553               AL645603.12        34759-35311         c
            554-1290            L27090.1           5-741
            1291-3431           AK167685.1         382-2522
            3432-4450           AL606521.24        183887-184905       c
            4451-4732           BX638106.1         1-282               c
FEATURES             Location/Qualifiers
     source          1..4732
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 3.0 cM"
     gene            1..4732
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /note="neurofibromin 2"
                     /db_xref="GeneID:18016"
                     /db_xref="MGI:MGI:97307"
     exon            1..673
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     CDS             560..2350
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /note="isoform 2 is encoded by transcript variant 3;
                     moesin-ezrin-radixin-like protein; neurofibromatosis 2;
                     schwannomin"
                     /codon_start=1
                     /product="merlin isoform 2"
                     /protein_id="NP_035028.2"
                     /db_xref="CCDS:CCDS24391.1"
                     /db_xref="GeneID:18016"
                     /db_xref="MGI:MGI:97307"
                     /translation="MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGK
                     DLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYP
                     ENAEEELVQEITQHLFFLQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKR
                     GFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYG
                     VNYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPL
                     DKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQM
                     ERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITE
                     EEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKE
                     ADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPPPLPPDIPSFDIIADSLSFD
                     FKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDVLHSESS
                     DRGGPSSKHNTIKKLTLQSAKSRVAFFEEL"
     exon            674..799
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            800..922
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1006
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1075
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1076..1158
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1234
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1235..1369
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1370..1444
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1445..1558
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1681
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1899
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2005
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..2133
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            2134..2299
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..4728
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4703..4708
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /note="hexamer: AATAAA"
     polyA_site      4721
                     /gene="Nf2"
                     /gene_synonym="merlin"
                     /note="major polyA site"
ORIGIN      
        1 atcacagtat cttagagaaa aaagtgttag ggtgagtcgc tgagtagcgt agtgggagtc
       61 cggagggcgg ggcggggcgg ggatccggca ggtcgctgag gtgggggttg gtagaggacg
      121 cttcccgagg gcgcgcggag cggagctggt gacagacacg cacgcgcgtg tgcgctccca
      181 actactgcgc ggccccgcga ccctcggggg tcgctgagag gcccggcgtc ggcgccgcag
      241 ccgtctagga tttctgtcca aaggcgtccc tggcgtcccc agcccgaagc tccaagctcg
      301 gggctgcgcg tgcttttgcc ggcatctccc cccgaccccc ccgtcgtcag agactgtccc
      361 ttaactcatc tttccgcacc cacagccggg tcctcgcggc ccatgctggc cgctggggac
      421 ccaggcagcc taggtctgtc tcgggccggc cagccggcca ccatggtggc cctgaggcct
      481 gtgcagctac tccagggggg ctaagagacc cagaacgcgg gcctaggggt gaggggatcc
      541 aaggccggta cctcgcgcca tggccggagc catcgcttct cgcatgagct tcagctcact
      601 caagaggaag cagcccaaga cattcacggt gcggatcgtc accatggacg ccgagatgga
      661 gttcaactgc gagatgaaat ggaaggggaa ggacctgttt gatttggtgt gccggacact
      721 ggggcttcgg gaaacctggt tctttggact gcagtataca atcaaggaca cggtggcctg
      781 gctcaaaatg gacaagaagg tgttggatca tgatgtttcg aaggaagaac cagttacctt
      841 tcacttcctg gccaaatttt atcctgaaaa tgctgaggag gagctagttc aagagatcac
      901 gcaacactta tttttcttac aggtgaagaa gcagattttg gatgaaaagg tctactgccc
      961 tcccgaggcg tccgtgctct tggcgtcata tgctgtccag gccaagtatg gcgactatga
     1021 cccctctgtg cacaagcggg gatttttagc ccaagaggaa ttgctcccga aaagggtgat
     1081 aaatctctat cagatgactc cggaaatgtg ggaggagaga attacggctt ggtatgcgga
     1141 gcaccggggc agagccaggg atgaagctga aatggagtat ttgaagatag ctcaggacct
     1201 ggagatgtat ggtgtgaact actttacaat ccggaataaa aagggcacag agttgctgct
     1261 tggagtggat gctcttgggc ttcatatcta tgaccctgag aacaggctga cccccaagat
     1321 ctccttccca tggaatgaaa tccgaaacat ctcctacagc gacaaggagt ttactattaa
     1381 accactggat aagaaaattg atgtcttcaa atttaactcc tcaaagcttc gtgttaataa
     1441 gctgattctt cagctatgta ttgggaacca tgacctattt atgaggcgac ggaaagctga
     1501 ctctttagaa gttcagcaga tgaaagccca ggccagggaa gagaaggcta gaaagcagat
     1561 ggaaaggcag cggctggctc gagagaagca gatgcgggag gaggccgagc gtacaagaga
     1621 tgagttagag aggaggctcc tgcagatgaa agaagaagca acgatggcca atgaagctct
     1681 gatgcgctct gaggagacag ctgatctgtt ggctgaaaag gctcagatca cagaggagga
     1741 ggccaagctt ttggcacaaa aggctgcaga ggctgagcaa gagatgcagc gaatcaaggc
     1801 cacggccatt cggacagagg aggagaagcg cctgatggag cagaaggtgc tggaggctga
     1861 agtgctggca ttgaagatgg ctgaggagtc agagaggagg gccaaggagg ctgatcagtt
     1921 aaagcaagac ttgcaagaag ccagagaagc agagcgaaga gccaagcaga agctcttaga
     1981 aatcgccacc aagcccacct atccacccat gaacccaatt ccaccaccac tgcctcctga
     2041 cataccgagc ttcgacatta ttgctgacag cttgtcattt gacttcaagg atacggacat
     2101 gaagcgactt tccatggaga tagagaaaga aaaagtggag tacatggaga agagcaagca
     2161 cctgcaggag cagctcaacg agctcaagac ggagatcgag gccttgaaac tcaaagagcg
     2221 ggagacggcc ttggacgtcc tacacagcga gagctcagac agaggcggcc ccagcagcaa
     2281 gcataatacc attaaaaagc tcactctgca gagcgccaag tcccgagtgg ccttctttga
     2341 agaactctag caggtgaccc ggccacctcc tgccacatct gctgctcctg acaccaacag
     2401 gatgggcctg acccaaaagg aaccatcagt agagggctgg cttgtttggg aactcttgag
     2461 ttgagggccc cgtgccactc tgaccctata gagaggtttc tcaatgtgtt ctagttctcc
     2521 ttgcctcctg catacctgca tatctctctc tccctccctc tctctctctc tccttctctc
     2581 tctctctctc tctctctctc tctctctctc tctctctctt atataaatac ttgttgtgtg
     2641 tgggctgcca tccttcctgc acccaagcac tgtggtgcac gggttgctgt gcttgctgac
     2701 attgagaatc ggctgtggga gtccagtgtg aaagctggct gaaatctacc atgcaggtgc
     2761 tacccactcc ccaactgggc ttctgggatg ggcctcccct ccaagcatgg ggtagaagtg
     2821 tggactggct tagctcagaa ccagcaatgg gggttgggga tttagctcag tgagagcgct
     2881 tactcgggcc ctgggttcgg tcctcagctc tgggggggga aaaaaaaaga accagcaacg
     2941 atggctcctt agccaggctc acctgaggca gtgtagctgt ctgaatggca ggtaacaggc
     3001 aagacagctg tggctaggaa gaggcttaag atagaggctg ttgggagaca ctgcacatga
     3061 gcctttggtg ggccaggagc ttcccagtca cattcccatc agtgcctggg aacccagctg
     3121 tgaccaggac ctctgtctcc tccccctcag cacatggaac cccagagccc tgctacccgt
     3181 ccatcatcct cttcaacacc taggcctcac tgtcattgtc cttttcttcc ccaggagccc
     3241 agcagtgtcc ttttagtcct tcctttcctg agcctgacag agatatcagg ctactaacag
     3301 tcacacaagc taacactatg ggttgcctcc atgctaggca acaaatgctt accatgtgcc
     3361 tcacacactc catgattggg cctatcttct atgtaactgg ggtcactagt gtagccgacc
     3421 agaacccttt aagtcctaca gagcaggtga tctgcctcag tccacaagca gatgtatatt
     3481 aactgaggac agctgagctg aggggctgag caaggcgatg ttccacagta cggtttgttt
     3541 ttgagaaact gaggcacacc accttgttcc cgggctgtta ttgggccact ttgtcatagg
     3601 cagccaccca atggtcacct cagcatcttt gggcacctgt gatagcactc tagtctgaaa
     3661 cctaaggctg aggagaaggt ctctggactt gacaccccag tatttgccga gtcttccctg
     3721 gctgctctga agttgagctg tgttctctgg cctgaaactg ctctctgact ttcttcctct
     3781 ctgtacactt gatttaacaa tggctgtggg acacgagaca atgatgctgg tttataaaaa
     3841 ttatgccagg ccttccttgg ctttttcatt taactacgct ttatatctca aatttgggaa
     3901 ataccaagct acataaccac gtgggcgccc tggtatttga ggaatggtgg gtgtaaccat
     3961 ttcgccattt cttggaaggt gaggtccaaa ccccactcag aagtacctca gctccgagag
     4021 agagagagag agagagaggg ggcggggggg agagagagag agagctcgaa tgggtcccca
     4081 gaatgtctcc agcctgcttt gagcctgtag ctgggttctt actggtagaa aattttagtc
     4141 aaagagaaac atctgaagtc caaagtgagg cccaaccctg gctcttccta gtttcaatgg
     4201 tttctgaagc ataggcaggg gtaccctgct actgaaacag caagtcactc tcagtgcagg
     4261 acactgaggc cttgctcttg cctgtggctg gtcacaaacc ctgattgagg cagtacctga
     4321 gccgccacag cactctgacc tgaggtcact gccaacccct gctagacaac accagtgggc
     4381 ttcacttact gctatatcct cttttagaca ggtttctcat gctcccatac tttcaaaaag
     4441 cccagaggct gactcccagc aacagtgact aaccgttcct gccaacaggg ccagagcctc
     4501 aaagtccctg gtacaagcag ccttcacaga ggacccagac tctcctaggt gccttgaggc
     4561 cacgccagtg cccatgggct tccattcctc tgttactctt ttcaaacagc tcttcatgtg
     4621 aggctcctgt cactcctatc ggggccagga catgaagctg gtttctgggg gttggggtga
     4681 ttataattta agtgattgtt ttaataaaaa ctctaagctg ctatagtcaa aa
//
