LOCUS       NM_001357206            2712 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus nexilin (Nexn), transcript variant 1, mRNA.
ACCESSION   NM_001357206 XM_006501992
VERSION     NM_001357206.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2712)
  AUTHORS   Fidalgo,M.F., Fonseca,C.G., Caldas,P., Raposo,A.A., Balboni,T.,
            Henao-Misikova,L., Grosso,A.R., Vasconcelos,F.F. and Franco,C.A.
  TITLE     Aerocyte specification and lung adaptation to breathing is
            dependent on alternative splicing changes
  JOURNAL   Life Sci Alliance 5 (12), e202201554 (2022)
   PUBMED   36220570
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2712)
  AUTHORS   Ehrman,J.M., Merchan-Sala,P., Ehrman,L.A., Chen,B., Lim,H.W.,
            Waclaw,R.R. and Campbell,K.
  TITLE     Formation of the Mouse Internal Capsule and Cerebral Peduncle: A
            Pioneering Role for Striatonigral Axons as Revealed in Isl1
            Conditional Mutants
  JOURNAL   J Neurosci 42 (16), 3344-3364 (2022)
   PUBMED   35273083
REFERENCE   3  (bases 1 to 2712)
  AUTHORS   Liu,C., Spinozzi,S., Feng,W., Chen,Z., Zhang,L., Zhu,S., Wu,T.,
            Fang,X., Ouyang,K., Evans,S.M. and Chen,J.
  TITLE     Homozygous G650del nexilin variant causes cardiomyopathy in mice
  JOURNAL   JCI Insight 5 (16), 138780 (2020)
   PUBMED   32814711
  REMARK    GeneRIF: Homozygous G650del nexilin variant causes cardiomyopathy
            in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2712)
  AUTHORS   Spinozzi,S., Liu,C., Chen,Z., Feng,W., Zhang,L., Ouyang,K.,
            Evans,S.M. and Chen,J.
  TITLE     Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular
            System in Adult Cardiomyocytes
  JOURNAL   Circ Heart Fail 13 (7), e006935 (2020)
   PUBMED   32635769
REFERENCE   5  (bases 1 to 2712)
  AUTHORS   Liu,C., Spinozzi,S., Chen,J.Y., Fang,X., Feng,W., Perkins,G.,
            Cattaneo,P., Guimaraes-Camboa,N., Dalton,N.D., Peterson,K.L.,
            Wu,T., Ouyang,K., Fu,X.D., Evans,S.M. and Chen,J.
  TITLE     Nexilin Is a New Component of Junctional Membrane Complexes
            Required for Cardiac T-Tubule Formation
  JOURNAL   Circulation 140 (1), 55-66 (2019)
   PUBMED   30982350
  REMARK    GeneRIF: NEXN is a pivotal component of the junctional membrane
            complex and is required for the formation of cardiac T-tubules.
REFERENCE   6  (bases 1 to 2712)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2712)
  AUTHORS   Yang,F., Zhou,L., Wang,Q., You,X., Li,Y., Zhao,Y., Han,X.,
            Chang,Z., He,X., Cheng,C., Wu,C., Wang,W.J., Hu,F.Y., Zhao,T.,
            Li,Y., Zhao,M., Zheng,G.Y., Dong,J., Fan,C., Yang,J., Meng,X.,
            Zhang,Y., Zhu,X., Xiong,J., Tian,X.L. and Cao,H.
  TITLE     NEXN inhibits GATA4 and leads to atrial septal defects in mice and
            humans
  JOURNAL   Cardiovasc Res 103 (2), 228-237 (2014)
   PUBMED   24866383
  REMARK    GeneRIF: NEXN as a novel gene for ASD and its function to inhibit
            GATA4 established a critical regulation of an F-actin binding
            protein on a transcription factor in cardiac development
REFERENCE   8  (bases 1 to 2712)
  AUTHORS   Li,C.L., Sathyamurthy,A., Oldenborg,A., Tank,D. and Ramanan,N.
  TITLE     SRF phosphorylation by glycogen synthase kinase-3 promotes axon
            growth in hippocampal neurons
  JOURNAL   J Neurosci 34 (11), 4027-4042 (2014)
   PUBMED   24623780
REFERENCE   9  (bases 1 to 2712)
  AUTHORS   Dorval,V., Mandemakers,W., Jolivette,F., Coudert,L., Mazroui,R., De
            Strooper,B. and Hebert,S.S.
  TITLE     Gene and MicroRNA transcriptome analysis of Parkinson's related
            LRRK2 mouse models
  JOURNAL   PLoS One 9 (1), e85510 (2014)
   PUBMED   24427314
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 2712)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123075.5.
            
            On Oct 4, 2022 this sequence version replaced NM_001357206.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.141512.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849390 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-58                AC123075.5         73387-73444
            59-139              AC123075.5         83792-83872
            140-331             AC123075.5         85354-85545
            332-410             AC123075.5         86028-86106
            411-559             AC123075.5         86201-86349
            560-601             AC123075.5         89456-89497
            602-790             AC123075.5         90789-90977
            791-961             AC123075.5         91054-91224
            962-1150            AC123075.5         91883-92071
            1151-1348           AC123075.5         95134-95331
            1349-1570           AC123075.5         96277-96498
            1571-1756           AC123075.5         100725-100910
            1757-2114           AC123075.5         101135-101492
            2115-2712           AC123075.5         101578-102175
FEATURES             Location/Qualifiers
     source          1..2712
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 77.07 cM"
     gene            1..2712
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /note="nexilin"
                     /db_xref="GeneID:68810"
                     /db_xref="MGI:MGI:1916060"
     exon            1..58
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            59..139
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             113..2128
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     F-actin-binding protein; nF actin binding protein; nexilin
                     alpha; nexilin beta; nexilin gamma"
                     /codon_start=1
                     /product="nexilin isoform 1"
                     /protein_id="NP_001344135.1"
                     /db_xref="CCDS:CCDS89710.1"
                     /db_xref="GeneID:68810"
                     /db_xref="MGI:MGI:1916060"
                     /translation="MNDVSQKAEILLSSCKPVPKSYVPKLGKGDVKDKFEAMQRAREE
                     RNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEESSPKIEKAYVPKLTGTV
                     KGKFDEMEKHRQEEQRKRTEEERKRRIEQDLLEKRKIQRELAKRAEQIEDINNTGTES
                     ASEEGDDSLLITVVPAKSYKTPGKTKDPEDLDREEGNGRTNHEEDKMRYEEECRVLKE
                     AKCLSLVMDDETEAKKESHFPGKLKSTFEELERQRQENRKKQAEEEARRRLEEERRSF
                     EEARRHMVNEEDENQDRETVFKEYRPGKLKLSFEEIERQRREDEKRKAEEEARRRIEE
                     EKAAFAEARRSMVLDDDSPEIYKTVSQESLTPGKLEINFEQLLRQKMEEERRRTEEER
                     RHKLEMEKQEFEQLRQEMGKEEEENESFGLSREYEELIKLKRSGSIQAKNLKSKFEKI
                     GQLSEKEVQKKIEEERAKRRAIDLEIKEREAENFHEDDDVDVRPAKKSESPFTHKVNM
                     KARFEQMAKAREEEEQRRIEEQKLLRMQFEQKEIDAALQKKREDEEEEEGSIVNGSTT
                     EDEEQTRSGAPWFKKPLRNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQ
                     YIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIEMDDY"
     exon            140..331
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            332..410
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            411..559
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            560..601
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            602..790
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            791..961
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1150
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1348
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1570
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1571..1756
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..2114
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2115..2712
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2616..2621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /note="hexamer: AATAAA"
     polyA_site      2638
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /note="major polyA site"
     regulatory      2689..2694
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
                     /note="hexamer: AATAAA"
     polyA_site      2712
                     /gene="Nexn"
                     /gene_synonym="1110046H09Rik; NELIN"
ORIGIN      
        1 gcagagcccg acacgcagcg cggagcggga ggagcggcgc ccgggcggcg gcaggcgggt
       61 acaaaaatat acaaggcttc agccccaaac cacataacca catatagcaa acatgaatga
      121 cgtttcgcaa aaggcagaga ttctgctttc ctcatgtaaa cctgtcccta agtcctatgt
      181 gccaaagctt ggcaagggag atgtaaagga caagtttgaa gccatgcaga gggccaggga
      241 agaaagaaat caaaggcgat ctagagacga aaagcaaaga agaaaagaac aatatattag
      301 agagagagaa tggaacagga gaaagcagga gattaaagaa atgcttgctt ctgatgatga
      361 ggaagaaagt tctcctaaaa tagaaaaggc ttatgtccca aagctaacag ggacagttaa
      421 aggtaaattc gatgaaatgg agaaacacag acaggaagaa caaagaaaga gaacagaaga
      481 agaaagaaaa cgcagaattg agcaggatct gttagaaaag aggaaaatac agcgcgaatt
      541 agcaaaaaga gcggagcaga ttgaggacat aaacaatacg ggaaccgagt ccgcatcaga
      601 ggaaggagat gactcactac ttataacagt ggtacctgcc aaatcataca aaacacctgg
      661 aaaaacaaag gatcctgagg acctggacag agaagaagga aatgggagaa ccaaccatga
      721 agaagataaa atgagatatg aagaagagtg ccgagttctc aaagaagcaa aatgtctttc
      781 attagtcatg gatgatgaaa cagaggccaa aaaagaatca cattttcctg gaaaattgaa
      841 atcaactttt gaagaactgg aacgacaaag acaagaaaat cgcaagaagc aagcggaaga
      901 ggaagcgaga cgacgcttag aagaagagag acgttccttt gaggaggcga gaaggcacat
      961 ggtaaatgag gaggatgaaa accaagatag agaaacagtt tttaaagagt accgcccagg
     1021 aaaactcaaa ctcagttttg aggaaataga aaggcaaagg agagaagacg aaaaacgaaa
     1081 agcagaggag gaggcccgaa ggagaataga ggaagagaag gcggcatttg ctgaagcaag
     1141 gagaagcatg gtattagatg atgattcccc agagatttat aaaacagtgt ctcaagaatc
     1201 tcttactcct ggaaaactag aaattaattt tgaacaatta ttaagacaaa aaatggaaga
     1261 agaaagacga cgaacagagg aagaacgcag gcataaacta gaaatggaga aacaggaatt
     1321 tgaacaactg agacaagaaa tgggaaagga agaagaagaa aatgaaagct ttgggttgag
     1381 tagagaatat gaagaattaa ttaaattaaa aaggagtggc tcaattcaag ctaaaaatct
     1441 aaaaagcaag tttgaaaaaa ttggacaatt gtctgaaaaa gaagtacaga aaaagataga
     1501 agaagagcga gcaaaaaggc gagcaattga ccttgaaatc aaagagcgag aagcagaaaa
     1561 cttccatgag gacgatgatg ttgatgtaag gcctgcaaag aagagtgagt ctccttttac
     1621 tcataaggtg aacatgaaag ccaggtttga acaaatggca aaggcaagag aagaggaaga
     1681 acaaagaaga attgaagaac aaaagttact acgaatgcag tttgaacaga aagaaatcga
     1741 tgcggcatta cagaagaaaa gagaagatga ggaggaagaa gaaggtagca ttgttaatgg
     1801 ctccactact gaagatgaag agcaaaccag atcaggagct ccatggttca aaaagccttt
     1861 aagaaatacc tcagttgtag acagtgagcc agtcagattt actgttaaag taacaggaga
     1921 acccaagccg gaaattacat ggtggtttga aggagaaata ctgcaggatg gagaagacta
     1981 tcagtacatc gaaagaggtg aaacttactg cctgtattta ccggaaacct tcccagaaga
     2041 tggaggagag tacatgtgta aggcagtcaa caataaaggc tcagcagcga gcacctgcat
     2101 tcttaccatt gaaatggatg actactaggc ttccctctgt ccttgggact ctctctctcg
     2161 ctgcatctct gtggaggggc caaaaaggag accagaggtg ccactataac tgacttaatc
     2221 tttccccaaa tcttcctctt aagaacttct catgcatatc aggttcatta ccatgctgtg
     2281 caaagtcaaa gcatagctga cagaaaaggg aaataaatgt acccattctg tcagaactaa
     2341 gacagaagct tcgtatttat agaactaaga cttaacatat acagtttgca tgaataaact
     2401 ggagattttt ttgccattgt caatgaaaat ggaccgatca gtagatttag taaaaagtga
     2461 ttttctagct ttaaaaataa gtctgtaaat gtcaagtgta gtgttgcatg ccttaatcta
     2521 aacacatggg ggtaggtgga tttctgagtt ccacgacggc cagaactata catagtgaga
     2581 ccatgtaacc ctggatccta acaacacagt ctgtaaataa aagtttatta tgttctaata
     2641 ttgggtggtt ttatatttaa ttttctggga aacgtgttgt gaaatcaaaa taaatttacc
     2701 tgtgcattaa aa
//
