LOCUS       NM_009719               1540 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus neurogenin 3 (Neurog3), mRNA.
ACCESSION   NM_009719
VERSION     NM_009719.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1540)
  AUTHORS   McKimpson,W.M., Spiegel,S., Mukhanova,M., Kraakman,M., Du,W.,
            Kitamoto,T., Yu,J., Deng,Z., Pajvani,U. and Accili,D.
  TITLE     Calorie restriction activates a gastric Notch-FOXO1 pathway to
            expand ghrelin cells
  JOURNAL   J Cell Biol 223 (10) (2024)
   PUBMED   38958606
REFERENCE   2  (bases 1 to 1540)
  AUTHORS   Davidson,R.K., Wu,W., Kanojia,S., George,R.M., Huter,K.,
            Sandoval,K., Osmulski,M., Casey,N. and Spaeth,J.M.
  TITLE     The SWI/SNF chromatin remodelling complex regulates pancreatic
            endocrine cell expansion and differentiation in mice in vivo
  JOURNAL   Diabetologia 67 (10), 2275-2288 (2024)
   PUBMED   38958700
REFERENCE   3  (bases 1 to 1540)
  AUTHORS   Lu,P., Xu,J., Shen,X., Sun,J., Liu,M., Niu,N., Wang,Q. and Xue,J.
  TITLE     Spatiotemporal role of SETD2-H3K36me3 in murine pancreatic
            organogenesis
  JOURNAL   Cell Rep 43 (2), 113703 (2024)
   PUBMED   38265933
REFERENCE   4  (bases 1 to 1540)
  AUTHORS   Liu,B., Hua,D., Shen,L., Li,T., Tao,Z., Fu,C., Tang,Z., Yang,J.,
            Zhang,L., Nie,A., Jiang,Y., Wang,J., Li,Y., Gu,Y. and Ning,G.
  TITLE     NPC1 is required for postnatal islet beta cell differentiation by
            maintaining mitochondria turnover
  JOURNAL   Theranostics 14 (5), 2058-2074 (2024)
   PUBMED   38505613
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1540)
  AUTHORS   Darrigrand,J.F., Salowka,A., Torres-Cano,A., Tapia-Rojo,R., Zhu,T.,
            Garcia-Manyes,S. and Spagnoli,F.M.
  TITLE     Acinar-ductal cell rearrangement drives branching morphogenesis of
            the murine pancreas in an IGF/PI3K-dependent manner
  JOURNAL   Dev Cell 59 (3), 326-338 (2024)
   PUBMED   38237591
REFERENCE   6  (bases 1 to 1540)
  AUTHORS   Jensen,J., Pedersen,E.E., Galante,P., Hald,J., Heller,R.S.,
            Ishibashi,M., Kageyama,R., Guillemot,F., Serup,P. and Madsen,O.D.
  TITLE     Control of endodermal endocrine development by Hes-1
  JOURNAL   Nat Genet 24 (1), 36-44 (2000)
   PUBMED   10615124
REFERENCE   7  (bases 1 to 1540)
  AUTHORS   Apelqvist,A., Li,H., Sommer,L., Beatus,P., Anderson,D.J., Honjo,T.,
            Hrabe de Angelis,M., Lendahl,U. and Edlund,H.
  TITLE     Notch signalling controls pancreatic cell differentiation
  JOURNAL   Nature 400 (6747), 877-881 (1999)
   PUBMED   10476967
REFERENCE   8  (bases 1 to 1540)
  AUTHORS   Briscoe,J., Sussel,L., Serup,P., Hartigan-O'Connor,D.,
            Jessell,T.M., Rubenstein,J.L. and Ericson,J.
  TITLE     Homeobox gene Nkx2.2 and specification of neuronal identity by
            graded Sonic hedgehog signalling
  JOURNAL   Nature 398 (6728), 622-627 (1999)
   PUBMED   10217145
REFERENCE   9  (bases 1 to 1540)
  AUTHORS   Cau,E., Gradwohl,G., Fode,C. and Guillemot,F.
  TITLE     Mash1 activates a cascade of bHLH regulators in olfactory neuron
            progenitors
  JOURNAL   Development 124 (8), 1611-1621 (1997)
   PUBMED   9108377
REFERENCE   10 (bases 1 to 1540)
  AUTHORS   Sommer,L., Ma,Q. and Anderson,D.J.
  TITLE     neurogenins, a novel family of atonal-related bHLH transcription
            factors, are putative mammalian neuronal determination genes that
            reveal progenitor cell heterogeneity in the developing CNS and PNS
  JOURNAL   Mol Cell Neurosci 8 (4), 221-241 (1996)
   PUBMED   9000438
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127417.3.
            
            On Sep 14, 2007 this sequence version replaced NM_009719.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008017.1, BY708009.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC127417.3         68257-68494
            239-1540            AC127417.3         68629-69930
FEATURES             Location/Qualifiers
     source          1..1540
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 32.35 cM"
     gene            1..1540
                     /gene="Neurog3"
                     /gene_synonym="Atoh5; bHLHa7; Math4B; ngn3"
                     /note="neurogenin 3"
                     /db_xref="GeneID:11925"
                     /db_xref="MGI:MGI:893591"
     exon            1..238
                     /gene="Neurog3"
                     /gene_synonym="Atoh5; bHLHa7; Math4B; ngn3"
                     /inference="alignment:Splign:2.1.0"
     exon            239..1540
                     /gene="Neurog3"
                     /gene_synonym="Atoh5; bHLHa7; Math4B; ngn3"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..884
                     /gene="Neurog3"
                     /gene_synonym="Atoh5; bHLHa7; Math4B; ngn3"
                     /note="protein atonal homolog 5; helix-loop-helix protein
                     mATH-4B; Neurogenin 3 (Atonal protein homolog 5)
                     (Helix-loop-helix protein mATH-4B) (MATH4B)"
                     /codon_start=1
                     /product="neurogenin-3"
                     /protein_id="NP_033849.3"
                     /db_xref="CCDS:CCDS23887.1"
                     /db_xref="GeneID:11925"
                     /db_xref="MGI:MGI:893591"
                     /translation="MAPHPLDALTIQVSPETQQPFPGASDHEVLSSNSTPPSPTLIPR
                     DCSEAEVGDCRGTSRKLRARRGGRNRPKSELALSKQRRSRRKKANDRERNRMHNLNSA
                     LDALRGVLPTFPDDAKLTKIETLRFAHNYIWALTQTLRIADHSFYGPEPPVPCGELGS
                     PGGGSNGDWGSIYSPVSQAGNLSPTASLEEFPGLQVPSSPSYLLPGALVFSDFL"
ORIGIN      
        1 atgcagctca gaaatccctc tgggtctcat cactgcagca gtggtcgagt acctcctcgg
       61 agcttttcta cgacttccag acgcaattta ctccaggcga gggcgcctgc agtttagcag
      121 aacttcagag ggagcagaga ggctcagcta tccactgctg cttgacactg accctatcca
      181 ctgctgcttg tcactgactg acctgctgct ctctattctt ttgagtcggg agaactagga
      241 tggcgcctca tcccttggat gcgctcacca tccaagtgtc cccagagaca caacaacctt
      301 ttcccggagc ctcggaccac gaagtgctca gttccaattc caccccacct agccccactc
      361 tcatacctag ggactgctcc gaagcagaag tgggtgactg ccgagggacc tcgaggaagc
      421 tccgcgcccg acgcggaggg cgcaacaggc ccaagagcga gttggcactc agcaaacagc
      481 gaagaagccg gcgcaagaag gccaatgatc gggagcgcaa tcgcatgcac aacctcaact
      541 cggcgctgga tgcgctgcgc ggtgtcctgc ccaccttccc ggatgacgcc aaacttacaa
      601 agatcgagac cctgcgcttc gcccacaact acatctgggc actgactcag acgctgcgca
      661 tagcggacca cagcttctat ggcccggagc cccctgtgcc ctgtggagag ctggggagcc
      721 ccggaggtgg ctccaacggg gactggggct ctatctactc cccagtctcc caagcgggta
      781 acctgagccc cacggcctca ttggaggaat tccctggcct gcaggtgccc agctccccat
      841 cctatctgct cccgggagca ctggtgttct cagacttctt gtgaagagac ctgtctggct
      901 ctgggtggtg ggtgctagtg gaaagggagg ggaccagagc cgtctggagt gggaggtagt
      961 ggaggctctc aagcatctcg cctcttctgg ctttcactac ttggatccct agccctctca
     1021 cagggcttaa ctaggcttct catcggtacc cttgctgctg cgcacagcag acattggggg
     1081 ctgctcttct cttaactctc ctcggtgcag ccacatcaaa ctctcgctcc aagcatttga
     1141 gaatggtagc actacctagt tggagactcc catacttcct ggtgagtctg ccctcattca
     1201 aatctgccgg cctccgacca tccatcactt tttccagggt gacctaatcc agtgttgcgt
     1261 cttacctcac tggctcctcc atccagctct tggcccatag atgatgttcg tcgtctttac
     1321 tgcccgctac atgcagggtt tctgagcttc tccattctgc cttagtccac gaaggtgatc
     1381 tgccttcttc tgcacttttc aagtcgttac ccttccccca agggagacca ggctgtgaac
     1441 cggaaagccc tagcctatgg ctagagcatc tctccaactt gtctcccgtg tctaaagtgt
     1501 gagttgcagg gacggttcct gaagcactgt ttgtctccct
//
