LOCUS       NM_009718               2226 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus neurogenin 2 (Neurog2), mRNA.
ACCESSION   NM_009718
VERSION     NM_009718.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2226)
  AUTHORS   Lo Giudice,Q., Wagener,R.J., Abe,P., Frangeul,L. and Jabaudon,D.
  TITLE     Developmental emergence of first- and higher-order thalamic neuron
            molecular identities
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39348458
REFERENCE   2  (bases 1 to 2226)
  AUTHORS   Barao,S., Xu,Y., Llongueras,J.P., Vistein,R., Goff,L.,
            Nielsen,K.J., Bae,B.I., Smith,R.S., Walsh,C.A., Stein-O'Brien,G.
            and Muller,U.
  TITLE     Conserved transcriptional regulation by BRN1 and BRN2 in
            neocortical progenitors drives mammalian neural specification and
            neocortical expansion
  JOURNAL   Nat Commun 15 (1), 8043 (2024)
   PUBMED   39271675
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2226)
  AUTHORS   Talifu,Z., Zhang,C., Xu,X., Pan,Y., Ke,H., Li,Z., Liu,W., Du,H.,
            Wang,X., Gao,F., Yang,D., Jing,Y., Yu,Y., Du,L. and Li,J.
  TITLE     Neuronal repair after spinal cord injury by in vivo astrocyte
            reprogramming mediated by the overexpression of NeuroD1 and
            Neurogenin-2
  JOURNAL   Biol Res 57 (1), 53 (2024)
   PUBMED   39135103
  REMARK    GeneRIF: Neuronal repair after spinal cord injury by in vivo
            astrocyte reprogramming mediated by the overexpression of NeuroD1
            and Neurogenin-2.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2226)
  AUTHORS   Pereira,A., Diwakar,J., Masserdotti,G., Beskardes,S., Simon,T.,
            So,Y., Martin-Loarte,L., Bergemann,F., Vasan,L., Schauer,T.,
            Danese,A., Bocchi,R., Colome-Tatche,M., Schuurmans,C., Philpott,A.,
            Straub,T., Bonev,B. and Gotz,M.
  TITLE     Direct neuronal reprogramming of mouse astrocytes is associated
            with multiscale epigenome remodeling and requires Yy1
  JOURNAL   Nat Neurosci 27 (7), 1260-1273 (2024)
   PUBMED   38956165
REFERENCE   5  (bases 1 to 2226)
  AUTHORS   Kane,E., Mak,T.C.S. and Latreille,M.
  TITLE     MicroRNA-7 regulates endocrine progenitor delamination and
            endocrine cell mass in developing pancreatic islets
  JOURNAL   iScience 27 (7), 110332 (2024)
   PUBMED   39055950
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2226)
  AUTHORS   Ma,Q., Chen,Z., del Barco Barrantes,I., de la Pompa,J.L. and
            Anderson,D.J.
  TITLE     neurogenin1 is essential for the determination of neuronal
            precursors for proximal cranial sensory ganglia
  JOURNAL   Neuron 20 (3), 469-482 (1998)
   PUBMED   9539122
REFERENCE   7  (bases 1 to 2226)
  AUTHORS   Cau,E., Gradwohl,G., Fode,C. and Guillemot,F.
  TITLE     Mash1 activates a cascade of bHLH regulators in olfactory neuron
            progenitors
  JOURNAL   Development 124 (8), 1611-1621 (1997)
   PUBMED   9108377
REFERENCE   8  (bases 1 to 2226)
  AUTHORS   de la Pompa,J.L., Wakeham,A., Correia,K.M., Samper,E., Brown,S.,
            Aguilera,R.J., Nakano,T., Honjo,T., Mak,T.W., Rossant,J. and
            Conlon,R.A.
  TITLE     Conservation of the Notch signalling pathway in mammalian
            neurogenesis
  JOURNAL   Development 124 (6), 1139-1148 (1997)
   PUBMED   9102301
REFERENCE   9  (bases 1 to 2226)
  AUTHORS   Gradwohl,G., Fode,C. and Guillemot,F.
  TITLE     Restricted expression of a novel murine atonal-related bHLH protein
            in undifferentiated neural precursors
  JOURNAL   Dev Biol 180 (1), 227-241 (1996)
   PUBMED   8948587
REFERENCE   10 (bases 1 to 2226)
  AUTHORS   Sommer,L., Ma,Q. and Anderson,D.J.
  TITLE     neurogenins, a novel family of atonal-related bHLH transcription
            factors, are putative mammalian neuronal determination genes that
            reveal progenitor cell heterogeneity in the developing CNS and PNS
  JOURNAL   Mol Cell Neurosci 8 (4), 221-241 (1996)
   PUBMED   9000438
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158308.4.
            
            On Dec 21, 2021 this sequence version replaced NM_009718.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC055743.1, AK143190.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-322               AC158308.4         84521-84842
            323-2226            AC158308.4         85113-87016
FEATURES             Location/Qualifiers
     source          1..2226
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 56.54 cM"
     gene            1..2226
                     /gene="Neurog2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; ngn2"
                     /note="neurogenin 2"
                     /db_xref="GeneID:11924"
                     /db_xref="MGI:MGI:109619"
     exon            1..322
                     /gene="Neurog2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; ngn2"
                     /inference="alignment:Splign:2.1.0"
     exon            323..2226
                     /gene="Neurog2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; ngn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             324..1115
                     /gene="Neurog2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; ngn2"
                     /note="protein atonal homolog 4; helix-loop-helix protein
                     mATH-4A"
                     /codon_start=1
                     /product="neurogenin-2"
                     /protein_id="NP_033848.1"
                     /db_xref="CCDS:CCDS17825.1"
                     /db_xref="GeneID:11924"
                     /db_xref="MGI:MGI:109619"
                     /translation="MFVKSETLELKEEEEVLMLLGSASPASATLTPMSSSADEEEDEE
                     LRRPGSARGQRGAEAGQGVQGSPASGAGGCRPGRLLGLMHECKRRPSRSRAVSRGAKT
                     AETVQRIKKTRRLKANNRERNRMHNLNAALDALREVLPTFPEDAKLTKIETLRFAHNY
                     IWALTETLRLADHCAGAGGLQGALFTEAVLLSPGAALGASGDSPSPPSSWSCTNSPAS
                     SSNSTSPYSCTLSPASPGSDVDYWQPPPPEKHRYAPHLPLARDCI"
     regulatory      2204..2209
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurog2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; ngn2"
                     /note="hexamer: AATAAA"
     polyA_site      2226
                     /gene="Neurog2"
                     /gene_synonym="Atoh4; bHLHa8; Math4A; ngn-2; ngn2"
                     /note="major polyA site"
ORIGIN      
        1 gccagacacg cagccactga accacaagca gctcggcttt aactggagtg ccttggagtc
       61 gcgtgccagc agccacacgg ccagggactg actgacagac aaccacgcac gagaacgaca
      121 acacacgaga ctcgggcgag ctgccgcggt cgtccgggct cttggcaaag tcgcccagcc
      181 gagaggcccc cccgcggagg tgcgcctagg aagcgccaag cccgcggcgc ggaggacacc
      241 gtgctcggtt ccgggctgcg gggacattcc cggacacaca ccggagcagc agctgcgccg
      301 cgacacatct ggagccgcgt aggatgttcg tcaaatctga gactctggag ttgaaggagg
      361 aagaggaggt actgatgctg ctgggctcgg cttccccggc ctcggcgacc ctgaccccga
      421 tgtcctccag cgcggacgag gaggaggacg aggagctgcg ccggccgggc tccgcgcgtg
      481 ggcagcgtgg agcggaagcc gggcaggggg tgcagggcag tccggcgtcg ggtgccgggg
      541 gttgccggcc agggcggctg ctgggcctga tgcacgagtg caagcgtcgc ccgtcgcgct
      601 cacgggccgt ctcccgaggt gccaagacgg cggagacggt gcagcgcatc aagaagaccc
      661 gcaggctcaa ggccaacaac cgcgagcgca accgcatgca caacctaaac gccgcgctgg
      721 acgcgctgcg cgaggtgctg cccaccttcc ccgaggatgc caagctcacg aagatcgaga
      781 cgctgcgctt cgcccacaat tacatctggg cgctcaccga gactctgcgc ctggcggacc
      841 actgcgccgg cgccggtggc ctccaggggg cgctcttcac ggaggcggtg ctcctgagcc
      901 cgggagctgc gctcggcgcc agcggggaca gcccttctcc accttcctcc tggagctgca
      961 ccaacagccc ggcgtcatcc tccaactcca cgtccccata cagctgcact ttatcgcccg
     1021 ctagccccgg gtcagacgtg gactactggc agcccccacc tccggagaag catcgttatg
     1081 cgcctcacct gcccctcgcc agggactgta tctagagctg cgggtctccc tctctcgtcc
     1141 tctacccggc cctcttccca tccttctccc gcccctcacc ctccacgccc cggactccac
     1201 ttcacagagc agaggtggcc cttgcaatcc cctcggcggc tggtgcattc gggggtggag
     1261 accagctctg gtttattgaa gatgtgagga tttatggtca aagaggacta tggcgtgtgg
     1321 gagtgggggc tggcgtgggg aacctcgtaa gactgtaaaa gacactgaga aaaagtacca
     1381 taactaacga gtgtgcagag cagactgacg ctcctcccct ctctcagagc tgctggagga
     1441 gaactccggg caggcagttc gtgtgaatct ctcagaggga atgcaactgg tccctgtgat
     1501 cttttcacct tcgtttctac atagagatgt taatgtcagt cgaaagaaat gtattttagc
     1561 atctgaatga atttactggt aataatatta tccacacatt tgcaatggct ggcatctgct
     1621 ctattcccat tgctgtctgc aggctgtggg aatttcacct gtcaaaccaa actttccctc
     1681 tctgatgtgc actttgtttt tttcccagat tcgtcacaat gcctattgtc ccgcccttct
     1741 ttttgctttt tttctccatt ttgccatctg tctcttatga tttataaggg ggaaaaactt
     1801 gttttgttag agggccaggt tagaagtcat tgtataattt gtaggctttt gtaagggttg
     1861 aatgcaagcg tggaaattta ggctgaattc tctatcaaaa gaaaaaatgt gaaggaaaaa
     1921 ggaaaaatca ggagggagga ttgcttcatg cattatttat ctcgaccttt taggggagaa
     1981 ggaactcccc catcctttca agagattaaa aataaatcaa cagtctgaaa acctaagcag
     2041 acacggggca ttgccaggat cagccacaca cgtgtttcct tctatttatt ttgaagaaaa
     2101 atttcatggg aaagtatgta tttttttgta tattctacag agtttattct agtatgtatt
     2161 tacatcccga agaataagaa aattgttttg tgattaagct ataaataaag tatctaattt
     2221 tcataa
//
