LOCUS       NP_035026                244 aa            linear   ROD 06-MAY-2025
DEFINITION  neurogenin-1 [Mus musculus].
ACCESSION   NP_035026
VERSION     NP_035026.1
DBSOURCE    REFSEQ: accession NM_010896.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 244)
  AUTHORS   Kaplan,M.M., Hudacova,E., Matejcek,M., Tuaima,H., Krivanek,J. and
            Machon,O.
  TITLE     Mesenchymal Meis2 controls whisker development independently from
            trigeminal sensory innervation
  JOURNAL   Elife 13, 100854 (2025)
   PUBMED   40183774
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 244)
  AUTHORS   Amato,E. Jr., Taroc,E.Z.M. and Forni,P.E.
  TITLE     Illuminating the terminal nerve: Uncovering the link between GnRH-1
            neuron and olfactory development
  JOURNAL   J Comp Neurol 532 (3), e25599 (2024)
   PUBMED   38488687
REFERENCE   3  (residues 1 to 244)
  AUTHORS   Xu,M., Li,S., Xie,X., Guo,L., Yu,D., Zhuo,J., Lin,J., Kol,L. and
            Gan,L.
  TITLE     ISL1 and POU4F1 Directly Interact to Regulate the Differentiation
            and Survival of Inner Ear Sensory Neurons
  JOURNAL   J Neurosci 44 (8), e1718232024 (2024)
   PUBMED   38267260
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 244)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 244)
  AUTHORS   Vermeiren,S., Cabochette,P., Dannawi,M., Desiderio,S., San
            Jose,A.S., Achouri,Y., Kricha,S., Sitte,M., Salinas-Riester,G.,
            Vanhollebeke,B., Brunet,J.F. and Bellefroid,E.J.
  TITLE     Prdm12 represses the expression of the visceral neuron determinants
            Phox2a/b in developing somatosensory ganglia
  JOURNAL   iScience 26 (12), 108364 (2023)
   PUBMED   38025786
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 244)
  AUTHORS   Cau,E., Gradwohl,G., Fode,C. and Guillemot,F.
  TITLE     Mash1 activates a cascade of bHLH regulators in olfactory neuron
            progenitors
  JOURNAL   Development 124 (8), 1611-1621 (1997)
   PUBMED   9108377
REFERENCE   7  (residues 1 to 244)
  AUTHORS   Tamimi,R.M., Steingrimsson,E., Montgomery-Dyer,K., Copeland,N.G.,
            Jenkins,N.A. and Tapscott,S.J.
  TITLE     NEUROD2 and NEUROD3 genes map to human chromosomes 17q12 and
            5q23-q31 and mouse chromosomes 11 and 13, respectively
  JOURNAL   Genomics 40 (2), 355-357 (1997)
   PUBMED   9119405
REFERENCE   8  (residues 1 to 244)
  AUTHORS   Ma,Q., Kintner,C. and Anderson,D.J.
  TITLE     Identification of neurogenin, a vertebrate neuronal determination
            gene
  JOURNAL   Cell 87 (1), 43-52 (1996)
   PUBMED   8858147
REFERENCE   9  (residues 1 to 244)
  AUTHORS   McCormick,M.B., Tamimi,R.M., Snider,L., Asakura,A., Bergstrom,D.
            and Tapscott,S.J.
  TITLE     NeuroD2 and neuroD3: distinct expression patterns and
            transcriptional activation potentials within the neuroD gene family
  JOURNAL   Mol Cell Biol 16 (10), 5792-5800 (1996)
   PUBMED   8816493
REFERENCE   10 (residues 1 to 244)
  AUTHORS   Sommer,L., Ma,Q. and Anderson,D.J.
  TITLE     neurogenins, a novel family of atonal-related bHLH transcription
            factors, are putative mammalian neuronal determination genes that
            reveal progenitor cell heterogeneity in the developing CNS and PNS
  JOURNAL   Mol Cell Neurosci 8 (4), 221-241 (1996)
   PUBMED   9000438
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124395.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC062148.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..244
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.06 cM"
     Protein         1..244
                     /product="neurogenin-1"
                     /note="NGN-1; helix-loop-helix protein mATH-4C; neurogenic
                     differentiation factor 3; neurogenic
                     basic-helix-loop-helix protein; neurogenic differentiation
                     3"
                     /calculated_mol_wt=26169
     Region          1..27
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70660.1)"
     Region          39..82
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70660.1)"
     Region          83..154
                     /region_name="bHLH_TS_NGN1_NeuroD3"
                     /note="basic helix-loop-helix (bHLH) domain found in
                     neurogenin-1 (NGN-1) and similar proteins; cd19716"
                     /db_xref="CDD:381559"
     Site            order(95,99,101..103,105,110,128..131)
                     /site_type="other"
                     /note="putative DNA binding site [nucleotide binding]"
                     /db_xref="CDD:381559"
     Site            order(108..109,112..113,115..116,132,135,139,141..142,146,
                     148..149)
                     /site_type="other"
                     /note="putative dimer interface [polypeptide binding]"
                     /db_xref="CDD:381559"
     CDS             1..244
                     /gene="Neurog1"
                     /gene_synonym="AKA; bHLHa6; Math4C; Neurod3; ngn1"
                     /coded_by="NM_010896.3:249..983"
                     /db_xref="CCDS:CCDS26559.1"
                     /db_xref="GeneID:18014"
                     /db_xref="MGI:MGI:107754"
ORIGIN      
        1 mpapletcis dldcsssnss sdlssfltde edcarlqpla stsglsvpar rsapalsgas
       61 nvpgaqdeeq errrrrgrar vrseallhsl rrsrrvkand rernrmhnln aaldalrsvl
      121 psfpddtklt kietlrfayn yiwalaetlr ladqglpggs arerllppqc vpclpgppsp
      181 asdteswgsg aaaspcatva splsdpssps asedftygpg dplfsfpglp kdllhttpcf
      241 ipyh
//
