LOCUS       NM_009717               2154 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus neurogenic differentiation 6 (Neurod6), mRNA.
ACCESSION   NM_009717
VERSION     NM_009717.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2154)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2154)
  AUTHORS   Loganathan,S., Menegaz,D., Delling,J.P., Eder,M. and Deussing,J.M.
  TITLE     Cacna1c deficiency in forebrain glutamatergic neurons alters
            behavior and hippocampal plasticity in female mice
  JOURNAL   Transl Psychiatry 14 (1), 421 (2024)
   PUBMED   39370418
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2154)
  AUTHORS   Maroto,I.B., Costas-Insua,C., Montero-Fernandez,C.,
            Hermoso-Lopez,A., Lebouc,M., Bajo-Graneras,R., Alvaro-Blazquez,A.,
            Blazquez,C., Cannich,A., Marsicano,G., Martin,R., Baufreton,J.,
            Rodriguez-Crespo,I., Bellocchio,L. and Guzman,M.
  TITLE     GAP43 Located on Corticostriatal Terminals Restrains
            Novelty-Induced Hyperactivity in Mice
  JOURNAL   J Neurosci 44 (39), e0701242024 (2024)
   PUBMED   39168654
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2154)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2154)
  AUTHORS   Ma,Q., Yang,Z., Yang,C., Lin,M., Gong,M., Deng,P., He,M., Lu,Y.,
            Zhang,K., Pi,H., Qu,M., Yu,Z., Zhou,Z. and Chen,C.
  TITLE     A single-cell transcriptomic landscape of cadmium-hindered brain
            development in mice
  JOURNAL   Commun Biol 7 (1), 997 (2024)
   PUBMED   39147853
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2154)
  AUTHORS   Gradwohl,G., Fode,C. and Guillemot,F.
  TITLE     Restricted expression of a novel murine atonal-related bHLH protein
            in undifferentiated neural precursors
  JOURNAL   Dev Biol 180 (1), 227-241 (1996)
   PUBMED   8948587
REFERENCE   7  (bases 1 to 2154)
  AUTHORS   Isaka,F., Shimizu,C., Nakanishi,S. and Kageyama,R.
  TITLE     Genetic mapping of four mouse bHLH genes related to Drosophila
            proneural gene atonal
  JOURNAL   Genomics 37 (3), 400-402 (1996)
   PUBMED   8938455
REFERENCE   8  (bases 1 to 2154)
  AUTHORS   Ben-Arie,N., McCall,A.E., Berkman,S., Eichele,G., Bellen,H.J. and
            Zoghbi,H.Y.
  TITLE     Evolutionary conservation of sequence and expression of the bHLH
            protein Atonal suggests a conserved role in neurogenesis
  JOURNAL   Hum Mol Genet 5 (9), 1207-1216 (1996)
   PUBMED   8872459
REFERENCE   9  (bases 1 to 2154)
  AUTHORS   Shimizu,C., Akazawa,C., Nakanishi,S. and Kageyama,R.
  TITLE     MATH-2, a mammalian helix-loop-helix factor structurally related to
            the product of Drosophila proneural gene atonal, is specifically
            expressed in the nervous system
  JOURNAL   Eur J Biochem 229 (1), 239-248 (1995)
   PUBMED   7744035
REFERENCE   10 (bases 1 to 2154)
  AUTHORS   Bartholoma,A. and Nave,K.A.
  TITLE     NEX-1: a novel brain-specific helix-loop-helix protein with
            autoregulation and sustained expression in mature cortical neurons
  JOURNAL   Mech Dev 48 (3), 217-228 (1994)
   PUBMED   7545978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK144360.1, AK144377.1 and CJ237964.1.
            
            On Oct 24, 2007 this sequence version replaced NM_009717.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144360.1, AK144377.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1251              AK144360.1         2-1252
            1252-2149           AK144377.1         1086-1983
            2150-2154           CJ237964.1         462-466
FEATURES             Location/Qualifiers
     source          1..2154
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 27.53 cM"
     gene            1..2154
                     /gene="Neurod6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; Math2; Nex; Nex1m"
                     /note="neurogenic differentiation 6"
                     /db_xref="GeneID:11922"
                     /db_xref="MGI:MGI:106593"
     exon            1..300
                     /gene="Neurod6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; Math2; Nex; Nex1m"
                     /inference="alignment:Splign:2.1.0"
     exon            301..2154
                     /gene="Neurod6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; Math2; Nex; Nex1m"
                     /inference="alignment:Splign:2.1.0"
     CDS             322..1335
                     /gene="Neurod6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; Math2; Nex; Nex1m"
                     /note="protein NEX-1; protein atonal homolog 2;
                     helix-loop-helix protein mATH-2"
                     /codon_start=1
                     /product="neurogenic differentiation factor 6"
                     /protein_id="NP_033847.1"
                     /db_xref="CCDS:CCDS20168.1"
                     /db_xref="GeneID:11922"
                     /db_xref="MGI:MGI:106593"
                     /translation="MLTLPFDESVVMPESQMCRKFARQCEDQKQIKKPESFPKQVVLR
                     GKSIKRAPGEETEKEEEEEDREEEDENGLSRRRGLRKKKTTKLRLERVKFRRQEANAR
                     ERNRMHGLNDALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRIGKRPDLLT
                     FVQNLCKGLSQPTTNLVAGCLQLNARSFLMGQGGEAAHHTRSPYSTFYPPYHSPELAT
                     PPGHGTLDNSKSMKPYNYCSAYESFYESTSPECASPQFEGPLSPPPINYNGIFSLKQE
                     ETLDYGKNYNYGMHYCAVPPRGPLGQGAMFRLPTDSHFPYDLHLRSQSLTMQDELNAV
                     FHN"
     regulatory      1674..1679
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurod6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; Math2; Nex; Nex1m"
                     /note="hexamer: AATAAA"
     polyA_site      1696
                     /gene="Neurod6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; Math2; Nex; Nex1m"
                     /note="major polyA site"
     regulatory      1840..1845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Neurod6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; Math2; Nex; Nex1m"
                     /note="hexamer: ATTAAA"
     polyA_site      1878
                     /gene="Neurod6"
                     /gene_synonym="Atoh2; bHLHa2; Math-2; Math2; Nex; Nex1m"
                     /note="major polyA site"
ORIGIN      
        1 agtctaacct cctgtgttga tgcatgaatg ctggtaccca cttacaggga tgccagatga
       61 tcagtgcaga atgaaggtcc caagagagga tcacatggct ctctctgccc tgtgacgtca
      121 ctagcagatg gcatgggtac cagctctggc agttggcatc aatgtcactt tttagagatc
      181 aatgagatag tgcagataca cacagatcta gaggctccag gagacgatgc gacactcagc
      241 ctgaaaagat ttggaagatc caaaatgaaa actgattatt gaatgaaatt aaaacctaag
      301 gtaaattaag gttaaagaac catgttaaca ctaccgtttg acgagtctgt cgtaatgccc
      361 gaatcccaga tgtgcagaaa gtttgctaga caatgtgagg accagaaaca aattaagaaa
      421 ccagagagct ttccaaaaca agttgtcctt cgaggaaaga gcattaaaag ggcccctgga
      481 gaagaaaccg agaaagaaga ggaggaagaa gacagagagg aagaagatga gaatggcttg
      541 tccagaagga gggggctcag gaaaaaaaag accaccaaac tacgactgga aagggtcaag
      601 ttcaggagac aggaagctaa tgcgcgcgag aggaaccgga tgcacggcct caatgatgct
      661 ctggacaatt tgcgaaaagt ggtcccctgt tactctaaaa cccaaaaact gtccaaaata
      721 gaaactttac gactggccaa aaattacatc tgggcacttt ctgaaattct gaggattggc
      781 aagagaccgg atctgctcac gttcgtccaa aacttatgca aaggtctttc ccagccaact
      841 acaaacttgg tggcaggctg cttacagctc aacgccagaa gtttcctgat gggtcagggt
      901 ggggaggctg cccaccacac aaggtcaccc tactccacat tctacccacc ctaccacagc
      961 cctgagctgg ccactccccc agggcatggg actcttgata attccaagtc catgaaaccc
     1021 tacaattact gcagtgcata tgaatccttc tatgaaagta cctcccctga gtgtgccagc
     1081 cctcagtttg aaggtccctt aagtcctccc ccaattaact ataatgggat attttccctg
     1141 aagcaagaag aaaccttgga ctatggcaaa aattacaatt atggcatgca ttactgtgca
     1201 gtgccaccca ggggtcccct tgggcagggt gccatgttca ggttgcccac cgacagccac
     1261 ttcccttacg acttacatct gcgcagccaa tctctcacta tgcaagatga attaaatgca
     1321 gtttttcata attaatgagg aaaatgaaaa taaacagtgg tcattcacct cccactctaa
     1381 ttaaggcaaa gcagatgctt gtgggctgcg taattggcac aactctatct aaggtgttta
     1441 ctagtttctg aagtgtgtct caaagattgt gaccattttc tatgtcataa taaatccctt
     1501 ttcgtatgag aacttccttt ccttccctct tgtctgtatc acactgtgat tctctctctc
     1561 tctctctctc tctctctctc tctctctctc ttactggcag aatatttctt tcttgtttta
     1621 gtttctttca aattcactta atttgtttga acaaggtgtc taagatgttg ctgaataaag
     1681 acatgcacac agcatacttc aatgtctatt tcagttgtac agttatgatg aaaatgcatg
     1741 ttataaaaat cagatgagta aaatgtgttt ataattacta ggattcatat atgtatctct
     1801 gaaattttag tttttaaaat attaagagct aaccatgaaa ttaaaaggtg catttgggga
     1861 tgcacaacgg tatcaaaagc tatgcaattt tctgtttatt agggacaaaa ataagtgtat
     1921 tcagttggta acaactattc ctcttcaagc attttcagag gaggaaacac ggtatttggg
     1981 ggaggttatc agtgtcataa tttggggaca attaattcaa tcatgaagaa aaaaaatatt
     2041 agcacttgtt ttgtattgtt caggattttt ctgtacaggt ttgttacagt gtataattgt
     2101 gttttccatc ctacagttta aaagcaatta aacatagata tttccactta caaa
//
